Motif ID: GTF2A1,2.p2

Z-value: 2.147


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GTF2A1hg19_v1_chr14_-_81687574_816875740.373.3e-01Click!
GTF2A2hg19_v1_chr15_-_59949536_59949765-0.294.5e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_145483877 4.320 NM_001029869
PLAC8L1
PLAC8-like 1
chr14_+_75745480 3.698 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr2_+_28616360 3.444 FOSL2
FOS-like antigen 2
chr11_-_1593149 3.339 NM_004420
DUSP8
dual specificity phosphatase 8
chr19_-_45909566 3.218 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr1_+_203274646 3.016 NM_006763
BTG2
BTG family, member 2
chr2_+_28616346 2.835 FOSL2
FOS-like antigen 2
chr3_+_50304989 2.675 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr2_+_28615695 2.392 FOSL2
FOS-like antigen 2
chr2_+_28615771 2.336 NM_005253
FOSL2
FOS-like antigen 2
chr9_+_35538890 2.154 RUSC2
RUN and SH3 domain containing 2
chr19_+_13906207 2.109 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr12_-_49504337 2.084 LMBR1L
limb region 1 homolog (mouse)-like
chr9_+_92219926 2.071 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr19_+_10222196 2.042 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr6_-_31689455 2.001 NM_025261
LY6G6C
lymphocyte antigen 6 complex, locus G6C
chr17_-_63557615 1.967 NM_004655
AXIN2
axin 2
chr19_+_48828627 1.929 NM_001425
EMP3
epithelial membrane protein 3
chr11_+_64692052 1.884 NM_006244
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr1_+_201979747 1.855 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr1_-_221915458 1.850 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr1_+_86046434 1.845 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr1_+_206643830 1.836 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr11_+_59522905 1.826 STX3
syntaxin 3
chr4_+_118955499 1.790 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr7_-_41742666 1.788 NM_002192
INHBA
inhibin, beta A
chr6_+_26104103 1.775 NM_003542
HIST2H4B
HIST1H4C
histone cluster 2, H4b
histone cluster 1, H4c
chr2_-_145277879 1.739 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr8_-_11324184 1.736 NM_053279
FAM167A
family with sequence similarity 167, member A
chr12_-_125399146 1.702 UBC
ubiquitin C
chr1_+_206643786 1.679 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr9_+_35538628 1.656 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr17_-_63557764 1.656 AXIN2
axin 2
chr1_-_221915426 1.598 DUSP10
dual specificity phosphatase 10
chr2_+_28615668 1.573 FOSL2
FOS-like antigen 2
chr19_+_55795766 1.562 BRSK1
BR serine/threonine kinase 1
chr22_-_41032684 1.545 NM_020831
MKL1
megakaryoblastic leukemia (translocation) 1
chr1_-_221915393 1.541 DUSP10
dual specificity phosphatase 10
chr2_+_132250500 1.540 LOC150776
sphingomyelin phosphodiesterase 4, neutral membrane pseudogene
chr1_+_168545710 1.529 NM_002995
XCL1
chemokine (C motif) ligand 1
chr1_+_206643585 1.504 NM_001193321
NM_001193322
NM_014002
IKBKE


inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon


chr17_+_7255427 1.502 KCTD11
potassium channel tetramerisation domain containing 11
chr2_-_198540583 1.457 NM_144629
RFTN2
raftlin family member 2
chr17_-_80009237 1.447 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr19_+_13263890 1.446 IER2
immediate early response 2
chr22_-_41032623 1.412 MKL1
megakaryoblastic leukemia (translocation) 1
chr11_+_66025070 1.411 NM_001134776
NM_001134774
NM_022822
KLC2


kinesin light chain 2


chr11_+_59522801 1.410 STX3
syntaxin 3
chr7_+_28530747 1.397 CREB5
cAMP responsive element binding protein 5
chr16_+_3162555 1.396 NM_001042428
NM_003456
ZNF205

zinc finger protein 205

chr17_+_41006094 1.393 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr9_+_131580719 1.363 NM_004435
ENDOG
endonuclease G
chr19_+_40697516 1.329 NM_002446
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr22_-_24096551 1.325 NM_013378
VPREB3
pre-B lymphocyte 3
chr15_-_74284518 1.310 NM_004809
STOML1
stomatin (EPB72)-like 1
chr20_+_61867234 1.292 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr11_-_73720281 1.277 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr21_-_43735462 1.264 TFF3
trefoil factor 3 (intestinal)
chr12_-_125399586 1.259 NM_021009
UBC
ubiquitin C
chr15_-_44969085 1.248 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr6_+_31783314 1.220 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr22_+_31487315 1.217 SMTN
smoothelin
chr2_+_242498118 1.212 NM_032515
BOK
BCL2-related ovarian killer
chr22_-_39268169 1.209 CBX6
chromobox homolog 6
chr12_-_76425207 1.196 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr3_-_53381533 1.187 NM_018403
DCP1A
DCP1 decapping enzyme homolog A (S. cerevisiae)
chr7_-_151071696 1.181


chr1_+_181057835 1.179 IER5
immediate early response 5
chr19_+_56153417 1.173 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr11_-_64825992 1.164 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr6_-_41006927 1.162 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr9_+_12693385 1.159 NM_000550
TYRP1
tyrosinase-related protein 1
chr17_+_37821598 1.131 NM_003673
TCAP
titin-cap (telethonin)
chr16_+_3115641 1.125 NM_001012632
NM_001012636
IL32

interleukin 32

chr19_+_48828820 1.125 EMP3
epithelial membrane protein 3
chr18_+_32335939 1.114 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr11_-_1619481 1.112 NM_001004325
KRTAP5-2
keratin associated protein 5-2
chr11_+_66024746 1.097 NM_001134775
KLC2
kinesin light chain 2
chr19_+_36239445 1.078 LIN37
lin-37 homolog (C. elegans)
chr22_-_39268214 1.063 CBX6
chromobox homolog 6
chr16_-_75282137 1.059 NM_001170719
BCAR1
breast cancer anti-estrogen resistance 1
chr2_+_30369749 1.059 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr18_-_74728963 1.051 MBP
myelin basic protein
chr2_+_205410465 1.037 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr19_+_2476122 1.030 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr12_-_49504646 1.024 NM_018113
LMBR1L
limb region 1 homolog (mouse)-like
chr9_-_29738 1.019 NM_182905
WASH1
WAS protein family homolog 1
chr6_+_43139190 1.013 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr15_+_32933869 1.011 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr11_+_118978087 1.009 NM_014807
C2CD2L
C2CD2-like
chr16_+_3115639 1.009 IL32
interleukin 32
chr7_+_100770378 1.006 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr12_-_49504612 0.999 LMBR1L
limb region 1 homolog (mouse)-like
chr6_-_46293215 0.987 RCAN2
regulator of calcineurin 2
chr12_-_371994 0.981 NM_001190997
NM_001243392
NM_016615
SLC6A13


solute carrier family 6 (neurotransmitter transporter, GABA), member 13


chr12_-_49582296 0.979 TUBA1A
tubulin, alpha 1a
chr19_+_47523045 0.976 NPAS1
neuronal PAS domain protein 1
chr2_-_88926863 0.974 NM_004836
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3
chr15_+_59908908 0.970 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr6_-_29527477 0.969 UBD
ubiquitin D
chr19_-_50316360 0.960 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr1_+_181057637 0.958 NM_016545
IER5
immediate early response 5
chr11_+_118978169 0.951 C2CD2L
C2CD2-like
chr11_+_13299260 0.943 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr1_+_78470593 0.939 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr12_-_46766563 0.937 NM_018976
SLC38A2
solute carrier family 38, member 2
chr16_+_83986826 0.934 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr19_-_55881740 0.928 NM_000641
IL11
interleukin 11
chr3_-_99594915 0.927 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr1_+_205473683 0.925 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr12_-_46766019 0.922 SLC38A2
solute carrier family 38, member 2
chr12_-_49582800 0.922 NM_006009
TUBA1A
tubulin, alpha 1a
chr16_+_50300461 0.922 ADCY7
adenylate cyclase 7
chr6_+_30130982 0.919 NM_033229
TRIM15
tripartite motif containing 15
chr12_+_52463746 0.905 NM_001098673
NM_021934
C12orf44

chromosome 12 open reading frame 44

chr11_+_46299161 0.895 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr1_+_22138757 0.892 NM_001013693
LDLRAD2
low density lipoprotein receptor class A domain containing 2
chr1_-_16482426 0.888 NM_004431
EPHA2
EPH receptor A2
chr17_-_41985112 0.888 NM_005374
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr4_-_74904329 0.887 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr12_+_52056547 0.886 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr6_-_53013581 0.885 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr17_+_26698666 0.880 SARM1
sterile alpha and TIR motif containing 1
chr17_-_80009649 0.872 NM_002917
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_-_63536112 0.867 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr22_-_42526792 0.866 CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr22_+_23522911 0.863 BCR
breakpoint cluster region
chr19_-_1479176 0.850 C19orf25
chromosome 19 open reading frame 25
chr22_+_31031672 0.837 NM_001001479
SLC35E4
solute carrier family 35, member E4
chrX_+_147800610 0.821 NM_001170628
AFF2
AF4/FMR2 family, member 2
chr3_-_109035239 0.821 NM_138815
DPPA2
developmental pluripotency associated 2
chr1_+_205473768 0.819 CDK18
cyclin-dependent kinase 18
chr12_-_109027615 0.819 SELPLG
selectin P ligand
chr16_-_3030473 0.817 NM_004203
NM_182687
PKMYT1

protein kinase, membrane associated tyrosine/threonine 1

chr14_-_92198383 0.809 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr12_-_22089627 0.804 NM_005691
NM_020297
ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

chr12_+_52463774 0.803 C12orf44
chromosome 12 open reading frame 44
chr3_-_42814734 0.800 NM_144719
CCDC13
coiled-coil domain containing 13
chr7_+_73082157 0.799 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr15_-_73661141 0.798 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr19_-_46389307 0.785 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr7_+_112120907 0.784 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr7_+_116395440 0.783


chr20_-_43729607 0.782 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr6_+_144607449 0.775 UTRN
utrophin
chr7_-_16505292 0.770 NM_015464
SOSTDC1
sclerostin domain containing 1
chrX_+_70521627 0.768 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr20_+_51588945 0.766 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr17_+_78935063 0.762 RPTOR
regulatory associated protein of MTOR, complex 1
chr6_-_43595079 0.755 GTPBP2
GTP binding protein 2
chr9_-_104145800 0.748 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr13_+_52436116 0.747 NM_031290
CCDC70
coiled-coil domain containing 70
chr10_-_116392099 0.747 ABLIM1
actin binding LIM protein 1
chr5_+_76382458 0.744 LOC728723
uncharacterized LOC728723
chr6_+_43139201 0.741 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr6_-_86388419 0.739 SNHG5
small nucleolar RNA host gene 5 (non-protein coding)
chr2_+_30369800 0.733 YPEL5
yippee-like 5 (Drosophila)
chr6_-_13615386 0.727


chr19_+_2222415 0.726 DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr22_-_39268230 0.722 NM_014292
CBX6
chromobox homolog 6
chr22_-_38668943 0.721 TMEM184B
transmembrane protein 184B
chr2_-_145277568 0.718 ZEB2
zinc finger E-box binding homeobox 2
chr17_-_41984888 0.712 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr22_-_38668966 0.711 NM_001195072
NM_012264
TMEM184B

transmembrane protein 184B

chr1_+_16010816 0.708 NM_015164
PLEKHM2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr18_-_47806361 0.702 NM_001204151
MBD1
methyl-CpG binding domain protein 1
chr5_+_150020201 0.702 NM_001109974
NM_007286
SYNPO

synaptopodin

chr17_-_39092714 0.700 KRT23
keratin 23 (histone deacetylase inducible)
chr2_+_171571800 0.699 NM_001003845
SP5
Sp5 transcription factor
chr9_-_35732115 0.699 TLN1
talin 1
chr8_+_128748476 0.699 MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr15_-_73661604 0.698 NM_005477
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr13_+_28712379 0.697 NM_175854
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr19_-_58090254 0.696 ZNF416
zinc finger protein 416
chr12_-_10562142 0.694 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chr11_+_13299376 0.694 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr13_-_24471124 0.693 NM_001007537
C1QTNF9B
C1q and tumor necrosis factor related protein 9B
chr16_+_3115638 0.688 NM_001012634
IL32
interleukin 32
chr12_-_76425375 0.688 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr19_+_6739697 0.687 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr6_+_33387846 0.685 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr7_-_87342569 0.675 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr6_+_20534686 0.673 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr12_-_109027654 0.673 NM_003006
SELPLG
selectin P ligand
chr6_+_31553955 0.670 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr7_-_105516923 0.669 NM_020725
NM_152749
ATXN7L1

ataxin 7-like 1

chr12_+_119616594 0.668 NM_014365
HSPB8
heat shock 22kDa protein 8
chr18_+_32073245 0.667 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr12_+_93964801 0.665 SOCS2
suppressor of cytokine signaling 2
chr5_+_156696351 0.661 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr15_-_86338017 0.660 KLHL25
kelch-like 25 (Drosophila)
chr6_+_43138919 0.660 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr5_-_81046943 0.659 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr9_-_134612924 0.659 NM_005312
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr16_+_30935895 0.655 NM_001099784
FBXL19
F-box and leucine-rich repeat protein 19
chr19_+_12902295 0.654 NM_002229
JUNB
jun B proto-oncogene
chr16_-_3030391 0.654 PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr16_-_776366 0.654 NM_001031737
CCDC78
coiled-coil domain containing 78
chr11_+_13299349 0.644 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr13_+_114145394 0.642 TMCO3
transmembrane and coiled-coil domains 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
8.33 1.95e-03 GO:0000165 MAPKKK cascade
2.56 3.09e-03 GO:0006950 response to stress
5.14 8.33e-03 GO:0080134 regulation of response to stress
3.55 1.02e-02 GO:0010941 regulation of cell death
5.09 2.47e-02 GO:0045859 regulation of protein kinase activity
4.88 3.40e-02 GO:0043549 regulation of kinase activity
11.29 3.45e-02 GO:0031098 stress-activated protein kinase signaling cascade
17.56 3.46e-02 GO:0043506 regulation of JUN kinase activity
3.38 3.52e-02 GO:0042981 regulation of apoptosis
3.35 3.84e-02 GO:0043067 regulation of programmed cell death
4.71 4.45e-02 GO:0051338 regulation of transferase activity

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.91 1.33e-02 GO:0046983 protein dimerization activity