Motif ID: ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2

Z-value: 1.923


Transcription factors associated with ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2:

Gene SymbolEntrez IDGene Name
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2
BHLHB2 8553 basic helix-loop-helix domain containing, class B, 2
MAX 4149 MYC associated factor X
MYC 4609 v-myc myelocytomatosis viral oncogene homolog (avian)
USF1 7391 upstream transcription factor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ARNThg19_v1_chr1_-_150849211_150849252-0.962.1e-03Click!
BHLHE40hg19_v1_chr3_+_5021096_5021136-0.891.7e-02Click!
USF1hg19_v1_chr1_-_161015752_1610157830.721.1e-01Click!
MYChg19_v1_chr8_+_128748312_128748338-0.582.3e-01Click!
MAXhg19_v1_chr14_-_65569056_65569208-0.552.6e-01Click!
ARNT2hg19_v1_chr15_+_80696569_80696899-0.256.3e-01Click!


Activity profile for motif ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2.

activity profile for motif ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2


Sorted Z-values histogram for motif ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2

Sorted Z-values for motif ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_49458151 3.814 BAX
BCL2-associated X protein
chr6_-_84937313 3.726 NM_014895
KIAA1009
KIAA1009
chr17_+_46019022 3.588 PNPO
pyridoxamine 5'-phosphate oxidase
chrX_-_100603673 3.114 NM_001145951
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr10_+_104474297 2.876 NM_178858
SFXN2
sideroflexin 2
chr9_-_131709783 2.807 NM_014908
DOLK
dolichol kinase
chr20_+_44520021 2.700 CTSA
cathepsin A
chr12_+_112451229 2.681


chr19_+_49458129 2.606 BAX
BCL2-associated X protein
chr1_-_155210887 2.520 GBA
glucosidase, beta, acid
chr19_+_49458031 2.487 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr1_-_154531083 2.445 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chrX_+_100663213 2.346 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr1_-_155211049 2.307 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr1_+_36689996 2.281 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chrX_+_100663205 2.260 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr1_+_11796211 2.229 AGTRAP
angiotensin II receptor-associated protein
chr20_-_44519629 2.225 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr8_+_75896707 2.212 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr5_+_149340346 2.193 SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr1_+_183605207 2.184 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chrX_+_100663229 2.176 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr17_+_40913233 2.150 RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr20_+_44519924 2.127 CTSA
cathepsin A
chr9_-_107690526 2.117 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr20_+_58515408 2.090 NM_001190827
NM_022106
C20orf177

chromosome 20 open reading frame 177

chr16_+_2570322 2.075 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr13_+_28494136 2.058 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr3_-_57113292 2.021 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr3_+_113465901 2.013 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr9_-_107690435 1.997 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr17_+_46018888 1.956 NM_018129
PNPO
pyridoxamine 5'-phosphate oxidase
chr20_+_44519965 1.928 CTSA
cathepsin A
chr17_+_42977141 1.921 NM_213607
CCDC103
coiled-coil domain containing 103
chr4_-_110650965 1.919 NM_030821
PLA2G12A
phospholipase A2, group XIIA
chr9_-_107690336 1.906 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr1_-_31845818 1.899 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr1_-_115259381 1.859 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr12_+_56862300 1.853 NM_207344
SPRYD4
SPRY domain containing 4
chr3_+_113465860 1.831 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr1_+_26798961 1.825 HMGN2
high mobility group nucleosomal binding domain 2
chr17_+_40913211 1.796 NM_005854
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr21_-_36421630 1.756 RUNX1
runt-related transcription factor 1
chr1_-_26232890 1.752 NM_001145454
NM_005563
STMN1

stathmin 1

chr19_-_40854410 1.734 C19orf47
chromosome 19 open reading frame 47
chr2_+_27309610 1.698 NM_000221
NM_006488
KHK

ketohexokinase (fructokinase)

chr1_+_154193294 1.698 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr5_+_149340437 1.695 SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr3_+_113465910 1.692 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr17_-_54991399 1.686 NM_005082
TRIM25
tripartite motif containing 25
chr15_-_73925658 1.678 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr22_-_36903033 1.646 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr2_-_133427624 1.631 LYPD1
LY6/PLAUR domain containing 1
chr16_-_81129882 1.614 NM_004483
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr19_+_10764987 1.607 ILF3
interleukin enhancer binding factor 3, 90kDa
chr8_+_98656428 1.586 MTDH
metadherin
chr2_+_177016112 1.573 NM_014621
HOXD4
homeobox D4
chr15_-_50978921 1.573 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr1_-_154193044 1.565 C1orf43
chromosome 1 open reading frame 43
chr15_-_73925555 1.562 NPTN
neuroplastin
chr21_-_36421586 1.558 NM_001754
RUNX1
runt-related transcription factor 1
chr21_-_46237978 1.551 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr2_+_178077421 1.550 NM_194247
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3
chr21_-_46237974 1.550 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr1_+_26798901 1.543 NM_005517
HMGN2
high mobility group nucleosomal binding domain 2
chr9_-_104249333 1.539 NM_032342
C9orf125
chromosome 9 open reading frame 125
chr11_+_33037397 1.512 NM_001077242
DEPDC7
DEP domain containing 7
chr2_-_238499317 1.500 RAB17
RAB17, member RAS oncogene family
chr21_-_46237966 1.479 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr5_+_149340287 1.463 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr8_+_98656494 1.458 MTDH
metadherin
chrX_-_100603956 1.430 NM_004085
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr1_+_11796128 1.422 NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350
AGTRAP




angiotensin II receptor-associated protein




chr13_+_113951537 1.417 LAMP1
lysosomal-associated membrane protein 1
chr21_-_36421578 1.412 RUNX1
runt-related transcription factor 1
chr6_+_151773421 1.408 NM_024573
C6orf211
chromosome 6 open reading frame 211
chr3_-_68981674 1.392 NM_001005527
NM_182522
FAM19A4

family with sequence similarity 19 (chemokine (C-C motif)-like), member A4

chr19_-_40854283 1.381 NM_178830
C19orf47
chromosome 19 open reading frame 47
chr10_-_21814610 1.376 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr9_-_140009167 1.373 DPP7
dipeptidyl-peptidase 7
chr19_+_10764896 1.345 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr13_-_28543143 1.341 CDX2
caudal type homeobox 2
chr13_-_51417831 1.326 NM_198989
DLEU7
deleted in lymphocytic leukemia, 7
chr8_+_120220554 1.325 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr22_-_36903086 1.319 NM_024955
NM_001102371
FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr2_+_27805892 1.311 NM_032434
ZNF512
zinc finger protein 512
chr17_+_7211260 1.306 NM_001143761
EIF5A
eukaryotic translation initiation factor 5A
chr19_+_10765106 1.305 ILF3
interleukin enhancer binding factor 3, 90kDa
chr16_-_5083933 1.298 NM_016256
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr3_+_158519911 1.293 MFSD1
major facilitator superfamily domain containing 1
chr17_+_7211693 1.291 NM_001143762
EIF5A
eukaryotic translation initiation factor 5A
chr16_+_5083671 1.287 LOC100507589
uncharacterized LOC100507589
chr1_+_182758871 1.278 NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr11_+_61560108 1.265 NM_004111
FEN1
flap structure-specific endonuclease 1
chr13_+_42846255 1.259 NM_016248
AKAP11
A kinase (PRKA) anchor protein 11
chr11_-_71814335 1.259 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr16_-_4897265 1.254 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chrX_+_100663120 1.244 NM_001032393
NM_019597
HNRNPH2

heterogeneous nuclear ribonucleoprotein H2 (H')

chr12_-_49318663 1.235 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr6_+_151773605 1.224 C6orf211
chromosome 6 open reading frame 211
chr6_-_109804432 1.220 NM_001164313
NM_014797
ZBTB24

zinc finger and BTB domain containing 24

chr20_+_44520203 1.217 CTSA
cathepsin A
chr7_+_150102376 1.215


chr4_-_103266577 1.215 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr13_+_49684388 1.208 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr1_-_154193073 1.208 NM_001098616
NM_015449
NM_138740
C1orf43


chromosome 1 open reading frame 43


chr6_-_109703661 1.195 CD164
CD164 molecule, sialomucin
chr12_+_56109851 1.194 BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr11_-_18343670 1.194 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr6_-_44225024 1.190 NM_178148
SLC35B2
solute carrier family 35, member B2
chr16_-_74401991 1.189 LOC283922
pyruvate dehydrogenase phosphatase regulatory subunit pseudogene
chr5_-_133706717 1.178 CDKL3
cyclin-dependent kinase-like 3
chr16_-_5083913 1.177 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chrX_+_149737019 1.165 NM_000252
MTM1
myotubularin 1
chr3_+_158519888 1.164 MFSD1
major facilitator superfamily domain containing 1
chr6_+_36562135 1.157 SRSF3
serine/arginine-rich splicing factor 3
chr17_-_7197811 1.156 YBX2
Y box binding protein 2
chr12_-_58146108 1.150 CDK4
cyclin-dependent kinase 4
chr17_-_7197896 1.148 YBX2
Y box binding protein 2
chrX_-_102510048 1.147 NM_001006684
NM_153333
TCEAL8

transcription elongation factor A (SII)-like 8

chr3_+_127317274 1.146 MCM2
minichromosome maintenance complex component 2
chr1_-_113498615 1.138 NM_001166496
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr1_-_26232643 1.131 NM_203401
STMN1
stathmin 1
chr12_+_113623364 1.129 NM_032848
C12orf52
chromosome 12 open reading frame 52
chr5_+_6633531 1.121 SRD5A1
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
chr8_+_38034066 1.119 NM_001204878
NM_004874
BAG4

BCL2-associated athanogene 4

chr5_-_180288275 1.118 NM_001172638
NM_152283
ZFP62

zinc finger protein 62 homolog (mouse)

chr1_+_11796177 1.116 AGTRAP
angiotensin II receptor-associated protein
chr20_-_58515258 1.116 NM_006242
PPP1R3D
protein phosphatase 1, regulatory subunit 3D
chr5_+_41904459 1.115 NM_175921
C5orf51
chromosome 5 open reading frame 51
chr15_+_45315301 1.112 NM_003104
SORD
sorbitol dehydrogenase
chr6_-_109703703 1.111 NM_001142401
NM_001142402
NM_001142403
NM_001142404
NM_006016
CD164




CD164 molecule, sialomucin




chr1_-_113498828 1.110 NM_003051
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr16_-_74401792 1.105


chrX_+_152224862 1.104 PNMA3
paraneoplastic antigen MA3
chr11_-_71814294 1.100 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr4_-_100871431 1.099 H2AFZ
H2A histone family, member Z
chr3_+_127317271 1.096 MCM2
minichromosome maintenance complex component 2
chr19_+_45909466 1.093 NM_012099
CD3EAP
CD3e molecule, epsilon associated protein
chr12_+_56109832 1.092 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 readthrough
biogenesis of lysosomal organelles complex-1, subunit 1
chr12_-_65153182 1.090 GNS
glucosamine (N-acetyl)-6-sulfatase
chr6_+_36562089 1.087 NM_003017
SRSF3
serine/arginine-rich splicing factor 3
chr8_+_98788014 1.084 LAPTM4B
lysosomal protein transmembrane 4 beta
chr19_+_33793743 1.080 LOC80054
uncharacterized LOC80054
chr17_+_49244082 1.080 NM_001018138
NME2
non-metastatic cells 2, protein (NM23B) expressed in
chr17_+_48450579 1.079 NM_001166131
NM_152463
EME1

essential meiotic endonuclease 1 homolog 1 (S. pombe)

chr10_+_25305507 1.078 NM_024838
THNSL1
threonine synthase-like 1 (S. cerevisiae)
chr20_+_18118473 1.069 NM_001164811
PET117
cytochrome c oxidase assembly factor-like
chr17_+_79885567 1.068 LOC92659
uncharacterized LOC92659
chr9_-_37904098 1.066 MCART1
mitochondrial carrier triple repeat 1
chr11_-_71814371 1.066 NM_017907
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr3_+_184032319 1.060 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr12_+_6833425 1.060 NM_001164093
COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chrX_+_149737083 1.055 MTM1
myotubularin 1
chr17_+_48172508 1.055 NM_001199900
NM_002611
NM_001199899
PDK2


pyruvate dehydrogenase kinase, isozyme 2


chr11_-_71814268 1.055 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr5_-_111312522 1.051 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr14_+_77564570 1.047 NM_033426
KIAA1737
KIAA1737
chr2_+_26987122 1.046 NM_017877
CENPA
C2orf18
centromere protein A
chromosome 2 open reading frame 18
chr2_-_193059599 1.042 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr21_-_36421195 1.039 RUNX1
runt-related transcription factor 1
chr10_-_72141347 1.035 NM_207119
LRRC20
leucine rich repeat containing 20
chr14_+_20923341 1.032 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr1_-_166845533 1.028 NM_053053
TADA1
transcriptional adaptor 1
chr12_-_65153148 1.026 GNS
glucosamine (N-acetyl)-6-sulfatase
chr7_-_99774821 1.026 NM_152742
GPC2
glypican 2
chr22_+_35777087 1.011 HMOX1
heme oxygenase (decycling) 1
chr10_-_46090191 1.003 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr1_-_23670743 0.999 NM_001102397
NM_001102398
NM_001102399
NM_005826
HNRNPR



heterogeneous nuclear ribonucleoprotein R



chr1_-_204329043 0.999 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr15_-_50978960 0.994 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr11_+_61560401 0.989 FEN1
flap structure-specific endonuclease 1
chr12_+_112451261 0.988 ERP29
endoplasmic reticulum protein 29
chr1_+_15853307 0.988 DNAJC16
DnaJ (Hsp40) homolog, subfamily C, member 16
chr1_+_15853348 0.986 NM_015291
DNAJC16
DnaJ (Hsp40) homolog, subfamily C, member 16
chr11_+_61560352 0.982 FEN1
flap structure-specific endonuclease 1
chr2_+_85766100 0.980 NM_005911
MAT2A
methionine adenosyltransferase II, alpha
chrX_-_100662788 0.977 GLA
galactosidase, alpha
chr3_+_127317212 0.973 NM_004526
MCM2
minichromosome maintenance complex component 2
chr11_+_121322848 0.972 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr2_+_173292344 0.972 ITGA6
integrin, alpha 6
chr12_+_51632589 0.972 DAZAP2
DAZ associated protein 2
chr12_+_51632620 0.971 DAZAP2
DAZ associated protein 2
chr8_+_38034357 0.968 BAG4
BCL2-associated athanogene 4
chr21_-_46238040 0.959 NM_006936
SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr12_-_58146110 0.958 CDK4
cyclin-dependent kinase 4
chr4_-_25032306 0.955 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chrX_+_150565693 0.954 VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr12_+_6833149 0.953 NM_001164094
NM_016319
NM_001164095
COPS7A


COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)


chr20_-_39766522 0.950


chr4_-_100871418 0.941 H2AFZ
H2A histone family, member Z
chrX_-_100662905 0.931 NM_000169
GLA
galactosidase, alpha
chr6_-_7313352 0.931 NM_003144
SSR1
signal sequence receptor, alpha
chr21_-_40720842 0.928 HMGN1
high mobility group nucleosome binding domain 1
chr15_-_50978726 0.927 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr12_-_63328857 0.925 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr1_-_154600446 0.924 NM_001025107
ADAR
adenosine deaminase, RNA-specific
chr10_+_51827710 0.924 FAM21A
family with sequence similarity 21, member A
chr6_-_109703553 0.914 CD164
CD164 molecule, sialomucin
chr12_-_110434187 0.913 NM_001135213
NM_001135214
NM_014776
NM_057169
NM_057170
NM_139201
GIT2





G protein-coupled receptor kinase interacting ArfGAP 2






Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
24.07 1.04e-02 GO:0007040 lysosome organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.85 6.52e-05 GO:0000323 lytic vacuole
6.85 6.52e-05 GO:0005764 lysosome
5.81 3.28e-04 GO:0005773 vacuole
9.98 7.09e-04 GO:0005765 lysosomal membrane
7.64 4.06e-03 GO:0005774 vacuolar membrane
7.30 5.44e-03 GO:0044437 vacuolar part
1.55 1.19e-02 GO:0044444 cytoplasmic part

Nothing significant found in function category.