Motif ID: GATA6.p2

Z-value: 1.697


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA6hg19_v1_chr18_+_19749403_197495500.147.2e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_36301999 3.240 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr12_+_25205180 2.857 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr11_-_115088628 2.791 CADM1
cell adhesion molecule 1
chr9_-_107665959 2.576 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr9_-_107666046 2.567 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chrX_-_105282714 2.392 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_+_186383770 2.355 NM_000412
HRG
histidine-rich glycoprotein
chr4_+_151503076 1.656 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr8_+_79428335 1.578 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr13_-_28543143 1.543 CDX2
caudal type homeobox 2
chr12_+_25205488 1.513 LRMP
lymphoid-restricted membrane protein
chr2_-_179914785 1.513 NM_173648
CCDC141
coiled-coil domain containing 141
chr8_-_38008332 1.512 NM_000349
STAR
steroidogenic acute regulatory protein
chr13_-_28543423 1.497 CDX2
caudal type homeobox 2
chr22_+_35462125 1.493 NM_001008494
ISX
intestine-specific homeobox
chr6_-_49712055 1.484 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr2_+_27719702 1.430 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr20_+_43029973 1.403 HNF4A
hepatocyte nuclear factor 4, alpha
chr20_+_12989616 1.366 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr6_-_134498973 1.364 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr10_-_129691202 1.302 NM_152311
CLRN3
clarin 3
chr19_+_10397642 1.299 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr16_-_46782104 1.264 NM_182493
MYLK3
myosin light chain kinase 3
chr2_+_44066102 1.260 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chrX_+_106161589 1.249 NM_001171095
CLDN2
claudin 2
chr6_-_30128688 1.240 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr8_-_30002199 1.238 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr1_+_215178884 1.202 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr10_-_129691047 1.179


chr4_+_69962191 1.153 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr12_+_7169192 1.136


chr11_+_89392464 1.103 NM_153696
FOLH1B
folate hydrolase 1B
chrX_+_106163605 1.093 NM_020384
CLDN2
claudin 2
chr15_-_50838901 1.077 NM_203494
USP50
ubiquitin specific peptidase 50
chr20_+_43029865 1.047 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr1_-_173176314 1.018 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr20_-_39928708 0.984 NM_015035
ZHX3
zinc fingers and homeoboxes 3
chr1_+_171217632 0.983 NM_002021
FMO1
flavin containing monooxygenase 1
chr1_-_155211049 0.983 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chrX_-_112066353 0.970 NM_001113490
AMOT
angiomotin
chr11_+_121461070 0.950 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr7_-_99332715 0.914 NM_000765
CYP3A7
CYP3A5
cytochrome P450, family 3, subfamily A, polypeptide 7
cytochrome P450, family 3, subfamily A, polypeptide 5
chr12_+_53818864 0.885 AMHR2
anti-Mullerian hormone receptor, type II
chr1_-_190446701 0.884 NM_199051
FAM5C
family with sequence similarity 5, member C
chr13_-_28543290 0.875 NM_001265
CDX2
caudal type homeobox 2
chrX_-_64196268 0.859 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr11_-_116708334 0.855 NM_000039
APOA1
apolipoprotein A-I
chr9_-_215892 0.852 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr16_-_49860917 0.842 NM_015069
ZNF423
zinc finger protein 423
chrX_-_15402469 0.834 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr2_+_220436953 0.823 NM_002191
INHA
inhibin, alpha
chr22_-_37584254 0.815 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr3_-_119379269 0.813 NM_022135
POPDC2
popeye domain containing 2
chr7_-_92855780 0.796 NM_001039372
HEPACAM2
HEPACAM family member 2
chr6_-_87804773 0.792 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr5_-_59783885 0.762 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_+_51176623 0.761 NM_001097
ACR
acrosin
chr5_-_35118223 0.759 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr1_-_197036350 0.750 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr8_-_20112691 0.750 NM_021020
LZTS1
leucine zipper, putative tumor suppressor 1
chr5_-_111312522 0.747 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr9_+_273025 0.738 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr1_+_101185195 0.719 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr7_-_150945731 0.703 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr7_+_94292737 0.692 PEG10
paternally expressed 10
chr2_-_99279935 0.691 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr19_+_15751706 0.684 NM_000896
NM_001199208
NM_001199209
CYP4F3


cytochrome P450, family 4, subfamily F, polypeptide 3


chr4_-_186697065 0.682 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr1_-_226187019 0.665 C1orf55
chromosome 1 open reading frame 55
chrX_-_24690740 0.665 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr4_+_39408541 0.665 KLB
klotho beta
chr10_+_115310589 0.664 NM_001177660
HABP2
hyaluronan binding protein 2
chr6_-_52668599 0.649 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr4_-_164534656 0.649 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr1_-_27240430 0.641 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr16_+_24802421 0.641 TNRC6A
trinucleotide repeat containing 6A
chr10_+_75673346 0.633 PLAU
plasminogen activator, urokinase
chr1_-_55089068 0.625 NM_176782
FAM151A
family with sequence similarity 151, member A
chr3_-_15563160 0.621 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr4_+_120056938 0.615 NM_016599
MYOZ2
myozenin 2
chr4_-_159094163 0.599 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr2_+_211458078 0.599 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr3_-_187009469 0.596 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr22_+_35779103 0.589 HMOX1
heme oxygenase (decycling) 1
chr2_-_88427535 0.585 NM_001443
FABP1
fatty acid binding protein 1, liver
chr18_+_29171729 0.582 NM_000371
TTR
transthyretin
chrX_+_107288199 0.576 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr3_+_100328432 0.571 NM_032787
GPR128
G protein-coupled receptor 128
chr9_+_684193 0.567


chr12_+_123944385 0.561 NM_180699
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr7_-_150945701 0.549 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_-_33647626 0.548 NM_018207
TRIM62
tripartite motif containing 62
chr10_-_14816895 0.547 NM_031453
FAM107B
family with sequence similarity 107, member B
chr2_-_74570533 0.542 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr10_+_24755440 0.532 KIAA1217
KIAA1217
chr11_+_118958696 0.531 NM_001024382
HMBS
hydroxymethylbilane synthase
chr12_+_9142136 0.530 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr5_+_140557370 0.524 NM_019120
PCDHB8
protocadherin beta 8
chr7_+_95115212 0.521 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr1_-_149858114 0.518 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr12_-_23737507 0.515 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chrX_-_55020510 0.511 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr19_-_36303766 0.506 PRODH2
proline dehydrogenase (oxidase) 2
chr17_-_10372875 0.504 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr20_-_45976626 0.503 ZMYND8
zinc finger, MYND-type containing 8
chr18_-_64271215 0.500 NM_021153
CDH19
cadherin 19, type 2
chr11_+_123986103 0.495 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr17_+_43224683 0.491 NM_006460
HEXIM1
hexamethylene bis-acetamide inducible 1
chrX_-_10851808 0.491 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_24755459 0.490 KIAA1217
KIAA1217
chr12_-_14849427 0.483 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr3_-_57234279 0.480 NM_003865
HESX1
HESX homeobox 1
chr1_-_120311466 0.479 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr4_+_155484131 0.478 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr7_+_73245192 0.474 NM_001305
CLDN4
claudin 4
chrX_-_24665225 0.468 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr1_-_232651227 0.459 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr11_+_61248584 0.459 NM_001170753
NM_145017
PPP1R32

protein phosphatase 1, regulatory subunit 32

chr3_+_49568370 0.458 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr1_-_226187027 0.454 C1orf55
chromosome 1 open reading frame 55
chr17_-_56084590 0.452 SRSF1
serine/arginine-rich splicing factor 1
chr14_-_65409445 0.440 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr7_-_107880492 0.433 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr1_+_63063186 0.433 NM_014495
ANGPTL3
angiopoietin-like 3
chr8_+_120079423 0.432 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr9_-_97356007 0.430 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chrX_-_100129127 0.427 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr6_-_2840683 0.427 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr2_+_189839078 0.424 NM_000090
COL3A1
collagen, type III, alpha 1
chr19_+_36132646 0.423 NM_014209
ETV2
ets variant 2
chrX_-_10535476 0.419 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr20_+_54967692 0.419 NM_001033522
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr15_-_76304762 0.414 NM_138573
NRG4
neuregulin 4
chr2_+_189839132 0.414 COL3A1
collagen, type III, alpha 1
chr18_-_21891469 0.412 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr21_-_35899046 0.411 NM_203418
RCAN1
regulator of calcineurin 1
chr1_+_81771844 0.409 LPHN2
latrophilin 2
chr17_-_56084571 0.405 SRSF1
serine/arginine-rich splicing factor 1
chrX_-_100307042 0.404 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr2_+_96991934 0.400 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-trisphosphate receptor interacting protein-like 1

chr12_+_86268072 0.398 NM_006183
NTS
neurotensin
chr5_+_42549657 0.396 NM_001242404
GHR
growth hormone receptor
chr11_+_72983246 0.391 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr5_+_140579182 0.389 NM_018931
PCDHB11
protocadherin beta 11
chr16_+_24788568 0.388 TNRC6A
trinucleotide repeat containing 6A
chr1_-_217113007 0.387 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr6_+_130339715 0.383 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr19_+_20959109 0.380


chr5_-_154230212 0.374 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr13_-_46756295 0.373 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_+_140602914 0.373 NM_018934
PCDHB14
protocadherin beta 14
chr17_-_72869068 0.369 NM_004110
NM_024417
FDXR

ferredoxin reductase

chr12_-_57410275 0.367 NM_001178054
NM_013251
TAC3

tachykinin 3

chr22_+_21128378 0.367 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr15_-_55652777 0.364 CCPG1
cell cycle progression 1
chr9_+_118916069 0.364 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr7_+_128379452 0.363 CALU
calumenin
chr7_+_128379400 0.363 CALU
calumenin
chr3_-_112359863 0.362 CCDC80
coiled-coil domain containing 80
chr7_+_129932973 0.362 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr1_+_43291230 0.358 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr7_+_128379428 0.358 CALU
calumenin
chr12_+_56075329 0.357 NM_152637
METTL7B
methyltransferase like 7B
chr1_-_39347258 0.354 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP readthrough
gap junction protein, alpha 9, 59kDa
chr1_+_180897572 0.352


chr3_-_168864325 0.352 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr3_+_158991090 0.345 SCHIP1
schwannomin interacting protein 1
chr5_-_35048239 0.344 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr5_+_42565963 0.340 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr8_-_95449131 0.339 NM_001205263
RAD54B
RAD54 homolog B (S. cerevisiae)
chr3_+_113616317 0.335 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr17_-_38721701 0.333 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr6_-_117996369 0.330


chr19_-_13213513 0.330 LYL1
lymphoblastic leukemia derived sequence 1
chr5_-_73937248 0.327 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr7_+_94297448 0.326 PEG10
paternally expressed 10
chr20_+_54967405 0.320 NM_001033521
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr1_+_66458389 0.318 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_-_31514620 0.313 NM_001204078
NM_130463
NM_138282
ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chrX_-_119445306 0.310 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr9_-_75567915 0.310 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr1_-_226187055 0.310 NM_152608
C1orf55
chromosome 1 open reading frame 55
chr1_+_244214576 0.307 ZNF238
zinc finger protein 238
chr2_+_201450579 0.306 AOX1
aldehyde oxidase 1
chr4_-_186733372 0.304 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr1_+_26644458 0.303 CD52
CD52 molecule
chr3_+_195943382 0.302 NM_152672
OSTalpha
organic solute transporter alpha
chr1_-_226186987 0.300 C1orf55
chromosome 1 open reading frame 55
chr4_-_70518964 0.299 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr3_-_186262114 0.298 NM_017541
CRYGS
crystallin, gamma S
chr11_-_57195052 0.298 NM_017611
SLC43A3
solute carrier family 43, member 3
chr21_-_43771069 0.297 NM_005423
TFF2
trefoil factor 2
chr12_+_53645369 0.296 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr13_-_49975734 0.296 NM_030925
CAB39L
calcium binding protein 39-like
chr14_+_100203998 0.295 EML1
echinoderm microtubule associated protein like 1
chr19_+_10781648 0.295 ILF3
interleukin enhancer binding factor 3, 90kDa
chr2_-_165551178 0.292 COBLL1
COBL-like 1
chr17_+_7517263 0.290 SHBG
sex hormone-binding globulin
chr4_-_76957139 0.289 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr17_-_64225496 0.287 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
36.59 8.75e-04 GO:0055088 lipid homeostasis
172.35 1.27e-02 GO:0055091 phospholipid homeostasis
6.51 1.43e-02 GO:0051049 regulation of transport
150.81 1.70e-02 GO:0034694 response to prostaglandin stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
109.69 8.03e-03 GO:0017127 cholesterol transporter activity
92.82 1.14e-02 GO:0015248 sterol transporter activity