Motif ID: SRF.p3

Z-value: 2.215


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRFhg19_v1_chr6_+_43139201_431393860.835.2e-03Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_137801178 15.247 NM_001964
EGR1
early growth response 1
chr5_+_137801166 12.566 EGR1
early growth response 1
chr19_+_45971249 5.622 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr11_-_65667809 4.617 FOSL1
FOS-like antigen 1
chr9_+_92219926 4.576 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr12_+_52445185 4.337 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr14_+_75745480 3.718 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr11_-_65667860 3.439 NM_005438
FOSL1
FOS-like antigen 1
chr19_+_49376488 3.149 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr22_+_31480981 3.119 NM_001207018
SMTN
smoothelin
chr10_-_64576074 3.098 EGR2
early growth response 2
chr10_-_64576123 2.770 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr6_-_29527701 2.635 NM_006398
UBD
ubiquitin D
chr19_+_48958765 2.271 NM_013348
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr2_-_161056762 2.112 ITGB6
integrin, beta 6
chr2_+_87754991 2.088 LINC00152
long intergenic non-protein coding RNA 152
chr19_+_2476122 1.980 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr7_+_112120907 1.974 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr1_+_223889253 1.957 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr6_-_109775423 1.953 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr19_-_36247917 1.881 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr4_+_108814419 1.859 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr12_+_75874512 1.848 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr3_-_99594915 1.828 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr9_+_139249251 1.724 NM_001200003
GPSM1
G-protein signaling modulator 1
chr2_-_106015423 1.707 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr10_-_29923900 1.691 NM_021738
SVIL
supervillin
chr1_+_181057835 1.687 IER5
immediate early response 5
chr11_-_65667858 1.687 FOSL1
FOS-like antigen 1
chr12_-_50616425 1.608 NM_001113547
LIMA1
LIM domain and actin binding 1
chr1_-_11907741 1.593 NM_006172
NPPA
natriuretic peptide A
chr19_+_13135368 1.569 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_+_13134782 1.502 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_16085245 1.494 NM_017556
FBLIM1
filamin binding LIM protein 1
chr6_-_29527477 1.487 UBD
ubiquitin D
chr10_-_90712510 1.476 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr17_+_57915192 1.475


chr1_+_167599503 1.441 RCSD1
RCSD domain containing 1
chr7_-_27183225 1.407 NM_019102
HOXA5
homeobox A5
chr20_-_62258330 1.399 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chrX_-_153602928 1.322 FLNA
filamin A, alpha
chr3_+_187930720 1.263 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_+_16318848 1.241 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr17_+_16318911 1.215 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr2_-_161056573 1.199 NM_000888
ITGB6
integrin, beta 6
chr19_+_1026608 1.199 CNN2
calponin 2
chr15_-_65360297 1.197 NM_016563
RASL12
RAS-like, family 12
chr6_-_26108320 1.170 NM_005323
HIST1H1T
histone cluster 1, H1t
chr6_+_151561094 1.159 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr15_+_45406518 1.113 NM_207581
DUOXA2
dual oxidase maturation factor 2
chr17_+_41003184 1.079 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr11_-_1606480 1.078 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr2_-_96810775 1.041 DUSP2
dual specificity phosphatase 2
chr17_-_4890920 1.027 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr1_-_935469 0.972 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr10_+_88428263 0.951 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr19_+_1026624 0.949 CNN2
calponin 2
chr19_+_54372659 0.937 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr6_-_88411948 0.936 AKIRIN2
akirin 2
chr6_+_43139190 0.925 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr6_+_43138919 0.871 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr19_+_1026582 0.850 CNN2
calponin 2
chr7_+_143078399 0.830 ZYX
zyxin
chr10_+_31610063 0.829 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr18_-_3219846 0.828 MYOM1
myomesin 1, 185kDa
chr20_-_62258422 0.824 GMEB2
glucocorticoid modulatory element binding protein 2
chr2_+_87755059 0.816 LINC00152
long intergenic non-protein coding RNA 152
chr6_+_151561508 0.804 AKAP12
A kinase (PRKA) anchor protein 12
chr2_-_225378320 0.804 CUL3
cullin 3
chr7_+_143078358 0.802 NM_001010972
NM_003461
ZYX

zyxin

chrX_-_153602998 0.801 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr17_-_79479831 0.797 NM_001199954
NM_001614
ACTG1

actin, gamma 1

chr17_+_3379295 0.787 NM_000049
ASPA
aspartoacylase
chr4_+_89299874 0.758 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr7_+_143078444 0.750 ZYX
zyxin
chr7_+_143078395 0.736 ZYX
zyxin
chr17_-_4890664 0.731 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr17_-_1389323 0.726 MYO1C
myosin IC
chr6_-_86388419 0.724 SNHG5
small nucleolar RNA host gene 5 (non-protein coding)
chr6_-_76203256 0.718 NM_015687
FILIP1
filamin A interacting protein 1
chr3_-_156878481 0.706 NM_020307
CCNL1
cyclin L1
chr19_+_1026627 0.705 CNN2
calponin 2
chr7_-_107643330 0.683 NM_002291
LAMB1
laminin, beta 1
chr11_-_16430425 0.681 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr1_-_89530890 0.675 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr8_-_22550708 0.674 NM_004430
EGR3
early growth response 3
chr3_+_63953419 0.670 NM_001128149
ATXN7
ataxin 7
chr12_+_50497790 0.651 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr6_-_88411649 0.650 AKIRIN2
akirin 2
chr6_-_88411872 0.647 AKIRIN2
akirin 2
chr6_+_43139201 0.646 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr7_+_143078447 0.641 ZYX
zyxin
chr21_-_47704166 0.618 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr7_+_143078457 0.607 ZYX
zyxin
chr14_+_105267378 0.597 ZBTB42
zinc finger and BTB domain containing 42
chr14_-_74226890 0.588 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr19_-_46283763 0.578 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr15_+_71433787 0.571 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr19_+_16178170 0.569 NM_001145160
TPM4
tropomyosin 4
chr17_-_39684585 0.568 NM_002276
KRT19
keratin 19
chr17_-_79479780 0.565 ACTG1
actin, gamma 1
chr22_+_38004676 0.563 GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr20_+_2276612 0.562 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr16_+_56966025 0.557 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr4_+_24797084 0.541 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr18_-_3219986 0.540 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr22_+_38004865 0.535 GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr5_-_124080773 0.515 NM_020747
ZNF608
zinc finger protein 608
chr22_+_38004454 0.512 NM_001001560
NM_001001561
NM_001172687
NM_013365
GGA1



golgi-associated, gamma adaptin ear containing, ARF binding protein 1



chr4_+_81118639 0.511 NM_001099403
PRDM8
PR domain containing 8
chr6_+_144612872 0.511 NM_007124
UTRN
utrophin
chr2_-_216248184 0.497 FN1
fibronectin 1
chr5_+_176875325 0.480 NM_001174102
PRR7
proline rich 7 (synaptic)
chr11_-_85780899 0.467 NM_001206947
PICALM
phosphatidylinositol binding clathrin assembly protein
chr6_-_16761600 0.466 NM_000332
NM_001128164
ATXN1

ataxin 1

chr7_+_143078608 0.456 ZYX
zyxin
chrX_-_153599719 0.447 FLNA
filamin A, alpha
chr14_-_74226634 0.442 C14orf43
chromosome 14 open reading frame 43
chr1_-_168106535 0.437 GPR161
G protein-coupled receptor 161
chr2_-_96811138 0.428 NM_004418
DUSP2
dual specificity phosphatase 2
chr20_-_42815732 0.427 JPH2
junctophilin 2
chr19_+_56153417 0.425 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr19_-_15343767 0.424 NM_001142886
EPHX3
epoxide hydrolase 3
chr7_+_115863004 0.421 NM_152829
TES
testis derived transcript (3 LIM domains)
chr22_-_36784055 0.416 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr3_+_49027281 0.410 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr12_-_57443858 0.410 NM_005379
MYO1A
myosin IA
chr4_-_10118460 0.410 WDR1
WD repeat domain 1
chr1_-_935352 0.405 HES4
hairy and enhancer of split 4 (Drosophila)
chr1_-_168106810 0.401 GPR161
G protein-coupled receptor 161
chr4_-_10118444 0.401 WDR1
WD repeat domain 1
chr5_-_39425297 0.384 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr3_-_185641596 0.374 TRA2B
transformer 2 beta homolog (Drosophila)
chr3_+_187871473 0.372 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_-_131762374 0.371 EBF3
early B-cell factor 3
chr2_-_128432642 0.371 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr14_-_102553344 0.370 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr10_+_123922940 0.350 TACC2
transforming, acidic coiled-coil containing protein 2
chr18_-_47806361 0.341 NM_001204151
MBD1
methyl-CpG binding domain protein 1
chr11_-_30605748 0.341 MPPED2
metallophosphoesterase domain containing 2
chr3_+_25470067 0.322 RARB
retinoic acid receptor, beta
chr15_-_70390226 0.321 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr5_+_6746100 0.320 NM_001171806
PAPD7
PAP associated domain containing 7
chr18_+_29598444 0.317 NM_017831
RNF125
ring finger protein 125
chr6_+_158402887 0.315 NM_003898
SYNJ2
synaptojanin 2
chr12_+_6881669 0.310 NM_002286
LAG3
lymphocyte-activation gene 3
chr4_-_185747051 0.306 ACSL1
acyl-CoA synthetase long-chain family member 1
chr16_-_67977956 0.296 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr1_+_154975041 0.294 NM_001252405
NM_015872
ZBTB7B

zinc finger and BTB domain containing 7B

chr11_+_63580922 0.282 NM_138471
C11orf84
chromosome 11 open reading frame 84
chr4_-_88450243 0.270 SPARCL1
SPARC-like 1 (hevin)
chr14_-_94442894 0.266 ASB2
ankyrin repeat and SOCS box containing 2
chr19_-_12792698 0.266 NM_001930
NM_013406
DHPS

deoxyhypusine synthase

chr16_+_22103861 0.265 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr19_+_47813074 0.265 NM_001736
C5AR1
complement component 5a receptor 1
chr6_-_88411984 0.259 NM_018064
AKIRIN2
akirin 2
chr1_-_150552077 0.242 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr17_-_41132019 0.242 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr4_+_15376174 0.240 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr9_-_134585107 0.233 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr12_+_62654120 0.214 NM_001252078
NM_001252079
NM_006313
USP15


ubiquitin specific peptidase 15


chrX_+_70521627 0.213 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr6_+_158402916 0.208 SYNJ2
synaptojanin 2
chr4_-_88450601 0.208 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr1_+_11994710 0.207 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr4_+_77227882 0.207 STBD1
starch binding domain 1
chr2_-_151344145 0.203 NM_005168
RND3
Rho family GTPase 3
chr17_+_41003360 0.202


chr1_-_91487769 0.201 NM_032186
NM_201269
ZNF644

zinc finger protein 644

chr1_+_219347123 0.198 NM_138794
LYPLAL1
lysophospholipase-like 1
chr19_-_12792676 0.198 DHPS
deoxyhypusine synthase
chr17_-_1389013 0.196 NM_001080950
MYO1C
myosin IC
chr18_+_3247527 0.195 NM_006471
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr17_-_74099855 0.194 NM_001013839
NM_001145297
NM_001145298
NM_001145299
NM_015219
EXOC7




exocyst complex component 7




chr19_+_1026271 0.193 NM_004368
NM_201277
CNN2

calponin 2

chr3_-_9834357 0.192 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr2_-_208031570 0.192 KLF7
Kruppel-like factor 7 (ubiquitous)
chr11_-_57282315 0.183 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr5_-_142000899 0.183 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr4_-_10118500 0.181 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr17_-_73505914 0.179 NM_001142643
CASKIN2
CASK interacting protein 2
chr7_-_107204705 0.176 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr20_-_656443 0.176


chr15_-_59665069 0.174 NM_004998
MYO1E
myosin IE
chr1_+_219347195 0.173 LYPLAL1
lysophospholipase-like 1
chr11_-_123065836 0.173 CLMP
CXADR-like membrane protein
chr17_-_49124128 0.172 NM_001251971
SPAG9
sperm associated antigen 9
chr3_-_9834065 0.170 TADA3
transcriptional adaptor 3
chr7_-_559479 0.166 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr1_+_151512760 0.157 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr11_+_66188474 0.156 NM_178864
NPAS4
neuronal PAS domain protein 4
chr1_-_168106727 0.154 GPR161
G protein-coupled receptor 161
chr10_+_114043413 0.152 NM_058222
TECTB
tectorin beta
chr6_+_158402928 0.152 SYNJ2
synaptojanin 2
chr20_-_33735060 0.151 NM_001145025
NM_018217
EDEM2

ER degradation enhancer, mannosidase alpha-like 2

chr2_-_242212244 0.150 NM_001243900
NM_203346
HDLBP

high density lipoprotein binding protein

chr6_+_44214786 0.150 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr3_-_42642571 0.143 NM_001201572
SEC22C
SEC22 vesicle trafficking protein homolog C (S. cerevisiae)
chr1_-_150552005 0.140 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr13_+_27825689 0.136 NM_000982
RPL21
ribosomal protein L21

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.63 4.43e-04 GO:0010628 positive regulation of gene expression
5.90 1.25e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
5.73 1.64e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
6.46 1.98e-03 GO:0045893 positive regulation of transcription, DNA-dependent
7.49 2.39e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
5.34 3.03e-03 GO:0031328 positive regulation of cellular biosynthetic process
6.02 3.49e-03 GO:0051254 positive regulation of RNA metabolic process
5.25 3.51e-03 GO:0009891 positive regulation of biosynthetic process
5.41 8.25e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
3.93 1.81e-02 GO:0009893 positive regulation of metabolic process
1.89 2.28e-02 GO:0050896 response to stimulus
2.80 3.21e-02 GO:0006950 response to stress
114.90 3.58e-02 GO:0000185 activation of MAPKKK activity
3.89 4.56e-02 GO:0010604 positive regulation of macromolecule metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.86 3.57e-04 GO:0015629 actin cytoskeleton
16.27 6.56e-03 GO:0005925 focal adhesion
3.38 7.61e-03 GO:0005856 cytoskeleton
15.49 7.94e-03 GO:0005924 cell-substrate adherens junction
14.92 9.19e-03 GO:0030055 cell-substrate junction
10.82 3.15e-02 GO:0005912 adherens junction
1.46 3.87e-02 GO:0043229 intracellular organelle
1.46 4.04e-02 GO:0043226 organelle
9.77 4.62e-02 GO:0070161 anchoring junction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.22 4.71e-03 GO:0046983 protein dimerization activity
23.22 1.21e-02 GO:0051015 actin filament binding