Motif ID: POU5F1.p2

Z-value: 1.959


Transcription factors associated with POU5F1.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU5F1hg19_v1_chr6_-_31134614_31134614-0.373.3e-01Click!


Activity profile for motif POU5F1.p2.

activity profile for motif POU5F1.p2


Sorted Z-values histogram for motif POU5F1.p2

Sorted Z-values for motif POU5F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_67410825 18.375 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr10_+_115312777 6.277 NM_004132
HABP2
hyaluronan binding protein 2
chr1_+_164528914 5.123 PBX1
pre-B-cell leukemia homeobox 1
chr5_-_36301999 4.249 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr17_-_36104874 3.996 HNF1B
HNF1 homeobox B
chr17_+_7554415 3.821 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr6_+_27100784 3.690 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr5_-_111091947 3.565 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr14_+_79745653 3.565 NM_001105250
NM_138970
NRXN3

neurexin 3

chr21_-_36421195 3.510 RUNX1
runt-related transcription factor 1
chr1_-_217262946 3.504 NM_001243506
NM_206594
NM_206595
ESRRG


estrogen-related receptor gamma


chr6_+_26124372 3.216 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr6_+_26251826 3.194 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr5_-_27038650 3.176 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr3_-_123603144 3.104 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr17_-_36105005 2.992 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr5_+_54455945 2.855 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr11_-_27494232 2.779 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr1_+_170115187 2.680 NM_001136107
METTL11B
methyltransferase like 11B
chr14_-_92413738 2.595 FBLN5
fibulin 5
chr20_-_34243118 2.592 RBM12
RNA binding motif protein 12
chrX_+_38660692 2.566 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chrX_+_38660653 2.513 NM_001098790
NM_001098791
MID1IP1

MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))

chrX_-_33357725 2.486 NM_000109
DMD
dystrophin
chr2_+_16080559 2.470 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr16_-_79634610 2.456 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr1_+_33722158 2.448 NM_152493
ZNF362
zinc finger protein 362
chrX_-_24665225 2.352 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr8_-_102803196 2.339 NCALD
neurocalcin delta
chr5_-_147162056 2.328 JAKMIP2
janus kinase and microtubule interacting protein 2
chr19_-_18314731 2.303 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr1_+_192605267 2.257 NM_002927
NM_144766
RGS13

regulator of G-protein signaling 13

chr1_-_108231122 2.206 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr8_+_26435590 2.205 DPYSL2
dihydropyrimidinase-like 2
chr2_+_16080639 2.203 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr3_+_181429711 2.185 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chrX_+_9431314 2.175 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr17_+_7554239 2.136 NM_001678
ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chrX_-_24665454 2.114 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr11_-_115375065 2.088 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr16_+_29789560 2.070 NM_152338
ZG16
zymogen granule protein 16 homolog (rat)
chr13_-_28543143 2.061 CDX2
caudal type homeobox 2
chr1_+_24840800 2.049 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr1_+_39875175 2.022 NM_015038
KIAA0754
KIAA0754
chr21_-_36421461 2.016 RUNX1
runt-related transcription factor 1
chr16_-_4323000 2.004 NM_003223
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr17_+_38219040 1.995 NM_001190918
NM_003250
NM_199334
THRA


thyroid hormone receptor, alpha


chr6_+_167536240 1.960 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr13_-_61989209 1.957 PCDH20
protocadherin 20
chrX_-_105282714 1.943 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr1_+_164528586 1.922 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr2_+_27310079 1.909 KHK
ketohexokinase (fructokinase)
chr17_+_7554711 1.897 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr5_-_111092918 1.864 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr10_-_21807120 1.853


chr6_-_42419782 1.846 NM_033502
TRERF1
transcriptional regulating factor 1
chr4_+_41614911 1.840 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr5_-_111092865 1.800 C5orf13
chromosome 5 open reading frame 13
chrX_-_13835313 1.785 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr12_+_25205488 1.780 LRMP
lymphoid-restricted membrane protein
chr12_-_81763127 1.777 NM_001220479
NM_001220480
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr1_-_23885916 1.770 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr18_-_53089722 1.761 NM_001243233
TCF4
transcription factor 4
chrX_-_106960268 1.736 NM_004089
TSC22D3
TSC22 domain family, member 3
chr7_-_92855780 1.726 NM_001039372
HEPACAM2
HEPACAM family member 2
chr7_-_27239724 1.725 NM_000522
HOXA13
homeobox A13
chr9_-_14086901 1.703 NFIB
nuclear factor I/B
chr3_-_186262114 1.700 NM_017541
CRYGS
crystallin, gamma S
chr6_+_84222252 1.695 PRSS35
protease, serine, 35
chr17_+_45908992 1.687 NM_033413
LRRC46
leucine rich repeat containing 46
chr1_+_101185195 1.663 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr8_+_26435339 1.654 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr4_+_154178525 1.612 TRIM2
tripartite motif containing 2
chr18_+_72922725 1.593 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr8_+_26435466 1.590 DPYSL2
dihydropyrimidinase-like 2
chr2_+_189839132 1.589 COL3A1
collagen, type III, alpha 1
chr16_-_4322695 1.589 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr6_+_27114860 1.576 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr18_+_33234532 1.559 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr12_+_25205180 1.558 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr8_+_56792399 1.551 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr1_+_244214552 1.548 NM_205768
ZNF238
zinc finger protein 238
chr12_-_102591547 1.522 NM_002674
PMCH
pro-melanin-concentrating hormone
chr1_+_244214576 1.492 ZNF238
zinc finger protein 238
chr7_+_94292737 1.490 PEG10
paternally expressed 10
chr2_+_65663812 1.490 FLJ16124
FLJ16124 protein
chr1_-_102462371 1.476 OLFM3
olfactomedin 3
chr4_+_88896868 1.450 SPP1
secreted phosphoprotein 1
chr4_+_184826427 1.446 NM_020225
STOX2
storkhead box 2
chr17_+_14204326 1.443 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr1_+_214161279 1.439 PROX1
prospero homeobox 1
chr4_+_88896838 1.433 SPP1
secreted phosphoprotein 1
chr5_-_88119604 1.432 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr4_-_164534656 1.428 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr5_-_111312522 1.425 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr3_+_186648273 1.411 NM_173216
NM_173217
ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chr8_+_24151579 1.397 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr3_-_57234279 1.396 NM_003865
HESX1
HESX homeobox 1
chr19_+_17337012 1.391 NM_024578
OCEL1
occludin/ELL domain containing 1
chr11_+_63057371 1.376 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr6_-_26033795 1.347 NM_003513
HIST1H2AB
histone cluster 1, H2ab
chr3_+_49568370 1.339 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr2_-_188419185 1.338 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr13_-_28543423 1.337 CDX2
caudal type homeobox 2
chr6_+_112375277 1.335 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr11_-_94964209 1.335 NM_144665
SESN3
sestrin 3
chr9_+_132083294 1.334 NM_001012715
C9orf106
chromosome 9 open reading frame 106
chrX_-_13835213 1.324 GPM6B
glycoprotein M6B
chr6_-_52668599 1.315 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr4_-_186733372 1.310 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chrX_-_21776158 1.306 NM_014332
SMPX
small muscle protein, X-linked
chr4_+_41700736 1.303 LIMCH1
LIM and calponin homology domains 1
chrX_-_106960028 1.287 TSC22D3
TSC22 domain family, member 3
chr3_-_14989616 1.286 LOC100505641
uncharacterized LOC100505641
chr1_-_216896640 1.282 NM_001243515
NM_001243518
NM_001243519
NM_001438
ESRRG



estrogen-related receptor gamma



chr1_+_66458389 1.280 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr2_+_242127923 1.276 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr10_-_42863435 1.271 LOC441666
zinc finger protein 91 pseudogene
chrX_+_22050920 1.253 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr1_+_87797301 1.244


chr2_-_152118258 1.244 NM_198557
RBM43
RNA binding motif protein 43
chr6_+_84222193 1.239 NM_001170423
NM_153362
PRSS35

protease, serine, 35

chr4_+_88896801 1.234 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr3_-_14989399 1.219 LOC100505641
uncharacterized LOC100505641
chrM_-_379 1.218


chr16_+_30483959 1.217 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr6_-_134498973 1.209 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr11_-_115088628 1.205 CADM1
cell adhesion molecule 1
chr4_-_141074122 1.205 MAML3
mastermind-like 3 (Drosophila)
chr3_-_71294229 1.201 NM_001244814
FOXP1
forkhead box P1
chr17_-_41276112 1.194 NM_007298
BRCA1
breast cancer 1, early onset
chr1_-_26185847 1.193 NM_024037
C1orf135
chromosome 1 open reading frame 135
chr5_-_147162251 1.192 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr8_+_56792345 1.189 NM_001111097
NM_002350
LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

chr1_-_211752052 1.188 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr2_-_165551178 1.186 COBLL1
COBL-like 1
chr14_+_90863302 1.176 NM_006888
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr16_+_2198607 1.171 NM_014353
RAB26
RAB26, member RAS oncogene family
chr11_+_5653484 1.166 NM_130390
TRIM34
tripartite motif containing 34
chr13_-_28543290 1.166 NM_001265
CDX2
caudal type homeobox 2
chr5_-_73936299 1.157 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr16_+_30484049 1.153 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr7_+_43152196 1.153 NM_015052
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr7_+_141478241 1.152 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr5_-_35230548 1.147 PRLR
prolactin receptor
chr1_+_92545861 1.137 NM_183242
BTBD8
BTB (POZ) domain containing 8
chr1_-_217250230 1.128 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr5_+_140602914 1.121 NM_018934
PCDHB14
protocadherin beta 14
chr6_+_21593963 1.110 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr5_+_140743755 1.097 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr12_+_54447660 1.094 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr20_+_19915716 1.090 RIN2
Ras and Rab interactor 2
chr14_-_92414004 1.089 NM_006329
FBLN5
fibulin 5
chr11_-_119599253 1.087 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr14_+_78870092 1.086 NM_004796
NRXN3
neurexin 3
chr14_+_62462540 1.083 NM_031914
SYT16
synaptotagmin XVI
chr1_-_72748491 1.076


chr17_+_41052813 1.071 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr1_-_23886284 1.070 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr22_-_31742329 1.063 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr5_+_140593508 1.057 NM_018933
PCDHB13
protocadherin beta 13
chr12_+_51318743 1.051 METTL7A
methyltransferase like 7A
chr12_-_16760935 1.045 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr19_-_44123732 1.045 ZNF428
zinc finger protein 428
chr11_-_118084073 1.039 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr19_-_40562107 1.038 NM_001005851
ZNF780B
zinc finger protein 780B
chr7_-_150754934 1.033 CDK5
cyclin-dependent kinase 5
chr12_-_81991959 1.031 NM_001220477
NM_001220478
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr3_+_3841079 1.031 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr21_-_36421630 1.028 RUNX1
runt-related transcription factor 1
chr4_+_88896899 1.025 SPP1
secreted phosphoprotein 1
chr19_-_44124013 1.023 NM_182498
ZNF428
zinc finger protein 428
chr6_-_134497069 1.021 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_6772252 1.018 NM_001127582
NM_001127583
NM_001127584
NM_001127585
NM_001127586
NM_016162
ING4





inhibitor of growth family, member 4





chr7_-_56101830 1.015 PSPH
phosphoserine phosphatase
chr20_+_34556528 1.015 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr2_+_232573226 1.009 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr2_+_232573249 1.008 PTMA
prothymosin, alpha
chr14_+_90863365 1.003 CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr21_-_36421586 1.000 NM_001754
RUNX1
runt-related transcription factor 1
chr4_+_113739203 0.999 NM_001127493
ANK2
ankyrin 2, neuronal
chr21_-_36421578 0.999 RUNX1
runt-related transcription factor 1
chrX_-_15402469 0.997 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr5_-_95158465 0.995 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr3_-_14989857 0.995 LOC100505641
uncharacterized LOC100505641
chr10_+_91061705 0.991 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chrX_-_63425484 0.986 NM_152424
FAM123B
family with sequence similarity 123B
chr2_+_234601511 0.985 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_+_81771844 0.985 LPHN2
latrophilin 2
chr2_-_188419049 0.982 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr4_-_139163222 0.978 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr15_+_96869156 0.977 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr2_+_172950207 0.971 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr19_-_46088074 0.970 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr12_-_63546589 0.967 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr11_-_66115016 0.967 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr6_-_26124130 0.966 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr4_-_141075232 0.958 NM_018717
MAML3
mastermind-like 3 (Drosophila)
chr10_-_91011586 0.956 NM_000235
NM_001127605
LIPA

lipase A, lysosomal acid, cholesterol esterase

chr12_-_123920967 0.953 RILPL2
Rab interacting lysosomal protein-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.89 3.57e-06 GO:0048513 organ development
2.31 4.89e-05 GO:0048731 system development
2.18 1.22e-04 GO:0048856 anatomical structure development
7.02 4.05e-04 GO:0048568 embryonic organ development
1.98 4.70e-04 GO:0032502 developmental process
2.04 5.75e-04 GO:0007275 multicellular organismal development
3.68 1.43e-03 GO:0007155 cell adhesion
3.68 1.43e-03 GO:0022610 biological adhesion
1.69 4.63e-03 GO:0032501 multicellular organismal process
31.02 5.84e-03 GO:0007157 heterophilic cell-cell adhesion
3.87 6.21e-03 GO:0009887 organ morphogenesis
3.58 8.03e-03 GO:0009790 embryo development
3.73 9.55e-03 GO:0045893 positive regulation of transcription, DNA-dependent
3.02 1.25e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.51 1.86e-02 GO:0009653 anatomical structure morphogenesis
3.31 2.11e-02 GO:0071844 cellular component assembly at cellular level
3.48 2.18e-02 GO:0051254 positive regulation of RNA metabolic process
3.45 2.44e-02 GO:0010628 positive regulation of gene expression
5.01 2.66e-02 GO:0016337 cell-cell adhesion
2.15 2.97e-02 GO:0006355 regulation of transcription, DNA-dependent
3.06 3.13e-02 GO:0009888 tissue development
7.47 3.57e-02 GO:0007156 homophilic cell adhesion
139.57 4.20e-02 GO:0060414 aorta smooth muscle tissue morphogenesis
38.07 4.68e-02 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
11.64 9.29e-03 GO:0000786 nucleosome
34.90 1.01e-02 GO:0043034 costamere

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.46 2.04e-05 GO:0001071 nucleic acid binding transcription factor activity
3.46 2.04e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
3.92 9.62e-05 GO:0043565 sequence-specific DNA binding
3.23 1.28e-04 GO:0030528 transcription regulator activity
6.48 1.44e-03 GO:0010843 promoter binding
6.23 1.99e-03 GO:0000975 regulatory region DNA binding
6.23 1.99e-03 GO:0001067 regulatory region nucleic acid binding
6.23 1.99e-03 GO:0044212 transcription regulatory region DNA binding
2.12 2.25e-03 GO:0003677 DNA binding