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Motif ID: ATF5_CREB3.p2

Z-value: 2.285

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr19_+_45971249	9.054	NM_001114171 NM_006732	FOSB	FBJ murine osteosarcoma viral oncogene homolog B
chr12_+_52445185	7.257	NM_002135 NM_173157	NR4A1	nuclear receptor subfamily 4, group A, member 1
chr14_+_75745480	7.082	NM_005252	FOS	FBJ murine osteosarcoma viral oncogene homolog
chr19_+_49375677	5.772		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr19_+_49375679	5.761		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr11_-_1593149	5.719	NM_004420	DUSP8	dual specificity phosphatase 8
chr19_+_49375638	5.589	NM_014330	PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr9_+_102584136	5.160	NM_006981 NM_173199 NM_173200	NR4A3	nuclear receptor subfamily 4, group A, member 3
chr4_+_75480628	4.515	NM_001657	AREG	amphiregulin
chr5_-_172198160	4.419	NM_004417	DUSP1	dual specificity phosphatase 1
chr8_-_95274540	4.409	NM_005261 NM_181702	GEM	GTP binding protein overexpressed in skeletal muscle
chr6_-_91006580	4.344	NM_001170794	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr2_+_28615695	4.316		FOSL2	FOS-like antigen 2
chr2_+_28615771	4.187	NM_005253	FOSL2	FOS-like antigen 2
chr22_+_38597938	4.177	NM_001161572 NM_001161574 NM_012323	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr6_-_91006460	4.165	NM_021813	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr6_+_89791510	4.097		PNRC1	proline-rich nuclear receptor coactivator 1
chr7_+_28448970	4.038		LOC401317	uncharacterized LOC401317
chr8_+_128806720	3.997		PVT1	Pvt1 oncogene (non-protein coding)
chr8_-_95274520	3.743		GEM	GTP binding protein overexpressed in skeletal muscle
chr5_+_137801178	3.679	NM_001964	EGR1	early growth response 1
chr22_+_38598065	3.562		MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr2_+_28615668	3.388		FOSL2	FOS-like antigen 2
chr12_-_123380608	3.376
chr1_+_212781969	3.343	NM_001040619 NM_001206484 NM_001206488 NM_001674	ATF3	activating transcription factor 3
chr10_+_104154228	3.332	NM_001077493 NM_001077494	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr1_+_212782103	3.268		ATF3	activating transcription factor 3
chr7_-_100808832	3.131	NM_003378	VGF	VGF nerve growth factor inducible
chr12_-_123380682	2.834	NM_024667	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr21_-_43430448	2.734	NM_001098402 NM_001098403 NM_020727	ZNF295	zinc finger protein 295
chr12_-_123380628	2.695		VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr4_-_89618928	2.694	NM_153757	NAP1L5	nucleosome assembly protein 1-like 5
chr5_+_137801166	2.585		EGR1	early growth response 1
chr11_-_65667809	2.509		FOSL1	FOS-like antigen 1
chr3_-_8543327	2.494		LOC100288428	uncharacterized LOC100288428
chr16_-_66959418	2.402	NM_001128850 NM_004165	RRAD	Ras-related associated with diabetes
chr2_+_220408352	2.365		TMEM198	transmembrane protein 198
chr14_-_23388294	2.329		RBM23	RNA binding motif protein 23
chr19_-_18392048	2.301		JUND	jun D proto-oncogene
chr14_-_23388380	2.286	NM_001077351 NM_001077352 NM_018107	RBM23	RNA binding motif protein 23
chr1_+_86046434	2.282	NM_001554	CYR61	cysteine-rich, angiogenic inducer, 61
chr7_+_1577118	2.235		MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr19_-_18392413	2.220	NM_005354	JUND	jun D proto-oncogene
chr2_+_220408742	2.216	NM_001005209	TMEM198	transmembrane protein 198
chr19_+_45504686	2.152	NM_006509	RELB	v-rel reticuloendotheliosis viral oncogene homolog B
chr20_-_44600939	2.143		ZNF335	zinc finger protein 335
chr1_+_37940074	2.110	NM_025079	ZC3H12A	zinc finger CCCH-type containing 12A
chr3_-_42814734	2.106	NM_144719	CCDC13	coiled-coil domain containing 13
chr2_-_145277568	2.095		ZEB2	zinc finger E-box binding homeobox 2
chr10_-_31320772	2.083	NM_001143766 NM_001143767 NM_001143768 NM_001143770 NM_001143771 NM_182755	ZNF438	zinc finger protein 438
chr19_+_35491225	1.982	NM_001136199 NM_020895	GRAMD1A	GRAM domain containing 1A
chr15_+_93447702	1.947		CHD2	chromodomain helicase DNA binding protein 2
chr11_+_111749947	1.941	NM_022761	C11orf1	chromosome 11 open reading frame 1
chr17_-_40828078	1.893		PLEKHH3	pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr13_-_21635629	1.889		LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)
chr19_-_18392436	1.886		JUND	jun D proto-oncogene
chr5_-_57755787	1.885	NM_001252226 NM_006622	PLK2	polo-like kinase 2
chr11_-_65667860	1.865	NM_005438	FOSL1	FOS-like antigen 1
chr2_-_172967627	1.843		DLX2	distal-less homeobox 2
chr13_-_21635703	1.826	NM_014572	LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)
chr3_+_50297644	1.819
chr19_+_12902295	1.805	NM_002229	JUNB	jun B proto-oncogene
chr10_+_104155431	1.781	NM_002502	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr19_-_47734215	1.776	NM_014417	BBC3	BCL2 binding component 3
chr2_-_145277879	1.774	NM_001171653 NM_014795	ZEB2	zinc finger E-box binding homeobox 2
chr11_+_73087396	1.756	NM_152222	RELT	RELT tumor necrosis factor receptor
chr3_-_53925871	1.734	NM_021237	SELK	selenoprotein K
chr1_-_16482426	1.722	NM_004431	EPHA2	EPH receptor A2
chr6_+_139456240	1.709	NM_016217	HECA	headcase homolog (Drosophila)
chr20_-_44600787	1.706	NM_022095	ZNF335	zinc finger protein 335
chr11_-_67141008	1.701	NM_013246	CLCF1	cardiotrophin-like cytokine factor 1
chr1_-_19536741	1.698	NM_020765	UBR4	ubiquitin protein ligase E3 component n-recognin 4
chr12_-_132628841	1.697	NM_175066	DDX51	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr10_+_134210691	1.695	NM_001098637 NM_138499	PWWP2B	PWWP domain containing 2B
chr6_+_135818938	1.689		LINC00271	long intergenic non-protein coding RNA 271
chr1_-_59249687	1.688	NM_002228	JUN	jun proto-oncogene
chr20_-_62258422	1.685		GMEB2	glucocorticoid modulatory element binding protein 2
chr8_-_144623579	1.680		ZC3H3	zinc finger CCCH-type containing 3
chr5_-_64777703	1.666	NM_197941	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr5_-_37839781	1.663	NM_000514	GDNF	glial cell derived neurotrophic factor
chr7_+_1580009	1.663		MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr19_+_12902286	1.660
chr1_+_45266035	1.644	NM_004073	PLK3	polo-like kinase 3
chr2_-_201729241	1.619	NM_001162407	CLK1	CDC-like kinase 1
chr1_-_193155723	1.619	NM_003783	B3GALT2	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr17_-_17399494	1.593	NM_001199989 NM_016084	RASD1	RAS, dexamethasone-induced 1
chr2_-_201729351	1.586		CLK1	CDC-like kinase 1
chr1_-_713985	1.571		LOC100288069	general transcription factor IIi pseudogene
chr7_-_45128492	1.569	NM_001146334	NACAD	NAC alpha domain containing
chr17_-_72968790	1.561	NM_030630	C17orf28	chromosome 17 open reading frame 28
chr18_+_23806385	1.558	NM_005640	TAF4B	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr10_-_77161424	1.535	NM_032772	ZNF503	zinc finger protein 503
chr11_+_66610882	1.513	NM_001032279 NM_005133	RCE1	RCE1 homolog, prenyl protein protease (S. cerevisiae)
chr2_+_43864405	1.502		PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr3_+_141087298	1.500		ZBTB38	zinc finger and BTB domain containing 38
chr1_+_45266048	1.483		PLK3	polo-like kinase 3
chr20_-_62258330	1.456	NM_012384	GMEB2	glucocorticoid modulatory element binding protein 2
chr2_+_43864433	1.456	NM_172069	PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr10_-_77161539	1.446		ZNF503	zinc finger protein 503
chr3_-_39195101	1.432	NM_033027	CSRNP1	cysteine-serine-rich nuclear protein 1
chr17_-_72968750	1.422
chr6_+_30295007	1.422	NM_172016	TRIM39	tripartite motif containing 39
chr17_+_27071008	1.419	NM_004295	TRAF4	TNF receptor-associated factor 4
chr3_+_183353355	1.412	NM_017644	KLHL24	kelch-like 24 (Drosophila)
chr2_+_220144024	1.403	NM_001039550 NM_006736	DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2
chr16_+_30773619	1.382		RNF40	ring finger protein 40
chr3_-_39195034	1.361		CSRNP1	cysteine-serine-rich nuclear protein 1
chr5_-_132299248	1.340		AFF4	AF4/FMR2 family, member 4
chr9_+_35538890	1.329		RUSC2	RUN and SH3 domain containing 2
chr20_+_51589752	1.326		TSHZ2	teashirt zinc finger homeobox 2
chr5_+_78532338	1.318
chr7_+_128312345	1.311	NM_001012454 NM_001128926	FAM71F2	family with sequence similarity 71, member F2
chr2_+_30369749	1.302	NM_001127399 NM_001127400 NM_001127401 NM_016061	YPEL5	yippee-like 5 (Drosophila)
chr2_+_169659099	1.273	NM_001039724 NM_001171632 NM_052946	NOSTRIN	nitric oxide synthase trafficker
chr5_+_78531848	1.272	NM_152405	JMY	junction mediating and regulatory protein, p53 cofactor
chr22_-_50683372	1.259	NM_020461	TUBGCP6	tubulin, gamma complex associated protein 6
chr8_-_29207795	1.254	NM_001394	DUSP4	dual specificity phosphatase 4
chr19_+_35491329	1.241		GRAMD1A	GRAM domain containing 1A
chr2_-_201729377	1.240	NM_004071	CLK1	CDC-like kinase 1
chr9_+_35538628	1.234	NM_001135999	RUSC2	RUN and SH3 domain containing 2
chr9_-_110251754	1.229		KLF4	Kruppel-like factor 4 (gut)
chr2_+_10184371	1.226	NM_001177718	KLF11	Kruppel-like factor 11
chr11_+_73087670	1.218	NM_032871	RELT	RELT tumor necrosis factor receptor
chr6_+_138188352	1.210	NM_006290	TNFAIP3	tumor necrosis factor, alpha-induced protein 3
chr3_+_42977833	1.200	NM_001205272	KRBOX1	KRAB box domain containing 1
chr10_+_99079017	1.196	NM_005479	FRAT1	frequently rearranged in advanced T-cell lymphomas
chr9_-_110252045	1.196	NM_004235	KLF4	Kruppel-like factor 4 (gut)
chr5_-_132299263	1.187	NM_014423	AFF4	AF4/FMR2 family, member 4
chr19_-_42721802	1.176	NM_133328	DEDD2	death effector domain containing 2
chr20_+_34203746	1.175	NM_003116	SPAG4	sperm associated antigen 4
chr19_-_3971032	1.172		DAPK3	death-associated protein kinase 3
chr17_-_8151373	1.171	NM_025099	CTC1	CTS telomere maintenance complex component 1
chr3_-_49823626	1.168	NM_001242829	IP6K1	inositol hexakisphosphate kinase 1
chr15_+_78556485	1.166	NM_018602	DNAJA4	DnaJ (Hsp40) homolog, subfamily A, member 4
chr15_+_90544608	1.164	NM_198526	ZNF710	zinc finger protein 710
chr4_-_926081	1.158		GAK	cyclin G associated kinase
chr3_-_49823953	1.147		IP6K1	inositol hexakisphosphate kinase 1
chr4_-_175204617	1.144		FBXO8	F-box protein 8
chr4_-_926101	1.141		GAK	cyclin G associated kinase
chr3_+_150125983	1.139		TSC22D2	TSC22 domain family, member 2
chr2_+_33172368	1.136	NM_206943	LTBP1	latent transforming growth factor beta binding protein 1
chr11_-_66610703	1.131
chr6_-_31939658	1.126		DOM3Z	dom-3 homolog Z (C. elegans)
chr11_+_64692052	1.122	NM_006244	PPP2R5B	protein phosphatase 2, regulatory subunit B', beta
chr13_+_73633097	1.116	NM_001730	KLF5	Kruppel-like factor 5 (intestinal)
chr11_+_66059364	1.111	NM_153266	TMEM151A	transmembrane protein 151A
chr1_+_45265896	1.108		PLK3	polo-like kinase 3
chr19_-_3971089	1.105		DAPK3	death-associated protein kinase 3
chr17_+_42385780	1.089	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr8_-_11324184	1.085	NM_053279	FAM167A	family with sequence similarity 167, member A
chrX_+_49126299	1.081	NM_001184745 NM_033215	PPP1R3F	protein phosphatase 1, regulatory subunit 3F
chr3_+_156544075	1.070	NM_001004316 NM_001193283	LEKR1	leucine, glutamate and lysine rich 1
chr4_+_157997181	1.067	NM_000824 NM_001166061 NM_001166060	GLRB	glycine receptor, beta
chrX_+_49126480	1.060		PPP1R3F	protein phosphatase 1, regulatory subunit 3F
chr17_-_8151353	1.060		CTC1	CTS telomere maintenance complex component 1
chr7_-_140624280	1.060	NM_004333	BRAF	v-raf murine sarcoma viral oncogene homolog B1
chr11_-_3818706	1.056		NUP98	nucleoporin 98kDa
chr9_-_86432546	1.053	NM_001135953 NM_025211	GKAP1	G kinase anchoring protein 1
chr6_+_30294620	1.053	NM_021253	TRIM39	tripartite motif containing 39
chr2_-_157189040	1.050	NM_006186	NR4A2	nuclear receptor subfamily 4, group A, member 2
chr2_+_149632772	1.044	NM_004522	KIF5C	kinesin family member 5C
chr19_+_55987698	1.041	NM_033113	ZNF628	zinc finger protein 628
chrX_-_52987610	1.036	NM_001242491	FAM156A FAM156B	family with sequence similarity 156, member A family with sequence similarity 156, member B
chrX_+_49126326	1.035		PPP1R3F	protein phosphatase 1, regulatory subunit 3F
chr11_-_77184549	1.029	NM_001128620 NM_002576	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1
chr22_+_42229105	1.028	NM_004599	SREBF2	sterol regulatory element binding transcription factor 2
chr12_-_6756533	1.025	NM_032489	ACRBP	acrosin binding protein
chr16_-_54320367	1.022	NM_024336	IRX3	iroquois homeobox 3
chr14_-_23388359	1.020		RBM23	RNA binding motif protein 23
chr19_+_34972866	1.014	NM_001080436	WTIP	Wilms tumor 1 interacting protein
chr3_-_49823972	1.011	NM_001006115 NM_153273	IP6K1	inositol hexakisphosphate kinase 1
chr16_+_18995255	1.002	NM_024847	TMC7	transmembrane channel-like 7
chr16_+_29912146	0.996	NM_181718	ASPHD1	aspartate beta-hydroxylase domain containing 1
chr5_-_175964824	0.993		RNF44	ring finger protein 44
chr16_+_18995508	0.992	NM_001160364	TMC7	transmembrane channel-like 7
chr5_-_132299191	0.991		AFF4	AF4/FMR2 family, member 4
chr22_-_50682915	0.988		TUBGCP6	tubulin, gamma complex associated protein 6
chr4_-_926114	0.987		GAK	cyclin G associated kinase
chr1_-_1284755	0.987		DVL1	dishevelled, dsh homolog 1 (Drosophila)
chr2_+_149632836	0.979		KIF5C	kinesin family member 5C
chr17_-_76836718	0.973		USP36	ubiquitin specific peptidase 36
chr11_+_66059335	0.970		TMEM151A	transmembrane protein 151A
chr8_+_118532970	0.968		MED30	mediator complex subunit 30
chr8_-_48650703	0.965	NM_005195	CEBPD	CCAAT/enhancer binding protein (C/EBP), delta
chr16_-_89768094	0.964	NM_152339	SPATA2L	spermatogenesis associated 2-like
chr17_-_76836852	0.958	NM_025090	USP36	ubiquitin specific peptidase 36
chr14_+_105219516	0.951		SIVA1	SIVA1, apoptosis-inducing factor
chr4_-_54930466	0.951		CHIC2	cysteine-rich hydrophobic domain 2
chr1_+_203274646	0.950	NM_006763	BTG2	BTG family, member 2
chr10_-_77161136	0.947		ZNF503	zinc finger protein 503
chr12_-_82752154	0.942	NM_014167	CCDC59	coiled-coil domain containing 59
chr17_-_49198084	0.938	NM_001130527 NM_001130528 NM_003971	SPAG9	sperm associated antigen 9
chr1_-_214724974	0.937	NM_005401	PTPN14	protein tyrosine phosphatase, non-receptor type 14
chrX_-_102319096	0.936	NM_018476	BEX1	brain expressed, X-linked 1
chrX_+_100805415	0.936	NM_016608	ARMCX1	armadillo repeat containing, X-linked 1
chr11_-_9286832	0.931	NM_001243254 NM_015213	DENND5A	DENN/MADD domain containing 5A
chr1_-_32110464	0.931		PEF1	penta-EF-hand domain containing 1
chr3_+_187871473	0.930	NM_001167672	LPP	LIM domain containing preferred translocation partner in lipoma
chr13_+_45915479	0.929		LOC100190939	uncharacterized LOC100190939
chr19_+_39390570	0.928		NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
2.30	2.26e-06	GO:0060255	regulation of macromolecule metabolic process
2.23	3.97e-06	GO:0080090	regulation of primary metabolic process
2.71	5.39e-06	GO:0006355	regulation of transcription, DNA-dependent
2.12	5.52e-06	GO:0019222	regulation of metabolic process
2.20	6.31e-06	GO:0031323	regulation of cellular metabolic process
2.58	6.94e-06	GO:2000112	regulation of cellular macromolecule biosynthetic process
2.51	1.43e-05	GO:0010556	regulation of macromolecule biosynthetic process
2.61	1.47e-05	GO:0051252	regulation of RNA metabolic process
2.40	3.17e-05	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.40	3.17e-05	GO:0031326	regulation of cellular biosynthetic process
2.44	3.19e-05	GO:0010468	regulation of gene expression
2.37	4.30e-05	GO:0009889	regulation of biosynthetic process
19.04	4.40e-05	GO:0051591	response to cAMP
2.33	7.17e-05	GO:0051171	regulation of nitrogen compound metabolic process
3.73	1.77e-04	GO:0006351	transcription, DNA-dependent
2.25	4.32e-04	GO:0048518	positive regulation of biological process
4.78	7.41e-04	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
3.36	8.93e-04	GO:0032774	RNA biosynthetic process
3.35	9.58e-04	GO:0006357	regulation of transcription from RNA polymerase II promoter
2.22	2.80e-03	GO:0048522	positive regulation of cellular process
2.41	6.45e-03	GO:0010467	gene expression
16.70	6.90e-03	GO:0001704	formation of primary germ layer
3.44	8.44e-03	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.63	8.81e-03	GO:0010628	positive regulation of gene expression
2.83	1.16e-02	GO:0010604	positive regulation of macromolecule metabolic process
2.73	1.21e-02	GO:0009893	positive regulation of metabolic process
3.34	1.22e-02	GO:0051173	positive regulation of nitrogen compound metabolic process
1.48	1.46e-02	GO:0050789	regulation of biological process
3.67	1.54e-02	GO:0045893	positive regulation of transcription, DNA-dependent
2.38	1.86e-02	GO:0016070	RNA metabolic process
1.50	1.92e-02	GO:0050794	regulation of cellular process
1.65	2.73e-02	GO:0043170	macromolecule metabolic process
3.29	2.75e-02	GO:0010557	positive regulation of macromolecule biosynthetic process
3.12	2.85e-02	GO:0031328	positive regulation of cellular biosynthetic process
3.42	3.31e-02	GO:0051254	positive regulation of RNA metabolic process
3.06	3.49e-02	GO:0009891	positive regulation of biosynthetic process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.83	1.09e-06	GO:0005634	nucleus
1.37	4.01e-03	GO:0043231	intracellular membrane-bounded organelle
1.37	4.21e-03	GO:0043227	membrane-bounded organelle
1.30	1.85e-02	GO:0043229	intracellular organelle
1.30	1.99e-02	GO:0043226	organelle

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
4.91	5.86e-12	GO:0001071	nucleic acid binding transcription factor activity
4.91	5.86e-12	GO:0003700	sequence-specific DNA binding transcription factor activity
5.03	3.18e-08	GO:0043565	sequence-specific DNA binding
2.64	4.16e-07	GO:0003677	DNA binding
2.09	3.18e-05	GO:0003676	nucleic acid binding
3.33	8.38e-03	GO:0046983	protein dimerization activity
33.90	9.57e-03	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
31.48	1.21e-02	GO:0033549	MAP kinase phosphatase activity
2.63	2.47e-02	GO:0030528	transcription regulator activity
4.78	3.07e-02	GO:0003702	RNA polymerase II transcription factor activity