Motif ID: EN1,2.p2

Z-value: 1.243


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2



Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_17282931 3.028 NM_153020
RBM24
RNA binding motif protein 24
chr2_-_87248942 2.079 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chrM_+_10123 1.962


chr17_-_63009302 1.292 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr2_-_152590983 1.284 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr11_+_62475113 1.121 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr2_-_145277879 1.085 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr10_+_114154522 0.993 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_41703938 0.991 NM_001167827
TFEB
transcription factor EB
chr7_+_28452143 0.966 NM_182898
CREB5
cAMP responsive element binding protein 5
chr6_-_43595046 0.862 GTPBP2
GTP binding protein 2
chr8_-_87755880 0.855 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr15_+_71433787 0.833 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr9_+_33026482 0.776 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr6_-_43595079 0.772 GTPBP2
GTP binding protein 2
chr13_+_42712177 0.761 NM_001204505
NM_001204506
DGKH

diacylglycerol kinase, eta

chr17_+_37821598 0.745 NM_003673
TCAP
titin-cap (telethonin)
chr9_+_74920329 0.727


chr19_+_41281281 0.723 NM_006533
MIA
melanoma inhibitory activity
chr1_-_27732069 0.691 WASF2
WAS protein family, member 2
chr7_+_28530747 0.624 CREB5
cAMP responsive element binding protein 5
chr17_+_7384720 0.621 NM_001102614
SLC35G6
solute carrier family 35, member G6
chr8_+_32579350 0.589 NM_001159996
NRG1
neuregulin 1
chr13_+_97874540 0.574 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr12_-_48597074 0.562 NM_001004134
OR10AD1
olfactory receptor, family 10, subfamily AD, member 1
chr4_-_88243994 0.550 NM_001136230
NM_178135
HSD17B13

hydroxysteroid (17-beta) dehydrogenase 13

chr11_+_6220375 0.538 NM_001005178
OR52W1
olfactory receptor, family 52, subfamily W, member 1
chr11_-_124253238 0.531 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr6_-_119470336 0.527 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr9_-_34691135 0.519 NM_006274
CCL19
chemokine (C-C motif) ligand 19
chr19_+_49376488 0.518 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr10_+_114133838 0.510 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_30652434 0.506 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr2_+_88047603 0.504 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr3_-_38992051 0.503 NM_014139
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr2_-_198540583 0.494 NM_144629
RFTN2
raftlin family member 2
chr5_-_145483877 0.491 NM_001029869
PLAC8L1
PLAC8-like 1
chr12_-_105322056 0.487 NM_032148
SLC41A2
solute carrier family 41, member 2
chr10_+_114133775 0.479 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_152702450 0.478 SYNE1
spectrin repeat containing, nuclear envelope 1
chr5_+_147582338 0.469 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr6_-_56507585 0.446 NM_001723
NM_015548
DST

dystonin

chr6_+_26273143 0.445 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr3_-_187452669 0.437 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr7_-_44105162 0.425 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr22_+_25591072 0.421 KIAA1671
KIAA1671
chr6_-_51952368 0.419 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr10_-_92680784 0.395 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr12_-_10978867 0.389 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr1_-_26680620 0.372 NM_001039775
AIM1L
absent in melanoma 1-like
chr6_-_53530505 0.364 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr10_-_65225605 0.363 NM_032776
JMJD1C
jumonji domain containing 1C
chr2_-_158182154 0.360 NM_020711
ERMN
ermin, ERM-like protein
chr19_-_45908288 0.352 NM_006663
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr12_-_18243052 0.351 NM_024730
RERGL
RERG/RAS-like
chr3_-_156878481 0.350 NM_020307
CCNL1
cyclin L1
chr1_-_42800902 0.347 NM_014947
FOXJ3
forkhead box J3
chr1_+_86934525 0.346 NM_001285
CLCA1
chloride channel accessory 1
chr15_+_93443559 0.344 CHD2
chromodomain helicase DNA binding protein 2
chr5_+_173472692 0.339 NM_015980
HMP19
HMP19 protein
chr11_+_65266642 0.338


chr1_-_150587879 0.336


chrX_+_30248552 0.331 NM_002365
MAGEB3
melanoma antigen family B, 3
chr4_+_74281884 0.329 ALB
albumin
chr9_-_96108695 0.328 NM_001098808
C9orf129
chromosome 9 open reading frame 129
chr15_+_93443418 0.323 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr12_-_15865847 0.320 EPS8
epidermal growth factor receptor pathway substrate 8
chr6_+_155411422 0.318 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr11_+_5968576 0.316 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr3_+_187870808 0.315 LPP
LIM domain containing preferred translocation partner in lipoma
chr12_+_21679190 0.315 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr19_-_14169970 0.310 NM_001145028
PALM3
paralemmin 3
chr6_-_41006927 0.309 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr10_-_62149487 0.308 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr21_-_34883620 0.306 GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr12_-_99548471 0.305 NM_001204068
NM_001204069
NM_001204070
NM_020140
NM_181670
NM_001204066
ANKS1B





ankyrin repeat and sterile alpha motif domain containing 1B





chr19_+_41281081 0.304 NM_001202553
MIA
melanoma inhibitory activity
chr6_+_116782555 0.304 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr12_-_10542616 0.298 NM_007360
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr15_+_86220267 0.295 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr2_-_26541916 0.294 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr5_-_64777703 0.294 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr2_-_158300517 0.292 NM_004288
CYTIP
cytohesin 1 interacting protein
chr5_+_68800003 0.283 NM_001205255
OCLN
occludin
chr1_-_42801529 0.283 NM_001198850
FOXJ3
forkhead box J3
chr6_+_42123143 0.283 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr2_-_161056573 0.281 NM_000888
ITGB6
integrin, beta 6
chr7_+_112120907 0.279 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr12_-_57630867 0.279 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr15_+_45021218 0.275 TRIM69
tripartite motif containing 69
chr7_+_141490016 0.272 NM_018980
TAS2R5
taste receptor, type 2, member 5
chr3_-_27498244 0.272 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr15_-_77176191 0.268 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr7_-_120498128 0.268 NM_012338
TSPAN12
tetraspanin 12
chr8_-_28347733 0.268 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr1_+_153940345 0.266 NM_130898
CREB3L4
cAMP responsive element binding protein 3-like 4
chr1_-_42800623 0.265 NM_001198851
FOXJ3
forkhead box J3
chr3_+_46448678 0.265 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chrX_-_76937157 0.259 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr13_+_97874704 0.258 MBNL2
muscleblind-like 2 (Drosophila)
chr12_+_75874512 0.258 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr8_+_11188494 0.256 NM_054028
SLC35G5
solute carrier family 35, member G5
chr6_-_31689455 0.256 NM_025261
LY6G6C
lymphocyte antigen 6 complex, locus G6C
chr11_-_26743545 0.255 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr4_+_89299874 0.255 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr1_-_150780705 0.255 NM_000396
CTSK
cathepsin K
chr10_+_13142055 0.253 NM_001008211
NM_001008212
NM_001008213
NM_021980
OPTN



optineurin



chr6_-_109775423 0.253 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr14_-_77889231 0.251 NM_001113475
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr1_+_201708648 0.250 NAV1
neuron navigator 1
chr10_+_99498233 0.246 NM_001002261
ZFYVE27
zinc finger, FYVE domain containing 27
chr1_+_16259046 0.246


chr10_+_104179570 0.246 NM_024326
FBXL15
F-box and leucine-rich repeat protein 15
chr2_-_145277568 0.244 ZEB2
zinc finger E-box binding homeobox 2
chr7_+_28338939 0.244 NM_182899
CREB5
cAMP responsive element binding protein 5
chr1_+_113236679 0.242 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr12_+_6554032 0.242 NM_001242
CD27
CD27 molecule
chr2_-_188312872 0.241 NM_005795
CALCRL
calcitonin receptor-like
chr11_-_5537815 0.241 NM_145053
UBQLNL
ubiquilin-like
chr3_+_138066489 0.237 NM_001252091
NM_012219
MRAS

muscle RAS oncogene homolog

chr4_-_74964996 0.237 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr10_-_104179468 0.236 PSD
pleckstrin and Sec7 domain containing
chrX_+_69488154 0.235 NM_004312
ARR3
arrestin 3, retinal (X-arrestin)
chrX_+_65384078 0.235 NM_001130860
NM_014799
HEPH

hephaestin

chr1_-_28520379 0.234 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr2_+_143635194 0.233 NM_001032998
NM_001199241
NM_003937
KYNU


kynureninase


chr11_-_101454658 0.231 NM_004621
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr15_-_45003513 0.231


chr1_+_32674694 0.231 NM_001099434
DCDC2B
doublecortin domain containing 2B
chr1_+_31882411 0.230 NM_001199038
SERINC2
serine incorporator 2
chr11_-_5863126 0.230 NM_001005167
OR52E6
olfactory receptor, family 52, subfamily E, member 6
chr20_+_54987167 0.230 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr7_-_141673572 0.224 NM_176817
TAS2R38
taste receptor, type 2, member 38
chr1_+_26503973 0.224 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr12_-_71148383 0.223 NM_130846
NM_001207016
PTPRR

protein tyrosine phosphatase, receptor type, R

chr21_-_40685418 0.221 BRWD1
bromodomain and WD repeat domain containing 1
chr4_-_40516567 0.219 RBM47
RNA binding motif protein 47
chr12_+_52056547 0.219 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr1_+_212797788 0.217 NM_153606
FAM71A
family with sequence similarity 71, member A
chr1_-_155774769 0.217 GON4L
gon-4-like (C. elegans)
chr18_+_32398225 0.217 NM_001198942
NM_001198944
NM_032980
NM_032981
DTNA



dystrobrevin, alpha



chr1_-_42800883 0.217 NM_001198852
FOXJ3
forkhead box J3
chr17_-_40828441 0.217 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr20_-_1309782 0.217 SDCBP2
syndecan binding protein (syntenin) 2
chr1_+_59775749 0.217 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chrX_+_100805415 0.216 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr7_+_140103842 0.216 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr10_-_94003002 0.213 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr3_-_183273407 0.213 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr1_-_145715561 0.212 NM_007053
CD160
CD160 molecule
chr13_+_73356179 0.211 NM_006346
PIBF1
progesterone immunomodulatory binding factor 1
chr12_+_56732658 0.211 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr5_-_43412417 0.209 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chrX_-_109683457 0.207 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr8_-_122653493 0.207 NM_005328
HAS2
hyaluronan synthase 2
chr1_+_33231260 0.205 KIAA1522
KIAA1522
chr3_-_114343791 0.203 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr9_-_34729463 0.203 NM_001141917
FAM205A
family with sequence similarity 205, member A
chr12_-_22089627 0.203 NM_005691
NM_020297
ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

chr21_+_34697277 0.202 IFNAR1
interferon (alpha, beta and omega) receptor 1
chr11_-_89956531 0.202 NM_001144073
NM_012124
CHORDC1

cysteine and histidine-rich domain (CHORD) containing 1

chr19_-_51472816 0.200 NM_002774
KLK6
kallikrein-related peptidase 6
chr6_-_31939658 0.198 DOM3Z
dom-3 homolog Z (C. elegans)
chr14_+_24838301 0.196 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr2_+_143635225 0.195 KYNU
kynureninase
chr3_+_69812620 0.194 NM_001184967
MITF
microphthalmia-associated transcription factor
chr11_-_121986800 0.194 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr12_-_57504088 0.193 NM_001178079
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr7_-_135412921 0.192 NM_012450
SLC13A4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr7_+_129906702 0.192 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr7_+_130020289 0.192 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr15_+_59903980 0.191 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr20_-_30288094 0.189


chr7_+_141463896 0.189 NM_016943
TAS2R3
taste receptor, type 2, member 3
chr1_+_33231227 0.189 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr22_+_50986461 0.188 NM_138433
KLHDC7B
kelch domain containing 7B
chr5_-_77844975 0.187 LHFPL2
lipoma HMGIC fusion partner-like 2
chr8_+_133879202 0.186 NM_003235
TG
thyroglobulin
chr3_-_111851967 0.186 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr1_+_203020310 0.185 NM_015053
PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr11_-_59633942 0.185 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr15_-_42386657 0.184 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr12_-_57914287 0.184 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr15_+_42696957 0.184 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr1_+_162351519 0.183 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr11_+_124439892 0.183 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr9_-_34662629 0.182 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr6_+_90272036 0.181 NM_001242811
ANKRD6
ankyrin repeat domain 6
chrX_+_128913897 0.180 SASH3
SAM and SH3 domain containing 3
chr13_+_50025687 0.180 NM_001160308
SETDB2
SET domain, bifurcated 2
chr7_-_20256942 0.178 NM_182762
MACC1
metastasis associated in colon cancer 1
chr3_-_114790221 0.177 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr12_+_7033625 0.177 NM_001007026
ATN1
atrophin 1
chr17_-_39093671 0.177 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr15_-_80263460 0.177 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr10_+_17270257 0.176 NM_003380
VIM
vimentin
chr17_-_62777621 0.176 LOC146880
Rho GTPase activating protein 27 pseudogene
chr1_+_223889253 0.176 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr7_+_112092112 0.176 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr10_+_70482210 0.175 CCAR1
cell division cycle and apoptosis regulator 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
124.29 1.55e-03 GO:0005834 heterotrimeric G-protein complex
98.31 2.49e-03 GO:0031234 extrinsic to internal side of plasma membrane
67.14 5.36e-03 GO:0019897 extrinsic to plasma membrane
52.90 8.66e-03 GO:0009898 internal side of plasma membrane
41.92 1.38e-02 GO:0019898 extrinsic to membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
844.48 1.81e-05 GO:0031702 type 1 angiotensin receptor binding
603.23 3.81e-05 GO:0031701 angiotensin receptor binding