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• Activity deltas table
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Motif ID: ATF4.p2

Z-value: 1.675

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_+_128806720	2.701		PVT1	Pvt1 oncogene (non-protein coding)
chr2_+_220408742	2.343	NM_001005209	TMEM198	transmembrane protein 198
chr22_+_38597938	2.092	NM_001161572 NM_001161574 NM_012323	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr6_+_139456240	2.083	NM_016217	HECA	headcase homolog (Drosophila)
chr22_+_38598065	1.852		MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr1_+_212782103	1.751		ATF3	activating transcription factor 3
chr6_-_91006580	1.691	NM_001170794	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr11_-_1593149	1.682	NM_004420	DUSP8	dual specificity phosphatase 8
chr12_-_123380628	1.671		VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr6_+_89791510	1.668		PNRC1	proline-rich nuclear receptor coactivator 1
chr6_-_91006460	1.564	NM_021813	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr4_-_120375770	1.561
chr8_-_95274540	1.560	NM_005261 NM_181702	GEM	GTP binding protein overexpressed in skeletal muscle
chr12_-_123380682	1.557	NM_024667	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr1_+_212781969	1.436	NM_001040619 NM_001206484 NM_001206488 NM_001674	ATF3	activating transcription factor 3
chr19_+_49375677	1.416		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr19_+_49375638	1.412	NM_014330	PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr19_+_45971249	1.386	NM_001114171 NM_006732	FOSB	FBJ murine osteosarcoma viral oncogene homolog B
chr8_-_95274520	1.383		GEM	GTP binding protein overexpressed in skeletal muscle
chr19_+_49375679	1.368		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr9_-_110251754	1.290		KLF4	Kruppel-like factor 4 (gut)
chr7_+_28448970	1.271		LOC401317	uncharacterized LOC401317
chr5_-_172198160	1.239	NM_004417	DUSP1	dual specificity phosphatase 1
chr19_-_42721802	1.173	NM_133328	DEDD2	death effector domain containing 2
chr19_-_47734215	1.084	NM_014417	BBC3	BCL2 binding component 3
chr9_-_110252045	1.082	NM_004235	KLF4	Kruppel-like factor 4 (gut)
chr3_+_194207685	1.050		FLJ34208	uncharacterized LOC401106
chr10_+_134210691	1.044	NM_001098637 NM_138499	PWWP2B	PWWP domain containing 2B
chr19_+_45504686	0.996	NM_006509	RELB	v-rel reticuloendotheliosis viral oncogene homolog B
chr12_-_123380608	0.970
chr9_-_99382073	0.961	NM_003671 NM_033331	CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr7_-_45128492	0.943	NM_001146334	NACAD	NAC alpha domain containing
chr4_-_111558150	0.863		PITX2	paired-like homeodomain 2
chr2_+_220408352	0.863		TMEM198	transmembrane protein 198
chr2_-_201729351	0.850		CLK1	CDC-like kinase 1
chr3_-_156877882	0.846		CCNL1	cyclin L1
chr19_-_460995	0.841	NM_012435	SHC2	SHC (Src homology 2 domain containing) transforming protein 2
chr2_+_96676277	0.840
chr2_+_28615771	0.838	NM_005253	FOSL2	FOS-like antigen 2
chr20_-_62258422	0.836		GMEB2	glucocorticoid modulatory element binding protein 2
chr6_-_31939658	0.825		DOM3Z	dom-3 homolog Z (C. elegans)
chr11_-_77184549	0.810	NM_001128620 NM_002576	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1
chr6_+_135818938	0.808		LINC00271	long intergenic non-protein coding RNA 271
chr2_-_201729241	0.802	NM_001162407	CLK1	CDC-like kinase 1
chr4_+_75480628	0.785	NM_001657	AREG	amphiregulin
chr2_+_28615695	0.777		FOSL2	FOS-like antigen 2
chr3_-_8543327	0.776		LOC100288428	uncharacterized LOC100288428
chr2_+_43864405	0.775		PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr19_+_13263890	0.751		IER2	immediate early response 2
chr3_+_141087298	0.746		ZBTB38	zinc finger and BTB domain containing 38
chr16_-_28414940	0.730		EIF3C	eukaryotic translation initiation factor 3, subunit C
chr9_+_102584136	0.722	NM_006981 NM_173199 NM_173200	NR4A3	nuclear receptor subfamily 4, group A, member 3
chr8_-_11324184	0.716	NM_053279	FAM167A	family with sequence similarity 167, member A
chr20_-_62258330	0.708	NM_012384	GMEB2	glucocorticoid modulatory element binding protein 2
chr17_-_8151353	0.705		CTC1	CTS telomere maintenance complex component 1
chr17_-_8151373	0.701	NM_025099	CTC1	CTS telomere maintenance complex component 1
chr1_-_16482426	0.698	NM_004431	EPHA2	EPH receptor A2
chr2_+_43864433	0.692	NM_172069	PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr11_+_64692052	0.686	NM_006244	PPP2R5B	protein phosphatase 2, regulatory subunit B', beta
chr11_+_102217947	0.686	NM_001166	BIRC2	baculoviral IAP repeat containing 2
chr1_+_149824180	0.685	NM_021059 NM_001005464	HIST2H3C HIST2H3A	histone cluster 2, H3c histone cluster 2, H3a
chr2_+_149632772	0.685	NM_004522	KIF5C	kinesin family member 5C
chr2_+_28615668	0.677		FOSL2	FOS-like antigen 2
chr10_+_38645293	0.671		HSD17B7P2	hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
chr11_+_62649160	0.670		SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr11_-_66610703	0.663
chr5_+_60628085	0.649	NM_020928	ZSWIM6	zinc finger, SWIM-type containing 6
chr2_-_201729377	0.641	NM_004071	CLK1	CDC-like kinase 1
chr15_+_76629101	0.641	NM_145805	ISL2	ISL LIM homeobox 2
chr4_-_104640828	0.638	NM_001059	TACR3	tachykinin receptor 3
chr2_-_202645573	0.634
chr9_-_70490067	0.608
chr22_+_18121540	0.608		BCL2L13	BCL2-like 13 (apoptosis facilitator)
chr19_-_7553867	0.606	NM_080662	PEX11G	peroxisomal biogenesis factor 11 gamma
chr19_+_35491225	0.602	NM_001136199 NM_020895	GRAMD1A	GRAM domain containing 1A
chr5_+_78532338	0.601
chr19_-_38878663	0.599	NM_152657	GGN	gametogenetin
chr1_+_45266035	0.578	NM_004073	PLK3	polo-like kinase 3
chr2_+_220144024	0.558	NM_001039550 NM_006736	DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2
chr2_+_149632836	0.552		KIF5C	kinesin family member 5C
chr19_-_4517715	0.548	NM_001080400	PLIN4	perilipin 4
chr2_+_74757243	0.532		HTRA2	HtrA serine peptidase 2
chr19_-_3971032	0.530		DAPK3	death-associated protein kinase 3
chr19_+_35491329	0.530		GRAMD1A	GRAM domain containing 1A
chr3_+_50297644	0.523
chr9_-_131644176	0.523	NM_001122671 NM_001122672 NM_004059	CCBL1	cysteine conjugate-beta lyase, cytoplasmic
chr5_-_16509106	0.520	NM_019000	FAM134B	family with sequence similarity 134, member B
chr20_+_361675	0.518		TRIB3	tribbles homolog 3 (Drosophila)
chr7_-_36406446	0.518	NM_001199707 NM_001199706 NM_015314 NM_001199708	KIAA0895	KIAA0895
chr6_-_121655606	0.514	NM_152730	C6orf170	chromosome 6 open reading frame 170
chr2_+_149633173	0.512
chr15_-_64126112	0.508		HERC1	hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr19_-_59066372	0.501		CHMP2A	charged multivesicular body protein 2A
chr14_+_105219516	0.499		SIVA1	SIVA1, apoptosis-inducing factor
chrX_-_102565805	0.498	NM_001168399 NM_001168400 NM_001168401 NM_032621	BEX2	brain expressed X-linked 2
chr2_+_10184371	0.494	NM_001177718	KLF11	Kruppel-like factor 11
chr1_+_45265896	0.482		PLK3	polo-like kinase 3
chr9_-_72873739	0.478		LOC100507299	uncharacterized LOC100507299
chr2_+_113403433	0.476	NM_005415	SLC20A1	solute carrier family 20 (phosphate transporter), member 1
chr1_+_70671375	0.473		SRSF11	serine/arginine-rich splicing factor 11
chr6_-_135818786	0.473		AHI1	Abelson helper integration site 1
chr17_+_25621105	0.471	NM_015626 NM_134265	WSB1	WD repeat and SOCS box containing 1
chr9_-_131038196	0.470	NM_004486	GOLGA2	golgin A2
chr12_-_125399146	0.470		UBC	ubiquitin C
chr9_-_3525973	0.468	NM_002919 NM_134428	RFX3	regulatory factor X, 3 (influences HLA class II expression)
chr17_-_62833246	0.468		PLEKHM1P	pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chr3_+_187871473	0.465	NM_001167672	LPP	LIM domain containing preferred translocation partner in lipoma
chr11_-_6633178	0.464		TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr1_+_45266048	0.460		PLK3	polo-like kinase 3
chr5_+_139927182	0.459	NM_003732	EIF4EBP3	eukaryotic translation initiation factor 4E binding protein 3
chr15_-_48470319	0.455		MYEF2	myelin expression factor 2
chr10_+_121411071	0.455		BAG3	BCL2-associated athanogene 3
chr8_-_101322180	0.451		RNF19A	ring finger protein 19A
chr17_-_62833264	0.451		PLEKHM1P	pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chr8_-_145025043	0.451	NM_201380	PLEC	plectin
chr15_+_32933869	0.446	NM_001144757 NM_003020	SCG5	secretogranin V (7B2 protein)
chr1_+_87794150	0.445	NM_006769	LMO4	LIM domain only 4
chr3_+_150126705	0.445	NM_014779	TSC22D2	TSC22 domain family, member 2
chr17_-_36831156	0.442	NM_001130677	C17orf96	chromosome 17 open reading frame 96
chr13_-_33002218	0.440	NM_001079691 NM_052818	N4BP2L1	NEDD4 binding protein 2-like 1
chr3_+_140660639	0.440	NM_001104647 NM_018155	SLC25A36	solute carrier family 25, member 36
chr5_-_178054072	0.440		CLK4	CDC-like kinase 4
chr22_-_20427814	0.439		PI4KAP1	phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr20_-_3388586	0.437		C20orf194	chromosome 20 open reading frame 194
chr14_-_102976096	0.437	NM_152326	ANKRD9	ankyrin repeat domain 9
chr1_+_6640094	0.433		ZBTB48	zinc finger and BTB domain containing 48
chr2_-_216300770	0.432	NM_002026 NM_054034 NM_212474 NM_212476 NM_212478 NM_212482	FN1	fibronectin 1
chr8_-_144623579	0.430		ZC3H3	zinc finger CCCH-type containing 3
chr16_+_1756161	0.426	NM_001040439 NM_015133	MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3
chr2_-_73340058	0.425		RAB11FIP5	RAB11 family interacting protein 5 (class I)
chr3_+_184053682	0.421	NM_001171093	FAM131A	family with sequence similarity 131, member A
chr15_+_74908195	0.421		CLK3	CDC-like kinase 3
chr1_+_201476283	0.418
chr2_-_86850935	0.416		RNF103	ring finger protein 103
chr17_-_7166263	0.415	NM_001185023 NM_001307	CLDN7	claudin 7
chr10_+_121411086	0.408		BAG3	BCL2-associated athanogene 3
chr1_+_6640047	0.407	NM_005341	ZBTB48	zinc finger and BTB domain containing 48
chr3_-_99594915	0.406	NM_014890	FILIP1L	filamin A interacting protein 1-like
chrX_+_48398162	0.405		TBC1D25	TBC1 domain family, member 25
chr5_-_178054089	0.404		CLK4	CDC-like kinase 4
chr22_+_18121446	0.401	NM_015367	BCL2L13	BCL2-like 13 (apoptosis facilitator)
chr16_+_2022039	0.397		TBL3	transducin (beta)-like 3
chr19_-_55628780	0.397	NM_017607	PPP1R12C	protein phosphatase 1, regulatory subunit 12C
chr12_-_49504612	0.397		LMBR1L	limb region 1 homolog (mouse)-like
chr14_-_103523619	0.395	NM_006035	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)
chr9_+_34179036	0.394		UBAP1	ubiquitin associated protein 1
chr2_-_68694389	0.391	NM_001024680	FBXO48	F-box protein 48
chr5_+_108084638	0.390		FER	fer (fps/fes related) tyrosine kinase
chr10_+_121411042	0.390		BAG3	BCL2-associated athanogene 3
chr4_-_186347037	0.390	NM_018359	UFSP2	UFM1-specific peptidase 2
chr2_-_220408264	0.390	NM_024536	CHPF	chondroitin polymerizing factor
chr11_-_3818971	0.389	NM_005387 NM_016320 NM_139131 NM_139132	NUP98	nucleoporin 98kDa
chr6_+_37225506	0.389	NM_017772	TBC1D22B	TBC1 domain family, member 22B
chr11_-_6440631	0.388	NM_145689	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr3_-_119182423	0.387	NM_018266	TMEM39A	transmembrane protein 39A
chr19_+_39897457	0.386	NM_003407	ZFP36	zinc finger protein 36, C3H type, homolog (mouse)
chr19_-_5720155	0.383		LONP1	lon peptidase 1, mitochondrial
chr12_+_22778008	0.383	NM_001039481 NM_018638	ETNK1	ethanolamine kinase 1
chr2_-_86850959	0.383	NM_001198951 NM_001198952 NM_005667	RNF103	ring finger protein 103
chr7_+_1580009	0.381		MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr10_+_99496891	0.380		ZFYVE27	zinc finger, FYVE domain containing 27
chr5_-_16617085	0.377	NM_001034850	FAM134B	family with sequence similarity 134, member B
chr7_+_157129659	0.376	NM_005494 NM_058246	DNAJB6 TMEM135	DnaJ (Hsp40) homolog, subfamily B, member 6 transmembrane protein 135
chr2_+_192542860	0.376	NM_001031716	OBFC2A	oligonucleotide/oligosaccharide-binding fold containing 2A
chr6_-_90529426	0.376	NM_014611	MDN1	MDN1, midasin homolog (yeast)
chr19_+_18668652	0.374		KXD1	KxDL motif containing 1
chr2_+_33172368	0.374	NM_206943	LTBP1	latent transforming growth factor beta binding protein 1
chr6_-_37225894	0.372	NM_001162900	TMEM217	transmembrane protein 217
chr6_+_32939974	0.370		BRD2	bromodomain containing 2
chr14_-_103523511	0.369
chr17_+_27071008	0.369	NM_004295	TRAF4	TNF receptor-associated factor 4
chr18_+_76829391	0.369	NM_198531	ATP9B	ATPase, class II, type 9B
chr16_+_56966025	0.368		HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_-_3971089	0.368		DAPK3	death-associated protein kinase 3
chr11_-_809465	0.367		PIDD	p53-induced death domain protein
chr7_+_17338182	0.366	NM_001621	AHR	aryl hydrocarbon receptor
chr17_+_25621141	0.366		WSB1	WD repeat and SOCS box containing 1
chr5_+_78531848	0.364	NM_152405	JMY	junction mediating and regulatory protein, p53 cofactor
chr13_+_45915479	0.363		LOC100190939	uncharacterized LOC100190939
chr9_+_34179047	0.363		UBAP1	ubiquitin associated protein 1
chr14_+_103995535	0.360		TRMT61A	tRNA methyltransferase 61 homolog A (S. cerevisiae)
chr5_-_178054001	0.357	NM_020666	CLK4	CDC-like kinase 4
chr11_+_9482511	0.357	NM_003442	ZNF143	zinc finger protein 143
chr11_+_108535773	0.355	NM_004398	DDX10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr14_+_76452053	0.354	NM_001102564 NM_052873	IFT43	intraflagellar transport 43 homolog (Chlamydomonas)
chr19_-_5720136	0.352		LONP1	lon peptidase 1, mitochondrial
chr10_-_18940515	0.351	NM_182543	NSUN6	NOP2/Sun domain family, member 6
chr17_+_7835441	0.351	NM_001037144 NM_053051	CNTROB	centrobin, centrosomal BRCA2 interacting protein
chr4_-_926081	0.351		GAK	cyclin G associated kinase
chr17_-_62833225	0.351		PLEKHM1P	pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chrX_+_153672449	0.350	NM_004699	FAM50A	family with sequence similarity 50, member A
chr7_-_158622202	0.350	NM_020728	ESYT2	extended synaptotagmin-like protein 2
chr9_+_70856838	0.350	NM_201453	CBWD5 CBWD3 CBWD6	COBW domain containing 5 COBW domain containing 3 COBW domain containing 6
chr9_-_130477918	0.349	NM_001002913	PTRH1	peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr3_-_197476567	0.347	NM_001145642	KIAA0226	KIAA0226
chr4_+_119512890	0.347		LOC729218	uncharacterized LOC729218
chr17_-_8059637	0.346		PER1	period homolog 1 (Drosophila)
chr3_-_126076057	0.346	NM_014079	KLF15	Kruppel-like factor 15
chr2_-_74756817	0.345		AUP1	ancient ubiquitous protein 1
chr9_+_34179023	0.345		UBAP1	ubiquitin associated protein 1

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
162.44	1.56e-03	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
150.84	1.82e-03	GO:0033549	MAP kinase phosphatase activity
8.27	4.80e-03	GO:0043565	sequence-specific DNA binding
50.32	1.70e-02	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
5.74	2.62e-02	GO:0001071	nucleic acid binding transcription factor activity
5.74	2.62e-02	GO:0003700	sequence-specific DNA binding transcription factor activity