Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 2.061


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA7hg19_v1_chr7_-_27196163_27196328-0.186.5e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_18535351 9.767 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chrM_+_10123 8.332


chr7_+_28452143 7.382 NM_182898
CREB5
cAMP responsive element binding protein 5
chr15_+_71839540 5.070 THSD4
thrombospondin, type I, domain containing 4
chr3_-_114478117 5.003 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr10_-_92681025 4.681 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_+_71494460 4.629 NM_031889
ENAM
enamelin
chr4_-_184243578 4.543 NM_001185149
CLDN24
claudin 24
chr4_+_108814419 4.202 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr13_+_36050885 4.094 NM_001204197
NBEA
neurobeachin
chrX_-_124097601 3.915 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chr2_-_145277568 3.872 ZEB2
zinc finger E-box binding homeobox 2
chr2_-_145277879 3.865 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr1_+_168545710 3.831 NM_002995
XCL1
chemokine (C motif) ligand 1
chr1_+_167298382 3.819 POU2F1
POU class 2 homeobox 1
chr7_+_18330044 3.773 HDAC9
histone deacetylase 9
chr7_+_28475233 3.730 NM_004904
CREB5
cAMP responsive element binding protein 5
chr8_-_42234562 3.721 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr17_-_39092714 3.572 KRT23
keratin 23 (histone deacetylase inducible)
chr3_-_114790221 3.539 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_167298280 3.385 NM_001198783
POU2F1
POU class 2 homeobox 1
chr7_+_18535817 3.382 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr6_-_76203256 3.323 NM_015687
FILIP1
filamin A interacting protein 1
chr17_-_39093671 3.270 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr7_-_41742666 3.098 NM_002192
INHBA
inhibin, beta A
chr3_-_101039403 3.052 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr2_+_210444364 2.952 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr16_+_69680959 2.900 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_+_168250277 2.883 NM_005149
TBX19
T-box 19
chr6_+_149721494 2.853 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr9_+_12693385 2.841 NM_000550
TYRP1
tyrosinase-related protein 1
chr15_+_93443559 2.808 CHD2
chromodomain helicase DNA binding protein 2
chr12_-_87232635 2.802 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr12_-_53901371 2.789 NM_003717
NPFF
neuropeptide FF-amide peptide precursor
chr10_-_92680784 2.776 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr8_-_6420454 2.771 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr15_+_93443418 2.752 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr10_-_32667543 2.699 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr1_+_177140062 2.645 FAM5B
family with sequence similarity 5, member B
chr2_-_161130151 2.594 RBMS1
RNA binding motif, single stranded interacting protein 1
chr19_+_13134782 2.586 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_171571800 2.555 NM_001003845
SP5
Sp5 transcription factor
chr1_-_27732069 2.496 WASF2
WAS protein family, member 2
chr4_-_83347778 2.491 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr10_+_126630691 2.452 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr2_+_29038862 2.433 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr2_-_233641225 2.403 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr7_+_28448970 2.332 LOC401317
uncharacterized LOC401317
chr14_-_57960432 2.264 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr3_-_114343052 2.253 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_212782103 2.188 ATF3
activating transcription factor 3
chr11_-_129062092 2.165 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr5_+_71502700 2.142 MAP1B
microtubule-associated protein 1B
chr1_+_212781969 2.126 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr12_+_28410132 2.122 NM_018318
CCDC91
coiled-coil domain containing 91
chr5_+_59784004 2.114 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr3_+_88188261 2.054 NM_018293
ZNF654
zinc finger protein 654
chr3_+_25470067 2.037 RARB
retinoic acid receptor, beta
chr7_+_28725597 2.030 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr13_+_97874704 2.017 MBNL2
muscleblind-like 2 (Drosophila)
chr12_+_119616594 2.013 NM_014365
HSPB8
heat shock 22kDa protein 8
chr10_-_65028825 1.993 NM_004241
JMJD1C
jumonji domain containing 1C
chr6_-_53013581 1.977 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr1_-_193155723 1.966 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr5_+_137673223 1.950 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr3_+_128532267 1.948


chr2_+_210444154 1.922 MAP2
microtubule-associated protein 2
chr5_+_174151531 1.917 NM_002449
MSX2
msh homeobox 2
chrX_+_70765479 1.915 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr9_-_5968367 1.914


chr3_+_115342302 1.863 GAP43
growth associated protein 43
chr18_+_32173281 1.836 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr12_-_28124915 1.822 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr3_+_63953419 1.816 NM_001128149
ATXN7
ataxin 7
chr12_-_15865847 1.803 EPS8
epidermal growth factor receptor pathway substrate 8
chr17_-_49124128 1.798 NM_001251971
SPAG9
sperm associated antigen 9
chr5_-_39394423 1.792 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr13_-_60325073 1.751


chr6_-_56716713 1.747 DST
dystonin
chr3_-_187452669 1.738 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr7_-_27166638 1.737 NM_153631
HOXA3
homeobox A3
chr15_+_100173182 1.736 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr7_+_112120907 1.692 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr3_+_157154579 1.690 NM_002852
PTX3
pentraxin 3, long
chr3_-_114102488 1.690 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr4_+_74286846 1.688 ALB
albumin
chr9_+_103340335 1.664 NM_001018116
MURC
muscle-related coiled-coil protein
chr1_-_100643770 1.660 NM_144620
LRRC39
leucine rich repeat containing 39
chr19_+_45971249 1.649 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr7_+_107110501 1.646 NM_005295
GPR22
G protein-coupled receptor 22
chr18_+_32290195 1.633 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr5_-_124080773 1.608 NM_020747
ZNF608
zinc finger protein 608
chr2_+_171571936 1.605


chr10_-_77161136 1.602 ZNF503
zinc finger protein 503
chr2_-_198540583 1.593 NM_144629
RFTN2
raftlin family member 2
chr3_+_156394452 1.587 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr11_-_83984230 1.582 NM_001142700
DLG2
discs, large homolog 2 (Drosophila)
chr10_-_77161424 1.578 NM_032772
ZNF503
zinc finger protein 503
chr12_+_50869531 1.573 LARP4
La ribonucleoprotein domain family, member 4
chr12_-_99548471 1.572 NM_001204068
NM_001204069
NM_001204070
NM_020140
NM_181670
NM_001204066
ANKS1B





ankyrin repeat and sterile alpha motif domain containing 1B





chr3_+_63884074 1.566 NM_001177387
ATXN7
ataxin 7
chr12_-_99548867 1.546 NM_001204067
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_+_74606222 1.537 NM_000584
IL8
interleukin 8
chr8_-_87755880 1.532 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr18_+_32073245 1.516 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr14_+_55168831 1.506 SAMD4A
sterile alpha motif domain containing 4A
chr1_+_46379258 1.495 MAST2
microtubule associated serine/threonine kinase 2
chr3_-_87325611 1.491 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr10_-_62149487 1.480 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr22_-_38506532 1.475 BAIAP2L2
BAI1-associated protein 2-like 2
chr7_+_116395440 1.468


chr21_-_33074101 1.461 SCAF4
SR-related CTD-associated factor 4
chr2_-_211018294 1.452 C2orf67
chromosome 2 open reading frame 67
chr7_+_39017608 1.442 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr4_-_153273683 1.435 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr11_-_84634219 1.430 DLG2
discs, large homolog 2 (Drosophila)
chr13_+_24144402 1.425 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr4_+_160188997 1.419 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr11_+_124481451 1.410 NM_052959
PANX3
pannexin 3
chr15_-_70390229 1.409 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr6_+_87964925 1.406 ZNF292
zinc finger protein 292
chr6_+_87969619 1.389 ZNF292
zinc finger protein 292
chr15_+_57511616 1.370 NM_207040
TCF12
transcription factor 12
chr6_-_56716412 1.363 DST
dystonin
chr17_-_63009302 1.354 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr12_-_53994783 1.349 NM_001130059
ATF7
activating transcription factor 7
chr7_-_37025696 1.348 ELMO1
engulfment and cell motility 1
chr18_+_32073343 1.336 DTNA
dystrobrevin, alpha
chr10_-_77161539 1.335 ZNF503
zinc finger protein 503
chr8_+_32579350 1.334 NM_001159996
NRG1
neuregulin 1
chr6_-_149806116 1.332 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr6_-_56507585 1.331 NM_001723
NM_015548
DST

dystonin

chr6_-_138189313 1.321


chr15_-_70390226 1.320 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr21_+_35736322 1.315 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr2_+_33359607 1.308 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr6_+_7579692 1.303 DSP
desmoplakin
chr3_+_141043054 1.301 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chrM_+_1670 1.299


chr19_+_13135368 1.296 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_213020947 1.292 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr11_-_84634437 1.287 NM_001364
DLG2
discs, large homolog 2 (Drosophila)
chr4_-_74088773 1.286 ANKRD17
ankyrin repeat domain 17
chr13_-_41593491 1.280 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr10_-_75335415 1.277 NM_152586
USP54
ubiquitin specific peptidase 54
chr4_+_88571453 1.269 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr4_-_82393025 1.259 NM_152545
RASGEF1B
RasGEF domain family, member 1B
chr3_-_105421044 1.259 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chrX_-_76814217 1.255 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr18_-_30352841 1.249 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr13_+_97928414 1.245 MBNL2
muscleblind-like 2 (Drosophila)
chr5_-_16509106 1.232 NM_019000
FAM134B
family with sequence similarity 134, member B
chr3_-_47933997 1.222 MAP4
microtubule-associated protein 4
chr2_-_133539627 1.220 NCKAP5
NCK-associated protein 5
chr6_-_46293215 1.219 RCAN2
regulator of calcineurin 2
chr8_+_77593522 1.219 ZFHX4
zinc finger homeobox 4
chr5_-_39424930 1.200 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr4_-_82392971 1.197 RASGEF1B
RasGEF domain family, member 1B
chr13_+_97874540 1.195 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr4_+_88529680 1.191 NM_014208
DSPP
dentin sialophosphoprotein
chr10_+_63808968 1.181 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_-_102874373 1.171 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr3_+_129247481 1.168 NM_000539
RHO
rhodopsin
chr1_+_151739130 1.167 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr10_+_77542518 1.164 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr20_-_55934877 1.161 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chr7_-_155601757 1.159 SHH
sonic hedgehog
chr10_-_126716452 1.156 NM_022802
CTBP2
C-terminal binding protein 2
chr9_-_110251308 1.151 KLF4
Kruppel-like factor 4 (gut)
chr13_-_41593405 1.144 ELF1
E74-like factor 1 (ets domain transcription factor)
chrX_+_69488154 1.138 NM_004312
ARR3
arrestin 3, retinal (X-arrestin)
chr6_+_144612872 1.138 NM_007124
UTRN
utrophin
chr17_-_73774447 1.137


chr20_+_32150139 1.136 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr17_-_46651809 1.135 NM_002146
HOXB3
homeobox B3
chr8_+_77593506 1.134 NM_024721
ZFHX4
zinc finger homeobox 4
chr22_+_39101954 1.134 GTPBP1
GTP binding protein 1
chr1_+_170632274 1.131 PRRX1
paired related homeobox 1
chr6_+_100054649 1.126 NM_021620
PRDM13
PR domain containing 13
chr4_+_118955499 1.126 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr13_-_41556188 1.114 ELF1
E74-like factor 1 (ets domain transcription factor)
chr9_+_2717525 1.103 NM_133497
KCNV2
potassium channel, subfamily V, member 2
chr3_+_119316694 1.101 NM_001206960
NM_001206961
NM_015900
PLA1A


phospholipase A1 member A


chr10_+_63661012 1.097 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr6_-_53530505 1.096 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr7_-_111428944 1.094 DOCK4
dedicator of cytokinesis 4
chr7_-_87342569 1.094 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chrM_+_11427 1.090


chr6_-_41703938 1.085 NM_001167827
TFEB
transcription factor EB
chr12_-_26277807 1.083 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr7_+_17382900 1.074 AHR
aryl hydrocarbon receptor
chrM_+_10361 1.055


chr11_-_85338313 1.054 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr1_+_167189948 1.052 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr14_-_81864726 1.049 NM_033104
STON2
stonin 2
chr6_+_54173202 1.045 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr22_+_39101806 1.035 NM_004286
GTPBP1
GTP binding protein 1
chr10_-_14372807 1.034 NM_018027
FRMD4A
FERM domain containing 4A
chr2_-_161056573 1.033 NM_000888
ITGB6
integrin, beta 6
chr12_-_51611476 1.033 POU6F1
POU class 6 homeobox 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.79 1.00e-09 GO:0050794 regulation of cellular process
2.89 4.81e-09 GO:0006355 regulation of transcription, DNA-dependent
2.84 4.81e-09 GO:0051252 regulation of RNA metabolic process
2.70 9.65e-09 GO:0010556 regulation of macromolecule biosynthetic process
2.71 1.37e-08 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.71 1.48e-08 GO:0050789 regulation of biological process
2.62 2.88e-08 GO:0010468 regulation of gene expression
2.56 4.00e-08 GO:0031326 regulation of cellular biosynthetic process
2.31 5.39e-08 GO:0060255 regulation of macromolecule metabolic process
2.53 6.06e-08 GO:0009889 regulation of biosynthetic process
2.48 1.21e-07 GO:0051171 regulation of nitrogen compound metabolic process
2.51 1.40e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.62 3.43e-07 GO:0065007 biological regulation
2.20 4.50e-07 GO:0080090 regulation of primary metabolic process
2.17 7.78e-07 GO:0031323 regulation of cellular metabolic process
2.03 4.13e-06 GO:0019222 regulation of metabolic process
1.87 9.11e-04 GO:0032502 developmental process
2.24 1.81e-03 GO:0048523 negative regulation of cellular process
1.65 2.67e-03 GO:0032501 multicellular organismal process
3.00 2.93e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
3.63 3.58e-03 GO:0045893 positive regulation of transcription, DNA-dependent
3.46 3.63e-03 GO:0009790 embryo development
2.09 4.85e-03 GO:0048522 positive regulation of cellular process
1.91 5.46e-03 GO:0048856 anatomical structure development
2.27 5.91e-03 GO:0048513 organ development
3.38 9.01e-03 GO:0051254 positive regulation of RNA metabolic process
1.98 9.10e-03 GO:0048518 positive regulation of biological process
3.22 9.79e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
3.35 1.02e-02 GO:0010628 positive regulation of gene expression
1.82 1.07e-02 GO:0007275 multicellular organismal development
1.94 1.19e-02 GO:0048731 system development
3.90 1.19e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
3.90 1.19e-02 GO:0072358 cardiovascular system development
3.90 1.19e-02 GO:0072359 circulatory system development
3.16 1.24e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.02 1.35e-02 GO:0031328 positive regulation of cellular biosynthetic process
2.04 1.46e-02 GO:0048519 negative regulation of biological process
2.97 1.70e-02 GO:0009891 positive regulation of biosynthetic process
3.06 1.86e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
2.94 1.96e-02 GO:0009888 tissue development
2.89 2.47e-02 GO:0006351 transcription, DNA-dependent
13.62 2.48e-02 GO:0060021 palate development
4.82 3.62e-02 GO:0001568 blood vessel development
5.29 4.26e-02 GO:0048514 blood vessel morphogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.60 4.63e-04 GO:0005634 nucleus
1.31 5.60e-03 GO:0043229 intracellular organelle
1.30 6.14e-03 GO:0043226 organelle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.00 3.51e-09 GO:0001071 nucleic acid binding transcription factor activity
4.00 3.51e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
4.10 2.66e-06 GO:0043565 sequence-specific DNA binding
2.32 1.39e-05 GO:0003677 DNA binding
1.90 3.58e-04 GO:0003676 nucleic acid binding
2.90 5.79e-04 GO:0030528 transcription regulator activity
4.00 3.21e-02 GO:0016564 transcription repressor activity
1.20 4.33e-02 GO:0005488 binding