Motif ID: HLF.p2

Z-value: 1.109


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HLFhg19_v1_chr17_+_53342320_533423440.978.4e-06Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_72088507 3.261 NM_001126102
NM_005143
HP

haptoglobin

chr16_+_72097124 3.171 NM_020995
HPR
haptoglobin-related protein
chr19_+_35773409 2.551 NM_021175
HAMP
hepcidin antimicrobial peptide
chr3_+_186383770 2.417 NM_000412
HRG
histidine-rich glycoprotein
chr9_-_107666046 1.670 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr1_-_230849936 1.602 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr16_+_30484049 1.593 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr5_+_126112314 1.466 NM_005573
LMNB1
lamin B1
chr2_-_99279935 1.454 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr16_+_30483959 1.382 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr12_-_46121248 1.373 LOC400027
uncharacterized LOC400027
chr8_+_24151579 1.300 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr6_+_131894343 1.280 NM_000045
NM_001244438
ARG1

arginase, liver

chr1_-_230849863 1.232 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_+_186435097 1.217 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr17_-_34328530 1.103 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr9_+_117085302 1.081 NM_000607
ORM1
orosomucoid 1
chr6_-_24489738 1.077 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr9_+_117092068 1.058 NM_000608
ORM2
orosomucoid 2
chr5_-_147162251 1.056 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr11_+_63057371 1.055 NM_001039752
SLC22A10
solute carrier family 22, member 10
chrX_+_152224862 1.033 PNMA3
paraneoplastic antigen MA3
chr8_-_120651019 1.012 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr1_-_230849847 1.009 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_-_170744458 0.980 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr6_+_27833033 0.952 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr1_+_150954498 0.936 NM_003568
ANXA9
annexin A9
chr10_-_82049178 0.927 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_-_173174611 0.854 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr2_-_73869493 0.831 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr5_-_140012730 0.825 CD14
CD14 molecule
chr12_-_46121489 0.818 LOC400027
uncharacterized LOC400027
chr3_-_190580464 0.809 NM_001146686
GMNC
geminin coiled-coil domain containing
chr11_-_116663106 0.800 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr19_-_18314731 0.795 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr8_+_40010986 0.792 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr1_-_62785067 0.790 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chrX_+_152224765 0.785 NM_013364
PNMA3
paraneoplastic antigen MA3
chr6_+_56819923 0.773 BEND6
BEN domain containing 6
chr8_+_120079423 0.764 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr5_+_150632612 0.742 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr17_-_36956145 0.740 NM_003559
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr17_-_10372875 0.713 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr3_-_195938256 0.697 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr9_-_95298251 0.694 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr2_+_179184970 0.689 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr15_+_63050761 0.676 TLN2
talin 2
chr6_-_114384008 0.675 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr3_-_169587598 0.664 NM_024727
LRRC31
leucine rich repeat containing 31
chr19_-_47617008 0.657 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr6_+_34216344 0.653


chr20_-_5100443 0.644 NM_182649
PCNA
proliferating cell nuclear antigen
chr17_+_67498391 0.642 MAP2K6
mitogen-activated protein kinase kinase 6
chr1_+_154377847 0.635 IL6R
interleukin 6 receptor
chr22_+_35462125 0.629 NM_001008494
ISX
intestine-specific homeobox
chr2_-_169887832 0.599 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr5_+_149151502 0.598 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr19_-_46088074 0.588 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr3_-_12586962 0.587 NM_001195279
LOC100129480
uncharacterized LOC100129480
chr8_-_103137134 0.566 NM_001040630
NCALD
neurocalcin delta
chrX_-_33229428 0.558 NM_004006
DMD
dystrophin
chr12_+_29376596 0.552 NM_018099
FAR2
fatty acyl CoA reductase 2
chr9_-_118416 0.550 NM_207305
FOXD4
forkhead box D4
chr2_-_88427535 0.545 NM_001443
FABP1
fatty acid binding protein 1, liver
chrX_+_9431314 0.527 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr19_-_6459735 0.524 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr20_+_62372436 0.523 SLC2A4RG
SLC2A4 regulator
chr16_+_57406398 0.518 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr10_+_74653338 0.517 NM_152635
OIT3
oncoprotein induced transcript 3
chr3_-_195306274 0.515 APOD
apolipoprotein D
chr15_-_66790068 0.514 NM_006049
SNAPC5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr5_-_147162264 0.512 JAKMIP2
janus kinase and microtubule interacting protein 2
chr5_-_111091947 0.499 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr10_+_89267589 0.495 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr1_-_62784971 0.493 KANK4
KN motif and ankyrin repeat domains 4
chr12_+_16500075 0.491 NM_145792
MGST1
microsomal glutathione S-transferase 1
chr7_-_83824216 0.484 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr20_+_33759773 0.484 NM_006404
PROCR
protein C receptor, endothelial
chr4_+_69962191 0.483 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr1_-_154600446 0.476 NM_001025107
ADAR
adenosine deaminase, RNA-specific
chr1_+_192605267 0.471 NM_002927
NM_144766
RGS13

regulator of G-protein signaling 13

chr17_-_34328607 0.463 CCL14-CCL15
CCL14-CCL15 readthrough
chr16_-_53537112 0.457 NM_001012398
NM_022476
AKTIP

AKT interacting protein

chr17_-_34329083 0.457 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr17_-_41277409 0.453 NM_007297
NM_007299
NM_007294
NM_007300
BRCA1



breast cancer 1, early onset



chr16_+_19079220 0.450 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr21_+_45079375 0.446 NM_015056
RRP1B
ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr5_-_58882274 0.446 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr16_+_31711914 0.446 KIAA0664L3
KIAA0664-like 3
chr5_+_36606456 0.441 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr19_-_35992798 0.440 NM_001035516
DMKN
dermokine
chr5_-_53606387 0.436 NM_019087
ARL15
ADP-ribosylation factor-like 15
chr20_+_42187634 0.436 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr4_+_108911008 0.430 HADH
hydroxyacyl-CoA dehydrogenase
chr1_-_154600383 0.427 ADAR
adenosine deaminase, RNA-specific
chr5_+_36606667 0.423 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_-_15601574 0.423 NM_001004320
AGMO
alkylglycerol monooxygenase
chr12_-_8043743 0.418 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr7_-_45026204 0.410 SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chr14_+_75894508 0.405 NM_001135047
JDP2
Jun dimerization protein 2
chr1_+_229440128 0.394 NM_006542
SPHAR
S-phase response (cyclin related)
chr15_-_42840910 0.393 LRRC57
leucine rich repeat containing 57
chr16_+_68057144 0.388 NM_017803
DUS2L
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
chr2_-_110962539 0.386 NPHP1
nephronophthisis 1 (juvenile)
chr2_-_191872322 0.384 STAT1
signal transducer and activator of transcription 1, 91kDa
chr15_-_23034365 0.383 NIPA2
non imprinted in Prader-Willi/Angelman syndrome 2
chr9_+_129724503 0.382 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr3_+_101280679 0.382 NM_017819
RG9MTD1
RNA (guanine-9-) methyltransferase domain containing 1
chr1_+_151032150 0.380 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr10_+_91152321 0.379 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr5_+_42548314 0.374 NM_001242403
GHR
growth hormone receptor
chr17_-_41277304 0.370 BRCA1
breast cancer 1, early onset
chr14_-_23285011 0.360 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr2_-_190627923 0.359 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr1_+_40839368 0.359 NM_022733
SMAP2
small ArfGAP2
chr3_-_185655833 0.350 NM_001243879
NM_004593
TRA2B

transformer 2 beta homolog (Drosophila)

chr16_-_30457197 0.350 NM_012248
SEPHS2
selenophosphate synthetase 2
chr20_+_23342786 0.348 GZF1
GDNF-inducible zinc finger protein 1
chr19_-_41356193 0.347 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr7_+_151722774 0.338 NM_022087
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chrX_-_117251302 0.337 NM_001168301
KLHL13
kelch-like 13 (Drosophila)
chr6_-_30080866 0.335 NM_007028
TRIM31
tripartite motif containing 31
chr17_-_41322211 0.331 BRCA1
breast cancer 1, early onset
chr11_-_6462129 0.329 NM_000613
HPX
hemopexin
chr13_-_41768533 0.328 NM_032138
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr6_-_30028755 0.328 ZNRD1-AS1
ZNRD1 antisense RNA 1 (non-protein coding)
chr7_+_94297448 0.326 PEG10
paternally expressed 10
chr14_-_23284617 0.326 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr9_-_77503009 0.326 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr19_-_49622278 0.325 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr9_-_6015606 0.320 NM_001243202
NM_001243203
NM_012416
RANBP6


RAN binding protein 6


chr1_-_230850335 0.319 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_+_100111430 0.318 NM_017734
PALMD
palmdelphin
chr12_+_124773709 0.316 NM_181709
FAM101A
family with sequence similarity 101, member A
chr1_+_196857143 0.313 NM_001201550
NM_001201551
NM_006684
CFHR4


complement factor H-related 4


chr6_-_2840683 0.312 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr5_+_140718353 0.312 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr21_+_45138973 0.309 NM_003681
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr2_+_219745243 0.308 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr9_+_111624545 0.308 NM_006687
ACTL7A
actin-like 7A
chr2_+_201756639 0.306 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr11_-_18062304 0.305 NM_004179
TPH1
tryptophan hydroxylase 1
chr3_-_185655806 0.304 TRA2B
transformer 2 beta homolog (Drosophila)
chr5_+_95997871 0.303 NM_001042440
CAST
calpastatin
chr9_-_77643307 0.301 NM_152420
C9orf41
chromosome 9 open reading frame 41
chr12_+_7013896 0.299 NM_001135217
NM_006992
NM_201650
LRRC23


leucine rich repeat containing 23


chr19_+_36486042 0.294 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr5_+_42425093 0.294 NM_001242401
GHR
growth hormone receptor
chr10_+_99496938 0.292 ZFYVE27
zinc finger, FYVE domain containing 27
chr3_+_122044010 0.292 NM_005213
CSTA
cystatin A (stefin A)
chr1_-_109935869 0.291 NM_001205228
SORT1
sortilin 1
chr6_-_56407681 0.290


chr8_+_38585703 0.287 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr17_+_74536114 0.286 NM_001077620
PRCD
progressive rod-cone degeneration
chr19_-_36233311 0.283 NM_024660
IGFLR1
IGF-like family receptor 1
chr20_+_23342844 0.278 GZF1
GDNF-inducible zinc finger protein 1
chr2_-_152684882 0.277 ARL5A
ADP-ribosylation factor-like 5A
chr1_-_173176314 0.277 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_-_63674074 0.276 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr3_+_119501556 0.274 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr19_-_46088021 0.273 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr3_-_185655776 0.270 TRA2B
transformer 2 beta homolog (Drosophila)
chr3_+_155860750 0.268 NM_003471
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_+_40839429 0.266 SMAP2
small ArfGAP2
chr3_+_124303505 0.265 NM_007064
KALRN
kalirin, RhoGEF kinase
chr5_+_140729723 0.261 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr3_-_170744529 0.258 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr6_+_26204779 0.256 NM_003545
HIST1H4E
histone cluster 1, H4e
chr11_-_33795892 0.255 NM_012175
NM_033406
FBXO3

F-box protein 3

chr4_+_155484131 0.255 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr4_-_159092509 0.252 FAM198B
family with sequence similarity 198, member B
chr5_+_150399980 0.251 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr16_+_103009 0.250 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr1_+_119683006 0.245


chr6_+_131148544 0.245 NM_001195597
LOC100507203
uncharacterized LOC100507203
chr4_+_108911042 0.243 HADH
hydroxyacyl-CoA dehydrogenase
chr2_-_86422892 0.243 NM_001100169
NM_001100170
NM_006839
IMMT


inner membrane protein, mitochondrial


chr1_-_102462371 0.242 OLFM3
olfactomedin 3
chr7_-_129592711 0.239 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr3_-_185655648 0.239 TRA2B
transformer 2 beta homolog (Drosophila)
chr6_+_150690027 0.238 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr8_+_98788014 0.238 LAPTM4B
lysosomal protein transmembrane 4 beta
chr16_-_30457168 0.236 SEPHS2
selenophosphate synthetase 2
chr15_+_91411884 0.234 NM_002569
FURIN
furin (paired basic amino acid cleaving enzyme)
chr4_-_104119475 0.233 NM_001813
CENPE
centromere protein E, 312kDa
chr11_-_68039327 0.232 C11orf24
chromosome 11 open reading frame 24
chr7_-_45808541 0.231 SEPT7P2
septin 7 pseudogene 2
chr9_-_77643179 0.230 C9orf41
chromosome 9 open reading frame 41
chr20_+_42187705 0.230 SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_158300517 0.230 NM_004288
CYTIP
cytohesin 1 interacting protein
chrX_-_13835213 0.229 GPM6B
glycoprotein M6B
chr1_-_67519698 0.229 SLC35D1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr6_-_116447225 0.229 NM_000493
COL10A1
collagen, type X, alpha 1
chr9_-_14398981 0.229 NM_001190738
NFIB
nuclear factor I/B
chr12_-_70083055 0.227 NM_152439
BEST3
bestrophin 3
chr10_-_104211244 0.227 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr3_+_186330844 0.226 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr11_-_64647136 0.225 EHD1
EH-domain containing 1
chr7_+_56019552 0.224 NM_015969
MRPS17
mitochondrial ribosomal protein S17
chr12_+_65224214 0.223



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
15.94 1.78e-03 GO:0006875 cellular metal ion homeostasis
15.39 2.11e-03 GO:0055065 metal ion homeostasis
14.46 2.86e-03 GO:0030003 cellular cation homeostasis
13.19 4.46e-03 GO:0055080 cation homeostasis
8.68 6.39e-03 GO:0048878 chemical homeostasis
10.23 1.51e-02 GO:0006873 cellular ion homeostasis
9.88 1.77e-02 GO:0055082 cellular chemical homeostasis
9.44 2.20e-02 GO:0050801 ion homeostasis
6.58 3.01e-02 GO:0006952 defense response
8.19 4.30e-02 GO:0019725 cellular homeostasis
6.12 4.48e-02 GO:0042592 homeostatic process
12.14 4.52e-02 GO:0006954 inflammatory response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.53 9.03e-07 GO:0005576 extracellular region
6.69 3.96e-04 GO:0044421 extracellular region part
7.60 7.59e-04 GO:0005615 extracellular space

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
268.10 9.10e-04 GO:0030492 hemoglobin binding
20.28 1.51e-03 GO:0001871 pattern binding
20.28 1.51e-03 GO:0030247 polysaccharide binding
21.78 1.33e-02 GO:0008201 heparin binding
16.57 2.97e-02 GO:0004866 endopeptidase inhibitor activity
16.46 3.03e-02 GO:0005539 glycosaminoglycan binding
15.92 3.34e-02 GO:0061135 endopeptidase regulator activity
15.71 3.47e-02 GO:0030414 peptidase inhibitor activity
8.86 3.65e-02 GO:0030246 carbohydrate binding
40.25 4.62e-02 GO:0004869 cysteine-type endopeptidase inhibitor activity