Motif ID: PAX4.p2

Z-value: 1.232


Transcription factors associated with PAX4.p2:

Gene SymbolEntrez IDGene Name
PAX4 5078 paired box 4



Activity profile for motif PAX4.p2.

activity profile for motif PAX4.p2


Sorted Z-values histogram for motif PAX4.p2

Sorted Z-values for motif PAX4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_28608367 1.177 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr3_+_46283871 1.056 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr6_+_31582978 1.055 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chr16_+_15528324 0.952 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr9_-_20622476 0.839 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr6_-_10694837 0.835 NM_001145020
C6orf52
chromosome 6 open reading frame 52
chr6_+_42751155 0.733 FLJ38717
FLJ38717 protein
chr2_-_122042767 0.726 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr9_-_20622433 0.695 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_+_151032880 0.650 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032150 0.644 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr10_+_95326397 0.638 NM_001195755
NM_181745
O3FAR1

omega-3 fatty acid receptor 1

chr19_+_6135650 0.635 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr1_+_151032683 0.620 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_-_123339423 0.599 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr19_-_4916814 0.599


chr19_-_49622278 0.586 NM_018111
C19orf73
chromosome 19 open reading frame 73
chrM_-_379 0.564


chr7_+_69064580 0.560 AUTS2
autism susceptibility candidate 2
chr16_+_29831714 0.557 NM_005115
NM_017458
MVP

major vault protein

chr3_+_119298522 0.553 NM_001125
ADPRH
ADP-ribosylarginine hydrolase
chr6_+_17282931 0.544 NM_153020
RBM24
RNA binding motif protein 24
chr1_+_151032906 0.535 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr15_-_82641705 0.520 NM_001164465
GOLGA6L10
golgin A6 family-like 10
chr6_-_36164973 0.504


chr3_-_123339178 0.486 MYLK
myosin light chain kinase
chr22_-_31688329 0.485 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr5_-_997408 0.484 NM_001242737
LOC100506688
uncharacterized LOC100506688
chr7_+_26191732 0.475 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr1_+_101702561 0.468 S1PR1
sphingosine-1-phosphate receptor 1
chr7_-_55930444 0.463 NM_207366
SEPT14
septin 14
chr2_+_122407564 0.454 LOC254128
uncharacterized LOC254128
chr12_+_105153258 0.450 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr22_-_38506532 0.441 BAIAP2L2
BAI1-associated protein 2-like 2
chr22_-_42765179 0.426


chr1_+_101702304 0.420 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr11_-_94964209 0.418 NM_144665
SESN3
sestrin 3
chr6_-_105627857 0.417 NM_022361
POPDC3
popeye domain containing 3
chrX_-_102531673 0.413 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr3_-_9921933 0.407 NM_001199551
NM_001199552
CIDEC

cell death-inducing DFFA-like effector c

chr4_+_88896899 0.392 SPP1
secreted phosphoprotein 1
chrX_+_7810302 0.390 NM_013452
VCX
variable charge, X-linked
chr4_-_40516567 0.387 RBM47
RNA binding motif protein 47
chr7_-_96654128 0.377 NM_005221
DLX5
distal-less homeobox 5
chr10_+_70980058 0.368 NM_025130
HKDC1
hexokinase domain containing 1
chr4_-_40517913 0.366 NM_019027
RBM47
RNA binding motif protein 47
chr8_+_26435466 0.363 DPYSL2
dihydropyrimidinase-like 2
chr4_-_113206883 0.362 NM_052864
TIFA
TRAF-interacting protein with forkhead-associated domain
chr12_+_104850986 0.354 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr18_-_60986508 0.354 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr1_-_209957872 0.349 NM_152485
C1orf74
chromosome 1 open reading frame 74
chr1_-_42965948 0.348 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr7_-_135613197 0.338 LUZP6
leucine zipper protein 6
chr11_+_20385230 0.336 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr1_-_149889362 0.334 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr12_-_95044205 0.332 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chrX_-_107682600 0.331 NM_001847
COL4A6
collagen, type IV, alpha 6
chr7_+_26331611 0.330 SNX10
sorting nexin 10
chr5_-_95158465 0.327 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr1_-_109618568 0.325 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr20_-_6103562 0.320 FERMT1
fermitin family member 1
chr10_+_91152321 0.320 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr9_-_97356007 0.317 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr11_+_20385259 0.317 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr2_+_102979096 0.313 NM_003855
IL18R1
interleukin 18 receptor 1
chr4_+_39184023 0.310 NM_025132
WDR19
WD repeat domain 19
chr11_+_20385324 0.309 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr9_-_27573444 0.305 NM_018325
C9orf72
chromosome 9 open reading frame 72
chr4_-_109089444 0.299 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr10_+_5136556 0.290 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_+_111805174 0.289 NM_001171747
NM_024616
C3orf52

chromosome 3 open reading frame 52

chr4_+_30722445 0.282 PCDH7
protocadherin 7
chr7_+_93551015 0.277 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr1_+_15480213 0.277 NM_001136218
NM_018022
TMEM51

transmembrane protein 51

chr9_+_79115548 0.274 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr8_+_32405727 0.274 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr2_-_217560247 0.274 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr7_-_112758604 0.268 LOC401397
uncharacterized LOC401397
chr6_+_15246299 0.266 NM_004973
JARID2
jumonji, AT rich interactive domain 2
chr6_+_25963398 0.265 TRIM38
tripartite motif containing 38
chr1_-_44482996 0.265 NM_006934
NM_201649
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr10_+_5136613 0.265 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_+_102594406 0.261 NM_033211
C5orf30
chromosome 5 open reading frame 30
chr8_+_26435920 0.261 NM_001244604
DPYSL2
dihydropyrimidinase-like 2
chr12_-_16760935 0.260 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr4_+_113739203 0.259 NM_001127493
ANK2
ankyrin 2, neuronal
chr12_-_95945226 0.257 NM_032147
USP44
ubiquitin specific peptidase 44
chr2_-_198540583 0.255 NM_144629
RFTN2
raftlin family member 2
chr5_+_140201221 0.255 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr1_-_89591685 0.253 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr4_+_2813966 0.252 SH3BP2
SH3-domain binding protein 2
chr2_-_232379049 0.248 LINC00471
long intergenic non-protein coding RNA 471
chr7_-_112758611 0.245 LOC401397
uncharacterized LOC401397
chr19_-_45996470 0.244 NM_206901
RTN2
reticulon 2
chr5_+_81601165 0.240 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr6_+_36644236 0.238 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr22_-_39640956 0.238 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide
chr4_+_47487230 0.238 NM_020453
ATP10D
ATPase, class V, type 10D
chr5_-_36301999 0.237 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr11_+_31391371 0.236 NM_181706
DNAJC24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr11_+_10482677 0.231 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr15_+_45248902 0.229 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr19_-_55836668 0.224 NM_001085488
TMEM150B
transmembrane protein 150B
chr20_-_6104056 0.223 NM_017671
FERMT1
fermitin family member 1
chr19_-_52552072 0.223 NM_014650
ZNF432
zinc finger protein 432
chr2_-_73492707 0.218 FBXO41
F-box protein 41
chr6_+_32407618 0.218 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr17_+_43299277 0.217 NM_005892
FMNL1
formin-like 1
chr6_-_130031278 0.216 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr11_+_6518489 0.213 NM_144666
NM_173589
DNHD1

dynein heavy chain domain 1

chr20_-_34117447 0.212 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr10_+_52751114 0.212 PRKG1
protein kinase, cGMP-dependent, type I
chr19_-_6767417 0.210 NM_005490
SH2D3A
SH2 domain containing 3A
chr1_-_85742586 0.206 NM_003921
BCL10
B-cell CLL/lymphoma 10
chr8_-_30002199 0.205 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr12_-_11422640 0.205 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr12_+_85430098 0.203 NM_001079910
LRRIQ1
leucine-rich repeats and IQ motif containing 1
chr10_-_61900659 0.201 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr6_+_42750465 0.199 FLJ38717
FLJ38717 protein
chr11_+_72975569 0.197 NM_176796
NM_176797
P2RY6

pyrimidinergic receptor P2Y, G-protein coupled, 6

chr11_+_27062508 0.195 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr6_+_111303240 0.194 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr10_+_114135013 0.194 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_32042085 0.192 NM_001204414
NM_022164
TINAGL1

tubulointerstitial nephritis antigen-like 1

chr6_+_135517051 0.192 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr7_-_130080823 0.191 NM_018718
CEP41
centrosomal protein 41kDa
chr5_-_101834548 0.190 NM_173488
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr6_-_24719286 0.187 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr7_+_69064316 0.185 AUTS2
autism susceptibility candidate 2
chr9_+_19049424 0.183 RRAGA
Ras-related GTP binding A
chr11_-_74109417 0.182 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chr15_+_80390757 0.181 NM_001242919
ZFAND6
zinc finger, AN1-type domain 6
chr9_+_19049376 0.180 RRAGA
Ras-related GTP binding A
chr3_-_156272909 0.180 NM_007107
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr22_-_24096551 0.178 NM_013378
VPREB3
pre-B lymphocyte 3
chr1_-_150207025 0.178 NM_001136479
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_+_25962978 0.177 NM_006355
TRIM38
tripartite motif containing 38
chr1_-_1623942 0.175 SLC35E2B
SLC35E2
solute carrier family 35, member E2B
solute carrier family 35, member E2
chr7_+_29603388 0.174 NM_175887
PRR15
proline rich 15
chr1_+_231376959 0.173 GNPAT
glyceronephosphate O-acyltransferase
chr3_-_23958500 0.171 NM_020345
NKIRAS1
NFKB inhibitor interacting Ras-like 1
chrX_-_102942968 0.171 NM_001142419
NM_001142420
NM_001142421
NM_001142422
NM_001142427
NM_001142428
NM_001142431
NM_001142432
MORF4L2







mortality factor 4 like 2







chr12_+_123717843 0.171 NM_152269
NM_001194995
C12orf65

chromosome 12 open reading frame 65

chr2_-_87088993 0.170 NM_001178100
NM_004931
NM_172101
NM_172102
NM_172213
CD8B




CD8b molecule




chr7_-_124405029 0.169 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr19_+_36157714 0.167 NM_007000
UPK1A
uroplakin 1A
chr9_+_19049417 0.167 RRAGA
Ras-related GTP binding A
chr12_+_31812120 0.167 NM_173802
METTL20
methyltransferase like 20
chr9_+_19049408 0.167 RRAGA
Ras-related GTP binding A
chr1_+_231376952 0.167 GNPAT
glyceronephosphate O-acyltransferase
chr4_-_120221702 0.166 NM_001001701
C4orf3
chromosome 4 open reading frame 3
chr19_-_23598867 0.164


chr3_+_69134057 0.163 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr14_+_69865095 0.162 NM_001252151
NM_001252152
SLC39A9

solute carrier family 39 (zinc transporter), member 9

chr7_-_140098256 0.162 NM_032295
NM_207113
SLC37A3

solute carrier family 37 (glycerol-3-phosphate transporter), member 3

chr10_+_5136589 0.161 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr7_-_23509972 0.160 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr22_-_38881529 0.157 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr1_+_231376918 0.156 NM_014236
GNPAT
glyceronephosphate O-acyltransferase
chr19_+_50472856 0.156 SIGLEC16
sialic acid binding Ig-like lectin 16 (gene/pseudogene)
chr8_-_146228260 0.156 ZNF252
zinc finger protein 252
chr9_+_19049355 0.155 NM_006570
RRAGA
Ras-related GTP binding A
chr12_+_56075418 0.155 METTL7B
methyltransferase like 7B
chr1_+_43253660 0.154 NM_001242750
LOC100129924
uncharacterized LOC100129924
chr9_+_6215785 0.153 NM_001199640
NM_001199641
NM_033439
IL33


interleukin 33


chr8_+_62200524 0.153 NM_173519
CLVS1
clavesin 1
chr12_-_6745087 0.152 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr11_+_28131830 0.152 METTL15
methyltransferase like 15
chr10_+_91092238 0.151 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_160160284 0.151 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr2_-_214015053 0.151 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr2_+_12856813 0.150 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr1_+_244816349 0.148 NM_016076
PPPDE1
PPPDE peptidase domain containing 1
chr14_+_24836144 0.148 NM_001136022
NM_001198967
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr4_-_170679027 0.148 NM_017867
C4orf27
chromosome 4 open reading frame 27
chr2_+_135011829 0.147 NM_002410
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr22_-_43117270 0.147 A4GALT
alpha 1,4-galactosyltransferase
chr16_-_4323055 0.147 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr8_+_17434700 0.146 PDGFRL
platelet-derived growth factor receptor-like
chr12_-_99288502 0.146 NM_001204065
NM_001204079
NM_001204080
NM_001204081
ANKS1B



ankyrin repeat and sterile alpha motif domain containing 1B



chr9_+_129677046 0.146 NM_001190729
NM_001190730
NM_014636
RALGPS1


Ral GEF with PH domain and SH3 binding motif 1


chr1_+_231376968 0.144 GNPAT
glyceronephosphate O-acyltransferase
chr18_-_74728677 0.143 MBP
myelin basic protein
chr20_-_39766522 0.142


chr11_+_63997941 0.142 DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr5_+_162930230 0.142 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr10_+_111967302 0.141 NM_130439
MXI1
MAX interactor 1
chr6_+_36098261 0.140 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr17_-_27949814 0.139 CORO6
coronin 6
chr5_-_95018659 0.138 NM_031952
SPATA9
spermatogenesis associated 9
chr10_+_95517565 0.138 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr6_-_66417069 0.138 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr5_+_68666861 0.136 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr18_-_65182507 0.136 DSEL
dermatan sulfate epimerase-like
chr8_+_26435339 0.135 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr2_+_233404436 0.135 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr19_+_49622480 0.134 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr2_+_143635194 0.132 NM_001032998
NM_001199241
NM_003937
KYNU


kynureninase


chr8_+_26435590 0.132 DPYSL2
dihydropyrimidinase-like 2
chr5_+_36608430 0.130 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
31.99 8.93e-03 GO:0006954 inflammatory response

Nothing significant found in compartment category.

Nothing significant found in function category.