Motif ID: KLF12.p2

Z-value: 3.224


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF12hg19_v1_chr13_-_74708361_747084310.511.6e-01Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_1606480 7.359 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr16_-_67978422 6.786 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr5_+_137801178 6.568 NM_001964
EGR1
early growth response 1
chr5_+_137801166 6.279 EGR1
early growth response 1
chr11_+_62475113 6.028 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr1_+_32827797 4.883 NM_052841
TSSK3
testis-specific serine kinase 3
chr6_+_149721494 4.748 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr11_+_62475165 4.692 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr7_+_28448970 4.587 LOC401317
uncharacterized LOC401317
chr22_+_31489343 4.468 SMTN
smoothelin
chr19_+_2249112 4.075 NM_000479
AMH
anti-Mullerian hormone
chr1_-_38471170 3.909 NM_001243878
NM_004468
FHL3

four and a half LIM domains 3

chr6_-_11382501 3.890 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr1_+_170633312 3.871 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr1_-_32827843 3.835 NM_001167676
LOC100128071
uncharacterized LOC100128071
chr3_-_169482847 3.814 TERC
telomerase RNA component
chr7_+_123295860 3.801 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr4_-_74964836 3.763 CXCL2
chemokine (C-X-C motif) ligand 2
chr7_+_127233688 3.570 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr13_+_97999289 3.456


chr12_+_121416294 3.409 HNF1A
HNF1 homeobox A
chr20_+_61867234 3.408 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr16_-_67977956 3.327 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr19_+_36208917 3.307 NM_014727
MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr1_+_200842082 3.300 NM_005298
GPR25
G protein-coupled receptor 25
chr22_+_31487315 3.278 SMTN
smoothelin
chr6_-_152702450 3.242 SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_-_91182777 3.227 NM_020063
BARHL2
BarH-like homeobox 2
chr12_+_57482886 3.224 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr12_+_57482922 3.223 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr1_-_213020947 3.187 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr19_-_14260728 3.169 LPHN1
latrophilin 1
chr19_-_46285752 3.157 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr12_+_121416548 3.133 NM_000545
HNF1A
HNF1 homeobox A
chr7_+_18535351 3.125 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr19_+_13263890 3.123 IER2
immediate early response 2
chrX_+_49126299 3.100 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory subunit 3F

chr4_-_74904329 3.002 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr19_-_46283281 2.962


chr15_-_65360297 2.892 NM_016563
RASL12
RAS-like, family 12
chr19_+_2476122 2.855 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr5_-_172198160 2.843 NM_004417
DUSP1
dual specificity phosphatase 1
chr12_-_58159386 2.824 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr6_-_44233244 2.813 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chrX_+_49126480 2.805 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr16_+_30675777 2.801 NM_001105079
FBRS
fibrosin
chr1_-_33841142 2.791 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr8_-_6420454 2.791 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr2_-_74709965 2.768 CCDC142
coiled-coil domain containing 142
chr14_+_58765209 2.753 NM_002892
NM_023000
NM_023001
ARID4A


AT rich interactive domain 4A (RBP1-like)


chr6_+_43457214 2.745 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr10_-_32636134 2.739 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr3_-_87040268 2.730 VGLL3
vestigial like 3 (Drosophila)
chr1_-_221915393 2.695 DUSP10
dual specificity phosphatase 10
chr17_+_27071008 2.694 NM_004295
TRAF4
TNF receptor-associated factor 4
chr2_+_70142236 2.675 MXD1
MAX dimerization protein 1
chr4_-_74964996 2.668 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr6_+_89790464 2.619 PNRC1
proline-rich nuclear receptor coactivator 1
chr8_-_29206321 2.614 NM_057158
DUSP4
dual specificity phosphatase 4
chr1_+_201857997 2.612 SHISA4
shisa homolog 4 (Xenopus laevis)
chr1_+_203274646 2.607 NM_006763
BTG2
BTG family, member 2
chr11_-_65667809 2.582 FOSL1
FOS-like antigen 1
chr19_+_49376488 2.576 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr2_+_28616360 2.565 FOSL2
FOS-like antigen 2
chr7_-_27135524 2.533 NM_005522
NM_153620
HOXA1

homeobox A1

chr15_+_64791618 2.531 NM_015042
ZNF609
zinc finger protein 609
chrX_+_70364680 2.525 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3


chr17_-_40828441 2.514 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr10_-_32636084 2.506 NM_025209
EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr1_-_221915458 2.504 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr22_-_20004251 2.498 NM_001670
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr3_-_172166202 2.489 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chrX_+_49126326 2.483 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr7_+_28475233 2.477 NM_004904
CREB5
cAMP responsive element binding protein 5
chr9_+_35538628 2.475 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr7_+_64498643 2.472 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr19_-_46285746 2.466 DMPK
dystrophia myotonica-protein kinase
chr9_+_35538890 2.466 RUSC2
RUN and SH3 domain containing 2
chr14_+_58765275 2.464 ARID4A
AT rich interactive domain 4A (RBP1-like)
chr2_-_74710356 2.456 NM_032779
CCDC142
coiled-coil domain containing 142
chr6_+_89790412 2.451 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr17_-_36831156 2.413 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr5_-_81046858 2.394 SSBP2
single-stranded DNA binding protein 2
chr10_-_92681025 2.369 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr8_-_8239188 2.363 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr1_-_221915426 2.359 DUSP10
dual specificity phosphatase 10
chr12_-_53575121 2.344 CSAD
cysteine sulfinic acid decarboxylase
chr10_+_104404195 2.343 NM_030912
TRIM8
tripartite motif containing 8
chr9_-_4299574 2.330 GLIS3
GLIS family zinc finger 3
chr19_+_45971249 2.297 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr11_-_1619481 2.294 NM_001004325
KRTAP5-2
keratin associated protein 5-2
chr10_-_92680784 2.293 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr2_+_220408742 2.279 NM_001005209
TMEM198
transmembrane protein 198
chr19_+_45504686 2.278 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr19_+_7660698 2.275 NM_001080429
NM_020902
CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chr20_-_3149070 2.274 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr5_-_81046943 2.265 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr11_+_6220375 2.264 NM_001005178
OR52W1
olfactory receptor, family 52, subfamily W, member 1
chr3_-_99833348 2.257 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr19_+_9271367 2.199


chr12_-_51591949 2.190 NM_002702
POU6F1
POU class 6 homeobox 1
chr9_+_139972195 2.183 UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr14_+_24837225 2.169 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr19_+_827821 2.155 NM_001700
AZU1
azurocidin 1
chr8_-_95274540 2.138 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr4_+_74735107 2.115 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr8_-_145060594 2.113 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr14_-_61190458 2.100 NM_017420
SIX4
SIX homeobox 4
chr9_+_139247508 2.099 NM_001145639
GPSM1
G-protein signaling modulator 1
chr2_+_169659099 2.088 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr22_-_37915209 2.082 NM_014550
CARD10
caspase recruitment domain family, member 10
chr8_-_145060563 2.078 PARP10
poly (ADP-ribose) polymerase family, member 10
chr7_-_151071696 2.073


chr6_-_143266283 2.066 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr10_-_77159851 2.053 ZNF503
zinc finger protein 503
chr12_+_79258517 2.052 SYT1
synaptotagmin I
chr15_+_78556485 2.049 NM_018602
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr6_-_31648140 2.047 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr19_+_17830302 2.040 NM_018174
MAP1S
microtubule-associated protein 1S
chr6_+_108881010 2.036 NM_201559
FOXO3
forkhead box O3
chr3_-_42814734 2.032 NM_144719
CCDC13
coiled-coil domain containing 13
chrX_+_95939661 2.028 NM_006729
NM_007309
DIAPH2

diaphanous homolog 2 (Drosophila)

chr6_-_33266297 2.025 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr6_-_30652434 2.021 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr22_-_40859423 2.019 MKL1
megakaryoblastic leukemia (translocation) 1
chr11_-_117100551 2.011 PCSK7
proprotein convertase subtilisin/kexin type 7
chr5_-_176936857 2.005 NM_024872
DOK3
docking protein 3
chr12_+_57482674 2.004 NM_005967
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr6_-_41703345 1.996 TFEB
transcription factor EB
chr13_+_24144402 1.991 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr7_+_100081549 1.989 NM_173564
NYAP1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
chr9_+_130860816 1.984 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr7_-_141673572 1.984 NM_176817
TAS2R38
taste receptor, type 2, member 38
chr19_+_36209125 1.981 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr17_-_7232455 1.977 NM_001005408
NM_032442
NEURL4

neuralized homolog 4 (Drosophila)

chr9_+_130860769 1.972 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr3_-_133614421 1.955 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr12_-_58160823 1.955 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_-_1507810 1.954 NM_001172223
MOB2
MOB kinase activator 2
chr3_+_50306578 1.953 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr11_+_5968576 1.951 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr17_-_1548992 1.939 NM_003693
NM_145350
NM_145352
SCARF1


scavenger receptor class F, member 1


chr7_-_100882100 1.933 NM_001185080
CLDN15
claudin 15
chr12_+_79258588 1.933 SYT1
synaptotagmin I
chr8_-_95274520 1.928 GEM
GTP binding protein overexpressed in skeletal muscle
chr19_+_11649578 1.920 NM_001299
CNN1
calponin 1, basic, smooth muscle
chrX_-_103087106 1.920 NM_016370
RAB9B
RAB9B, member RAS oncogene family
chr12_+_79258448 1.917 NM_005639
SYT1
synaptotagmin I
chr5_+_55149149 1.916 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr8_-_8175860 1.898 SGK223
homolog of rat pragma of Rnd2
chr1_-_221910801 1.893 NM_144728
DUSP10
dual specificity phosphatase 10
chr17_+_37821598 1.893 NM_003673
TCAP
titin-cap (telethonin)
chr9_-_123689172 1.891 NM_005658
TRAF1
TNF receptor-associated factor 1
chr22_-_39268169 1.881 CBX6
chromobox homolog 6
chrX_+_49047887 1.875


chr22_-_39268214 1.873 CBX6
chromobox homolog 6
chr1_-_114354906 1.872 NM_018364
RSBN1
round spermatid basic protein 1
chr4_-_185726865 1.867 ACSL1
acyl-CoA synthetase long-chain family member 1
chr4_+_3443659 1.864 HGFAC
HGF activator
chr2_+_220408352 1.856 TMEM198
transmembrane protein 198
chr17_+_7743233 1.854 NM_001080424
KDM6B
lysine (K)-specific demethylase 6B
chr10_-_32635842 1.845 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr3_+_50306305 1.845 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr19_+_544026 1.844 NM_005317
GZMM
granzyme M (lymphocyte met-ase 1)
chr18_+_29598787 1.837 RNF125
ring finger protein 125
chr16_-_75301950 1.832 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr1_-_234743488 1.831 IRF2BP2
interferon regulatory factor 2 binding protein 2
chr12_-_112630525 1.825 C12orf51
chromosome 12 open reading frame 51
chr14_+_55168831 1.822 SAMD4A
sterile alpha motif domain containing 4A
chr14_-_24020766 1.816 NM_033400
ZFHX2
zinc finger homeobox 2
chr8_+_128806720 1.811 PVT1
Pvt1 oncogene (non-protein coding)
chr7_+_107110501 1.810 NM_005295
GPR22
G protein-coupled receptor 22
chr22_+_31480981 1.808 NM_001207018
SMTN
smoothelin
chr15_+_89182038 1.802 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr2_+_29038862 1.800 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr16_+_69984809 1.796 NM_182619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr19_-_40724272 1.793 NM_152479
TTC9B
tetratricopeptide repeat domain 9B
chr4_+_108745718 1.790 NM_001136258
SGMS2
sphingomyelin synthase 2
chr1_+_36554452 1.785 NM_017825
ADPRHL2
ADP-ribosylhydrolase like 2
chr14_+_103592663 1.782 NM_006291
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr22_-_37640287 1.781 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr3_-_114478117 1.777 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr6_-_33267128 1.774 NM_001243738
NM_004761
RGL2

ral guanine nucleotide dissociation stimulator-like 2

chr3_+_119421865 1.773 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr15_+_85359910 1.771 NM_020778
ALPK3
alpha-kinase 3
chr1_-_45272956 1.763 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr3_-_87040246 1.762 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr9_+_34179058 1.751 UBAP1
ubiquitin associated protein 1
chr9_-_34662629 1.742 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr17_+_18855477 1.726 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr1_+_177140530 1.719 NM_021165
FAM5B
family with sequence similarity 5, member B
chr16_-_58033761 1.711 NM_020807
ZNF319
zinc finger protein 319
chr17_-_1395950 1.711 NM_001080779
MYO1C
myosin IC
chr12_-_54778298 1.711 ZNF385A
zinc finger protein 385A
chr17_-_37353731 1.706 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr1_+_63788729 1.706 NM_012183
FOXD3
forkhead box D3
chr1_-_114354864 1.705 RSBN1
round spermatid basic protein 1
chr7_+_18330044 1.701 HDAC9
histone deacetylase 9
chr17_+_26698666 1.700 SARM1
sterile alpha and TIR motif containing 1
chr19_-_13947101 1.694 LOC284454
uncharacterized LOC284454

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.82 7.61e-06 GO:0051254 positive regulation of RNA metabolic process
1.82 2.80e-05 GO:0051252 regulation of RNA metabolic process
2.59 4.82e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
2.48 5.30e-05 GO:0031328 positive regulation of cellular biosynthetic process
2.55 7.77e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.44 8.59e-05 GO:0009891 positive regulation of biosynthetic process
2.65 9.61e-05 GO:0010628 positive regulation of gene expression
1.61 1.17e-04 GO:0060255 regulation of macromolecule metabolic process
2.71 1.21e-04 GO:0045893 positive regulation of transcription, DNA-dependent
2.47 1.74e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.57 1.76e-04 GO:0031323 regulation of cellular metabolic process
1.69 1.90e-04 GO:0031326 regulation of cellular biosynthetic process
1.72 2.08e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.78 2.13e-04 GO:0006355 regulation of transcription, DNA-dependent
1.52 2.94e-04 GO:0019222 regulation of metabolic process
1.67 3.19e-04 GO:0009889 regulation of biosynthetic process
1.71 5.16e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.55 5.35e-04 GO:0080090 regulation of primary metabolic process
1.67 7.68e-04 GO:0010468 regulation of gene expression
1.67 1.45e-03 GO:0048522 positive regulation of cellular process
1.30 1.46e-03 GO:0050789 regulation of biological process
2.05 1.73e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.62 2.38e-03 GO:0048518 positive regulation of biological process
2.21 3.14e-03 GO:0006351 transcription, DNA-dependent
2.13 3.23e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.00 3.85e-03 GO:0031325 positive regulation of cellular metabolic process
1.60 4.78e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.48 5.19e-03 GO:0023052 signaling
1.30 6.27e-03 GO:0050794 regulation of cellular process
1.92 8.49e-03 GO:0009893 positive regulation of metabolic process
1.57 8.86e-03 GO:0051171 regulation of nitrogen compound metabolic process
2.63 1.00e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.48 1.60e-02 GO:0007275 multicellular organismal development
1.25 2.16e-02 GO:0065007 biological regulation
1.48 2.16e-02 GO:0007165 signal transduction
1.99 3.56e-02 GO:0032774 RNA biosynthetic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.37 2.15e-04 GO:0005634 nucleus

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.57 2.76e-05 GO:0043565 sequence-specific DNA binding
2.20 8.39e-05 GO:0001071 nucleic acid binding transcription factor activity
2.20 8.39e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.62 1.73e-03 GO:0003677 DNA binding
2.63 1.08e-02 GO:0000988 protein binding transcription factor activity
2.63 1.08e-02 GO:0000989 transcription factor binding transcription factor activity
1.88 2.22e-02 GO:0030528 transcription regulator activity
2.69 2.65e-02 GO:0016563 transcription activator activity
2.51 2.99e-02 GO:0003712 transcription cofactor activity