Motif ID: NHLH1,2.p2

Z-value: 1.680


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NHLH1hg19_v1_chr1_+_160336856_160336873-0.703.7e-02Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_16082148 4.020 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr12_+_56137063 2.900 NM_005811
GDF11
growth differentiation factor 11
chr10_-_42863435 2.712 LOC441666
zinc finger protein 91 pseudogene
chr2_+_16081945 2.640 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr19_-_11266451 2.297 NM_182513
SPC24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr3_-_12200339 2.288 TIMP4
TIMP metallopeptidase inhibitor 4
chr14_+_90863365 2.271 CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr15_-_34659245 2.213 NM_153613
LPCAT4
lysophosphatidylcholine acyltransferase 4
chr10_+_99473478 2.122 MARVELD1
MARVEL domain containing 1
chr11_-_86666089 2.104 FZD4
frizzled family receptor 4
chr11_-_86666211 2.077 NM_012193
FZD4
frizzled family receptor 4
chr9_+_108006990 2.025 SLC44A1
solute carrier family 44, member 1
chr7_-_84816170 1.998 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr10_+_99473456 1.966 NM_031484
MARVELD1
MARVEL domain containing 1
chr18_+_11689135 1.829 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr1_+_78511747 1.798 GIPC2
GIPC PDZ domain containing family, member 2
chr19_-_35454952 1.795 NM_175872
ZNF792
zinc finger protein 792
chr2_-_178483372 1.794 TTC30A
tetratricopeptide repeat domain 30A
chr17_-_59668540 1.768 NM_199290
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr2_+_233498206 1.756 NM_025202
EFHD1
EF-hand domain family, member D1
chr6_-_74079514 1.732 NM_001080507
OOEP
oocyte expressed protein homolog (dog)
chr1_+_90098693 1.690 LRRC8C
leucine rich repeat containing 8 family, member C
chr6_+_24495166 1.672 NM_001080
NM_170740
ALDH5A1

aldehyde dehydrogenase 5 family, member A1

chr1_+_3773844 1.570 NM_004402
DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr19_-_6502224 1.569 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr7_-_2883649 1.555 NM_007353
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr17_+_7554415 1.553 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr2_+_16080639 1.538 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr14_+_90863302 1.527 NM_006888
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr3_+_159943628 1.513 C3orf80
chromosome 3 open reading frame 80
chr12_-_63328857 1.510 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr1_+_89990442 1.505 LRRC8B
leucine rich repeat containing 8 family, member B
chr1_-_47184730 1.489 NM_014774
KIAA0494
KIAA0494
chr7_+_139877154 1.479 LOC100134229
uncharacterized LOC100134229
chr11_+_44587212 1.475 CD82
CD82 molecule
chr2_+_16080559 1.470 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr1_-_32403975 1.454 NM_080391
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr9_+_108006892 1.445 NM_080546
SLC44A1
solute carrier family 44, member 1
chr17_+_28256873 1.442 NM_001145053
EFCAB5
EF-hand calcium binding domain 5
chr1_+_78511588 1.437 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr12_+_125478151 1.433 NM_080626
BRI3BP
BRI3 binding protein
chr3_-_149688886 1.429 PFN2
profilin 2
chr1_+_21766559 1.420 NM_032264
NBPF3
neuroblastoma breakpoint family, member 3
chr10_-_81205091 1.411 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr6_+_24495016 1.405 ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr1_-_47184790 1.403


chr1_+_110198873 1.394 GSTM2
GSTM4
glutathione S-transferase mu 2 (muscle)
glutathione S-transferase mu 4
chr1_+_90098643 1.391 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr1_+_213123853 1.390 NM_001136474
NM_001136475
NM_024749
VASH2


vasohibin 2


chr2_-_230135954 1.362 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr1_+_90287543 1.356 LRRC8D
leucine rich repeat containing 8 family, member D
chr17_-_54991352 1.341 TRIM25
tripartite motif containing 25
chr12_+_125478234 1.321 BRI3BP
BRI3 binding protein
chr14_+_31343642 1.315 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr14_-_59932051 1.293 NM_022571
GPR135
G protein-coupled receptor 135
chr16_+_22217369 1.290 NM_013302
EEF2K
eukaryotic elongation factor-2 kinase
chr7_+_98246595 1.286 NM_002523
NPTX2
neuronal pentraxin II
chr6_+_125474800 1.272 NM_001003396
NM_001003397
NM_003287
TPD52L1


tumor protein D52-like 1


chr14_+_73957608 1.268 NM_024644
C14orf169
chromosome 14 open reading frame 169
chr3_-_149688638 1.267 NM_002628
NM_053024
PFN2

profilin 2

chr1_+_90287404 1.252 NM_018103
LRRC8D
leucine rich repeat containing 8 family, member D
chr9_+_108006937 1.248 SLC44A1
solute carrier family 44, member 1
chr2_-_209119751 1.229 NM_005896
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr20_-_44563684 1.218 FLJ40606
uncharacterized LOC643549
chr1_-_144994943 1.200 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr15_+_79603544 1.192 TMED3
transmembrane emp24 protein transport domain containing 3
chr1_-_33647626 1.183 NM_018207
TRIM62
tripartite motif containing 62
chr3_+_170136652 1.179 NM_005602
CLDN11
claudin 11
chr4_+_41362750 1.177 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr9_+_114393543 1.174 NM_001015882
NM_004125
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chr8_+_97506020 1.171 SDC2
syndecan 2
chr1_-_55266870 1.166 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr15_+_43809805 1.165 NM_002373
MAP1A
microtubule-associated protein 1A
chr3_-_68981674 1.160 NM_001005527
NM_182522
FAM19A4

family with sequence similarity 19 (chemokine (C-C motif)-like), member A4

chr17_-_27278324 1.160 PHF12
PHD finger protein 12
chr20_+_10199455 1.157 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr8_+_97506141 1.155 SDC2
syndecan 2
chr12_+_100750856 1.152 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr6_+_3259134 1.152 NM_001128591
NM_001128592
NM_001135750
PSMG4


proteasome (prosome, macropain) assembly chaperone 4


chr13_-_96296919 1.152 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr2_-_178483677 1.151 NM_152275
TTC30A
tetratricopeptide repeat domain 30A
chr20_-_3219835 1.139 NM_001174089
SLC4A11
solute carrier family 4, sodium borate transporter, member 11
chr7_-_138720770 1.138 NM_080660
ZC3HAV1L
zinc finger CCCH-type, antiviral 1-like
chr4_+_184826427 1.138 NM_020225
STOX2
storkhead box 2
chr10_+_115803805 1.133 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr12_-_104234968 1.128 NM_001031701
NT5DC3
5'-nucleotidase domain containing 3
chrX_+_38663503 1.120 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr8_+_97506071 1.116 SDC2
syndecan 2
chr19_-_35454867 1.111 ZNF792
zinc finger protein 792
chr14_+_50087400 1.103 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr11_-_207324 1.103 BET1L
blocked early in transport 1 homolog (S. cerevisiae)-like
chr1_-_145039631 1.097 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr14_+_73957685 1.094 C14orf169
chromosome 14 open reading frame 169
chr1_+_89990396 1.091 NM_001134476
LRRC8B
leucine rich repeat containing 8 family, member B
chrX_+_38663450 1.091 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr1_+_213124008 1.082 VASH2
vasohibin 2
chr8_+_97506478 1.078 SDC2
syndecan 2
chr16_+_67465019 1.077 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr2_+_10262853 1.073 NM_001034
RRM2
ribonucleotide reductase M2
chr22_+_50609159 1.073 NM_001160300
NM_052839
PANX2

pannexin 2

chr3_-_9920471 1.065 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr3_-_73673978 1.054 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr22_-_39239733 1.049


chr19_-_18314731 1.048 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr6_-_46138584 1.044 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr12_-_12503135 1.042 NM_018050
MANSC1
MANSC domain containing 1
chr2_+_150187028 1.031 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr14_+_73957657 1.018 C14orf169
chromosome 14 open reading frame 169
chr12_-_104234783 1.017 NT5DC3
5'-nucleotidase domain containing 3
chr3_-_184429609 1.015 NM_022149
MAGEF1
melanoma antigen family F, 1
chr14_+_73957670 1.008 C14orf169
chromosome 14 open reading frame 169
chr9_-_107690336 1.002 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr10_+_30723050 0.995 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr12_+_27933162 0.994 NM_020782
KLHDC5
kelch domain containing 5
chr19_-_6199536 0.993


chr17_-_54991399 0.992 NM_005082
TRIM25
tripartite motif containing 25
chr2_+_10262694 0.988 NM_001165931
RRM2
ribonucleotide reductase M2
chr17_-_27949814 0.987 CORO6
coronin 6
chr5_+_129240453 0.987 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr4_-_13549293 0.984 LOC285548
uncharacterized LOC285548
chr9_+_74764382 0.984 GDA
guanine deaminase
chr4_+_174089889 0.981 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr5_+_149109850 0.978 PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr7_-_27239724 0.978 NM_000522
HOXA13
homeobox A13
chr17_-_39341126 0.977 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr11_+_126152979 0.974 NM_001039661
NM_148910
TIRAP

toll-interleukin 1 receptor (TIR) domain containing adaptor protein

chr19_+_5904842 0.969 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr7_+_30174343 0.966 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr16_+_11439279 0.965 NM_152308
RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr13_-_99738639 0.962 NM_001130049
NM_015296
DOCK9

dedicator of cytokinesis 9

chr12_-_69326946 0.960 NM_001005502
NM_198320
CPM

carboxypeptidase M

chr1_+_220960038 0.955 NM_022746
MARC1
mitochondrial amidoxime reducing component 1
chr7_-_143105897 0.949 NM_005232
EPHA1
EPH receptor A1
chrX_-_50213589 0.946 NM_001013742
DGKK
diacylglycerol kinase, kappa
chr19_-_11450254 0.945 NM_004283
RAB3D
RAB3D, member RAS oncogene family
chr3_-_9920633 0.945 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr5_-_138739755 0.939 NM_194296
SPATA24
spermatogenesis associated 24
chr5_-_101631965 0.937 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr6_+_126112057 0.934 NCOA7
nuclear receptor coactivator 7
chr16_+_11439311 0.934 RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr2_-_47797469 0.933 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr15_+_41221530 0.932 NM_019074
DLL4
delta-like 4 (Drosophila)
chr1_+_90286595 0.927 LRRC8D
leucine rich repeat containing 8 family, member D
chr11_+_44587140 0.925 NM_001024844
NM_002231
CD82

CD82 molecule

chr10_+_1102741 0.920 NM_014023
WDR37
WD repeat domain 37
chr5_-_112630301 0.919 MCC
mutated in colorectal cancers
chr1_-_32403888 0.916 PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr9_-_34376831 0.915 NM_020702
KIAA1161
KIAA1161
chr1_-_53793743 0.912 NM_001018054
NM_004631
NM_017522
NM_033300
LRP8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr9_+_79074067 0.907 NM_001097633
NM_001490
GCNT1

glucosaminyl (N-acetyl) transferase 1, core 2

chr1_+_90286469 0.901 NM_001134479
LRRC8D
leucine rich repeat containing 8 family, member D
chr8_+_21881587 0.901 NPM2
nucleophosmin/nucleoplasmin 2
chr6_+_14118002 0.898 CD83
CD83 molecule
chr6_+_150464156 0.896 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr3_+_3841079 0.892 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr15_+_41062158 0.887 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr5_+_111496547 0.883 EPB41L4A-AS1
EPB41L4A antisense RNA 1 (non-protein coding)
chr17_-_66596736 0.880 FAM20A
family with sequence similarity 20, member A
chr20_+_58515408 0.877 NM_001190827
NM_022106
C20orf177

chromosome 20 open reading frame 177

chr12_-_63328663 0.873 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr15_+_41245635 0.873 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr15_+_90895476 0.872 NM_001004309
ZNF774
zinc finger protein 774
chr20_+_49575347 0.867 NM_014484
MOCS3
molybdenum cofactor synthesis 3
chr15_-_52472075 0.861 NM_006578
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr8_+_98788014 0.861 LAPTM4B
lysosomal protein transmembrane 4 beta
chr7_-_1067927 0.861 C7orf50
chromosome 7 open reading frame 50
chr18_+_9334820 0.860 TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr19_+_16187047 0.856 NM_003290
TPM4
tropomyosin 4
chr8_+_98787808 0.856 NM_018407
LAPTM4B
lysosomal protein transmembrane 4 beta
chr8_+_25042379 0.854 DOCK5
dedicator of cytokinesis 5
chr4_-_2420252 0.852 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr8_-_91657898 0.852 NM_001008495
NM_001146273
TMEM64

transmembrane protein 64

chr9_+_100615406 0.851 NM_004473
FOXE1
forkhead box E1 (thyroid transcription factor 2)
chr20_+_30193083 0.850 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr1_+_16330730 0.850 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr1_-_114447338 0.849 AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr1_-_144994908 0.849 PDE4DIP
phosphodiesterase 4D interacting protein
chr7_-_150038689 0.847 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr7_+_87563432 0.847 NM_004194
NM_016351
NM_021721
NM_021722
NM_021723
ADAM22




ADAM metallopeptidase domain 22




chr13_+_100634257 0.847 ZIC2
Zic family member 2
chr15_+_76352323 0.845 C15orf27
chromosome 15 open reading frame 27
chr12_-_72057389 0.843


chr5_+_140557370 0.843 NM_019120
PCDHB8
protocadherin beta 8
chr2_+_7057471 0.837 NM_014746
RNF144A
ring finger protein 144A
chr5_-_127418658 0.833 FLJ33630
uncharacterized LOC644873
chr9_+_74764417 0.833 GDA
guanine deaminase
chrX_-_119763804 0.832 NM_001011551
NM_152692
C1GALT1C1

C1GALT1-specific chaperone 1

chr11_-_82904680 0.831 DKFZp547G183
uncharacterized LOC55525
chr2_+_65663812 0.829 FLJ16124
FLJ16124 protein
chr15_+_79603497 0.828 TMED3
transmembrane emp24 protein transport domain containing 3
chr1_+_11796211 0.825 AGTRAP
angiotensin II receptor-associated protein
chr10_+_112257624 0.823 NM_004419
DUSP5
dual specificity phosphatase 5
chr2_+_25264913 0.822 NM_014971
EFR3B
EFR3 homolog B (S. cerevisiae)
chr18_+_9334762 0.816 NM_020648
TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr1_-_6295989 0.815 ICMT
isoprenylcysteine carboxyl methyltransferase
chr1_+_206680863 0.815 NM_182663
NM_182664
RASSF5

Ras association (RalGDS/AF-6) domain family member 5

chr12_-_47473424 0.814 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr17_-_66596934 0.813 NM_001243746
NM_017565
FAM20A

family with sequence similarity 20, member A

chr12_+_6309475 0.806 NM_001769
CD9
CD9 molecule
chr6_-_168720389 0.806 NM_214462
DACT2
dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.