Motif ID: NRF1.p2

Z-value: 3.914


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NRF1hg19_v1_chr7_+_129251579_1292516450.627.6e-02Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_260092 8.445 NM_001013672
C17orf97
chromosome 17 open reading frame 97
chrX_+_7065820 3.347 STS
steroid sulfatase (microsomal), isozyme S
chr5_-_1594617 2.690 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr6_+_30614815 2.545 NM_001109938
NM_001161376
NM_145029
C6orf136


chromosome 6 open reading frame 136


chr1_-_110052285 2.321 NM_020703
AMIGO1
adhesion molecule with Ig-like domain 1
chr19_-_41870001 2.248 NM_030578
B9D2
B9 protein domain 2
chr2_-_74734498 2.218 PCGF1
polycomb group ring finger 1
chr4_+_668250 2.062 MYL5
myosin, light chain 5, regulatory
chr16_+_27215295 1.991 NM_001145348
JMJD5
jumonji domain containing 5
chr17_-_34257730 1.985 NM_001034836
NM_001163120
NM_001163121
NM_145654
RDM1



RAD52 motif 1



chr6_+_26021906 1.921 NM_003538
HIST1H4A
histone cluster 1, H4a
chr9_-_139981102 1.841 LOC100289341
uncharacterized LOC100289341
chr11_+_1331048 1.736 LOC255512
uncharacterized LOC255512
chr6_+_75994713 1.730 LOC100506804
uncharacterized LOC100506804
chr6_+_26217145 1.678 NM_021052
HIST1H2AE
histone cluster 1, H2ae
chr4_-_7044664 1.598 NM_153376
CCDC96
coiled-coil domain containing 96
chr9_-_139981268 1.582 LOC100289341
uncharacterized LOC100289341
chr19_+_18794487 1.530 CRTC1
CREB regulated transcription coactivator 1
chr16_+_28565279 1.496 CCDC101
coiled-coil domain containing 101
chr11_+_65029312 1.464 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr9_+_110045516 1.458 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr7_-_142985270 1.403


chr19_+_18794391 1.379 NM_001098482
NM_015321
CRTC1

CREB regulated transcription coactivator 1

chr22_+_24200040 1.364 NM_001024939
SLC2A11
solute carrier family 2 (facilitated glucose transporter), member 11
chr16_+_28565225 1.362 NM_138414
CCDC101
coiled-coil domain containing 101
chr6_+_26199712 1.353 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr3_+_49449638 1.306 NM_022171
TCTA
T-cell leukemia translocation altered gene
chr7_+_113726490 1.282 FOXP2
forkhead box P2
chr20_+_13976263 1.277 MACROD2
MACRO domain containing 2
chr1_+_226411318 1.254 NM_031944
MIXL1
Mix paired-like homeobox
chr11_-_777470 1.245 NM_182612
PDDC1
Parkinson disease 7 domain containing 1
chr17_-_26220372 1.239 NM_001076680
C17orf108
chromosome 17 open reading frame 108
chr2_+_101179395 1.234 NM_024065
PDCL3
phosducin-like 3
chr16_-_11350038 1.229 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr4_-_184425610 1.221 LOC389247
uncharacterized LOC389247
chr11_-_64545231 1.184 NM_001178031
SF1
splicing factor 1
chr19_-_44259072 1.175 SMG9
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr9_+_110045551 1.153 RAD23B
RAD23 homolog B (S. cerevisiae)
chr9_+_110045822 1.140 RAD23B
RAD23 homolog B (S. cerevisiae)
chr18_-_74534205 1.128 LOC100131655
uncharacterized LOC100131655
chr5_-_11903964 1.118 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr10_-_124639077 1.115 NM_001204364
NM_152644
FAM24B-CUZD1
FAM24B

FAM24B-CUZD1 readthrough
family with sequence similarity 24, member B

chr13_-_21348054 1.113 NM_174928
N6AMT2
N-6 adenine-specific DNA methyltransferase 2 (putative)
chr3_+_49449753 1.081 TCTA
T-cell leukemia translocation altered gene
chr11_-_45939361 1.075 PEX16
peroxisomal biogenesis factor 16
chr11_+_65101345 1.071 DPF2
D4, zinc and double PHD fingers family 2
chr6_-_153304590 1.065 NM_001142522
FBXO5
F-box protein 5
chr20_-_44563573 1.054 FLJ40606
uncharacterized LOC643549
chr10_-_134145333 1.046 STK32C
serine/threonine kinase 32C
chr6_+_27775898 1.044 NM_003509
HIST1H2AI
HIST1H2AM
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H2am
histone cluster 1, H3f
chr13_-_49107185 1.042 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr19_-_14016908 1.034 NM_024323
C19orf57
chromosome 19 open reading frame 57
chr5_-_11904127 1.033 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr7_+_100027404 1.033 MEPCE
methylphosphate capping enzyme
chr3_-_126373957 1.022 NM_001173513
NM_052883
TXNRD3

thioredoxin reductase 3

chr3_+_149689065 1.016 LOC646903
uncharacterized LOC646903
chr7_+_100027253 1.005 NM_019606
MEPCE
methylphosphate capping enzyme
chr4_-_146019296 0.998 NM_014885
ANAPC10
anaphase promoting complex subunit 10
chr1_+_167189948 0.997 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr2_+_203776930 0.991 NM_001104586
NM_024744
ALS2CR8

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8

chr11_+_65101224 0.980 NM_006268
DPF2
D4, zinc and double PHD fingers family 2
chr22_+_19159198 0.978 LOC100652736
uncharacterized LOC100652736
chr19_-_44259115 0.977 NM_019108
SMG9
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr21_-_30257611 0.976 NM_013240
NM_182749
N6AMT1

N-6 adenine-specific DNA methyltransferase 1 (putative)

chr2_+_17721806 0.973 NM_003385
VSNL1
visinin-like 1
chr6_+_27861202 0.967 NM_003527
HIST1H2BO
histone cluster 1, H2bo
chr17_+_7387773 0.957 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr4_-_668035 0.956 NM_007100
ATP5I
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
chr2_-_130939146 0.954 NM_001171083
NM_017751
NM_017951
SMPD4


sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)


chrX_+_13671224 0.952 NM_152634
TCEANC
transcription elongation factor A (SII) N-terminal and central domain containing
chr10_-_134145325 0.947 STK32C
serine/threonine kinase 32C
chr2_+_17721983 0.942 VSNL1
visinin-like 1
chr19_-_44258971 0.938 SMG9
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr1_+_91966365 0.935 NM_001134419
NM_003503
CDC7

cell division cycle 7 homolog (S. cerevisiae)

chr12_+_2921786 0.927 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr12_+_31226824 0.911 DDX11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
chr16_-_3661579 0.910 NM_032444
SLX4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
chr11_+_1330977 0.905 LOC255512
uncharacterized LOC255512
chr11_+_76092336 0.903 LOC100506127
putative uncharacterized protein FLJ37770-like
chr3_-_59035700 0.901 NM_198463
C3orf67
chromosome 3 open reading frame 67
chrX_+_21392396 0.900 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr9_-_34522972 0.888 NM_198573
ENHO
energy homeostasis associated
chr19_+_36236460 0.887 NM_172341
PSENEN
presenilin enhancer 2 homolog (C. elegans)
chr14_-_102771469 0.887 NM_014226
MOK
MOK protein kinase
chr22_-_31742217 0.887 NM_014323
NM_032050
NM_032051
NM_032052
PATZ1



POZ (BTB) and AT hook containing zinc finger 1



chr1_-_3773620 0.887 CEP104
centrosomal protein 104kDa
chr3_+_51705221 0.885 NM_001129884
NM_001243727
NM_015926
NM_001243725
NM_001243726
TEX264




testis expressed 264




chr9_+_110045565 0.881 RAD23B
RAD23 homolog B (S. cerevisiae)
chr13_-_49107218 0.874 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr17_+_40811261 0.869 NM_016437
TUBG2
tubulin, gamma 2
chr17_+_7387688 0.863 NM_000937
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr17_+_7487125 0.863 MPDU1
mannose-P-dolichol utilization defect 1
chr9_-_140513222 0.861 NM_032937
C9orf37
chromosome 9 open reading frame 37
chr8_-_65711104 0.850 NM_004820
CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1
chr11_-_106888829 0.840 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr13_-_49107250 0.840 NM_001268
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr16_+_89753068 0.838 NM_001098533
NM_001160367
NM_052987
NM_052988
CDK10



cyclin-dependent kinase 10



chr20_-_10654429 0.838 NM_000214
JAG1
jagged 1
chrX_-_30907408 0.828 NM_152787
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr12_-_54069856 0.822 ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr7_+_72300044 0.820 SBDSP1
Shwachman-Bodian-Diamond syndrome pseudogene 1
chr19_-_55769920 0.815 NM_014931
PPP6R1
protein phosphatase 6, regulatory subunit 1
chr19_-_42721802 0.814 NM_133328
DEDD2
death effector domain containing 2
chr19_+_54041332 0.813 NM_001079906
NM_001253798
NM_001253799
ZNF331


zinc finger protein 331


chr11_-_59436488 0.811 NM_152716
PATL1
protein associated with topoisomerase II homolog 1 (yeast)
chr6_-_42981656 0.810 MEA1
male-enhanced antigen 1
chr13_-_20357081 0.802 PSPC1
paraspeckle component 1
chr19_-_2236648 0.800 PLEKHJ1
pleckstrin homology domain containing, family J member 1
chr1_+_91966653 0.798 NM_001134420
CDC7
cell division cycle 7 homolog (S. cerevisiae)
chr19_-_36236291 0.797 NM_001040425
NM_144987
U2AF1L4

U2 small nuclear RNA auxiliary factor 1-like 4

chr6_+_111408648 0.793 SLC16A10
solute carrier family 16, member 10 (aromatic amino acid transporter)
chr13_-_20356788 0.786 PSPC1
paraspeckle component 1
chr12_+_109535377 0.785 NM_080911
UNG
uracil-DNA glycosylase
chr10_+_102820914 0.782 NM_030929
KAZALD1
Kazal-type serine peptidase inhibitor domain 1
chr1_+_24104906 0.776 PITHD1
PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
chr3_+_150321065 0.767 NM_016275
SELT
selenoprotein T
chr1_+_76262555 0.767 NM_002440
MSH4
mutS homolog 4 (E. coli)
chr6_+_27114860 0.767 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr19_+_59056017 0.763 TRIM28
tripartite motif containing 28
chr12_-_54070108 0.762 NM_005176
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr17_+_7388080 0.761


chr12_-_53574379 0.761 NM_015989
CSAD
cysteine sulfinic acid decarboxylase
chr22_-_31741761 0.757 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr17_-_3571819 0.753 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr6_-_31774579 0.752 LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr3_-_113233661 0.751 SPICE1
spindle and centriole associated protein 1
chr18_+_74534458 0.748 ZNF236
zinc finger protein 236
chrX_-_152864435 0.742 FAM58A
family with sequence similarity 58, member A
chr17_+_7487153 0.741 MPDU1
mannose-P-dolichol utilization defect 1
chr9_+_134378353 0.739 POMT1
protein-O-mannosyltransferase 1
chr1_-_202858225 0.736 NM_002871
RABIF
RAB interacting factor
chr7_+_154795131 0.734 LOC202781
uncharacterized LOC202781
chr5_+_137774632 0.732 NM_016606
REEP2
receptor accessory protein 2
chr9_+_134378324 0.732 POMT1
protein-O-mannosyltransferase 1
chr14_+_67827060 0.727 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr4_+_47033294 0.725 NM_000812
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr19_-_55770340 0.723 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr9_+_115142188 0.722 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr22_+_45559858 0.721 NUP50
nucleoporin 50kDa
chr3_-_50374749 0.721 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr19_+_7968774 0.720 MAP2K7
mitogen-activated protein kinase kinase 7
chr19_+_56165415 0.718 NM_001012478
NM_007279
U2AF2

U2 small nuclear RNA auxiliary factor 2

chr18_-_12884140 0.717 NM_001207013
NM_002828
NM_080422
NM_080423
PTPN2



protein tyrosine phosphatase, non-receptor type 2



chr19_+_59055866 0.717 TRIM28
tripartite motif containing 28
chr3_+_49591897 0.714 NM_003458
BSN
bassoon (presynaptic cytomatrix protein)
chr19_-_44079707 0.714 NM_006297
XRCC1
X-ray repair complementing defective repair in Chinese hamster cells 1
chrX_+_17755562 0.713 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr6_-_33168438 0.709 RXRB
retinoid X receptor, beta
chr20_-_30539803 0.709 PDRG1
p53 and DNA-damage regulated 1
chr19_+_2328679 0.706 SPPL2B
signal peptide peptidase-like 2B
chr17_+_4843585 0.704 NM_015528
RNF167
ring finger protein 167
chr22_-_31741565 0.704 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr9_+_115142395 0.700 HSDL2
hydroxysteroid dehydrogenase like 2
chr12_+_57916607 0.698 NM_052897
MBD6
methyl-CpG binding domain protein 6
chr14_-_47120940 0.695 NM_080746
RPL10L
ribosomal protein L10-like
chr7_+_73588602 0.690 EIF4H
eukaryotic translation initiation factor 4H
chr16_+_89753093 0.687 CDK10
cyclin-dependent kinase 10
chr22_-_31742329 0.686 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr3_+_122513870 0.685 NM_032839
DIRC2
disrupted in renal carcinoma 2
chr7_-_75115536 0.685 NM_001099415
POM121C
POM121 membrane glycoprotein C
chr10_-_15139301 0.679 NM_153244
C10orf111
chromosome 10 open reading frame 111
chr6_-_31774725 0.674 NM_021177
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr19_-_58874078 0.671 NM_001207009
NM_198458
ZNF497

zinc finger protein 497

chr21_-_47878592 0.667


chr7_+_44836309 0.665 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr7_+_149571029 0.664 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr9_+_71395079 0.663


chr6_-_99963301 0.663 USP45
ubiquitin specific peptidase 45
chr19_+_1269244 0.662 NM_001280
CIRBP
cold inducible RNA binding protein
chr11_-_59436366 0.658 PATL1
protein associated with topoisomerase II homolog 1 (yeast)
chr4_+_158141735 0.658 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr17_+_18128868 0.656 NM_004140
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr16_+_30710461 0.655 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr16_+_30709913 0.647


chr2_+_242673972 0.643 NM_152783
D2HGDH
D-2-hydroxyglutarate dehydrogenase
chr1_+_211556141 0.642 LINC00467
long intergenic non-protein coding RNA 467
chr16_+_4475804 0.642 NM_001135110
NM_005147
DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr6_+_31126340 0.642 TCF19
transcription factor 19
chr6_+_31126114 0.641 NM_001077511
NM_007109
TCF19

transcription factor 19

chr16_+_3019466 0.638 PAQR4
progestin and adipoQ receptor family member IV
chr7_+_107384573 0.636 CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr3_+_126261178 0.632 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr1_+_24104841 0.632 NM_020362
PITHD1
PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
chr14_+_75536298 0.630 NM_001042430
NM_024643
FAM164C

family with sequence similarity 164, member C

chr17_+_57970486 0.630 RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr19_+_56159400 0.628 CCDC106
coiled-coil domain containing 106
chr14_+_101193313 0.627 DLK1
delta-like 1 homolog (Drosophila)
chr20_-_10654139 0.626 JAG1
jagged 1
chr17_-_4843204 0.626 NM_001165417
NM_001165418
NM_003562
SLC25A11


solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11


chr3_-_50374795 0.626 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr6_-_170151627 0.625 NM_174910
TCTE3
t-complex-associated-testis-expressed 3
chr2_-_106810781 0.624 NM_025076
UXS1
UDP-glucuronate decarboxylase 1
chr1_+_211556158 0.622 LINC00467
long intergenic non-protein coding RNA 467
chr1_+_24104907 0.620 PITHD1
PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
chr4_-_8160435 0.619 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr12_-_48551269 0.619 NM_024095
ASB8
ankyrin repeat and SOCS box containing 8
chr15_+_96873845 0.618 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr17_-_15902907 0.615 NM_001042697
NM_001042698
ZSWIM7

zinc finger, SWIM-type containing 7

chr8_-_117887045 0.615 NM_006265
RAD21
RAD21 homolog (S. pombe)
chr14_+_75229995 0.612 NM_019589
YLPM1
YLP motif containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
24.83 3.04e-04 GO:0006334 nucleosome assembly
23.55 3.95e-04 GO:0031497 chromatin assembly
7.39 4.09e-04 GO:0051276 chromosome organization
22.40 5.07e-04 GO:0034728 nucleosome organization
21.56 6.13e-04 GO:0065004 protein-DNA complex assembly
20.40 8.04e-04 GO:0071824 protein-DNA complex subunit organization
18.00 1.49e-03 GO:0006323 DNA packaging
16.93 2.00e-03 GO:0006333 chromatin assembly or disassembly
15.45 3.13e-03 GO:0071103 DNA conformation change
3.80 6.14e-03 GO:0006996 organelle organization
7.47 6.21e-03 GO:0006325 chromatin organization
8.15 1.53e-02 GO:0034622 cellular macromolecular complex assembly

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
28.85 2.68e-06 GO:0032993 protein-DNA complex
38.06 9.59e-06 GO:0000786 nucleosome
9.95 6.93e-03 GO:0000785 chromatin
6.26 1.74e-02 GO:0044427 chromosomal part
5.25 4.44e-02 GO:0005694 chromosome

Nothing significant found in function category.