Motif ID: IRF1,2,7.p3

Z-value: 1.380


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRF2hg19_v1_chr4_-_185395616_1853957460.531.4e-01Click!
IRF7hg19_v1_chr11_-_615998_616004-0.393.0e-01Click!
IRF1hg19_v1_chr5_-_131826426_131826536-0.137.4e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_91152321 2.450 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr22_+_36044412 1.820 NM_030641
APOL6
apolipoprotein L, 6
chr3_-_172241060 1.386 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr6_+_116782555 1.202 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr6_+_26440699 1.083 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr5_-_95158365 1.072 GLRX
glutaredoxin (thioltransferase)
chr1_+_948846 1.043 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr1_+_79086087 0.985 NM_006820
IFI44L
interferon-induced protein 44-like
chr6_+_26402464 0.985 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr22_+_36044475 0.931 APOL6
apolipoprotein L, 6
chr10_+_91087601 0.928 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr22_-_36635552 0.897 APOL2
apolipoprotein L, 2
chr5_-_95158465 0.859 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr1_-_148176392 0.701


chr8_-_23540401 0.679 NM_006167
NKX3-1
NK3 homeobox 1
chr6_+_26365397 0.675 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr8_+_143808593 0.671 NM_016647
C8orf55
chromosome 8 open reading frame 55
chr22_-_22874597 0.659 NM_080740
ZNF280A
zinc finger protein 280A
chr16_-_3422282 0.650 NM_001190476
MTRNR2L4
MT-RNR2-like 4
chr2_-_231084600 0.618 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr9_+_74764266 0.607 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr17_-_40264687 0.587 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr1_+_150480486 0.570 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr5_+_140739589 0.564 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr11_-_4414887 0.557 NM_003141
TRIM21
tripartite motif containing 21
chr1_+_150480584 0.552 ECM1
extracellular matrix protein 1
chr19_+_10196972 0.543 C19orf66
chromosome 19 open reading frame 66
chr5_+_131746579 0.540 C5orf56
chromosome 5 open reading frame 56
chr22_+_18632841 0.523 USP18
ubiquitin specific peptidase 18
chr10_+_91061705 0.517 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr10_+_91092238 0.514 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr12_+_53442972 0.509 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr5_+_96212167 0.508 ERAP2
endoplasmic reticulum aminopeptidase 2
chr9_+_74764382 0.505 GDA
guanine deaminase
chr22_-_36635666 0.499 NM_030882
APOL2
apolipoprotein L, 2
chr6_-_121655606 0.486 NM_152730
C6orf170
chromosome 6 open reading frame 170
chrX_+_71364033 0.480 NM_207422
FLJ44635
TPT1-like protein
chr1_+_156030965 0.473 NM_020387
RAB25
RAB25, member RAS oncogene family
chr19_-_43032525 0.469 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr7_+_105603656 0.467 NM_152750
CDHR3
cadherin-related family member 3
chr1_-_24469571 0.464 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr17_-_43339433 0.463 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr3_+_122399665 0.463 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chrX_-_100603956 0.460 NM_004085
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr6_-_87804773 0.459 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr10_-_102279590 0.454 NM_015490
SEC31B
SEC31 homolog B (S. cerevisiae)
chr1_-_168106727 0.449 GPR161
G protein-coupled receptor 161
chr11_-_114271052 0.447 NM_019021
C11orf71
chromosome 11 open reading frame 71
chr6_+_49518112 0.439 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chr21_+_34144410 0.438 C21orf49
chromosome 21 open reading frame 49
chr6_+_26087447 0.430 NM_000410
NM_139003
NM_139004
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011
HFE








hemochromatosis








chr1_-_168106535 0.427 GPR161
G protein-coupled receptor 161
chr6_-_31239489 0.426 HLA-B
HLA-C
major histocompatibility complex, class I, B
major histocompatibility complex, class I, C
chr13_+_39612440 0.425 NM_001012754
NM_001017370
NHLRC3

NHL repeat containing 3

chr9_-_73483933 0.424 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr3_+_46448678 0.422 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr8_+_9911797 0.414 NM_001135670
NM_012331
MSRA

methionine sulfoxide reductase A

chr6_-_26197477 0.408 HIST1H3D
histone cluster 1, H3d
chr21_+_42733916 0.406 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr4_+_77135192 0.401 NM_001242936
FAM47E
family with sequence similarity 47, member E
chr19_+_10196757 0.400 NM_018381
C19orf66
chromosome 19 open reading frame 66
chr12_+_25205488 0.395 LRMP
lymphoid-restricted membrane protein
chr2_+_132480063 0.395 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr10_+_101542554 0.386 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chrX_+_30261847 0.383 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr9_+_74764417 0.382 GDA
guanine deaminase
chr2_-_152146373 0.381 NM_004688
NMI
N-myc (and STAT) interactor
chr6_+_3259134 0.381 NM_001128591
NM_001128592
NM_001135750
PSMG4


proteasome (prosome, macropain) assembly chaperone 4


chr17_+_46908371 0.378 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr9_-_115818967 0.375 NM_003408
ZFP37
zinc finger protein 37 homolog (mouse)
chr19_+_10197023 0.372 C19orf66
chromosome 19 open reading frame 66
chr1_-_47695442 0.370 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr11_+_28129797 0.366 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr17_+_41363845 0.365 NM_145041
TMEM106A
transmembrane protein 106A
chrX_+_77166178 0.363 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr22_-_36635999 0.363 NM_145637
APOL2
apolipoprotein L, 2
chrX_-_100603673 0.360 NM_001145951
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr5_+_36606667 0.360 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_133119625 0.360 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr16_-_75529289 0.359


chr2_+_88047603 0.358 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr6_-_46889620 0.356 NM_001098518
GPR116
G protein-coupled receptor 116
chrX_+_77166223 0.354 ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr5_+_140579182 0.354 NM_018931
PCDHB11
protocadherin beta 11
chr4_+_186990308 0.350 NM_003265
TLR3
toll-like receptor 3
chr9_-_95298251 0.345 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr5_-_111093251 0.345 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr10_+_5005685 0.338 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr10_+_101542460 0.334 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_-_168106810 0.331 GPR161
G protein-coupled receptor 161
chr3_+_118892363 0.331 NM_006952
UPK1B
uroplakin 1B
chr16_-_21289637 0.329 CRYM
crystallin, mu
chr5_-_149792276 0.326 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr2_+_61389628 0.324 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr16_+_66968360 0.322 CES2
carboxylesterase 2
chr9_-_100881515 0.322 TRIM14
tripartite motif containing 14
chr16_-_75529278 0.319


chr21_-_34185943 0.318 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr16_+_66968319 0.317 NM_003869
NM_198061
CES2

carboxylesterase 2

chr6_+_25963398 0.315 TRIM38
tripartite motif containing 38
chr8_+_27631902 0.314 NM_001017420
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr9_+_74764354 0.313 GDA
guanine deaminase
chr7_+_93551015 0.310 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr3_-_123339178 0.306 MYLK
myosin light chain kinase
chr8_+_132916405 0.303


chr5_+_140174443 0.302 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chrX_+_100878101 0.301 NM_016607
NM_177947
ARMCX3

armadillo repeat containing, X-linked 3

chr11_+_28131830 0.299 METTL15
methyltransferase like 15
chr13_+_53216564 0.299 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr8_+_132916376 0.297 EFR3A
EFR3 homolog A (S. cerevisiae)
chr3_+_46283871 0.296 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr8_+_132916383 0.292 EFR3A
EFR3 homolog A (S. cerevisiae)
chr11_+_32112607 0.292 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr1_+_120254418 0.290 NM_006623
PHGDH
phosphoglycerate dehydrogenase
chr9_-_100881462 0.289 NM_014788
NM_033219
NM_033220
TRIM14


tripartite motif containing 14


chr15_+_78832746 0.288 NM_001102667
NM_001102668
NM_002789
PSMA4


proteasome (prosome, macropain) subunit, alpha type, 4


chr9_+_74764394 0.287 GDA
guanine deaminase
chr3_-_196230365 0.287 NM_152617
RNF168
ring finger protein 168
chr10_-_14996008 0.286 NM_001033855
NM_001033857
NM_001033858
NM_022487
DCLRE1C



DNA cross-link repair 1C



chr18_-_48346297 0.285 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr15_+_78832787 0.284 PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr5_-_35118223 0.284 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr3_-_123339423 0.283 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr19_-_12992140 0.283 DNASE2
deoxyribonuclease II, lysosomal
chr10_+_82173574 0.281 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr3_+_159706622 0.280 NM_000882
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr21_+_37507209 0.280 NM_001236
CBR3
carbonyl reductase 3
chr12_+_29376596 0.277 NM_018099
FAR2
fatty acyl CoA reductase 2
chr10_-_5045967 0.275 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr17_-_38074842 0.274 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr11_-_18343670 0.272 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr1_+_36387788 0.269 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr11_+_72983246 0.267 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr10_+_5005601 0.266 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_+_181003143 0.264 MR1
major histocompatibility complex, class I-related
chr20_-_5100443 0.263 NM_182649
PCNA
proliferating cell nuclear antigen
chr1_-_182558344 0.263 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chrX_+_38211735 0.262 NM_000531
OTC
ornithine carbamoyltransferase
chr2_+_85811530 0.262 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr12_+_102271082 0.260 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr13_+_50069745 0.259 NM_001040443
PHF11
PHD finger protein 11
chr9_-_88874518 0.259 NM_001010907
C9orf153
chromosome 9 open reading frame 153
chr3_-_100712248 0.259 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr14_-_70883680 0.258 NM_001202547
NM_001202548
NM_001202549
NM_018373
SYNJ2BP-COX16


SYNJ2BP
SYNJ2BP-COX16 readthrough


synaptojanin 2 binding protein
chr15_-_89456549 0.258 MFGE8
milk fat globule-EGF factor 8 protein
chr3_-_122283423 0.257 NM_001146103
NM_031458
PARP9

poly (ADP-ribose) polymerase family, member 9

chr16_+_66968390 0.257 CES2
carboxylesterase 2
chr16_-_67970651 0.256 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr3_+_122044010 0.256 NM_005213
CSTA
cystatin A (stefin A)
chr2_-_77749335 0.256 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr2_-_21230572 0.254 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_-_142889269 0.254 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr6_-_32806545 0.251 NM_000544
NM_018833
TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

chr10_+_97515408 0.251 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr2_-_152118258 0.250 NM_198557
RBM43
RNA binding motif protein 43
chr2_+_179278371 0.249


chr18_-_55253785 0.247 NM_000140
NM_001012515
FECH

ferrochelatase

chr1_+_181003138 0.246 MR1
major histocompatibility complex, class I-related
chr16_-_67970734 0.246 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr17_-_67057046 0.244 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr18_-_65182507 0.244 DSEL
dermatan sulfate epimerase-like
chr10_+_5005453 0.243 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr21_+_45177862 0.240 PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr7_-_138794125 0.238 ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr16_-_11350038 0.238 NM_003745
SOCS1
suppressor of cytokine signaling 1
chrX_-_15620191 0.235 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_-_145968819 0.233 PLSCR4
phospholipid scramblase 4
chrX_+_146993663 0.233


chr3_-_122283077 0.231 NM_001146102
NM_001146105
NM_001146104
NM_001146106
PARP9



poly (ADP-ribose) polymerase family, member 9



chr8_+_132916339 0.231 NM_015137
EFR3A
EFR3 homolog A (S. cerevisiae)
chr12_+_104850641 0.228 NM_001173982
NM_018413
CHST11

carbohydrate (chondroitin 4) sulfotransferase 11

chr16_+_66968365 0.227 CES2
carboxylesterase 2
chr6_-_46703042 0.227 PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr15_-_89456592 0.224 NM_001114614
NM_005928
MFGE8

milk fat globule-EGF factor 8 protein

chr20_-_45976626 0.221 ZMYND8
zinc finger, MYND-type containing 8
chr12_+_12224401 0.219 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr2_+_202047803 0.218 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr6_-_105584542 0.217 NM_007073
BVES
blood vessel epicardial substance
chr2_+_69240137 0.217 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr6_-_24719286 0.216 NM_030939
C6orf62
chromosome 6 open reading frame 62
chrX_+_146993450 0.216 NM_001185075
NM_001185076
NM_001185081
NM_001185082
NM_002024
FMR1




fragile X mental retardation 1




chr5_+_36606456 0.215 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chrX_-_106362018 0.214 RBM41
RNA binding motif protein 41
chr11_+_124933007 0.214 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr1_-_38412704 0.214 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr2_-_68290114 0.213 C1D
C1D nuclear receptor corepressor
chr21_+_45139018 0.213


chr6_+_15246299 0.212 NM_004973
JARID2
jumonji, AT rich interactive domain 2
chr3_-_160822625 0.212 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr1_+_179262936 0.211 SOAT1
sterol O-acyltransferase 1
chrX_+_119384490 0.211 NM_006777
NM_001184742
ZBTB33

zinc finger and BTB domain containing 33

chr11_+_7506599 0.211 NM_198474
OLFML1
olfactomedin-like 1
chr11_+_5646206 0.210 NM_021616
TRIM34
tripartite motif containing 34
chr2_-_152146133 0.210 NMI
N-myc (and STAT) interactor
chr7_+_140103842 0.209 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr9_+_79056581 0.209 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_-_38412667 0.207 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr6_+_31913708 0.206 NM_001710
CFB
complement factor B
chr10_+_91174303 0.205 NM_012420
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr14_-_60097314 0.205 RTN1
reticulon 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.