Motif ID: NFE2L2.p2

Z-value: 1.604


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2L2hg19_v1_chr2_-_178129858_178129858-0.333.8e-01Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_75919051 3.244 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr7_+_134212343 2.943 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr3_-_186262114 2.899 NM_017541
CRYGS
crystallin, gamma S
chr20_-_633844 2.869 NM_080725
SRXN1
sulfiredoxin 1
chr12_+_56075329 2.837 NM_152637
METTL7B
methyltransferase like 7B
chr11_+_72983246 2.809 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr14_-_65409445 2.610 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr12_+_56075418 2.419 METTL7B
methyltransferase like 7B
chr5_-_90610218 2.367 LOC100505994
uncharacterized LOC100505994
chr19_-_49658645 2.257 NM_002152
HRC
histidine rich calcium binding protein
chr11_+_62380212 2.253 NM_000327
ROM1
retinal outer segment membrane protein 1
chr6_+_56819923 2.191 BEND6
BEN domain containing 6
chr10_+_115312777 2.167 NM_004132
HABP2
hyaluronan binding protein 2
chr17_-_76921205 2.120 TIMP2
TIMP metallopeptidase inhibitor 2
chr5_-_95158365 2.069 GLRX
glutaredoxin (thioltransferase)
chr5_-_95158465 1.935 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr20_+_34742656 1.866 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr19_-_51587466 1.859 NM_022046
KLK14
kallikrein-related peptidase 14
chr16_-_69760444 1.815 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr1_-_94374949 1.762 GCLM
glutamate-cysteine ligase, modifier subunit
chrX_+_99899162 1.718 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr7_+_93551015 1.644 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr1_-_94374986 1.642 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr7_+_73245192 1.626 NM_001305
CLDN4
claudin 4
chr5_-_151150939 1.613 LOC100652758
uncharacterized LOC100652758
chr16_+_30076993 1.498 NM_001243177
NM_184041
ALDOA

aldolase A, fructose-bisphosphate

chr7_+_37960418 1.409 EPDR1
ependymin related protein 1 (zebrafish)
chr12_-_70083055 1.379 NM_152439
BEST3
bestrophin 3
chr1_-_94375028 1.368 GCLM
glutamate-cysteine ligase, modifier subunit
chr10_-_71892514 1.321 AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chr10_-_71892596 1.317 NM_001198696
NM_032797
AIFM2

apoptosis-inducing factor, mitochondrion-associated, 2

chr16_+_83986826 1.312 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr2_+_133174146 1.296 NM_001508
GPR39
G protein-coupled receptor 39
chrX_-_24665454 1.290 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr2_-_99871569 1.286 NM_175735
LYG2
lysozyme G-like 2
chr2_-_224866616 1.281 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr6_+_56819706 1.258 NM_152731
BEND6
BEN domain containing 6
chr2_-_169887832 1.253 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr6_+_74405505 1.249 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr8_-_68658577 1.237 NM_020361
CPA6
carboxypeptidase A6
chr17_+_80317122 1.220 NM_207459
TEX19
testis expressed 19
chr18_+_21693316 1.211 TTC39C
tetratricopeptide repeat domain 39C
chr16_+_2083264 1.179 NM_001252073
NM_001252075
NM_001252076
SLC9A3R2


solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2


chr7_+_139528951 1.163 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_-_55266870 1.159 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr6_-_84140758 1.153 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr17_-_76921453 1.152 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr4_+_84457256 1.133 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr1_-_33366838 1.121 NM_033504
TMEM54
transmembrane protein 54
chr17_+_30771520 1.108 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_18625335 1.092 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr6_-_84140854 1.088 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chrX_-_24665225 1.074 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_+_30771522 1.062 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr16_-_28607694 1.059 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr8_-_30585220 1.055 GSR
glutathione reductase
chr17_+_30771532 1.044 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_+_74405764 1.038 CD109
CD109 molecule
chr16_+_30077146 1.032 ALDOA
aldolase A, fructose-bisphosphate
chr6_-_84140744 1.030 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr7_+_37960920 1.019 NM_001242948
EPDR1
ependymin related protein 1 (zebrafish)
chr17_+_30771485 1.016 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr18_+_158586 0.995 USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr9_+_140083053 0.995 NM_003731
SSNA1
Sjogren syndrome nuclear autoantigen 1
chrX_+_99899388 0.992 SRPX2
sushi-repeat containing protein, X-linked 2
chr3_-_46608039 0.991 NM_024512
LRRC2
leucine rich repeat containing 2
chr6_-_84140651 0.987 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr22_+_45072936 0.980 PRR5
proline rich 5 (renal)
chr4_+_154178525 0.973 TRIM2
tripartite motif containing 2
chr1_-_114302093 0.971 PHTF1
putative homeodomain transcription factor 1
chr16_+_30077120 0.970 ALDOA
aldolase A, fructose-bisphosphate
chr9_+_140135738 0.969 TUBB4B
tubulin, beta 4B class IVb
chr5_-_33892292 0.954 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr20_+_42187705 0.945 SGK2
serum/glucocorticoid regulated kinase 2
chr17_+_30771494 0.944 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr14_+_103800678 0.940 EIF5
eukaryotic translation initiation factor 5
chr1_+_154377847 0.935 IL6R
interleukin 6 receptor
chr1_+_14075917 0.934 PRDM2
PR domain containing 2, with ZNF domain
chr17_-_72889704 0.924 NM_178128
FADS6
fatty acid desaturase domain family, member 6
chr1_+_14075931 0.909 PRDM2
PR domain containing 2, with ZNF domain
chr20_-_633808 0.900 SRXN1
sulfiredoxin 1
chr6_+_74405909 0.884 CD109
CD109 molecule
chrX_+_9431314 0.870 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr6_+_32121228 0.870 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr10_+_91061705 0.866 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr6_-_24645955 0.865 NM_001168375
NM_001168376
NM_001168374
NM_001168377
NM_014809
KIAA0319




KIAA0319




chr19_-_36004553 0.863 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr22_+_45072687 0.840 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr17_+_14204326 0.839 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chrX_-_154493736 0.837 NM_171998
RAB39B
RAB39B, member RAS oncogene family
chr9_+_140135698 0.833 NM_006088
TUBB4B
tubulin, beta 4B class IVb
chr4_+_41258941 0.831 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr5_-_149535420 0.820 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_-_177939347 0.815 SEC16B
SEC16 homolog B (S. cerevisiae)
chr7_-_93519990 0.805 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr1_-_84464728 0.801 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr1_-_177939049 0.800 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr2_+_120189342 0.800 NM_183240
TMEM37
transmembrane protein 37
chr11_-_118134956 0.765 MPZL2
myelin protein zero-like 2
chr10_+_85899184 0.752 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr18_+_158480 0.742 NM_001037334
NM_005151
USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

chr14_+_79745653 0.739 NM_001105250
NM_138970
NRXN3

neurexin 3

chr2_+_27505296 0.723 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr10_-_76868853 0.713 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr17_-_28618836 0.709 BLMH
bleomycin hydrolase
chr9_-_77502635 0.709 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr11_-_118134986 0.694 MPZL2
myelin protein zero-like 2
chr7_+_44078677 0.691 FLJ35390
uncharacterized LOC255031
chr1_+_32043745 0.687 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr3_-_71774407 0.682 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr1_+_154378044 0.681 IL6R
interleukin 6 receptor
chr8_-_125740378 0.676 MTSS1
metastasis suppressor 1
chr16_+_57662301 0.675 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr12_-_10282680 0.674 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr4_+_123747815 0.673 NM_002006
FGF2
fibroblast growth factor 2 (basic)
chr9_-_100935173 0.668 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr18_-_48346297 0.659 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr1_+_154377668 0.656 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr7_-_150721551 0.654 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr3_-_56809594 0.653 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr20_+_42187634 0.649 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr11_-_118134868 0.639


chr15_-_40630272 0.639 C15orf52
chromosome 15 open reading frame 52
chr3_-_9920471 0.637 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr2_-_28113954 0.628 LOC100302650
uncharacterized LOC100302650
chr6_-_64029847 0.628 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr6_+_44195008 0.625 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr5_-_149535309 0.623 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr11_-_10590078 0.623 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr16_-_1429612 0.622 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr17_-_65362667 0.621 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr18_+_61637262 0.615 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr2_-_142889269 0.610 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr14_+_69726868 0.594 GALNTL1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
chr21_-_46237966 0.594 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr16_+_28505920 0.582 NM_018690
APOBR
apolipoprotein B receptor
chr1_-_201123560 0.582 TMEM9
transmembrane protein 9
chr11_+_10476665 0.580 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr22_+_21369441 0.574 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr16_+_58534045 0.573 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr19_+_3366589 0.569 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chrX_-_106960268 0.568 NM_004089
TSC22D3
TSC22 domain family, member 3
chr21_-_46237882 0.564 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr16_-_67517715 0.560 NM_001138
AGRP
agouti related protein homolog (mouse)
chrX_+_149531439 0.554 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr15_-_29562008 0.553 NM_138704
NDNL2
necdin-like 2
chr17_-_28619183 0.550 NM_000386
BLMH
bleomycin hydrolase
chr7_-_75988315 0.546 NM_012479
YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr11_-_3862183 0.546 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr12_-_56101667 0.544 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr6_-_24719286 0.538 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr2_+_231921625 0.538 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr1_+_3388170 0.537 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr12_+_56137063 0.536 NM_005811
GDF11
growth differentiation factor 11
chr9_-_77503009 0.536 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chrX_-_133930234 0.534 NM_001170756
NM_145284
FAM122B

family with sequence similarity 122B

chr12_+_64798050 0.531 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr12_-_56101465 0.528 ITGA7
integrin, alpha 7
chr7_+_23286277 0.527 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr1_-_225616556 0.527 NM_194442
LBR
lamin B receptor
chr4_+_2813945 0.527 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr13_-_41768533 0.523 NM_032138
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr17_+_2497233 0.518 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr5_+_132209354 0.517 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr17_-_65362635 0.513 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr1_+_40506347 0.510 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr14_+_69726680 0.508 NM_001168368
NM_020692
GALNTL1

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1

chr1_-_114301753 0.501 NM_006608
PHTF1
putative homeodomain transcription factor 1
chr11_-_118135197 0.500 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr16_+_74330730 0.500 PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr12_-_121711980 0.499 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chrX_-_119445306 0.499 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr1_+_14075861 0.497 NM_001007257
PRDM2
PR domain containing 2, with ZNF domain
chr11_+_2924504 0.495 SLC22A18
solute carrier family 22, member 18
chr7_+_23286390 0.492 GPNMB
glycoprotein (transmembrane) nmb
chr16_+_89988416 0.489 NM_001197181
TUBB3
tubulin, beta 3 class III
chr19_-_6502224 0.489 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr17_+_21191347 0.481 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr16_-_28620648 0.476 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr13_-_41768392 0.474 KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr7_-_17980102 0.472 NM_015132
SNX13
sorting nexin 13
chr22_-_19466725 0.469 NM_001035247
NM_005659
UFD1L

ubiquitin fusion degradation 1 like (yeast)

chr3_-_98241357 0.467 CLDND1
claudin domain containing 1
chr15_-_64385988 0.466 NM_001014812
NM_032231
FAM96A

family with sequence similarity 96, member A

chr6_+_34206567 0.462 NM_145905
HMGA1
high mobility group AT-hook 1
chr12_+_78225068 0.457 NM_014903
NAV3
neuron navigator 3
chr6_+_1611544 0.457 FOXC1
forkhead box C1
chr8_-_125580745 0.456 MTSS1
metastasis suppressor 1
chr21_+_33031932 0.455 NM_000454
SOD1
superoxide dismutase 1, soluble
chr19_+_34855594 0.453 NM_001184722
NM_000175
GPI

glucose-6-phosphate isomerase

chr1_-_183559463 0.449 NCF2
neutrophil cytosolic factor 2
chr8_+_87354958 0.447 NM_007013
WWP1
WW domain containing E3 ubiquitin protein ligase 1
chr3_-_120400957 0.444 HGD
homogentisate 1,2-dioxygenase
chr7_+_23286384 0.443 GPNMB
glycoprotein (transmembrane) nmb
chr11_-_3862137 0.441 RHOG
ras homolog gene family, member G (rho G)
chr2_-_238499317 0.440 RAB17
RAB17, member RAS oncogene family
chr18_-_55253785 0.433 NM_000140
NM_001012515
FECH

ferrochelatase

chr7_-_115670774 0.426 TFEC
transcription factor EC
chr11_+_63448868 0.426 NM_006054
NM_201428
NM_201429
NM_201430
RTN3



reticulon 3



chr1_-_183560010 0.425 NM_001127651
NCF2
neutrophil cytosolic factor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.71 6.86e-03 GO:0055114 oxidation-reduction process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
13.57 3.33e-04 GO:0009055 electron carrier activity
255.89 1.44e-03 GO:0015038 glutathione disulfide oxidoreductase activity
191.92 2.88e-03 GO:0015037 peptide disulfide oxidoreductase activity
5.19 3.03e-03 GO:0016491 oxidoreductase activity
22.60 2.25e-02 GO:0016209 antioxidant activity
22.60 2.25e-02 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors