Motif ID: KLF4.p3

Z-value: 2.336


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF4hg19_v1_chr9_-_110251308_1102515890.771.6e-02Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_995109 4.964 LOC100288175
uncharacterized LOC100288175
chr20_-_3388219 4.762 NM_001009984
C20orf194
chromosome 20 open reading frame 194
chr21_-_37528578 4.059 LOC100506428
uncharacterized LOC100506428
chr19_+_45504686 3.853 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr13_-_110438896 3.529 NM_003749
IRS2
insulin receptor substrate 2
chr9_+_139972195 3.189 UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr20_-_3388586 3.113 C20orf194
chromosome 20 open reading frame 194
chr20_-_56884488 3.082 PPP4R1L
protein phosphatase 4, regulatory subunit 1-like
chr9_-_110251754 3.081 KLF4
Kruppel-like factor 4 (gut)
chr5_+_172484353 3.066 C5orf41
chromosome 5 open reading frame 41
chr7_+_64498643 2.974 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr2_+_10183630 2.920 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr22_+_50354428 2.917 PIM3
pim-3 oncogene
chr19_-_47734215 2.903 NM_014417
BBC3
BCL2 binding component 3
chr6_+_37137882 2.900 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr3_-_114866090 2.849 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr19_+_55795766 2.754 BRSK1
BR serine/threonine kinase 1
chr19_+_41284161 2.729 RAB4B-EGLN2
RAB4B
RAB4B-EGLN2 readthrough
RAB4B, member RAS oncogene family
chr9_+_139971938 2.721 NM_207309
UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr17_+_43299277 2.626 NM_005892
FMNL1
formin-like 1
chr15_-_72410108 2.616 MYO9A
myosin IXA
chr22_-_50708720 2.539 NM_002751
MAPK11
mitogen-activated protein kinase 11
chr10_+_104155431 2.501 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr7_-_100493481 2.495 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr19_+_33166312 2.478 NM_207391
RGS9BP
regulator of G protein signaling 9 binding protein
chr19_-_41196419 2.456 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr19_-_38878663 2.438 NM_152657
GGN
gametogenetin
chr5_+_177540465 2.431 NM_015111
N4BP3
NEDD4 binding protein 3
chr1_+_212782103 2.427 ATF3
activating transcription factor 3
chr3_-_129830273 2.402


chr19_-_10679328 2.337 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr7_+_1570321 2.329 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr12_+_52400725 2.309 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr5_+_172483285 2.308 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr12_-_57914287 2.270 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr3_-_129830320 2.265


chr7_+_28448970 2.246 LOC401317
uncharacterized LOC401317
chr1_+_28585959 2.218 NM_031459
SESN2
sestrin 2
chr20_-_3154169 2.215 ProSAPiP1
ProSAPiP1 protein
chr15_-_72410226 2.198 NM_006901
MYO9A
myosin IXA
chr10_+_13142055 2.158 NM_001008211
NM_001008212
NM_001008213
NM_021980
OPTN



optineurin



chr22_+_50354139 2.151 NM_001001852
PIM3
pim-3 oncogene
chr17_+_81037504 2.123 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr1_-_38471170 2.120 NM_001243878
NM_004468
FHL3

four and a half LIM domains 3

chr1_+_160336856 2.112 NM_005598
NHLH1
nescient helix loop helix 1
chr16_-_2185824 2.100 NM_000296
NM_001009944
PKD1

polycystic kidney disease 1 (autosomal dominant)

chrX_-_48828250 2.078 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr19_+_42788605 2.073 NM_015125
CIC
capicua homolog (Drosophila)
chr8_+_8086103 2.026 FLJ10661
family with sequence similarity 86, member A pseudogene
chr2_-_145274916 2.023 ZEB2
zinc finger E-box binding homeobox 2
chr8_+_22457098 2.023 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr19_+_47778099 2.015 NM_178511
PRR24
proline rich 24
chr17_-_74497406 1.998 NM_024599
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr12_-_49582296 1.996 TUBA1A
tubulin, alpha 1a
chr19_-_50143350 1.977 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr19_+_4969123 1.967 NM_015015
KDM4B
lysine (K)-specific demethylase 4B
chr19_-_46000159 1.961 NM_005619
NM_206900
RTN2

reticulon 2

chr11_-_65667809 1.929 FOSL1
FOS-like antigen 1
chr19_+_40697516 1.920 NM_002446
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr7_+_100081549 1.915 NM_173564
NYAP1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
chr4_-_186392847 1.903 NM_001145411
NM_152775
CCDC110

coiled-coil domain containing 110

chr1_-_1475739 1.892 NM_001114748
TMEM240
transmembrane protein 240
chr16_-_402617 1.889 NM_003502
NM_181050
AXIN1

axin 1

chr1_+_110753313 1.858 NM_001039574
NM_004978
KCNC4

potassium voltage-gated channel, Shaw-related subfamily, member 4

chr5_-_176037091 1.856 NM_052899
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr19_+_41305100 1.847 EGLN2
egl nine homolog 2 (C. elegans)
chr19_+_48828820 1.844 EMP3
epithelial membrane protein 3
chr8_+_32405727 1.843 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr5_+_141016516 1.836 NM_001130029
NM_173828
RELL2

RELT-like 2

chr16_-_89768094 1.803 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr19_+_41305041 1.799 NM_080732
EGLN2
egl nine homolog 2 (C. elegans)
chrX_+_153237990 1.795 NM_003492
TMEM187
transmembrane protein 187
chr11_-_33722285 1.781 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr17_+_78234626 1.777 NM_020914
NM_020954
RNF213

ring finger protein 213

chr8_-_145013628 1.773 NM_201384
PLEC
plectin
chr19_-_56135931 1.769 ZNF784
zinc finger protein 784
chr17_-_18907988 1.764 NM_001039999
FAM83G
family with sequence similarity 83, member G
chr10_-_126849556 1.743 NM_001083914
CTBP2
C-terminal binding protein 2
chr19_-_56135934 1.698 NM_203374
ZNF784
zinc finger protein 784
chr17_+_7758380 1.694 NM_203411
TMEM88
transmembrane protein 88
chr1_+_212781969 1.688 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr2_+_30369868 1.687 YPEL5
yippee-like 5 (Drosophila)
chr5_-_16617085 1.684 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr6_-_31633587 1.681 NM_001199238
NM_001199239
GPANK1

G patch domain and ankyrin repeats 1

chr9_-_35115844 1.680 NM_025182
FAM214B
family with sequence similarity 214, member B
chr1_-_156470538 1.679 MEF2D
myocyte enhancer factor 2D
chr19_-_2721337 1.673 NM_145173
DIRAS1
DIRAS family, GTP-binding RAS-like 1
chr16_-_66959418 1.664 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr19_-_10679620 1.660 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr22_+_38597938 1.654 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr2_+_149633173 1.638


chr19_+_13906207 1.625 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr1_+_45266048 1.623 PLK3
polo-like kinase 3
chr3_-_109035239 1.623 NM_138815
DPPA2
developmental pluripotency associated 2
chr19_+_4969126 1.618 KDM4B
lysine (K)-specific demethylase 4B
chr12_+_120933916 1.612 DYNLL1
dynein, light chain, LC8-type 1
chr19_-_19738973 1.612 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr9_-_139890984 1.611 NM_004669
CLIC3
chloride intracellular channel 3
chr2_+_28615668 1.608 FOSL2
FOS-like antigen 2
chr22_+_38599026 1.606 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr22_+_38598065 1.603 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr22_+_31477231 1.599 NM_006932
NM_134269
NM_134270
SMTN


smoothelin


chr1_-_156470506 1.592 NM_005920
MEF2D
myocyte enhancer factor 2D
chr15_-_60884615 1.591 NM_134262
RORA
RAR-related orphan receptor A
chr9_-_110252045 1.591 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr6_-_44233499 1.583 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr15_+_90931470 1.580 NM_003870
IQGAP1
IQ motif containing GTPase activating protein 1
chr8_+_144329105 1.579 NM_173832
ZFP41
zinc finger protein 41 homolog (mouse)
chr19_-_1237840 1.579 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr14_-_71275732 1.578 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr2_+_30369749 1.571 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr19_+_47759802 1.570 CCDC9
coiled-coil domain containing 9
chr14_-_105767328 1.566 NM_001242788
NM_001242790
NM_001519
BRF1


BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)


chr3_-_132441302 1.551 NM_153240
NPHP3-ACAD11
NPHP3
NPHP3-ACAD11 readthrough
nephronophthisis 3 (adolescent)
chr12_+_58148775 1.546 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr6_-_41702734 1.545 NM_007162
TFEB
transcription factor EB
chr12_+_57482922 1.543 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr12_+_120933832 1.537 NM_001037495
NM_003746
DYNLL1

dynein, light chain, LC8-type 1

chr19_-_18632886 1.527 NM_006532
ELL
elongation factor RNA polymerase II
chr6_-_44233244 1.512 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr11_-_1593149 1.511 NM_004420
DUSP8
dual specificity phosphatase 8
chr8_-_145050896 1.499 NM_000445
PLEC
plectin
chr12_-_100378431 1.481 NM_152788
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr6_-_33266735 1.480 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr19_+_7660698 1.480 NM_001080429
NM_020902
CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chr12_+_106696508 1.476 NM_152772
TCP11L2
t-complex 11 (mouse)-like 2
chr12_-_49582800 1.476 NM_006009
TUBA1A
tubulin, alpha 1a
chr20_+_388717 1.472 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_+_35331533 1.472


chr6_-_33285718 1.471 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr17_-_49198084 1.471 NM_001130527
NM_001130528
NM_003971
SPAG9


sperm associated antigen 9


chr17_-_72968790 1.469 NM_030630
C17orf28
chromosome 17 open reading frame 28
chr16_+_66638652 1.468 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr4_-_82392971 1.467 RASGEF1B
RasGEF domain family, member 1B
chr19_-_46283281 1.463


chr1_-_212873197 1.462 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr19_+_55795533 1.461 NM_032430
BRSK1
BR serine/threonine kinase 1
chr7_-_2354050 1.459 NM_013321
SNX8
sorting nexin 8
chr19_-_36523540 1.451 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr8_-_29207795 1.443 NM_001394
DUSP4
dual specificity phosphatase 4
chr19_+_49617631 1.438 LIN7B
lin-7 homolog B (C. elegans)
chr8_+_144680073 1.438 NM_032862
TIGD5
tigger transposable element derived 5
chr12_+_58120029 1.425 LOC100130776
uncharacterized LOC100130776
chr19_-_4065467 1.423 ZBTB7A
zinc finger and BTB domain containing 7A
chr12_-_112819755 1.422 NM_001109662
C12orf51
chromosome 12 open reading frame 51
chr6_-_33266700 1.418 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr9_+_139221931 1.417 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr19_-_18632857 1.412 ELL
elongation factor RNA polymerase II
chr6_+_138188352 1.411 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr1_-_6321034 1.411 NM_207370
GPR153
G protein-coupled receptor 153
chr8_+_144328990 1.409 ZFP41
zinc finger protein 41 homolog (mouse)
chr11_-_65667860 1.409 NM_005438
FOSL1
FOS-like antigen 1
chr7_+_99775521 1.409 NM_012447
STAG3
stromal antigen 3
chr19_-_11373117 1.407 NM_020812
DOCK6
dedicator of cytokinesis 6
chr5_+_141016567 1.406 RELL2
RELT-like 2
chr11_+_46299161 1.402 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr7_-_2354010 1.401 SNX8
sorting nexin 8
chr17_-_17109601 1.400 PLD6
phospholipase D family, member 6
chr2_+_10184371 1.394 NM_001177718
KLF11
Kruppel-like factor 11
chr2_+_23608297 1.394 NM_052920
KLHL29
kelch-like 29 (Drosophila)
chr12_+_57482674 1.390 NM_005967
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr9_-_110251308 1.390 KLF4
Kruppel-like factor 4 (gut)
chr19_-_1111972 1.389 SBNO2
strawberry notch homolog 2 (Drosophila)
chr22_+_51039178 1.389 MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr8_-_145016691 1.389 NM_201383
PLEC
plectin
chr17_-_17109630 1.387 NM_178836
PLD6
phospholipase D family, member 6
chr19_+_49622480 1.386 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr14_+_24838301 1.379 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr5_+_179234002 1.377 NM_001142299
SQSTM1
sequestosome 1
chr9_-_35732389 1.376 NM_006289
TLN1
talin 1
chr6_+_108882104 1.372 FOXO3
forkhead box O3
chr19_+_41305333 1.367 NM_053046
EGLN2
egl nine homolog 2 (C. elegans)
chr11_+_77899857 1.366 NM_020798
USP35
ubiquitin specific peptidase 35
chr6_+_17281773 1.361 NM_001143942
RBM24
RNA binding motif protein 24
chr2_-_17699705 1.359 NM_001099218
RAD51AP2
RAD51 associated protein 2
chr16_+_66638632 1.354 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr12_+_57482886 1.354 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr1_+_45266035 1.350 NM_004073
PLK3
polo-like kinase 3
chr15_+_90931489 1.347 IQGAP1
IQ motif containing GTPase activating protein 1
chr16_-_30381487 1.344 NM_015527
TBC1D10B
TBC1 domain family, member 10B
chr8_-_144650998 1.343 C8orf73
chromosome 8 open reading frame 73
chr6_-_33285493 1.340 NM_005453
ZBTB22
zinc finger and BTB domain containing 22
chr17_-_41910439 1.340 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr14_+_75745480 1.337 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr16_+_2039945 1.334 NM_004209
SYNGR3
synaptogyrin 3
chr12_+_111843743 1.327 NM_005475
SH2B3
SH2B adaptor protein 3
chr9_+_99212379 1.325 NM_014282
HABP4
hyaluronan binding protein 4
chr19_-_40971623 1.324 NM_000713
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
chr15_-_61521416 1.322 RORA
RAR-related orphan receptor A
chr7_-_4923246 1.319 NM_018059
RADIL
Ras association and DIL domains
chr1_-_38273852 1.315 NM_024640
YRDC
yrdC domain containing (E. coli)
chr1_+_233463513 1.315 NM_032435
KIAA1804
mixed lineage kinase 4
chr16_+_1203240 1.314 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr11_-_64684606 1.313 NM_015104
ATG2A
ATG2 autophagy related 2 homolog A (S. cerevisiae)
chr19_+_41284068 1.307 NM_016154
RAB4B
RAB4B, member RAS oncogene family
chr7_+_73082157 1.304 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr1_+_37940129 1.302 ZC3H12A
zinc finger CCCH-type containing 12A
chr13_+_52027435 1.301


chr14_+_105331581 1.299 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr15_+_90931449 1.296 IQGAP1
IQ motif containing GTPase activating protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.22 1.72e-03 GO:0035556 intracellular signal transduction
6.32 4.46e-03 GO:0031098 stress-activated protein kinase signaling cascade
2.78 4.61e-03 GO:0042325 regulation of phosphorylation
1.59 6.66e-03 GO:0032502 developmental process
1.89 6.77e-03 GO:0030154 cell differentiation
2.70 7.64e-03 GO:0019220 regulation of phosphate metabolic process
2.70 7.64e-03 GO:0051174 regulation of phosphorus metabolic process
1.73 8.92e-03 GO:0048518 positive regulation of biological process
6.54 1.02e-02 GO:0046328 regulation of JNK cascade
3.84 1.03e-02 GO:0071900 regulation of protein serine/threonine kinase activity
4.08 1.03e-02 GO:0000165 MAPKKK cascade
1.35 1.04e-02 GO:0050789 regulation of biological process
1.60 1.08e-02 GO:0031323 regulation of cellular metabolic process
1.36 1.13e-02 GO:0050794 regulation of cellular process
1.60 1.25e-02 GO:0080090 regulation of primary metabolic process
1.83 1.45e-02 GO:0048869 cellular developmental process
2.72 1.58e-02 GO:0001932 regulation of protein phosphorylation
8.60 1.67e-02 GO:0043506 regulation of JUN kinase activity
6.08 1.84e-02 GO:0070302 regulation of stress-activated protein kinase signaling cascade
1.95 2.44e-02 GO:0023051 regulation of signaling
2.01 2.46e-02 GO:0065009 regulation of molecular function
1.60 2.60e-02 GO:0060255 regulation of macromolecule metabolic process
1.31 2.94e-02 GO:0065007 biological regulation
4.23 3.17e-02 GO:0043405 regulation of MAP kinase activity
1.53 3.17e-02 GO:0019222 regulation of metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.84 4.21e-04 GO:0046983 protein dimerization activity
3.02 6.20e-04 GO:0008092 cytoskeletal protein binding
1.36 6.49e-04 GO:0005515 protein binding
2.33 1.78e-03 GO:0001071 nucleic acid binding transcription factor activity
2.33 1.78e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
20.79 6.87e-03 GO:0070412 R-SMAD binding
2.42 2.09e-02 GO:0043565 sequence-specific DNA binding
3.76 4.21e-02 GO:0019901 protein kinase binding
13.51 4.29e-02 GO:0043621 protein self-association
2.72 4.60e-02 GO:0019904 protein domain specific binding