Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 2.588


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
JUNDhg19_v1_chr19_-_18392413_183924350.941.3e-04Click!
FOSL1hg19_v1_chr11_-_65667860_656680370.941.8e-04Click!
FOSBhg19_v1_chr19_+_45971249_459712900.835.9e-03Click!
JUNBhg19_v1_chr19_+_12902295_129023320.827.3e-03Click!
FOShg19_v1_chr14_+_75745480_757456850.801.0e-02Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_58159386 9.323 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr1_+_223889253 7.645 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr4_+_74606222 7.295 NM_000584
IL8
interleukin 8
chr19_-_56056908 7.097 NM_001199824
SGK110
putative uncharacterized serine/threonine-protein kinase SgK110-like
chr5_+_176875325 6.198 NM_001174102
PRR7
proline rich 7 (synaptic)
chr19_-_47735858 6.009 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr13_+_97794050 5.345 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_28725597 5.061 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr19_-_46285645 4.987 DMPK
dystrophia myotonica-protein kinase
chr11_-_65667809 4.776 FOSL1
FOS-like antigen 1
chr19_+_49376488 4.737 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr2_+_28615771 4.549 NM_005253
FOSL2
FOS-like antigen 2
chr7_+_1577118 4.080 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr17_-_18907988 4.042 NM_001039999
FAM83G
family with sequence similarity 83, member G
chr9_-_34662629 4.012 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr1_-_45272956 3.985 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr7_+_28448970 3.983 LOC401317
uncharacterized LOC401317
chr19_-_40931880 3.900 NM_013376
SERTAD1
SERTA domain containing 1
chr13_-_41593405 3.885 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_+_52436116 3.820 NM_031290
CCDC70
coiled-coil domain containing 70
chr2_+_87754991 3.652 LINC00152
long intergenic non-protein coding RNA 152
chr19_+_38794800 3.561 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr2_+_28615695 3.550 FOSL2
FOS-like antigen 2
chr2_+_87755059 3.513 LINC00152
long intergenic non-protein coding RNA 152
chr1_+_212738675 3.508 NM_001030287
ATF3
activating transcription factor 3
chr13_-_110438896 3.491 NM_003749
IRS2
insulin receptor substrate 2
chr5_+_150020201 3.481 NM_001109974
NM_007286
SYNPO

synaptopodin

chr10_+_17270469 3.330 VIM
vimentin
chr11_-_65667860 3.280 NM_005438
FOSL1
FOS-like antigen 1
chr6_-_152702450 3.200 SYNE1
spectrin repeat containing, nuclear envelope 1
chr16_-_75301950 3.191 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr19_-_36019194 3.141 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr11_-_65150107 3.117 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr15_+_59903980 3.117 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr18_+_55888838 3.083 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_31648140 3.019 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr22_-_23974486 2.979 NM_016449
C22orf43
chromosome 22 open reading frame 43
chr11_-_67141647 2.961 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr6_-_44233499 2.952 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr15_+_59904090 2.950 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr7_+_18535351 2.949 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr11_-_10590078 2.948 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr6_-_41703938 2.913 NM_001167827
TFEB
transcription factor EB
chr15_+_89182038 2.901 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr4_+_108745718 2.897 NM_001136258
SGMS2
sphingomyelin synthase 2
chr18_+_55888750 2.896 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_223900212 2.866 CAPN2
calpain 2, (m/II) large subunit
chr13_-_41593491 2.858 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_-_44233244 2.857 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr1_+_223900226 2.847 CAPN2
calpain 2, (m/II) large subunit
chr2_-_145274916 2.794 ZEB2
zinc finger E-box binding homeobox 2
chr4_-_114900802 2.789 NM_024590
ARSJ
arylsulfatase family, member J
chr19_-_3969734 2.781 NM_001348
DAPK3
death-associated protein kinase 3
chr5_+_177540465 2.710 NM_015111
N4BP3
NEDD4 binding protein 3
chr1_+_223900328 2.703 CAPN2
calpain 2, (m/II) large subunit
chr10_+_17270257 2.691 NM_003380
VIM
vimentin
chr18_-_74207145 2.647 NM_014643
ZNF516
zinc finger protein 516
chr17_-_7493389 2.629 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr15_+_41136178 2.617 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_-_179112178 2.591 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr19_-_46285752 2.543 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr22_+_38598065 2.540 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr10_-_76868853 2.508 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr12_-_57914287 2.485 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr18_+_55888799 2.459 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr15_+_41136622 2.458 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr22_+_38597938 2.451 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr3_-_114343791 2.439 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr16_-_122573 2.409 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr16_-_4665002 2.353 FAM100A
family with sequence similarity 100, member A
chr14_+_55168831 2.336 SAMD4A
sterile alpha motif domain containing 4A
chr2_+_28615668 2.322 FOSL2
FOS-like antigen 2
chr11_+_62649160 2.314 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr1_-_244006471 2.288 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr6_-_41673677 2.278 TFEB
transcription factor EB
chr5_+_55149149 2.278 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr6_-_149806116 2.268 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr16_+_67571342 2.255 NM_001193524
FAM65A
family with sequence similarity 65, member A
chr13_+_97928414 2.255 MBNL2
muscleblind-like 2 (Drosophila)
chr6_-_46293215 2.241 RCAN2
regulator of calcineurin 2
chr8_+_126442557 2.234 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr5_+_179247903 2.212 SQSTM1
sequestosome 1
chr19_-_18385166 2.207 NM_001145304
NM_001145305
NM_025249
KIAA1683


KIAA1683


chr5_+_179247841 2.201 NM_003900
SQSTM1
sequestosome 1
chr8_-_103666018 2.200 NM_001032282
KLF10
Kruppel-like factor 10
chr10_+_104155431 2.179 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr16_+_50300461 2.177 ADCY7
adenylate cyclase 7
chr19_-_44008984 2.143 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr5_+_179247911 2.142 SQSTM1
sequestosome 1
chr6_+_138188352 2.138 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr14_+_55221505 2.124 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr21_-_37528578 2.110 LOC100506428
uncharacterized LOC100506428
chr11_-_65430427 2.098 NM_001145138
NM_001243984
NM_001243985
NM_021975
RELA



v-rel reticuloendotheliosis viral oncogene homolog A (avian)



chr17_+_74261280 2.082 NM_182565
FAM100B
family with sequence similarity 100, member B
chr15_+_78558522 2.065 NM_001130183
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr19_-_46285746 2.049 DMPK
dystrophia myotonica-protein kinase
chr13_+_42712177 2.040 NM_001204505
NM_001204506
DGKH

diacylglycerol kinase, eta

chr22_-_39529021 2.026 CBX7
chromobox homolog 7
chr9_+_103191795 2.010 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr1_+_156084458 2.003 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr17_+_74261431 1.973 FAM100B
family with sequence similarity 100, member B
chr13_+_97928196 1.960 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_156675237 1.945 NM_001878
NM_001199723
CRABP2

cellular retinoic acid binding protein 2

chr9_+_74920329 1.939


chr7_+_112063131 1.938 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr11_-_65430214 1.931 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr12_+_52445185 1.903 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr1_+_168545710 1.890 NM_002995
XCL1
chemokine (C motif) ligand 1
chr17_-_79881304 1.888 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr6_+_12290528 1.887 NM_001168319
NM_001955
EDN1

endothelin 1

chr13_-_101185944 1.846 NM_033110
A2LD1
AIG2-like domain 1
chr17_-_17399494 1.813 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr9_-_110252045 1.794 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr10_+_5238756 1.791 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr10_-_31288420 1.777 NM_001143769
ZNF438
zinc finger protein 438
chrX_-_48937560 1.775 NM_001029896
WDR45
WD repeat domain 45
chr3_+_141087298 1.775 ZBTB38
zinc finger and BTB domain containing 38
chr5_+_147582338 1.732 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr16_+_3115639 1.691 IL32
interleukin 32
chr11_-_2950593 1.683 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr6_-_152702329 1.674 SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_+_48128225 1.671 NM_181597
UPP1
uridine phosphorylase 1
chr15_+_86220267 1.670 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr1_+_186798031 1.659 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_+_49027281 1.654 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr5_-_90610218 1.652 LOC100505994
uncharacterized LOC100505994
chr14_+_68168602 1.640 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr12_-_15815073 1.636 EPS8
epidermal growth factor receptor pathway substrate 8
chr1_+_36621751 1.619 NM_018067
MAP7D1
MAP7 domain containing 1
chr16_-_4664780 1.612 FAM100A
family with sequence similarity 100, member A
chr3_-_9920633 1.610 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr4_+_87857394 1.606


chr12_-_56236614 1.590 NM_002429
MMP19
matrix metallopeptidase 19
chr12_-_39299335 1.587 NM_153634
CPNE8
copine VIII
chr5_+_145317297 1.585 SH3RF2
SH3 domain containing ring finger 2
chr2_-_73316782 1.574 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr16_+_30419363 1.562 ZNF771
zinc finger protein 771
chrX_-_48937457 1.546 WDR45
WD repeat domain 45
chr16_-_75272524 1.539 BCAR1
breast cancer anti-estrogen resistance 1
chr1_-_155006235 1.534 NM_144622
DCST2
DC-STAMP domain containing 2
chr2_-_85641128 1.527 CAPG
capping protein (actin filament), gelsolin-like
chr15_-_56209305 1.511 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr16_+_67563539 1.502 NM_001193523
FAM65A
family with sequence similarity 65, member A
chr4_+_108814419 1.478 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr1_-_27816542 1.462 WASF2
WAS protein family, member 2
chr1_+_156084541 1.440 LMNA
lamin A/C
chr11_-_65667858 1.439 FOSL1
FOS-like antigen 1
chr16_-_48266181 1.429 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr1_+_156084565 1.428 LMNA
lamin A/C
chr1_-_27816676 1.428 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chrX_+_153770458 1.416 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr7_-_100881030 1.400 NM_014343
CLDN15
claudin 15
chr3_-_9920471 1.397 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr9_-_139890984 1.391 NM_004669
CLIC3
chloride intracellular channel 3
chr1_+_168250277 1.379 NM_005149
TBX19
T-box 19
chr16_+_83986826 1.375 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr19_+_2476122 1.362 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr11_+_101918168 1.354 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr9_-_35111534 1.354 FAM214B
family with sequence similarity 214, member B
chr12_+_121416294 1.353 HNF1A
HNF1 homeobox A
chr12_+_7023490 1.351 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr10_+_88428263 1.348 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr17_-_8022134 1.337 NM_001165960
ALOXE3
arachidonate lipoxygenase 3
chr6_-_149806025 1.336 ZC3H12D
zinc finger CCCH-type containing 12D
chr6_-_31745048 1.332 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr11_-_128894008 1.331 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr10_+_104154228 1.314 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr2_-_85641153 1.310 CAPG
capping protein (actin filament), gelsolin-like
chr17_+_27573874 1.294 NM_005208
CRYBA1
crystallin, beta A1
chr17_+_79651072 1.289 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr13_-_60325073 1.286


chr1_-_27816667 1.286 WASF2
WAS protein family, member 2
chr20_-_1309782 1.279 SDCBP2
syndecan binding protein (syntenin) 2
chr14_-_23445885 1.271 AJUBA
ajuba LIM protein
chr13_-_30423599 1.268 UBL3
ubiquitin-like 3
chr10_-_62332666 1.263 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_36621457 1.262 MAP7D1
MAP7 domain containing 1
chr3_-_99833348 1.252 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr1_+_223900061 1.230 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr22_-_30642683 1.219 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr3_-_187454247 1.212 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr12_+_10365415 1.210 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr2_-_145275086 1.210 ZEB2
zinc finger E-box binding homeobox 2
chr6_+_33387846 1.209 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr19_-_1132109 1.206 NM_001100122
SBNO2
strawberry notch homolog 2 (Drosophila)
chr16_-_28607694 1.205 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr3_+_160394946 1.202 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr17_+_79651035 1.198 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr1_+_183155393 1.193 LAMC2
laminin, gamma 2
chrX_-_48900752 1.193 TFE3
transcription factor binding to IGHM enhancer 3
chr4_+_169753105 1.190 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr2_+_33359607 1.190 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr14_-_24020766 1.188 NM_033400
ZFHX2
zinc finger homeobox 2
chr5_+_59784004 1.185 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr5_-_141030934 1.177 FCHSD1
FCH and double SH3 domains 1
chr11_+_64692052 1.176 NM_006244
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr10_+_121410751 1.162 NM_004281
BAG3
BCL2-associated athanogene 3
chr21_+_30517897 1.159 C21orf7
chromosome 21 open reading frame 7
chrX_-_48900932 1.159 NM_006521
TFE3
transcription factor binding to IGHM enhancer 3
chr2_-_202563353 1.158 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.15 3.59e-04 GO:0048522 positive regulation of cellular process
2.02 1.04e-03 GO:0048518 positive regulation of biological process
2.90 2.65e-03 GO:0042127 regulation of cell proliferation
1.81 3.03e-03 GO:0080090 regulation of primary metabolic process
1.84 3.17e-03 GO:0060255 regulation of macromolecule metabolic process
1.96 4.46e-03 GO:0031326 regulation of cellular biosynthetic process
2.02 4.85e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.09 5.82e-03 GO:0006355 regulation of transcription, DNA-dependent
2.06 5.83e-03 GO:0051252 regulation of RNA metabolic process
1.94 6.02e-03 GO:0009889 regulation of biosynthetic process
29.79 7.46e-03 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
1.71 9.08e-03 GO:0019222 regulation of metabolic process
1.97 9.41e-03 GO:0010556 regulation of macromolecule biosynthetic process
2.90 1.15e-02 GO:0031328 positive regulation of cellular biosynthetic process
2.85 1.48e-02 GO:0009891 positive regulation of biosynthetic process
1.44 1.61e-02 GO:0050794 regulation of cellular process
1.91 1.95e-02 GO:0010468 regulation of gene expression
1.41 2.76e-02 GO:0050789 regulation of biological process
21.95 2.78e-02 GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein
2.40 2.83e-02 GO:0009893 positive regulation of metabolic process
1.38 3.71e-02 GO:0065007 biological regulation
13.04 3.77e-02 GO:0046425 regulation of JAK-STAT cascade
1.69 4.78e-02 GO:0031323 regulation of cellular metabolic process
1.46 4.79e-02 GO:0050896 response to stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.70 1.57e-03 GO:0001071 nucleic acid binding transcription factor activity
2.70 1.57e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
3.09 2.37e-03 GO:0043565 sequence-specific DNA binding
104.25 1.61e-02 GO:0019871 sodium channel inhibitor activity