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• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: ATF4.p2

Z-value: 1.342

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_+_128806720	2.514		PVT1	Pvt1 oncogene (non-protein coding)
chr6_+_139456240	2.246	NM_016217	HECA	headcase homolog (Drosophila)
chr12_-_123380628	1.917		VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr22_+_38597938	1.893	NM_001161572 NM_001161574 NM_012323	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr7_+_28448970	1.851		LOC401317	uncharacterized LOC401317
chr6_+_89791510	1.816		PNRC1	proline-rich nuclear receptor coactivator 1
chr6_-_91006580	1.783	NM_001170794	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr2_+_220408742	1.779	NM_001005209	TMEM198	transmembrane protein 198
chr12_-_123380682	1.774	NM_024667	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr22_+_38598065	1.731		MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr8_-_95274540	1.726	NM_005261 NM_181702	GEM	GTP binding protein overexpressed in skeletal muscle
chr6_-_91006460	1.669	NM_021813	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr1_+_212782103	1.647		ATF3	activating transcription factor 3
chr4_-_120375770	1.585
chr11_-_1593149	1.534	NM_004420	DUSP8	dual specificity phosphatase 8
chr8_-_95274520	1.477		GEM	GTP binding protein overexpressed in skeletal muscle
chr1_+_212781969	1.381	NM_001040619 NM_001206484 NM_001206488 NM_001674	ATF3	activating transcription factor 3
chr19_+_49375638	1.239	NM_014330	PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr19_+_49375677	1.238		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr19_+_49375679	1.201		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr10_+_134210691	1.183	NM_001098637 NM_138499	PWWP2B	PWWP domain containing 2B
chr19_+_45971249	1.169	NM_001114171 NM_006732	FOSB	FBJ murine osteosarcoma viral oncogene homolog B
chr2_+_96676277	1.143
chr5_-_172198160	1.129	NM_004417	DUSP1	dual specificity phosphatase 1
chr9_-_99382073	1.092	NM_003671 NM_033331	CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr9_-_110251754	1.077		KLF4	Kruppel-like factor 4 (gut)
chr7_-_45128492	1.040	NM_001146334	NACAD	NAC alpha domain containing
chr19_-_42721802	1.011	NM_133328	DEDD2	death effector domain containing 2
chr19_+_45504686	1.003	NM_006509	RELB	v-rel reticuloendotheliosis viral oncogene homolog B
chr19_-_47734215	0.920	NM_014417	BBC3	BCL2 binding component 3
chr11_-_77184549	0.844	NM_001128620 NM_002576	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1
chr5_-_16617085	0.840	NM_001034850	FAM134B	family with sequence similarity 134, member B
chr3_-_156877882	0.834		CCNL1	cyclin L1
chr9_-_110252045	0.829	NM_004235	KLF4	Kruppel-like factor 4 (gut)
chr2_-_202645573	0.806
chr4_-_111558150	0.804		PITX2	paired-like homeodomain 2
chr2_+_28615771	0.801	NM_005253	FOSL2	FOS-like antigen 2
chr3_+_194207685	0.800		FLJ34208	uncharacterized LOC401106
chr19_-_460995	0.799	NM_012435	SHC2	SHC (Src homology 2 domain containing) transforming protein 2
chr2_+_43864405	0.793		PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr20_-_62258422	0.790		GMEB2	glucocorticoid modulatory element binding protein 2
chr12_-_123380608	0.790
chr19_-_51014344	0.763	NM_138334	JOSD2	Josephin domain containing 2
chr3_-_8543327	0.755		LOC100288428	uncharacterized LOC100288428
chr6_+_135818938	0.747		LINC00271	long intergenic non-protein coding RNA 271
chr2_+_43864433	0.746	NM_172069	PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr11_-_66610703	0.744
chr1_+_149824180	0.744	NM_021059 NM_001005464	HIST2H3C HIST2H3A	histone cluster 2, H3c histone cluster 2, H3a
chr11_+_102217947	0.742	NM_001166	BIRC2	baculoviral IAP repeat containing 2
chr5_-_16509106	0.741	NM_019000	FAM134B	family with sequence similarity 134, member B
chr6_-_31939658	0.732		DOM3Z	dom-3 homolog Z (C. elegans)
chr2_+_28615668	0.714		FOSL2	FOS-like antigen 2
chr2_+_149632772	0.713	NM_004522	KIF5C	kinesin family member 5C
chr2_+_28615695	0.711		FOSL2	FOS-like antigen 2
chr2_-_201729351	0.698		CLK1	CDC-like kinase 1
chr8_-_11324184	0.688	NM_053279	FAM167A	family with sequence similarity 167, member A
chr11_+_64692052	0.688	NM_006244	PPP2R5B	protein phosphatase 2, regulatory subunit B', beta
chr9_+_102584136	0.664	NM_006981 NM_173199 NM_173200	NR4A3	nuclear receptor subfamily 4, group A, member 3
chr2_-_201729241	0.662	NM_001162407	CLK1	CDC-like kinase 1
chr3_+_141087298	0.661		ZBTB38	zinc finger and BTB domain containing 38
chr19_+_13263890	0.642		IER2	immediate early response 2
chr17_-_8151373	0.639	NM_025099	CTC1	CTS telomere maintenance complex component 1
chr11_+_62649160	0.638		SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr19_-_7553867	0.621	NM_080662	PEX11G	peroxisomal biogenesis factor 11 gamma
chr16_-_28414940	0.618		EIF3C	eukaryotic translation initiation factor 3, subunit C
chr20_-_62258330	0.613	NM_012384	GMEB2	glucocorticoid modulatory element binding protein 2
chr2_+_220408352	0.609		TMEM198	transmembrane protein 198
chr22_+_18121540	0.608		BCL2L13	BCL2-like 13 (apoptosis facilitator)
chr5_+_60628085	0.602	NM_020928	ZSWIM6	zinc finger, SWIM-type containing 6
chr5_+_78532338	0.601
chr2_+_74757243	0.595		HTRA2	HtrA serine peptidase 2
chr17_-_8151353	0.594		CTC1	CTS telomere maintenance complex component 1
chr9_+_70856838	0.589	NM_201453	CBWD5 CBWD3 CBWD6	COBW domain containing 5 COBW domain containing 3 COBW domain containing 6
chr19_+_35491225	0.577	NM_001136199 NM_020895	GRAMD1A	GRAM domain containing 1A
chr2_+_149632836	0.569		KIF5C	kinesin family member 5C
chr2_+_149633173	0.564
chr20_+_361675	0.558		TRIB3	tribbles homolog 3 (Drosophila)
chr2_-_201729377	0.547	NM_004071	CLK1	CDC-like kinase 1
chr2_+_10184371	0.542	NM_001177718	KLF11	Kruppel-like factor 11
chr4_-_104640828	0.541	NM_001059	TACR3	tachykinin receptor 3
chr1_+_201476283	0.539
chr15_+_76629101	0.529	NM_145805	ISL2	ISL LIM homeobox 2
chr20_+_34203746	0.524	NM_003116	SPAG4	sperm associated antigen 4
chr1_-_16482426	0.523	NM_004431	EPHA2	EPH receptor A2
chr2_+_220144024	0.518	NM_001039550 NM_006736	DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2
chr19_-_3971032	0.515		DAPK3	death-associated protein kinase 3
chr6_-_135818786	0.507		AHI1	Abelson helper integration site 1
chr14_+_105219516	0.507		SIVA1	SIVA1, apoptosis-inducing factor
chr10_+_38645293	0.506		HSD17B7P2	hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
chr19_-_38878663	0.501	NM_152657	GGN	gametogenetin
chr7_-_36406446	0.501	NM_001199707 NM_001199706 NM_015314 NM_001199708	KIAA0895	KIAA0895
chr17_+_25621105	0.498	NM_015626 NM_134265	WSB1	WD repeat and SOCS box containing 1
chr14_-_102976096	0.497	NM_152326	ANKRD9	ankyrin repeat domain 9
chr6_-_121655606	0.496	NM_152730	C6orf170	chromosome 6 open reading frame 170
chr4_+_75480628	0.493	NM_001657	AREG	amphiregulin
chr9_-_3525973	0.493	NM_002919 NM_134428	RFX3	regulatory factor X, 3 (influences HLA class II expression)
chr19_+_35491329	0.491		GRAMD1A	GRAM domain containing 1A
chr15_+_32933869	0.490	NM_001144757 NM_003020	SCG5	secretogranin V (7B2 protein)
chr5_+_139927182	0.486	NM_003732	EIF4EBP3	eukaryotic translation initiation factor 4E binding protein 3
chr14_-_103523619	0.485	NM_006035	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)
chr2_-_86850935	0.484		RNF103	ring finger protein 103
chr9_-_72873739	0.481		LOC100507299	uncharacterized LOC100507299
chr1_+_45266035	0.474	NM_004073	PLK3	polo-like kinase 3
chr8_-_101322180	0.467		RNF19A	ring finger protein 19A
chr5_-_178054089	0.466		CLK4	CDC-like kinase 4
chr2_+_113403433	0.460	NM_005415	SLC20A1	solute carrier family 20 (phosphate transporter), member 1
chr6_-_37225894	0.458	NM_001162900	TMEM217	transmembrane protein 217
chr15_-_64126112	0.458		HERC1	hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr3_+_187871473	0.449	NM_001167672	LPP	LIM domain containing preferred translocation partner in lipoma
chr19_-_4517715	0.448	NM_001080400	PLIN4	perilipin 4
chr2_-_86850959	0.447	NM_001198951 NM_001198952 NM_005667	RNF103	ring finger protein 103
chr9_-_131038196	0.447	NM_004486	GOLGA2	golgin A2
chr12_+_22778008	0.443	NM_001039481 NM_018638	ETNK1	ethanolamine kinase 1
chr1_+_87794150	0.441	NM_006769	LMO4	LIM domain only 4
chr18_+_23806385	0.440	NM_005640	TAF4B	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr2_-_220408264	0.438	NM_024536	CHPF	chondroitin polymerizing factor
chr1_-_155881063	0.437		RIT1	Ras-like without CAAX 1
chr15_-_48470319	0.434		MYEF2	myelin expression factor 2
chr17_-_36831156	0.433	NM_001130677	C17orf96	chromosome 17 open reading frame 96
chr3_+_50297644	0.433
chr3_+_150126705	0.432	NM_014779	TSC22D2	TSC22 domain family, member 2
chr12_-_125399146	0.430		UBC	ubiquitin C
chr18_+_76829391	0.430	NM_198531	ATP9B	ATPase, class II, type 9B
chr8_-_145025043	0.428	NM_201380	PLEC	plectin
chr9_-_131644176	0.423	NM_001122671 NM_001122672 NM_004059	CCBL1	cysteine conjugate-beta lyase, cytoplasmic
chr9_-_70490067	0.423
chr11_-_6633178	0.420		TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr3_-_99594915	0.419	NM_014890	FILIP1L	filamin A interacting protein 1-like
chr5_-_178054072	0.417		CLK4	CDC-like kinase 4
chr1_-_155881163	0.416	NM_006912	RIT1	Ras-like without CAAX 1
chr1_+_162760491	0.412	NM_016371	HSD17B7	hydroxysteroid (17-beta) dehydrogenase 7
chr1_+_45265896	0.411		PLK3	polo-like kinase 3
chr18_+_57567191	0.411	NM_021127	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
chr9_-_140353612	0.409		NELF	nasal embryonic LHRH factor
chrX_-_102565805	0.408	NM_001168399 NM_001168400 NM_001168401 NM_032621	BEX2	brain expressed X-linked 2
chr17_-_62833264	0.407		PLEKHM1P	pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chr5_+_108084638	0.406		FER	fer (fps/fes related) tyrosine kinase
chr1_+_70671375	0.403		SRSF11	serine/arginine-rich splicing factor 11
chr20_-_3388586	0.402		C20orf194	chromosome 20 open reading frame 194
chr1_+_6640094	0.399		ZBTB48	zinc finger and BTB domain containing 48
chr19_-_55628780	0.395	NM_017607	PPP1R12C	protein phosphatase 1, regulatory subunit 12C
chr14_-_77494974	0.395	NM_024496	IRF2BPL	interferon regulatory factor 2 binding protein-like
chr14_-_103523511	0.394
chr19_-_59066372	0.393		CHMP2A	charged multivesicular body protein 2A
chr12_-_49504612	0.392		LMBR1L	limb region 1 homolog (mouse)-like
chr22_+_18121446	0.390	NM_015367	BCL2L13	BCL2-like 13 (apoptosis facilitator)
chr17_+_25621141	0.389		WSB1	WD repeat and SOCS box containing 1
chr1_+_45266048	0.388		PLK3	polo-like kinase 3
chr3_+_140660639	0.386	NM_001104647 NM_018155	SLC25A36	solute carrier family 25, member 36
chr13_-_33002218	0.385	NM_001079691 NM_052818	N4BP2L1	NEDD4 binding protein 2-like 1
chr22_-_20427814	0.381		PI4KAP1	phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr6_-_90529426	0.379	NM_014611	MDN1	MDN1, midasin homolog (yeast)
chr2_-_73340058	0.377		RAB11FIP5	RAB11 family interacting protein 5 (class I)
chr9_+_34179036	0.377		UBAP1	ubiquitin associated protein 1
chr16_+_2039945	0.375	NM_004209	SYNGR3	synaptogyrin 3
chr7_+_157129659	0.373	NM_005494 NM_058246	DNAJB6 TMEM135	DnaJ (Hsp40) homolog, subfamily B, member 6 transmembrane protein 135
chr12_+_10365415	0.373	NM_031412	GABARAPL1	GABA(A) receptor-associated protein like 1
chr17_+_42385780	0.373	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr11_-_6440631	0.372	NM_145689	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chrX_+_153672449	0.371	NM_004699	FAM50A	family with sequence similarity 50, member A
chr7_+_1580009	0.371		MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr16_+_56966025	0.368		HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr4_-_186347037	0.367	NM_018359	UFSP2	UFM1-specific peptidase 2
chrX_+_48398162	0.367		TBC1D25	TBC1 domain family, member 25
chr17_-_62833246	0.365		PLEKHM1P	pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chr19_-_3971089	0.363		DAPK3	death-associated protein kinase 3
chr3_-_126076057	0.362	NM_014079	KLF15	Kruppel-like factor 15
chr4_-_926081	0.361		GAK	cyclin G associated kinase
chr2_-_288181	0.360	NM_001002919	FAM150B	family with sequence similarity 150, member B
chr5_+_78531848	0.359	NM_152405	JMY	junction mediating and regulatory protein, p53 cofactor
chr11_+_66059364	0.358	NM_153266	TMEM151A	transmembrane protein 151A
chr13_+_103249285	0.357	NM_003291	TPP2	tripeptidyl peptidase II
chr19_+_39897457	0.357	NM_003407	ZFP36	zinc finger protein 36, C3H type, homolog (mouse)
chr8_-_144623579	0.356		ZC3H3	zinc finger CCCH-type containing 3
chr2_-_68694389	0.356	NM_001024680	FBXO48	F-box protein 48
chr16_+_2022039	0.355		TBL3	transducin (beta)-like 3
chr19_-_5720155	0.355		LONP1	lon peptidase 1, mitochondrial
chr1_+_6640047	0.355	NM_005341	ZBTB48	zinc finger and BTB domain containing 48
chr9_-_140353785	0.354	NM_001130969 NM_001130970 NM_001130971 NM_001178064 NM_015537	NELF	nasal embryonic LHRH factor
chr7_+_17338182	0.354	NM_001621	AHR	aryl hydrocarbon receptor
chr11_+_9482511	0.353	NM_003442	ZNF143	zinc finger protein 143
chr19_+_18668652	0.352		KXD1	KxDL motif containing 1
chr9_-_140353748	0.349		NELF	nasal embryonic LHRH factor
chr9_-_90589360	0.348		CDK20	cyclin-dependent kinase 20
chr17_+_39845141	0.346		EIF1	eukaryotic translation initiation factor 1
chr2_-_216300770	0.346	NM_002026 NM_054034 NM_212474 NM_212476 NM_212478 NM_212482	FN1	fibronectin 1
chr10_-_18940515	0.345	NM_182543	NSUN6	NOP2/Sun domain family, member 6
chrX_+_153672490	0.344		FAM50A	family with sequence similarity 50, member A
chr10_+_121411071	0.344		BAG3	BCL2-associated athanogene 3
chr17_+_27071008	0.340	NM_004295	TRAF4	TNF receptor-associated factor 4
chr9_+_34179047	0.339		UBAP1	ubiquitin associated protein 1
chr10_-_64576074	0.338		EGR2	early growth response 2
chr17_+_40610899	0.338		ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1
chr12_+_110011499	0.337	NM_000431 NM_001114185	MVK	mevalonate kinase
chr19_+_17186569	0.337	NM_001130065 NM_004145	MYO9B	myosin IXB
chr16_-_89768094	0.336	NM_152339	SPATA2L	spermatogenesis associated 2-like
chr2_+_192542860	0.336	NM_001031716	OBFC2A	oligonucleotide/oligosaccharide-binding fold containing 2A
chr16_+_1756161	0.333	NM_001040439 NM_015133	MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3
chr9_+_34179023	0.331		UBAP1	ubiquitin associated protein 1
chr12_-_92539614	0.330	NM_001731	BTG1	B-cell translocation gene 1, anti-proliferative

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
2.23	2.07e-02	GO:0005634	nucleus

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
67.07	2.81e-04	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
144.39	2.17e-03	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
134.08	2.53e-03	GO:0033549	MAP kinase phosphatase activity
29.07	3.49e-03	GO:0004725	protein tyrosine phosphatase activity
6.11	6.02e-03	GO:0001071	nucleic acid binding transcription factor activity
6.11	6.02e-03	GO:0003700	sequence-specific DNA binding transcription factor activity
7.35	9.97e-03	GO:0043565	sequence-specific DNA binding
17.87	1.47e-02	GO:0004721	phosphoprotein phosphatase activity