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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: EGR1..3.p2

Z-value: 2.595

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_-_38471170	4.885	NM_001243878 NM_004468	FHL3	four and a half LIM domains 3
chr3_-_39195101	3.690	NM_033027	CSRNP1	cysteine-serine-rich nuclear protein 1
chr7_-_100493481	3.468	NM_000665 NM_015831	ACHE	acetylcholinesterase
chr3_-_39195034	3.388		CSRNP1	cysteine-serine-rich nuclear protein 1
chr19_+_47778099	3.084	NM_178511	PRR24	proline rich 24
chr9_-_110251754	2.795		KLF4	Kruppel-like factor 4 (gut)
chr13_-_110438896	2.444	NM_003749	IRS2	insulin receptor substrate 2
chr12_+_57482886	2.248		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr5_+_172483285	2.177	NM_001168393 NM_001168394 NM_153607	C5orf41	chromosome 5 open reading frame 41
chr11_-_65667809	2.162		FOSL1	FOS-like antigen 1
chr6_-_109777171	2.119	NM_001159291 NM_022765	MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1
chr2_+_28616360	2.070		FOSL2	FOS-like antigen 2
chr9_-_110252045	2.067	NM_004235	KLF4	Kruppel-like factor 4 (gut)
chr20_-_3388586	2.049		C20orf194	chromosome 20 open reading frame 194
chr6_-_109776946	2.039		MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1
chr19_+_55795533	2.023	NM_032430	BRSK1	BR serine/threonine kinase 1
chr6_+_37137882	2.022	NM_001243186 NM_002648	PIM1	pim-1 oncogene
chr11_+_61447816	1.963	NM_006133	DAGLA	diacylglycerol lipase, alpha
chr22_+_38598065	1.929		MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr12_+_57482922	1.924		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chrX_-_48814758	1.914		OTUD5	OTU domain containing 5
chr12_+_57482674	1.880	NM_005967	NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr15_+_40733302	1.873	NM_014952	BAHD1	bromo adjacent homology domain containing 1
chr20_-_62258422	1.846		GMEB2	glucocorticoid modulatory element binding protein 2
chr8_-_8175860	1.815		SGK223	homolog of rat pragma of Rnd2
chr19_+_42788605	1.806	NM_015125	CIC	capicua homolog (Drosophila)
chr17_+_43299277	1.804	NM_005892	FMNL1	formin-like 1
chr22_-_20004251	1.796	NM_001670	ARVCF	armadillo repeat gene deleted in velocardiofacial syndrome
chrX_-_48814853	1.787	NM_001136157 NM_001136158 NM_017602	OTUD5	OTU domain containing 5
chr19_+_55795766	1.787		BRSK1	BR serine/threonine kinase 1
chr9_-_110251308	1.762		KLF4	Kruppel-like factor 4 (gut)
chr8_+_16884745	1.741	NM_181723	EFHA2	EF-hand domain family, member A2
chr9_-_86432546	1.734	NM_001135953 NM_025211	GKAP1	G kinase anchoring protein 1
chr20_-_62258330	1.733	NM_012384	GMEB2	glucocorticoid modulatory element binding protein 2
chr16_-_66959418	1.725	NM_001128850 NM_004165	RRAD	Ras-related associated with diabetes
chr19_-_47734215	1.723	NM_014417	BBC3	BCL2 binding component 3
chr6_-_109776942	1.722		MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1
chr22_+_50354428	1.719		PIM3	pim-3 oncogene
chr5_+_137801178	1.715	NM_001964	EGR1	early growth response 1
chr19_+_13105970	1.713	NM_002501	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_143266283	1.703	NM_006734	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2
chr4_-_82393025	1.678	NM_152545	RASGEF1B	RasGEF domain family, member 1B
chr19_-_1863425	1.658		KLF16	Kruppel-like factor 16
chr6_-_109777085	1.636		MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1
chr19_+_45504686	1.635	NM_006509	RELB	v-rel reticuloendotheliosis viral oncogene homolog B
chr10_-_77161136	1.633		ZNF503	zinc finger protein 503
chr6_-_91006460	1.628	NM_021813	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr4_+_108745718	1.592	NM_001136258	SGMS2	sphingomyelin synthase 2
chr19_+_4969126	1.565		KDM4B	lysine (K)-specific demethylase 4B
chr1_-_16302272	1.565	NM_001242884 NM_003443	ZBTB17	zinc finger and BTB domain containing 17
chr16_+_1203240	1.564	NM_001005407 NM_021098	CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit
chr10_-_77159851	1.562		ZNF503	zinc finger protein 503
chr7_-_32931409	1.535	NM_015483	KBTBD2	kelch repeat and BTB (POZ) domain containing 2
chr19_-_4065467	1.516		ZBTB7A	zinc finger and BTB domain containing 7A
chr6_+_36164528	1.500	NM_015695	BRPF3	bromodomain and PHD finger containing, 3
chr2_+_28616346	1.476		FOSL2	FOS-like antigen 2
chr11_-_65667860	1.470	NM_005438	FOSL1	FOS-like antigen 1
chr1_+_32827797	1.454	NM_052841	TSSK3	testis-specific serine kinase 3
chr20_-_3388219	1.434	NM_001009984	C20orf194	chromosome 20 open reading frame 194
chr19_+_4969123	1.430	NM_015015	KDM4B	lysine (K)-specific demethylase 4B
chr12_-_28122884	1.422	NM_198964 NM_198966	PTHLH	parathyroid hormone-like hormone
chr22_+_50354139	1.417	NM_001001852	PIM3	pim-3 oncogene
chr7_+_64498643	1.396		CCT6P3	chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr11_+_45907198	1.387		MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1
chr4_-_82392971	1.387		RASGEF1B	RasGEF domain family, member 1B
chr8_-_103666018	1.381	NM_001032282	KLF10	Kruppel-like factor 10
chrX_+_153686620	1.361	NM_017514	PLXNA3	plexin A3
chr6_-_43423215	1.360	NM_023932	DLK2	delta-like 2 homolog (Drosophila)
chrX_-_48815088	1.347		OTUD5	OTU domain containing 5
chr19_-_1237840	1.345	NM_152769	C19orf26	chromosome 19 open reading frame 26
chr14_-_21566497	1.337		ZNF219	zinc finger protein 219
chr6_-_13711643	1.335	NM_005493	RANBP9	RAN binding protein 9
chr17_-_63557615	1.328	NM_004655	AXIN2	axin 2
chrX_+_49126299	1.326	NM_001184745 NM_033215	PPP1R3F	protein phosphatase 1, regulatory subunit 3F
chr19_-_1567875	1.288	NM_001174118 NM_203304	MEX3D	mex-3 homolog D (C. elegans)
chr19_-_18392436	1.280		JUND	jun D proto-oncogene
chr19_-_460995	1.274	NM_012435	SHC2	SHC (Src homology 2 domain containing) transforming protein 2
chr2_+_220408352	1.267		TMEM198	transmembrane protein 198
chr22_+_21771661	1.267	NM_015094	HIC2	hypermethylated in cancer 2
chr19_-_40931880	1.264	NM_013376	SERTAD1	SERTA domain containing 1
chr16_-_73092533	1.252	NM_001164766	ZFHX3	zinc finger homeobox 3
chr2_+_220408742	1.233	NM_001005209	TMEM198	transmembrane protein 198
chr5_+_137801166	1.205		EGR1	early growth response 1
chr21_-_37528578	1.194		LOC100506428	uncharacterized LOC100506428
chr18_-_48724031	1.183	NM_016626	MEX3C	mex-3 homolog C (C. elegans)
chr19_-_42759151	1.181		ERF	Ets2 repressor factor
chr19_-_42759279	1.180	NM_006494	ERF	Ets2 repressor factor
chr5_+_60628085	1.177	NM_020928	ZSWIM6	zinc finger, SWIM-type containing 6
chr15_-_72410108	1.168		MYO9A	myosin IXA
chr16_-_402617	1.158	NM_003502 NM_181050	AXIN1	axin 1
chr2_-_145274916	1.146		ZEB2	zinc finger E-box binding homeobox 2
chr2_+_241508103	1.131		RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1
chr22_-_17602142	1.129	NM_031890 NM_001163079	CECR6	cat eye syndrome chromosome region, candidate 6
chr10_+_104155431	1.127	NM_002502	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr19_-_18392413	1.115	NM_005354	JUND	jun D proto-oncogene
chr19_-_15443307	1.111		BRD4	bromodomain containing 4
chr16_-_87417309	1.111	NM_024735	FBXO31	F-box protein 31
chr16_-_3930685	1.105		CREBBP	CREB binding protein
chr1_-_1475739	1.098	NM_001114748	TMEM240	transmembrane protein 240
chr11_-_67141008	1.096	NM_013246	CLCF1	cardiotrophin-like cytokine factor 1
chr7_-_152132924	1.084		MLL3	myeloid/lymphoid or mixed-lineage leukemia 3
chr1_-_156470538	1.079		MEF2D	myocyte enhancer factor 2D
chr19_+_2476122	1.079	NM_015675	GADD45B	growth arrest and DNA-damage-inducible, beta
chr1_+_35331533	1.078
chr19_-_46272102	1.072
chr9_+_139221931	1.070	NM_001145638 NM_015597	GPSM1	G-protein signaling modulator 1
chr1_+_212781969	1.070	NM_001040619 NM_001206484 NM_001206488 NM_001674	ATF3	activating transcription factor 3
chr18_-_48723105	1.069		MEX3C	mex-3 homolog C (C. elegans)
chr6_-_33266700	1.062		RGL2	ral guanine nucleotide dissociation stimulator-like 2
chr4_+_186317964	1.062		ANKRD37	ankyrin repeat domain 37
chr19_+_41305041	1.058	NM_080732	EGLN2	egl nine homolog 2 (C. elegans)
chrX_+_49126480	1.055		PPP1R3F	protein phosphatase 1, regulatory subunit 3F
chr15_-_61521416	1.052		RORA	RAR-related orphan receptor A
chr15_-_72410226	1.051	NM_006901	MYO9A	myosin IXA
chrX_-_135333519	1.050	NM_001173517 NM_024597	MAP7D3	MAP7 domain containing 3
chr5_+_56111379	1.042		MAP3K1	mitogen-activated protein kinase kinase kinase 1
chr22_+_24551944	1.041		CABIN1	calcineurin binding protein 1
chr6_+_89791510	1.037		PNRC1	proline-rich nuclear receptor coactivator 1
chr7_-_32931363	1.036		KBTBD2	kelch repeat and BTB (POZ) domain containing 2
chr22_+_42229268	1.031		SREBF2	sterol regulatory element binding transcription factor 2
chr3_+_183948216	1.027	NM_138345	VWA5B2	von Willebrand factor A domain containing 5B2
chr16_-_1020981	1.015	NM_022773	LMF1	lipase maturation factor 1
chr1_+_212782103	1.013		ATF3	activating transcription factor 3
chr2_+_149402321	1.012		EPC2	enhancer of polycomb homolog 2 (Drosophila)
chr6_-_13711952	1.012		RANBP9	RAN binding protein 9
chr14_+_105331581	1.009	NM_001112726 NM_015005	KIAA0284	KIAA0284
chr2_+_10183630	1.005	NM_003597 NM_001177716	KLF11	Kruppel-like factor 11
chr11_-_1593149	0.999	NM_004420	DUSP8	dual specificity phosphatase 8
chr10_+_98592015	0.998	NM_001170765 NM_001170766	LCOR	ligand dependent nuclear receptor corepressor
chr19_-_18548788	0.992	NM_001170939	ISYNA1	inositol-3-phosphate synthase 1
chr11_+_560868	0.990	NM_001143993	RASSF7	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr17_+_17584772	0.990	NM_030665	RAI1	retinoic acid induced 1
chr15_+_99191671	0.988		IGF1R	insulin-like growth factor 1 receptor
chr22_-_50221195	0.987		BRD1	bromodomain containing 1
chr22_-_31503484	0.985	NM_080430	SELM	selenoprotein M
chr19_+_45971249	0.985	NM_001114171 NM_006732	FOSB	FBJ murine osteosarcoma viral oncogene homolog B
chr11_+_66059364	0.984	NM_153266	TMEM151A	transmembrane protein 151A
chr16_+_1664640	0.983	NM_020825	CRAMP1L	Crm, cramped-like (Drosophila)
chr14_-_21566728	0.978	NM_016423	ZNF219	zinc finger protein 219
chrX_+_152953751	0.977	NM_001142805 NM_005629	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr22_-_50964573	0.977	NM_001169110	SCO2	SCO cytochrome oxidase deficient homolog 2 (yeast)
chr14_+_105886253	0.976		MTA1	metastasis associated 1
chr12_+_50017340	0.972	NM_012272	PRPF40B	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr22_+_51039178	0.970		MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2
chr19_+_7660698	0.967	NM_001080429 NM_020902	CAMSAP3	calmodulin regulated spectrin-associated protein family, member 3
chr16_-_3930120	0.963	NM_001079846 NM_004380	CREBBP	CREB binding protein
chr19_+_36208917	0.962	NM_014727	MLL4	myeloid/lymphoid or mixed-lineage leukemia 4
chr9_+_139971938	0.956	NM_207309	UAP1L1	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr20_+_49348050	0.953	NM_032521	PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)
chr5_+_56111352	0.949		MAP3K1	mitogen-activated protein kinase kinase kinase 1
chr5_+_179248089	0.948		SQSTM1	sequestosome 1
chr6_-_11232883	0.946		NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr2_+_42275017	0.945	NM_138370	PKDCC	protein kinase domain containing, cytoplasmic homolog (mouse)
chr22_-_50708720	0.941	NM_002751	MAPK11	mitogen-activated protein kinase 11
chr11_+_119076974	0.939	NM_005188	CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr11_-_63933204	0.939		MACROD1	MACRO domain containing 1
chr5_+_179247841	0.937	NM_003900	SQSTM1	sequestosome 1
chr5_+_179247903	0.934		SQSTM1	sequestosome 1
chr14_+_105886146	0.930	NM_001203258 NM_004689	MTA1	metastasis associated 1
chr10_-_77160650	0.929		ZNF503	zinc finger protein 503
chr22_-_39268169	0.928		CBX6	chromobox homolog 6
chr19_+_11457160	0.928	NM_001080503	CCDC159	coiled-coil domain containing 159
chr3_+_50297644	0.927
chr9_+_35605614	0.924		TESK1	testis-specific kinase 1
chr19_-_6279927	0.918	NM_005934	MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr6_+_17281773	0.914	NM_001143942	RBM24	RNA binding motif protein 24
chr17_-_79885544	0.912	NM_002359	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr19_+_36209125	0.907		MLL4	myeloid/lymphoid or mixed-lineage leukemia 4
chr19_-_15443133	0.907		BRD4	bromodomain containing 4
chr1_+_68150858	0.907	NM_001199741 NM_001199742 NM_001924	GADD45A	growth arrest and DNA-damage-inducible, alpha
chr1_-_935469	0.905	NM_001142467 NM_021170	HES4	hairy and enhancer of split 4 (Drosophila)
chr4_-_105412466	0.905	NM_025212	CXXC4	CXXC finger protein 4
chr16_+_89787383	0.904	NM_152287	ZNF276	zinc finger protein 276
chr6_+_19838612	0.897
chr22_+_42229137	0.895		SREBF2	sterol regulatory element binding transcription factor 2
chr16_-_57570455	0.895	NM_033212	CCDC102A	coiled-coil domain containing 102A
chr10_+_69644708	0.892		SIRT1	sirtuin 1
chr20_+_44034632	0.888	NM_001197139 NM_001048221 NM_001048222 NM_001197140 NM_018478	DBNDD2	dysbindin (dystrobrevin binding protein 1) domain containing 2
chr7_+_1577118	0.887		MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr22_+_38597938	0.886	NM_001161572 NM_001161574 NM_012323	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr17_-_8066254	0.882	NM_014232	VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)
chr19_+_16683360	0.882
chr7_+_28530747	0.881		CREB5	cAMP responsive element binding protein 5
chr19_-_15443304	0.880		BRD4	bromodomain containing 4
chr22_+_51039100	0.880	NM_012324	MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2
chr20_+_2673193	0.879	NM_001110514	EBF4	early B-cell factor 4
chr4_-_102267952	0.878		PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chr14_-_71275732	0.874	NM_033141	MAP3K9	mitogen-activated protein kinase kinase kinase 9
chr1_+_33207343	0.872	NM_020888	KIAA1522	KIAA1522
chr16_-_4664780	0.869		FAM100A	family with sequence similarity 100, member A
chr15_-_60884615	0.869	NM_134262	RORA	RAR-related orphan receptor A
chr10_+_69644341	0.868	NM_012238	SIRT1	sirtuin 1
chr17_-_48207113	0.865	NM_174920	SAMD14	sterile alpha motif domain containing 14
chr19_+_8429010	0.863	NM_001039667 NM_139314	ANGPTL4	angiopoietin-like 4
chr4_-_74124305	0.863
chr12_+_52445185	0.860	NM_002135 NM_173157	NR4A1	nuclear receptor subfamily 4, group A, member 1
chrX_+_49126326	0.860		PPP1R3F	protein phosphatase 1, regulatory subunit 3F
chr12_-_26277807	0.856	NM_030762	BHLHE41	basic helix-loop-helix family, member e41
chr22_-_39268214	0.855		CBX6	chromobox homolog 6
chr17_-_72968750	0.854

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
3.34	6.21e-09	GO:0051252	regulation of RNA metabolic process
3.37	1.05e-08	GO:0006355	regulation of transcription, DNA-dependent
3.13	4.18e-08	GO:2000112	regulation of cellular macromolecule biosynthetic process
3.04	8.88e-08	GO:0010556	regulation of macromolecule biosynthetic process
2.63	1.22e-07	GO:0060255	regulation of macromolecule metabolic process
2.96	2.06e-07	GO:0010468	regulation of gene expression
2.83	6.95e-07	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.83	6.95e-07	GO:0031326	regulation of cellular biosynthetic process
2.80	9.48e-07	GO:0009889	regulation of biosynthetic process
2.75	1.59e-06	GO:0051171	regulation of nitrogen compound metabolic process
2.44	2.52e-06	GO:0080090	regulation of primary metabolic process
2.40	3.82e-06	GO:0031323	regulation of cellular metabolic process
2.29	5.77e-06	GO:0019222	regulation of metabolic process
4.52	1.36e-05	GO:0006351	transcription, DNA-dependent
1.76	2.13e-05	GO:0050794	regulation of cellular process
1.72	2.30e-05	GO:0050789	regulation of biological process
1.67	3.64e-05	GO:0065007	biological regulation
4.08	6.92e-05	GO:0032774	RNA biosynthetic process
3.85	3.71e-04	GO:0006357	regulation of transcription from RNA polymerase II promoter
32.64	3.31e-03	GO:0060350	endochondral bone morphogenesis
2.25	6.55e-03	GO:0048518	positive regulation of biological process
51.18	1.26e-02	GO:0002076	osteoblast development
2.24	2.44e-02	GO:0048522	positive regulation of cellular process
19.76	2.59e-02	GO:0060349	bone morphogenesis
40.22	2.74e-02	GO:0001958	endochondral ossification
9.02	2.90e-02	GO:0048705	skeletal system morphogenesis
8.88	3.17e-02	GO:0001503	ossification
2.83	4.50e-02	GO:0009893	positive regulation of metabolic process
2.52	4.69e-02	GO:0034645	cellular macromolecule biosynthetic process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.90	4.96e-06	GO:0005634	nucleus

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
5.06	7.81e-10	GO:0001071	nucleic acid binding transcription factor activity
5.06	7.81e-10	GO:0003700	sequence-specific DNA binding transcription factor activity
2.68	1.08e-05	GO:0003677	DNA binding
4.39	1.31e-04	GO:0043565	sequence-specific DNA binding
2.13	3.30e-04	GO:0003676	nucleic acid binding
2.46	1.37e-03	GO:0008270	zinc ion binding
2.33	1.43e-03	GO:0046914	transition metal ion binding
2.97	1.34e-02	GO:0030528	transcription regulator activity
75.06	2.73e-02	GO:0031434	mitogen-activated protein kinase kinase binding
1.75	3.44e-02	GO:0046872	metal ion binding
62.56	4.08e-02	GO:0008432	JUN kinase binding
1.73	4.28e-02	GO:0043169	cation binding
1.72	4.48e-02	GO:0043167	ion binding