Motif ID: PDX1.p2

Z-value: 0.342


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PDX1hg19_v1_chr13_+_28494136_28494272-0.809.5e-03Click!


Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_108814419 0.450 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr6_-_43423785 0.273 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chr15_-_44969085 0.266 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr12_+_47610244 0.242 FAM113B
family with sequence similarity 113, member B
chr10_+_63808968 0.232 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr8_+_32579350 0.224 NM_001159996
NRG1
neuregulin 1
chr17_+_47923271 0.193 NM_001242791
FLJ45513
uncharacterized LOC729220
chr2_-_166060552 0.190 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr15_+_67841341 0.187 NM_001206804
MAP2K5
mitogen-activated protein kinase kinase 5
chr4_+_74606222 0.175 NM_000584
IL8
interleukin 8
chr8_+_76452202 0.170 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr12_-_54019633 0.164 NM_001206683
ATF7
activating transcription factor 7
chr18_+_55888799 0.163 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_167191808 0.156 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr18_+_55888750 0.156 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_51952368 0.147 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr16_-_70557430 0.143 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr16_-_3085541 0.137 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr16_-_67517715 0.119 NM_001138
AGRP
agouti related protein homolog (mouse)
chr14_-_81864726 0.117 NM_033104
STON2
stonin 2
chr1_+_36636690 0.117 MAP7D1
MAP7 domain containing 1
chr4_+_88720701 0.113 NM_004967
IBSP
integrin-binding sialoprotein
chr6_-_133035180 0.098 NM_004666
VNN1
vanin 1
chr3_+_174577069 0.094 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr6_-_143266283 0.093 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr3_+_100238063 0.092 TMEM45A
transmembrane protein 45A
chr3_-_114343791 0.090 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr12_+_119616594 0.085 NM_014365
HSPB8
heat shock 22kDa protein 8
chr18_+_55888838 0.084 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_33841142 0.082 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr15_-_40398286 0.079 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr11_-_5323174 0.076 NM_033179
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr6_+_167704802 0.075 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr3_-_114478117 0.073 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chrX_+_49091926 0.070 NM_014008
CCDC22
coiled-coil domain containing 22
chr12_-_121454285 0.069 NM_022895
C12orf43
chromosome 12 open reading frame 43
chr19_-_36019194 0.068 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr12_-_57873364 0.068 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr9_+_33026482 0.067 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr14_-_77889231 0.063 NM_001113475
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr2_+_185463235 0.061 ZNF804A
zinc finger protein 804A
chr13_-_41593491 0.056 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_-_54020081 0.055 NM_001130060
NM_001206682
NM_006856
ATF7


activating transcription factor 7


chr11_-_104905849 0.054 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr4_-_46996423 0.051 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr8_-_145060594 0.051 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr20_+_43990576 0.048 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr7_-_44580857 0.046 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr4_+_123161119 0.045 KIAA1109
KIAA1109
chr16_+_70557688 0.045 NM_012426
SF3B3
splicing factor 3b, subunit 3, 130kDa
chr10_-_62332666 0.044 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr10_+_35484829 0.042 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr12_+_4829751 0.040 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr17_+_76000248 0.039 NM_001142640
NM_018996
TNRC6C

trinucleotide repeat containing 6C

chr6_+_144612872 0.038 NM_007124
UTRN
utrophin
chr7_-_99474655 0.034 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr2_+_185463292 0.032 ZNF804A
zinc finger protein 804A
chr12_+_80838125 0.032 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chrX_+_123234462 0.032 STAG2
stromal antigen 2
chr11_+_124134699 0.032 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr16_+_70557726 0.031 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr5_-_172083569 0.031


chr17_-_38859976 0.030 NM_019016
KRT24
keratin 24
chr7_-_87342569 0.029 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr1_+_101003692 0.029 NM_022049
GPR88
G protein-coupled receptor 88
chr2_+_24807345 0.028 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr5_-_16509106 0.028 NM_019000
FAM134B
family with sequence similarity 134, member B
chrX_+_49091931 0.027 CCDC22
coiled-coil domain containing 22
chrX_-_62780748 0.026 LOC92249
uncharacterized LOC92249
chr16_-_48269087 0.026 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr2_-_158300517 0.025 NM_004288
CYTIP
cytohesin 1 interacting protein
chrX_-_76814217 0.025 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr7_-_41742666 0.025 NM_002192
INHBA
inhibin, beta A
chr19_+_48828627 0.024 NM_001425
EMP3
epithelial membrane protein 3
chr11_-_6913730 0.022 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr1_-_155649243 0.022


chr6_+_158733691 0.021 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr15_+_80364902 0.021 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr11_+_22696318 0.020 NM_005256
GAS2
growth arrest-specific 2
chr15_-_40398573 0.020 NM_033503
BMF
Bcl2 modifying factor
chr9_+_82187599 0.020 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_-_155649597 0.019 NM_001198899
YY1AP1
YY1 associated protein 1
chr17_-_29641094 0.019 NM_006495
EVI2B
ecotropic viral integration site 2B
chr10_+_94594469 0.019 NM_001013848
EXOC6
exocyst complex component 6
chr10_+_86184685 0.018 FAM190B
family with sequence similarity 190, member B
chr4_-_170077807 0.018 SH3RF1
SH3 domain containing ring finger 1
chr7_-_27166638 0.018 NM_153631
HOXA3
homeobox A3
chr3_+_45017729 0.017 NM_015004
EXOSC7
exosome component 7
chr1_+_186265404 0.016 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr4_+_74281884 0.015 ALB
albumin
chr11_-_66488712 0.015 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr17_+_7960201 0.015


chr4_+_187187342 0.014 F11
coagulation factor XI
chr2_+_204055404 0.014 RPL12
ribosomal protein L12
chr13_-_70682458 0.014 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr2_-_96947640 0.014 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr6_+_147524866 0.014 STXBP5
syntaxin binding protein 5 (tomosyn)
chrX_+_118708540 0.014 UBE2A
ubiquitin-conjugating enzyme E2A
chr9_+_82187469 0.014 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr18_+_28898051 0.013 NM_001942
DSG1
desmoglein 1
chr7_+_116395440 0.012


chr2_-_216259197 0.012 FN1
fibronectin 1
chr1_-_16763887 0.011 NM_198546
SPATA21
spermatogenesis associated 21
chr3_+_11178778 0.011 NM_001098213
HRH1
histamine receptor H1
chr17_-_7082654 0.011 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr5_+_147648374 0.011 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr17_-_42143937 0.011 LSM12
LSM12 homolog (S. cerevisiae)
chr14_+_101295409 0.011 MEG3
maternally expressed 3 (non-protein coding)
chr16_+_29674979 0.010 SPN
sialophorin
chr12_+_31800093 0.010 NM_001135864
METTL20
methyltransferase like 20
chr18_-_47376156 0.010 MYO5B
myosin VB
chr5_-_142815076 0.010 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr17_-_29641068 0.010 EVI2B
ecotropic viral integration site 2B
chr6_+_25754926 0.010 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr2_-_100046262 0.009 REV1
REV1 homolog (S. cerevisiae)
chr4_-_24981769 0.009 NM_173463
CCDC149
coiled-coil domain containing 149
chr12_+_75784849 0.008 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr12_-_121454210 0.008 C12orf43
chromosome 12 open reading frame 43
chr14_+_23789396 0.007 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr4_+_77356252 0.007 NM_020859
SHROOM3
shroom family member 3
chr5_+_140227356 0.007 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr6_-_131291480 0.007 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chrX_-_132095422 0.007 NM_001077188
NM_147175
HS6ST2

heparan sulfate 6-O-sulfotransferase 2

chr17_-_29641087 0.007 EVI2B
ecotropic viral integration site 2B
chr1_+_17906941 0.006 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr10_+_32856650 0.006 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr12_+_15475190 0.006 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr3_+_45017749 0.006 EXOSC7
exosome component 7
chr7_+_120965420 0.006 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr1_+_79086087 0.005 NM_006820
IFI44L
interferon-induced protein 44-like
chr9_-_34620483 0.005 DCTN3
dynactin 3 (p22)
chr7_+_80275967 0.005 CD36
CD36 molecule (thrombospondin receptor)
chr3_+_52811601 0.005 NM_002215
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr1_+_28764660 0.005 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr12_-_50616425 0.005 NM_001113547
LIMA1
LIM domain and actin binding 1
chr9_+_33624214 0.005 ANXA2P2
annexin A2 pseudogene 2
chr7_+_104681378 0.005 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr2_+_228192227 0.004 NM_020194
MFF
mitochondrial fission factor
chr6_-_138539626 0.004 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chrX_+_48687282 0.004 NM_181532
ERAS
ES cell expressed Ras
chr5_+_68667280 0.004 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr11_+_28131830 0.003 METTL15
methyltransferase like 15
chr17_-_1412995 0.003 INPP5K
inositol polyphosphate-5-phosphatase K
chr6_+_42531736 0.003 NM_001184801
NM_015255
UBR2

ubiquitin protein ligase E3 component n-recognin 2

chr3_-_47933997 0.003 MAP4
microtubule-associated protein 4
chr2_-_218808705 0.003 NM_022648
TNS1
tensin 1
chr12_-_14849427 0.002 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr6_+_35310399 0.002 PPARD
peroxisome proliferator-activated receptor delta
chr15_+_40509628 0.002 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr4_-_72649734 0.002 NM_000583
GC
group-specific component (vitamin D binding protein)
chr7_-_92777657 0.002 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr7_+_143792140 0.001 NM_001004135
OR2A12
olfactory receptor, family 2, subfamily A, member 12
chr17_+_68071386 0.001 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr7_+_93535819 0.001 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr1_-_186417855 0.001 NM_022576
PDC
phosducin
chr14_-_23504353 0.001 NM_001144932
NM_002797
NM_001130725
PSMB5


proteasome (prosome, macropain) subunit, beta type, 5


chr4_-_10023094 0.001 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr6_-_131321868 0.000 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr10_+_70980058 0.000 NM_025130
HKDC1
hexokinase domain containing 1
chr14_+_70918873 0.000 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr12_+_105153258 0.000 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.