Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.574


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)



Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_46293215 0.578 RCAN2
regulator of calcineurin 2
chr7_+_18535817 0.501 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr22_-_38506532 0.412 BAIAP2L2
BAI1-associated protein 2-like 2
chr3_-_119963141 0.320 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr13_+_36050885 0.320 NM_001204197
NBEA
neurobeachin
chr2_+_29038862 0.287 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr17_-_39092714 0.267 KRT23
keratin 23 (histone deacetylase inducible)
chr7_+_18535351 0.267 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr2_+_171571800 0.265 NM_001003845
SP5
Sp5 transcription factor
chr4_+_90033967 0.257 NM_145715
TIGD2
tigger transposable element derived 2
chr9_+_12693385 0.249 NM_000550
TYRP1
tyrosinase-related protein 1
chr10_+_126630691 0.249 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr12_-_10588543 0.245 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr3_-_114790221 0.241 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr20_-_55934877 0.240 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chr3_-_139195300 0.239 NM_004164
RBP2
retinol binding protein 2, cellular
chr3_-_114478117 0.235 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr6_-_53530505 0.223 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr17_+_59489111 0.215 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr8_-_72268720 0.213 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr10_-_32667543 0.209 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr6_+_16143281 0.208 MYLIP
myosin regulatory light chain interacting protein
chr14_+_21756135 0.207 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr14_+_62462540 0.205 NM_031914
SYT16
synaptotagmin XVI
chr12_-_10324675 0.202 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr3_+_156394452 0.201 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr13_-_46425756 0.200 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr6_-_119252887 0.198 NM_017696
MCM9
minichromosome maintenance complex component 9
chr2_-_145277879 0.198 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr2_+_210444364 0.198 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr4_-_69817478 0.198 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr5_+_71502700 0.196 MAP1B
microtubule-associated protein 1B
chr17_-_39093671 0.194 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr7_-_27205123 0.194 HOXA9
homeobox A9
chr7_-_27205148 0.193 NM_152739
HOXA9
homeobox A9
chr13_+_99058147 0.193


chr9_-_85882093 0.192 NM_001244962
FRMD3
FERM domain containing 3
chr12_+_119616594 0.187 NM_014365
HSPB8
heat shock 22kDa protein 8
chr9_+_82187599 0.184 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr6_+_100054649 0.183 NM_021620
PRDM13
PR domain containing 13
chr5_+_174151531 0.181 NM_002449
MSX2
msh homeobox 2
chr4_-_152149042 0.174 NM_001243349
SH3D19
SH3 domain containing 19
chr4_+_71494460 0.173 NM_031889
ENAM
enamelin
chr2_-_211018294 0.170 C2orf67
chromosome 2 open reading frame 67
chr5_+_55149149 0.170 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr7_+_28475233 0.167 NM_004904
CREB5
cAMP responsive element binding protein 5
chr7_+_28452143 0.167 NM_182898
CREB5
cAMP responsive element binding protein 5
chr4_-_184243578 0.165 NM_001185149
CLDN24
claudin 24
chr3_+_63884074 0.163 NM_001177387
ATXN7
ataxin 7
chr1_-_167883243 0.157 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr9_+_82187469 0.156 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr9_+_130860769 0.154 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr7_+_129984629 0.154 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr3_-_112218383 0.154 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chrX_+_30248552 0.153 NM_002365
MAGEB3
melanoma antigen family B, 3
chr1_+_168250277 0.151 NM_005149
TBX19
T-box 19
chr7_+_116451073 0.151 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr9_+_130860816 0.150 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr3_+_151488214 0.148 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr1_-_110155672 0.147 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chrX_+_70765479 0.145 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr19_+_48828820 0.143 EMP3
epithelial membrane protein 3
chr7_-_27205075 0.142 HOXA9
homeobox A9
chr11_+_87032428 0.140 TMEM135
transmembrane protein 135
chr7_-_27166638 0.140 NM_153631
HOXA3
homeobox A3
chr1_+_50574589 0.140 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr1_+_167298382 0.136 POU2F1
POU class 2 homeobox 1
chr19_+_16244837 0.135 NM_032855
HSH2D
hematopoietic SH2 domain containing
chr1_+_174933904 0.135 NM_001243764
RABGAP1L
RAB GTPase activating protein 1-like
chr6_-_53013581 0.133 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr1_+_50569581 0.130 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr22_-_41257998 0.129 NM_145174
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chr4_+_86749045 0.128 ARHGAP24
Rho GTPase activating protein 24
chr5_-_22853730 0.128 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_-_53901371 0.126 NM_003717
NPFF
neuropeptide FF-amide peptide precursor
chr22_-_24096551 0.126 NM_013378
VPREB3
pre-B lymphocyte 3
chr12_-_123201319 0.124 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr1_+_117297056 0.124 NM_001767
CD2
CD2 molecule
chrX_+_115567746 0.122 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_-_15114495 0.122 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr7_-_41742666 0.121 NM_002192
INHBA
inhibin, beta A
chr13_+_24144402 0.120 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr10_-_98031154 0.120 NM_001114094
NM_013314
BLNK

B-cell linker

chr5_-_88199868 0.120 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr10_-_96829074 0.119 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr2_-_99871569 0.116 NM_175735
LYG2
lysozyme G-like 2
chr15_+_40294749 0.115 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr3_-_99833348 0.114 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr6_+_152011630 0.111 NM_001122742
ESR1
estrogen receptor 1
chr13_-_41593491 0.111 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_+_97928414 0.111 MBNL2
muscleblind-like 2 (Drosophila)
chr4_-_82393025 0.110 NM_152545
RASGEF1B
RasGEF domain family, member 1B
chr15_-_61521478 0.109 NM_134261
RORA
RAR-related orphan receptor A
chr12_+_28410132 0.108 NM_018318
CCDC91
coiled-coil domain containing 91
chr3_+_157154579 0.108 NM_002852
PTX3
pentraxin 3, long
chr1_+_167298280 0.108 NM_001198783
POU2F1
POU class 2 homeobox 1
chr16_+_69680959 0.107 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr4_+_160188997 0.106 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr12_-_16759420 0.106 LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_46395574 0.105 CCR2
chemokine (C-C motif) receptor 2
chr13_+_50025687 0.105 NM_001160308
SETDB2
SET domain, bifurcated 2
chr12_-_27924208 0.104 NM_001146221
MANSC4
MANSC domain containing 4
chrM_+_1670 0.104


chr15_+_100173182 0.104 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr19_-_46285752 0.104 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr4_-_105416050 0.104 CXXC4
CXXC finger protein 4
chrM_+_5245 0.102


chr7_+_139528951 0.102 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr11_-_129062092 0.102 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr12_-_10573041 0.101 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr3_+_25470067 0.101 RARB
retinoic acid receptor, beta
chr17_+_56833231 0.100 NM_014906
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chrX_+_107288199 0.099 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr2_-_172967627 0.099 DLX2
distal-less homeobox 2
chr10_+_81073763 0.099 ZMIZ1
zinc finger, MIZ-type containing 1
chr10_-_13749622 0.099 FRMD4A
FERM domain containing 4A
chr13_-_41593405 0.098 ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_-_46285645 0.097 DMPK
dystrophia myotonica-protein kinase
chr11_+_65988165 0.096 PACS1
phosphofurin acidic cluster sorting protein 1
chr13_-_61989654 0.096 NM_022843
PCDH20
protocadherin 20
chr4_+_186350543 0.095 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr2_-_128100673 0.094 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr5_+_139505519 0.094 NM_001007189
IGIP
IgA-inducing protein homolog (Bos taurus)
chr2_+_171571936 0.094


chr1_-_150738232 0.093 CTSS
cathepsin S
chr3_+_159943252 0.093 NM_001168214
C3orf80
chromosome 3 open reading frame 80
chr8_+_104310660 0.093 NM_001164615
FZD6
frizzled family receptor 6
chr1_-_200377262 0.093 ZNF281
zinc finger protein 281
chr3_-_8543327 0.093 LOC100288428
uncharacterized LOC100288428
chr12_-_16757944 0.093 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_49488570 0.091 NM_021044
DHH
desert hedgehog
chr11_-_104972147 0.090 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr1_+_50575465 0.090 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_+_151985828 0.089 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr2_-_192016293 0.089 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr4_+_69681709 0.088 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr9_+_82186846 0.088 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_-_114343052 0.088 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr10_-_74283693 0.088 NM_001195519
MICU1
mitochondrial calcium uptake 1
chr6_-_117747017 0.087 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr19_-_41812991 0.086


chr12_+_75874512 0.085 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr2_+_33738941 0.084 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_-_61191027 0.084 SIX4
SIX homeobox 4
chrX_+_123234462 0.083 STAG2
stromal antigen 2
chr12_-_11150473 0.083 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr7_-_37024664 0.082 NM_001039459
ELMO1
engulfment and cell motility 1
chr16_-_4852856 0.082


chr8_+_11188494 0.081 NM_054028
SLC35G5
solute carrier family 35, member G5
chr8_-_110620220 0.080 SYBU
syntabulin (syntaxin-interacting)
chr1_-_200377488 0.080 ZNF281
zinc finger protein 281
chr6_+_135517051 0.080 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_+_68150858 0.080 NM_001199741
NM_001199742
NM_001924
GADD45A


growth arrest and DNA-damage-inducible, alpha


chr13_+_49050585 0.080 RB1
retinoblastoma 1
chr1_-_120484230 0.079 NOTCH2
notch 2
chr4_+_88571453 0.078 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr1_-_173962050 0.078 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr6_+_135516879 0.078


chr19_-_48614013 0.078 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr2_+_87144737 0.078 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr12_-_16759531 0.077 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr17_+_57915192 0.077


chr12_-_22089627 0.077 NM_005691
NM_020297
ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

chr17_-_49124128 0.077 NM_001251971
SPAG9
sperm associated antigen 9
chr2_+_198380294 0.077 NM_199482
MOB4
MOB family member 4, phocein
chr6_+_87969619 0.076 ZNF292
zinc finger protein 292
chr11_-_83393436 0.075 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr3_+_178254223 0.075 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr12_-_15865847 0.075 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_-_153273683 0.074 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chrX_+_70521627 0.073 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr8_-_12973752 0.072 NM_001164271
DLC1
deleted in liver cancer 1
chr15_+_89739234 0.072 ABHD2
abhydrolase domain containing 2
chr12_+_32654976 0.072 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr5_-_37835592 0.071 NM_199231
GDNF
glial cell derived neurotrophic factor
chr12_-_6484904 0.071 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_+_177140062 0.071 FAM5B
family with sequence similarity 5, member B
chr12_-_16759430 0.071 LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_210444154 0.071 MAP2
microtubule-associated protein 2
chr17_-_67138013 0.071 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr1_-_160832466 0.070 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr5_-_147162264 0.070 JAKMIP2
janus kinase and microtubule interacting protein 2
chr2_-_55199894 0.070


chr10_-_61900659 0.069 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chrM_+_4770 0.069


chr12_-_15815073 0.069 EPS8
epidermal growth factor receptor pathway substrate 8
chr7_+_115863004 0.068 NM_152829
TES
testis derived transcript (3 LIM domains)
chr6_+_87964925 0.068 ZNF292
zinc finger protein 292
chr6_-_123957941 0.068 NM_001251987
NM_006073
TRDN

triadin

chr1_+_210501595 0.068 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr13_-_41556188 0.067 ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_+_143929316 0.067 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr19_-_3772208 0.067 NM_032753
RAX2
retina and anterior neural fold homeobox 2
chr6_+_155538096 0.067 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr7_-_87342569 0.066 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr11_+_27015668 0.066


chr12_-_28124915 0.066 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr6_-_33754712 0.066 NM_001143944
LEMD2
LEM domain containing 2
chr4_+_88529680 0.066 NM_014208
DSPP
dentin sialophosphoprotein
chr12_-_58135853 0.064 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.