Motif ID: NFKB1_REL_RELA.p2

Z-value: 3.415


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFKB1hg19_v1_chr4_+_103422479_1034225180.925.3e-04Click!
RELhg19_v1_chr2_+_61108702_611087080.909.7e-04Click!
RELAhg19_v1_chr11_-_65430427_654304550.845.0e-03Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_104154228 9.600 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr10_+_104155431 7.542 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr4_-_74964836 6.720 CXCL2
chemokine (C-X-C motif) ligand 2
chr7_+_18548899 6.353 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr19_+_45504686 5.747 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr16_-_66959418 5.271 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr9_+_35560424 5.151 RUSC2
RUN and SH3 domain containing 2
chr7_+_18548963 5.018 HDAC9
histone deacetylase 9
chr7_+_1570321 4.972 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr8_-_103667882 4.749 NM_005655
KLF10
Kruppel-like factor 10
chr4_-_74864296 4.728 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr4_+_74735107 4.481 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr12_+_52445185 4.457 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr8_-_95274540 4.320 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr4_-_74964996 4.303 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr19_+_45971249 4.302 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr12_-_76425375 4.279 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr11_+_122526339 4.111 NM_032873
UBASH3B
ubiquitin associated and SH3 domain containing B
chr12_-_76425207 4.032 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr11_+_102188180 4.000 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr4_+_74702272 3.835 NM_002993
CXCL6
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chr8_-_95274520 3.781 GEM
GTP binding protein overexpressed in skeletal muscle
chr19_-_47734215 3.711 NM_014417
BBC3
BCL2 binding component 3
chr19_+_2476122 3.597 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr19_-_4338750 3.596 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr19_+_40697516 3.560 NM_002446
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr4_-_74904329 3.550 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr16_+_3115639 3.515 IL32
interleukin 32
chr1_+_201979689 3.505 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr1_+_201979747 3.385 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr1_+_45274153 3.371 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr16_+_3115312 3.348 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr10_-_73533196 3.284 NM_022153
C10orf54
chromosome 10 open reading frame 54
chr1_+_35331533 3.280


chr17_+_7461591 3.254 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr10_-_3827205 3.240 KLF6
Kruppel-like factor 6
chr1_+_170633312 3.207 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr19_-_48614013 3.180 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr1_+_110453232 3.151 NM_000757
NM_172210
NM_172212
CSF1


colony stimulating factor 1 (macrophage)


chr16_+_50775960 3.137 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr15_+_85923739 3.131 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr1_+_110453456 3.126 CSF1
colony stimulating factor 1 (macrophage)
chr7_-_100061893 3.042 NM_001004323
C7orf61
chromosome 7 open reading frame 61
chr12_+_120740123 2.988 NM_012240
SIRT4
sirtuin 4
chr2_+_28615668 2.988 FOSL2
FOS-like antigen 2
chr1_-_59248287 2.943 JUN
jun proto-oncogene
chr1_+_45266035 2.929 NM_004073
PLK3
polo-like kinase 3
chr6_+_29974352 2.913 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr1_-_1475739 2.892 NM_001114748
TMEM240
transmembrane protein 240
chr16_-_2059759 2.857 NM_178167
ZNF598
zinc finger protein 598
chr3_+_157154579 2.854 NM_002852
PTX3
pentraxin 3, long
chr3_-_42814734 2.849 NM_144719
CCDC13
coiled-coil domain containing 13
chr1_+_45266048 2.821 PLK3
polo-like kinase 3
chr2_-_74669005 2.820 RTKN
rhotekin
chr19_+_39390618 2.819 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr8_-_11324184 2.817 NM_053279
FAM167A
family with sequence similarity 167, member A
chr10_+_13142055 2.816 NM_001008211
NM_001008212
NM_001008213
NM_021980
OPTN



optineurin



chr4_+_103422730 2.805 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr16_+_3115611 2.802 NM_001012635
IL32
interleukin 32
chr6_-_29527701 2.759 NM_006398
UBD
ubiquitin D
chr1_+_37940180 2.742 ZC3H12A
zinc finger CCCH-type containing 12A
chr19_+_39390570 2.701 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr16_+_3115638 2.691 NM_001012634
IL32
interleukin 32
chr19_+_13205956 2.620 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr16_-_122573 2.610 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr6_-_29527477 2.601 UBD
ubiquitin D
chr5_+_177540465 2.581 NM_015111
N4BP3
NEDD4 binding protein 3
chr4_+_103422822 2.579 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr16_+_50776012 2.558 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr17_+_16318848 2.551 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr11_+_46299554 2.514 CREB3L1
cAMP responsive element binding protein 3-like 1
chr9_-_110250707 2.512 KLF4
Kruppel-like factor 4 (gut)
chr19_+_39390258 2.499 NM_001243116
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr7_+_149412027 2.464 NM_032534
KRBA1
KRAB-A domain containing 1
chr3_-_39195101 2.450 NM_033027
CSRNP1
cysteine-serine-rich nuclear protein 1
chr1_-_89641722 2.432 NM_207398
GBP7
guanylate binding protein 7
chr1_+_203274646 2.429 NM_006763
BTG2
BTG family, member 2
chr4_+_103422479 2.403 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr15_-_40398286 2.391 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr19_-_46295647 2.385 DMWD
dystrophia myotonica, WD repeat containing
chr14_-_35873823 2.359 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr2_-_74669026 2.356 RTKN
rhotekin
chr19_+_55795533 2.353 NM_032430
BRSK1
BR serine/threonine kinase 1
chr1_+_212788359 2.351 NM_001206486
ATF3
activating transcription factor 3
chr19_-_46283281 2.334


chr6_-_31324955 2.333 HLA-B
major histocompatibility complex, class I, B
chr4_+_103422553 2.309 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr19_+_55795766 2.287 BRSK1
BR serine/threonine kinase 1
chr12_+_93964801 2.284 SOCS2
suppressor of cytokine signaling 2
chr5_-_150466696 2.253 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr3_-_39195034 2.245 CSRNP1
cysteine-serine-rich nuclear protein 1
chr22_-_50708720 2.215 NM_002751
MAPK11
mitogen-activated protein kinase 11
chr17_+_16318911 2.188 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr2_+_228678556 2.161 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr17_-_39092714 2.149 KRT23
keratin 23 (histone deacetylase inducible)
chr19_-_4831711 2.130 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr18_+_23806385 2.118 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr20_-_44600787 2.083 NM_022095
ZNF335
zinc finger protein 335
chr5_+_176875325 2.079 NM_001174102
PRR7
proline rich 7 (synaptic)
chr20_-_44600939 2.039 ZNF335
zinc finger protein 335
chr3_-_156878481 2.024 NM_020307
CCNL1
cyclin L1
chr19_+_827821 2.011 NM_001700
AZU1
azurocidin 1
chr7_+_17338182 2.005 NM_001621
AHR
aryl hydrocarbon receptor
chr22_-_38506532 1.997 BAIAP2L2
BAI1-associated protein 2-like 2
chr7_+_150745604 1.996 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr11_+_46299161 1.973 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr22_+_38599026 1.950 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr5_+_60628085 1.936 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr11_+_59522905 1.917 STX3
syntaxin 3
chr10_-_125851850 1.914 NM_014863
NM_015892
CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr11_+_65984213 1.897 PACS1
phosphofurin acidic cluster sorting protein 1
chr6_+_17281773 1.890 NM_001143942
RBM24
RNA binding motif protein 24
chr12_-_58160823 1.889 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr19_+_48673936 1.875 C19orf68
chromosome 19 open reading frame 68
chr2_-_74669055 1.874 NM_001015055
RTKN
rhotekin
chr2_+_61108702 1.865 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr6_+_138188352 1.859 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr6_+_29910246 1.849 NM_001242758
NM_002116
HLA-A

major histocompatibility complex, class I, A

chr14_+_75988765 1.845 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr8_+_128806720 1.827 PVT1
Pvt1 oncogene (non-protein coding)
chr6_+_108882068 1.827 NM_001455
FOXO3
forkhead box O3
chr7_-_100808832 1.823 NM_003378
VGF
VGF nerve growth factor inducible
chr16_+_67571342 1.821 NM_001193524
FAM65A
family with sequence similarity 65, member A
chr11_+_59522801 1.818 STX3
syntaxin 3
chr6_+_31540092 1.815 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr2_+_61108724 1.814 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr17_+_38474513 1.813 RARA
retinoic acid receptor, alpha
chr2_+_43864405 1.809 PLEKHH2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr19_-_40724272 1.803 NM_152479
TTC9B
tetratricopeptide repeat domain 9B
chr6_-_150039219 1.798 LATS1
LATS, large tumor suppressor, homolog 1 (Drosophila)
chr6_+_108882104 1.793 FOXO3
forkhead box O3
chr17_+_38474472 1.785 NM_001145301
NM_001145302
RARA

retinoic acid receptor, alpha

chr9_-_86432546 1.779 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr6_+_36646455 1.772 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr11_+_6625000 1.768 ILK
integrin-linked kinase
chr20_-_3388586 1.757 C20orf194
chromosome 20 open reading frame 194
chr17_+_38474544 1.750 RARA
retinoic acid receptor, alpha
chr1_-_202129731 1.743 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr13_+_42614171 1.742 NM_001204504
DGKH
diacylglycerol kinase, eta
chr12_-_15942116 1.725 EPS8
epidermal growth factor receptor pathway substrate 8
chr5_+_172571444 1.721 NM_001205
NM_013978
NM_013979
NM_013980
BNIP1



BCL2/adenovirus E1B 19kDa interacting protein 1



chr19_-_1513187 1.712 NM_213604
ADAMTSL5
ADAMTS-like 5
chr22_-_18484183 1.705 MICAL3
microtubule associated monoxygenase, calponin and LIM domain containing 3
chr19_-_41859830 1.693 NM_000660
TGFB1
transforming growth factor, beta 1
chr9_+_130860769 1.690 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr19_+_48111437 1.686 NM_015711
GLTSCR1
glioma tumor suppressor candidate region gene 1
chr5_-_150460550 1.683 TNIP1
TNFAIP3 interacting protein 1
chr7_-_104654049 1.681 LOC100216545
uncharacterized LOC100216545
chr1_+_162039469 1.679 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr13_+_21872248 1.678 MIPEPP3
mitochondrial intermediate peptidase pseudogene 3
chr12_-_15942350 1.675 NM_004447
EPS8
epidermal growth factor receptor pathway substrate 8
chr11_+_46299585 1.675 CREB3L1
cAMP responsive element binding protein 3-like 1
chr2_+_61108775 1.661 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr15_+_76352270 1.658 NM_152335
C15orf27
chromosome 15 open reading frame 27
chr5_-_148758787 1.644 NM_014443
IL17B
interleukin 17B
chr5_-_150460599 1.644 NM_001252385
NM_001252386
NM_001252393
NM_006058
TNIP1



TNFAIP3 interacting protein 1



chr10_-_116527955 1.644 ABLIM1
actin binding LIM protein 1
chr14_-_65879245 1.635 LOC645431
uncharacterized LOC645431
chr20_-_3388219 1.630 NM_001009984
C20orf194
chromosome 20 open reading frame 194
chr11_+_6625206 1.629 NM_001014795
ILK
integrin-linked kinase
chr11_+_66059364 1.625 NM_153266
TMEM151A
transmembrane protein 151A
chr19_+_56152281 1.614 NM_207115
ZNF580
zinc finger protein 580
chr13_+_51796363 1.613 NM_001242312
NM_145019
FAM124A

family with sequence similarity 124A

chr19_+_41222915 1.613 NM_025194
ITPKC
inositol-trisphosphate 3-kinase C
chr5_+_612454 1.613 CEP72
centrosomal protein 72kDa
chr6_+_41514133 1.609 NM_001012426
NM_001012427
NM_138457
FOXP4


forkhead box P4


chr5_+_172484353 1.595 C5orf41
chromosome 5 open reading frame 41
chr2_-_206950895 1.594 NM_017759
INO80D
INO80 complex subunit D
chr16_-_54318889 1.581 IRX3
iroquois homeobox 3
chr1_-_156675237 1.575 NM_001878
NM_001199723
CRABP2

cellular retinoic acid binding protein 2

chr1_-_236030170 1.572


chr10_-_32667543 1.568 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr9_-_110251308 1.568 KLF4
Kruppel-like factor 4 (gut)
chr19_+_39390567 1.565 NM_002503
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr6_+_41514289 1.560 FOXP4
forkhead box P4
chr14_+_24616095 1.557 RNF31
ring finger protein 31
chr19_+_13135809 1.552 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_-_211035913 1.551 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr2_+_43864433 1.542 NM_172069
PLEKHH2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr10_-_98273444 1.540 NM_012465
TLL2
tolloid-like 2
chr4_+_139936938 1.539 NM_012118
CCRN4L
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr17_+_45973515 1.537 NM_003110
SP2
Sp2 transcription factor
chr11_+_66059335 1.531 TMEM151A
transmembrane protein 151A
chr19_+_1067536 1.530 HMHA1
histocompatibility (minor) HA-1
chr17_-_18907988 1.526 NM_001039999
FAM83G
family with sequence similarity 83, member G
chr6_+_36646489 1.525 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr5_+_612404 1.524 NM_018140
CEP72
centrosomal protein 72kDa
chr21_-_47705235 1.515 NM_003906
MCM3AP
minichromosome maintenance complex component 3 associated protein
chr2_-_96700662 1.513 NM_207328
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr3_-_50605062 1.506 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr19_+_52839497 1.500 NM_001161425
NM_001161426
NM_001161427
ZNF610


zinc finger protein 610


chr6_-_109775423 1.495 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr22_-_37640287 1.493 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr9_+_130860816 1.490 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr3_+_19189969 1.480 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr5_-_150467220 1.477 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr4_-_82392971 1.474 RASGEF1B
RasGEF domain family, member 1B
chr19_+_13135745 1.473 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_150039391 1.470 NM_004690
LATS1
LATS, large tumor suppressor, homolog 1 (Drosophila)
chr13_-_31735718 1.466 HSPH1
heat shock 105kDa/110kDa protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.43 3.26e-09 GO:0051252 regulation of RNA metabolic process
2.45 5.73e-09 GO:0006355 regulation of transcription, DNA-dependent
5.70 2.15e-08 GO:0051098 regulation of binding
6.26 2.91e-08 GO:0051101 regulation of DNA binding
2.04 3.12e-08 GO:0060255 regulation of macromolecule metabolic process
6.47 4.76e-08 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
6.36 6.49e-08 GO:0090046 regulation of transcription regulator activity
2.96 8.31e-08 GO:0002376 immune system process
2.22 8.98e-08 GO:0010468 regulation of gene expression
1.57 1.23e-07 GO:0050794 regulation of cellular process
3.63 1.67e-07 GO:0006955 immune response
2.24 1.76e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.22 1.94e-07 GO:0010556 regulation of macromolecule biosynthetic process
1.93 3.65e-07 GO:0031323 regulation of cellular metabolic process
1.94 4.61e-07 GO:0080090 regulation of primary metabolic process
3.05 4.77e-07 GO:0010941 regulation of cell death
3.05 8.68e-07 GO:0042981 regulation of apoptosis
3.02 1.10e-06 GO:0043067 regulation of programmed cell death
2.09 1.62e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.09 1.62e-06 GO:0031326 regulation of cellular biosynthetic process
1.50 2.01e-06 GO:0050789 regulation of biological process
2.06 2.21e-06 GO:0051171 regulation of nitrogen compound metabolic process
2.07 2.59e-06 GO:0009889 regulation of biosynthetic process
1.82 3.41e-06 GO:0019222 regulation of metabolic process
2.12 5.12e-06 GO:0048522 positive regulation of cellular process
3.24 5.25e-06 GO:0006952 defense response
3.02 5.46e-06 GO:0042127 regulation of cell proliferation
2.04 7.13e-06 GO:0048518 positive regulation of biological process
3.32 3.17e-05 GO:0002682 regulation of immune system process
2.03 6.90e-05 GO:0006950 response to stress
1.42 1.11e-04 GO:0065007 biological regulation
11.21 1.12e-04 GO:0050864 regulation of B cell activation
2.72 3.04e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.98 3.78e-04 GO:0048519 negative regulation of biological process
2.75 9.68e-04 GO:0006351 transcription, DNA-dependent
2.87 1.07e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
12.76 1.24e-03 GO:0050871 positive regulation of B cell activation
8.11 1.90e-03 GO:0043392 negative regulation of DNA binding
2.84 1.98e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
9.49 2.17e-03 GO:0034138 toll-like receptor 3 signaling pathway
3.91 2.22e-03 GO:0006917 induction of apoptosis
2.22 2.31e-03 GO:0065009 regulation of molecular function
3.90 2.31e-03 GO:0012502 induction of programmed cell death
7.92 2.33e-03 GO:0002224 toll-like receptor signaling pathway
2.95 2.75e-03 GO:0010628 positive regulation of gene expression
9.20 2.76e-03 GO:0002756 MyD88-independent toll-like receptor signaling pathway
1.61 3.39e-03 GO:0051716 cellular response to stimulus
7.56 3.43e-03 GO:0002221 pattern recognition receptor signaling pathway
3.45 3.53e-03 GO:0050776 regulation of immune response
2.31 3.53e-03 GO:0009893 positive regulation of metabolic process
1.94 3.61e-03 GO:0048523 negative regulation of cellular process
1.70 3.61e-03 GO:0007165 signal transduction
1.45 3.80e-03 GO:0050896 response to stimulus
2.38 3.98e-03 GO:0010604 positive regulation of macromolecule metabolic process
8.67 4.37e-03 GO:0034130 toll-like receptor 1 signaling pathway
8.67 4.37e-03 GO:0034134 toll-like receptor 2 signaling pathway
7.31 4.52e-03 GO:0002758 innate immune response-activating signal transduction
8.54 4.88e-03 GO:0051092 positive regulation of NF-kappaB transcription factor activity
7.16 5.41e-03 GO:0002218 activation of innate immune response
8.19 6.71e-03 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
3.30 6.76e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
3.16 7.10e-03 GO:0010942 positive regulation of cell death
2.31 7.26e-03 GO:0031325 positive regulation of cellular metabolic process
2.48 7.42e-03 GO:0032774 RNA biosynthetic process
8.08 7.43e-03 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
8.08 7.43e-03 GO:0090048 negative regulation of transcription regulator activity
1.63 7.72e-03 GO:0023052 signaling
2.85 7.72e-03 GO:0051254 positive regulation of RNA metabolic process
3.39 8.17e-03 GO:0043066 negative regulation of apoptosis
2.93 8.23e-03 GO:0045893 positive regulation of transcription, DNA-dependent
7.87 9.09e-03 GO:0008063 Toll signaling pathway
7.87 9.09e-03 GO:0034142 toll-like receptor 4 signaling pathway
3.36 9.37e-03 GO:0043069 negative regulation of programmed cell death
2.23 1.06e-02 GO:0010033 response to organic substance
6.60 1.06e-02 GO:0051100 negative regulation of binding
3.30 1.19e-02 GO:0002684 positive regulation of immune system process
5.14 1.22e-02 GO:0031349 positive regulation of defense response
6.47 1.25e-02 GO:0070663 regulation of leukocyte proliferation
3.26 1.40e-02 GO:0060548 negative regulation of cell death
2.67 1.45e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
3.56 1.46e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
3.73 1.61e-02 GO:0031347 regulation of defense response
3.94 1.70e-02 GO:0006954 inflammatory response
3.08 1.75e-02 GO:0009607 response to biotic stimulus
2.46 1.79e-02 GO:0050793 regulation of developmental process
3.08 1.80e-02 GO:0043065 positive regulation of apoptosis
3.49 1.88e-02 GO:0045087 innate immune response
3.06 1.97e-02 GO:0043068 positive regulation of programmed cell death
4.81 2.28e-02 GO:0002757 immune response-activating signal transduction
3.28 2.29e-02 GO:0008285 negative regulation of cell proliferation
3.02 2.35e-02 GO:0080134 regulation of response to stress
1.95 2.49e-02 GO:0007166 cell surface receptor linked signaling pathway
4.70 2.83e-02 GO:0002764 immune response-regulating signaling pathway
3.20 3.17e-02 GO:0032583 regulation of gene-specific transcription
9.97 3.27e-02 GO:0002274 myeloid leukocyte activation
5.09 3.37e-02 GO:0002697 regulation of immune effector process
2.48 3.45e-02 GO:0031328 positive regulation of cellular biosynthetic process
2.14 3.52e-02 GO:0051239 regulation of multicellular organismal process
5.56 4.20e-02 GO:0045089 positive regulation of innate immune response
2.43 4.56e-02 GO:0009891 positive regulation of biosynthetic process
2.87 4.63e-02 GO:0051253 negative regulation of RNA metabolic process
2.54 4.94e-02 GO:2000026 regulation of multicellular organismal development
3.80 4.99e-02 GO:0001817 regulation of cytokine production

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
59.78 2.17e-05 GO:0033256 I-kappaB/NF-kappaB complex
1.45 1.49e-03 GO:0005634 nucleus
74.73 2.49e-02 GO:0033257 Bcl3/NF-kappaB2 complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.54 3.36e-11 GO:0001071 nucleic acid binding transcription factor activity
3.54 3.36e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
3.14 3.14e-05 GO:0043565 sequence-specific DNA binding
5.40 7.52e-05 GO:0005125 cytokine activity
3.69 4.55e-04 GO:0000988 protein binding transcription factor activity
3.69 4.55e-04 GO:0000989 transcription factor binding transcription factor activity
3.49 1.80e-03 GO:0003712 transcription cofactor activity
2.36 2.38e-03 GO:0030528 transcription regulator activity
1.79 4.05e-03 GO:0003677 DNA binding
4.57 6.57e-03 GO:0005126 cytokine receptor binding
9.75 6.66e-03 GO:0008009 chemokine activity
1.33 8.84e-03 GO:0005515 protein binding
8.80 1.21e-02 GO:0042379 chemokine receptor binding
3.40 1.52e-02 GO:0016563 transcription activator activity
3.40 2.74e-02 GO:0008134 transcription factor binding