Motif ID: PITX1..3.p2

Z-value: 2.682


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX1hg19_v1_chr5_-_134369571_1343696800.818.3e-03Click!
PITX2hg19_v1_chr4_-_111544206_111544345-0.541.4e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_74483806 6.789 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr1_-_213020947 6.578 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr15_+_85359910 5.967 NM_020778
ALPK3
alpha-kinase 3
chr7_-_98805088 5.852 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr11_-_1606480 5.486 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr19_-_47735858 5.391 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr19_+_48964505 4.920 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr22_-_24096551 4.912 NM_013378
VPREB3
pre-B lymphocyte 3
chr12_+_52416615 4.349 NM_001202233
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr19_-_48614013 3.793 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr1_+_212788359 3.780 NM_001206486
ATF3
activating transcription factor 3
chr19_-_2256415 3.647 NM_144616
JSRP1
junctional sarcoplasmic reticulum protein 1
chr6_-_44233499 3.608 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr22_+_29834571 3.369 NM_021026
RFPL1
ret finger protein-like 1
chr7_-_100858312 3.073 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr1_+_26503973 3.066 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr6_-_27858569 2.970 NM_003535
HIST1H3J
histone cluster 1, H3j
chr19_+_10222196 2.949 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr4_+_2627158 2.901 NM_003704
FAM193A
family with sequence similarity 193, member A
chr11_-_46612913 2.877 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr19_+_49375679 2.802 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr19_+_49375677 2.797 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr7_+_1570321 2.795 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr17_+_7384720 2.790 NM_001102614
SLC35G6
solute carrier family 35, member G6
chr19_-_51893791 2.784 NM_001193623
LOC147646
uncharacterized LOC147646
chr19_+_49375638 2.752 NM_014330
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr19_+_544026 2.734 NM_005317
GZMM
granzyme M (lymphocyte met-ase 1)
chr19_-_55836668 2.728 NM_001085488
TMEM150B
transmembrane protein 150B
chr21_+_35736322 2.690 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr6_-_31648140 2.686 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr16_+_89984286 2.667 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr2_+_169643048 2.500 NM_001171631
NOSTRIN
nitric oxide synthase trafficker
chr12_-_6756533 2.485 NM_032489
ACRBP
acrosin binding protein
chr12_-_52225700 2.483 NM_001013690
FIGNL2
fidgetin-like 2
chr4_-_88243994 2.419 NM_001136230
NM_178135
HSD17B13

hydroxysteroid (17-beta) dehydrogenase 13

chr14_+_68168602 2.406 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr15_+_71433787 2.374 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr1_+_26504024 2.357 CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr10_-_92681025 2.340 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_10206562 2.308 NM_001570
IRAK2
interleukin-1 receptor-associated kinase 2
chr12_-_49177876 2.305 NM_015270
ADCY6
adenylate cyclase 6
chr17_-_79838899 2.298


chr20_+_51801821 2.263 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr1_+_28655512 2.249 NM_001127350
NM_017638
MED18

mediator complex subunit 18

chr2_-_211018294 2.244 C2orf67
chromosome 2 open reading frame 67
chr19_-_45908288 2.242 NM_006663
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chrX_-_23761396 2.238 NM_001033583
NM_001037171
ACOT9

acyl-CoA thioesterase 9

chr12_-_123594974 2.201 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr16_+_67571342 2.170 NM_001193524
FAM65A
family with sequence similarity 65, member A
chr16_+_230332 2.139 NM_005331
HBQ1
hemoglobin, theta 1
chr15_-_23115243 2.105 LOC283683
uncharacterized LOC283683
chr20_+_361272 2.101 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr4_-_74964996 2.069 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr7_+_99724319 2.057 NM_203397
MBLAC1
metallo-beta-lactamase domain containing 1
chr16_-_21854755 1.968 LOC100132247
NPIPL3
LOC613037
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
nuclear pore complex interacting protein pseudogene
chr14_-_89016806 1.933 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr2_+_10186284 1.917


chr22_+_20918810 1.897 MED15
mediator complex subunit 15
chr6_-_42162693 1.894 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr19_+_47759730 1.889 NM_015603
CCDC9
coiled-coil domain containing 9
chr15_-_41836458 1.845 NM_015540
RPAP1
RNA polymerase II associated protein 1
chr3_-_109035239 1.829 NM_138815
DPPA2
developmental pluripotency associated 2
chr19_+_17622420 1.749 NM_012088
PGLS
6-phosphogluconolactonase
chr19_+_17622445 1.747 PGLS
6-phosphogluconolactonase
chr19_+_2389768 1.747 NM_182973
TMPRSS9
transmembrane protease, serine 9
chr1_+_995109 1.739 LOC100288175
uncharacterized LOC100288175
chr6_-_44233244 1.738 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr19_-_12792698 1.735 NM_001930
NM_013406
DHPS

deoxyhypusine synthase

chr11_+_65101224 1.735 NM_006268
DPF2
D4, zinc and double PHD fingers family 2
chr15_-_41836442 1.731 RPAP1
RNA polymerase II associated protein 1
chr18_+_3453771 1.731 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr6_-_31763551 1.723 NM_006295
VARS
valyl-tRNA synthetase
chr11_-_69490014 1.714 ORAOV1
oral cancer overexpressed 1
chr7_+_48128225 1.703 NM_181597
UPP1
uridine phosphorylase 1
chr2_+_203130480 1.676 NM_015934
NOP58
NOP58 ribonucleoprotein homolog (yeast)
chr16_+_4382224 1.666 NM_032575
GLIS2
GLIS family zinc finger 2
chr7_+_73868236 1.629 GTF2IRD1
GTF2I repeat domain containing 1
chr16_-_75301950 1.628 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr15_+_32933869 1.626 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr16_+_30210548 1.624 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr4_-_74864296 1.620 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr10_-_125853102 1.620 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr10_-_99160987 1.591 RRP12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr11_-_9225780 1.584 DENND5A
DENN/MADD domain containing 5A
chr11_+_65101345 1.584 DPF2
D4, zinc and double PHD fingers family 2
chr19_+_48774653 1.582 NM_153608
ZNF114
zinc finger protein 114
chr10_-_99161013 1.576 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr7_-_143956720 1.572 NM_001005328
OR2A7
olfactory receptor, family 2, subfamily A, member 7
chr19_-_55549612 1.568 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr7_-_100061893 1.555 NM_001004323
C7orf61
chromosome 7 open reading frame 61
chr16_+_50321822 1.547 NM_001114
ADCY7
adenylate cyclase 7
chr20_+_36011936 1.478 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr1_+_10534992 1.476 NM_004565
PEX14
peroxisomal biogenesis factor 14
chr17_-_7493389 1.475 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr4_-_184243578 1.472 NM_001185149
CLDN24
claudin 24
chr3_+_9691198 1.461 MTMR14
myotubularin related protein 14
chr1_+_186369703 1.457 NM_022375
OCLM
oculomedin
chr7_+_17382900 1.450 AHR
aryl hydrocarbon receptor
chr7_+_73868397 1.447 GTF2IRD1
GTF2I repeat domain containing 1
chr7_-_99680358 1.446 ZNF3
zinc finger protein 3
chr15_+_42696957 1.443 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr12_-_117537090 1.425 NM_001168325
NM_017899
TESC

tescalcin

chr17_+_40703983 1.421 NM_000413
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chr10_-_69752385 1.410 HERC4
hect domain and RLD 4
chr6_-_88038995 1.392 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr1_+_10509775 1.391 NM_001302
CORT
cortistatin
chr9_-_27005649 1.387 NM_022901
LRRC19
leucine rich repeat containing 19
chr7_+_73868111 1.372 NM_001199207
NM_005685
NM_016328
GTF2IRD1


GTF2I repeat domain containing 1


chr8_+_38965049 1.363 NM_145004
ADAM32
ADAM metallopeptidase domain 32
chr4_+_41983712 1.357 NM_001029955
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr9_+_131464770 1.350 NM_013355
PKN3
protein kinase N3
chr17_+_7982752 1.332


chr19_+_45596159 1.331 PPP1R37
protein phosphatase 1, regulatory subunit 37
chr9_+_6720862 1.329 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr3_+_9691116 1.312 NM_001077525
NM_001077526
NM_022485
MTMR14


myotubularin related protein 14


chr20_+_361675 1.309 TRIB3
tribbles homolog 3 (Drosophila)
chr7_+_23530136 1.308 RPS2P32
ribosomal protein S2 pseudogene 32
chr7_-_99756329 1.305 C7orf43
chromosome 7 open reading frame 43
chr16_+_67001377 1.297 NM_001185176
CES3
carboxylesterase 3
chr11_-_62607627 1.296 NM_018093
WDR74
WD repeat domain 74
chr13_-_46961634 1.296 NM_025113
KIAA0226L
KIAA0226-like
chr7_-_140302311 1.294 NM_015689
DENND2A
DENN/MADD domain containing 2A
chr14_-_75530716 1.286 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr19_+_48828627 1.283 NM_001425
EMP3
epithelial membrane protein 3
chr7_-_47988036 1.282 NM_138295
PKD1L1
polycystic kidney disease 1 like 1
chr1_+_95558072 1.277 NM_001199679
TMEM56
transmembrane protein 56
chr7_-_99756275 1.272 NM_018275
C7orf43
chromosome 7 open reading frame 43
chr9_+_135894806 1.271 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr20_-_62436855 1.254 NM_025224
ZBTB46
zinc finger and BTB domain containing 46
chr2_+_219575507 1.250 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr5_+_55147206 1.248 NM_001242637
NM_001242638
NM_139017
IL31RA


interleukin 31 receptor A


chr6_-_74161978 1.237 MB21D1
Mab-21 domain containing 1
chr8_-_101315457 1.235 NM_015435
RNF19A
ring finger protein 19A
chr9_+_129567260 1.231 NM_001135776
NM_014007
ZBTB43

zinc finger and BTB domain containing 43

chr1_-_150738292 1.230 NM_001199739
NM_004079
CTSS

cathepsin S

chr1_-_38019828 1.230 NM_024700
SNIP1
Smad nuclear interacting protein 1
chr8_-_124253584 1.229 NM_032847
C8orf76
chromosome 8 open reading frame 76
chr19_+_4183350 1.214 NM_133475
ANKRD24
ankyrin repeat domain 24
chr17_-_56769375 1.210 NM_001201457
NM_031272
NM_198393
TEX14


testis expressed 14


chr14_-_73453651 1.210 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr22_-_18484183 1.202 MICAL3
microtubule associated monoxygenase, calponin and LIM domain containing 3
chr19_-_46142662 1.200 NM_012155
EML2
echinoderm microtubule associated protein like 2
chr11_-_73720281 1.185 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr22_-_41636855 1.184 NM_138481
CHADL
chondroadherin-like
chr6_-_43423785 1.183 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chr7_+_100770378 1.178 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr3_-_50375650 1.178 NM_170712
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr3_+_9691184 1.173 MTMR14
myotubularin related protein 14
chr6_+_31598366 1.170 PRRC2A
proline-rich coiled-coil 2A
chr16_-_1922079 1.169 NM_152764
C16orf73
chromosome 16 open reading frame 73
chr2_-_197664335 1.154 NM_001206774
NM_012086
GTF3C3

general transcription factor IIIC, polypeptide 3, 102kDa

chr2_-_74542149 1.145 NM_021196
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr19_+_11200146 1.137 LDLR
low density lipoprotein receptor
chr7_+_74508346 1.132 NM_001003795
GTF2IRD2B
GTF2IRD2
GTF2I repeat domain containing 2B
GTF2I repeat domain containing 2
chr3_+_195447751 1.130 NM_152673
MUC20
mucin 20, cell surface associated
chr9_-_110252045 1.122 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr9_-_35115844 1.119 NM_025182
FAM214B
family with sequence similarity 214, member B
chr16_+_90015138 1.118 NM_001242816
NM_001242817
NM_001242818
NM_001242820
NM_001242821
NM_001242822
NM_017702
NM_207514
DEF8







differentially expressed in FDCP 8 homolog (mouse)







chr16_-_3074225 1.112 NM_001002017
NM_001002018
NM_017885
HCFC1R1


host cell factor C1 regulator 1 (XPO1 dependent)


chr1_+_151009028 1.112 NM_001159642
NM_138278
BNIPL

BCL2/adenovirus E1B 19kD interacting protein like

chrX_-_23761264 1.109 ACOT9
acyl-CoA thioesterase 9
chr10_-_70287249 1.108 NM_152707
SLC25A16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr1_-_151826042 1.107 NM_182578
THEM5
thioesterase superfamily member 5
chr7_+_72848108 1.105 NM_003508
FZD9
frizzled family receptor 9
chr1_-_221910801 1.100 NM_144728
DUSP10
dual specificity phosphatase 10
chr12_-_15865847 1.099 EPS8
epidermal growth factor receptor pathway substrate 8
chr14_+_21756135 1.095 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr19_-_3969734 1.095 NM_001348
DAPK3
death-associated protein kinase 3
chr22_-_38240341 1.094 NM_138797
ANKRD54
ankyrin repeat domain 54
chr1_+_223889253 1.093 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr19_+_3585541 1.093 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr16_-_29937354 1.088 KCTD13
potassium channel tetramerisation domain containing 13
chr7_-_1595746 1.086 NM_001097620
TMEM184A
transmembrane protein 184A
chr3_-_15382874 1.085 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr9_+_132388404 1.082 NM_014064
METTL11A
methyltransferase like 11A
chr13_-_21635703 1.081 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr17_+_40086875 1.067 NM_031421
TTC25
tetratricopeptide repeat domain 25
chr1_-_150738255 1.059 CTSS
cathepsin S
chr1_+_59775749 1.058 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr9_-_117156684 1.058 NM_030767
AKNA
AT-hook transcription factor
chr4_+_72904848 1.052 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr10_+_70502251 1.047 CCAR1
cell division cycle and apoptosis regulator 1
chr16_+_88003623 1.046 NM_001173543
BANP
BTG3 associated nuclear protein
chr1_-_150849211 1.043 NM_001197325
NM_001668
NM_178427
ARNT


aryl hydrocarbon receptor nuclear translocator


chr1_+_236681513 1.041 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr3_+_194304717 1.039


chr12_+_7023490 1.039 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr19_+_47759802 1.035 CCDC9
coiled-coil domain containing 9
chr22_+_39795745 1.034 NM_006116
NM_153497
TAB1

TGF-beta activated kinase 1/MAP3K7 binding protein 1

chr3_-_121740968 1.030 NM_001199799
NM_001199800
NM_175924
ILDR1


immunoglobulin-like domain containing receptor 1


chr15_-_65398578 1.029 NM_001163692
UBAP1L
ubiquitin associated protein 1-like
chrX_+_69488154 1.028 NM_004312
ARR3
arrestin 3, retinal (X-arrestin)
chr4_+_62362838 1.023 NM_015236
LPHN3
latrophilin 3
chr22_+_24819855 1.021 ADORA2A
adenosine A2a receptor
chr10_+_96443250 1.019 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr16_-_75241052 1.014 NM_001025200
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr16_-_71748697 1.012 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr20_-_33999780 1.008 NM_001184977
NM_018244
NM_199487
UQCC


ubiquinol-cytochrome c reductase complex chaperone


chr7_-_6487573 1.006 NM_001142936
NM_139179
DAGLB

diacylglycerol lipase, beta

chr16_-_1922161 1.004 NM_001163560
C16orf73
chromosome 16 open reading frame 73

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.