Motif ID: GATA6.p2

Z-value: 2.426


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA6hg19_v1_chr18_+_19749403_197495500.305.6e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_36301999 4.666 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr9_-_107665959 4.066 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr9_-_107666046 3.943 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr12_+_25205180 3.658 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chrX_-_105282714 3.470 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr11_-_115088628 3.458 CADM1
cell adhesion molecule 1
chr3_+_186383770 2.889 NM_000412
HRG
histidine-rich glycoprotein
chr10_-_129691202 2.704 NM_152311
CLRN3
clarin 3
chr13_-_28543143 2.558 CDX2
caudal type homeobox 2
chr10_-_129691047 2.479


chr2_-_179914785 2.473 NM_173648
CCDC141
coiled-coil domain containing 141
chr6_-_30128688 2.467 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr22_+_35462125 2.355 NM_001008494
ISX
intestine-specific homeobox
chr13_-_28543423 2.275 CDX2
caudal type homeobox 2
chr8_+_79428335 2.223 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr8_-_30002199 2.159 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr6_-_49712055 2.028 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr12_+_25205488 1.930 LRMP
lymphoid-restricted membrane protein
chr12_+_7169192 1.862


chr20_+_12989616 1.852 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr20_+_43029973 1.841 HNF4A
hepatocyte nuclear factor 4, alpha
chr19_+_10397642 1.672 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr11_+_121461070 1.656 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr6_-_134498973 1.641 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chrX_+_106161589 1.611 NM_001171095
CLDN2
claudin 2
chr8_-_38008332 1.569 NM_000349
STAR
steroidogenic acute regulatory protein
chrX_+_106163605 1.561 NM_020384
CLDN2
claudin 2
chr1_+_171217632 1.486 NM_002021
FMO1
flavin containing monooxygenase 1
chr4_+_151503076 1.460 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr13_-_28543290 1.438 NM_001265
CDX2
caudal type homeobox 2
chr4_+_69962191 1.435 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr1_-_173176314 1.427 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chrX_-_15402469 1.408 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr16_-_46782104 1.388 NM_182493
MYLK3
myosin light chain kinase 3
chr20_+_43029865 1.379 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr7_-_99332715 1.374 NM_000765
CYP3A7
CYP3A5
cytochrome P450, family 3, subfamily A, polypeptide 7
cytochrome P450, family 3, subfamily A, polypeptide 5
chr1_+_215178884 1.373 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr1_-_155211049 1.344 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chrX_-_112066353 1.340 NM_001113490
AMOT
angiomotin
chr20_-_39928708 1.275 NM_015035
ZHX3
zinc fingers and homeoboxes 3
chr11_+_89392464 1.259 NM_153696
FOLH1B
folate hydrolase 1B
chr19_+_15751706 1.235 NM_000896
NM_001199208
NM_001199209
CYP4F3


cytochrome P450, family 4, subfamily F, polypeptide 3


chr4_-_164534656 1.225 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr2_+_44066102 1.223 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr15_-_90222572 1.219 NM_001145311
NM_002666
PLIN1

perilipin 1

chr2_+_27719702 1.218 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chrX_-_64196268 1.210 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr2_-_74570533 1.198 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chrX_-_24690740 1.196 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr1_-_190446701 1.185 NM_199051
FAM5C
family with sequence similarity 5, member C
chr9_-_215892 1.176 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr6_-_87804773 1.132 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr2_+_220436953 1.125 NM_002191
INHA
inhibin, alpha
chr5_-_35118223 1.117 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr16_+_24802421 1.105 TNRC6A
trinucleotide repeat containing 6A
chr8_-_20112691 1.080 NM_021020
LZTS1
leucine zipper, putative tumor suppressor 1
chr16_-_49860917 1.070 NM_015069
ZNF423
zinc finger protein 423
chr5_-_111312522 1.069 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr1_-_27240430 1.059 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr14_-_65409445 1.058 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr9_+_273025 1.054 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr2_-_99279935 1.040 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr11_-_116708334 1.037 NM_000039
APOA1
apolipoprotein A-I
chr12_+_9142136 1.027 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr17_+_74536114 0.988 NM_001077620
PRCD
progressive rod-cone degeneration
chr3_-_187009469 0.984 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr9_-_97356007 0.975 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr1_+_101185195 0.953 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr11_+_123986103 0.950 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr7_+_94292737 0.933 PEG10
paternally expressed 10
chr10_-_14816895 0.927 NM_031453
FAM107B
family with sequence similarity 107, member B
chr10_+_24755440 0.913 KIAA1217
KIAA1217
chr1_-_197036350 0.909 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr10_+_115310589 0.906 NM_001177660
HABP2
hyaluronan binding protein 2
chr5_-_59783885 0.897 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_226187019 0.894 C1orf55
chromosome 1 open reading frame 55
chrX_-_10851808 0.893 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr7_-_92855780 0.892 NM_001039372
HEPACAM2
HEPACAM family member 2
chr1_-_55089068 0.888 NM_176782
FAM151A
family with sequence similarity 151, member A
chr17_-_10372875 0.876 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr12_+_53818864 0.870 AMHR2
anti-Mullerian hormone receptor, type II
chr4_-_186697065 0.861 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr22_+_51176623 0.850 NM_001097
ACR
acrosin
chr22_-_37584254 0.844 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr7_-_107880492 0.841 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr4_-_159094163 0.826 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr5_+_140557370 0.822 NM_019120
PCDHB8
protocadherin beta 8
chr10_+_75673346 0.822 PLAU
plasminogen activator, urokinase
chr6_-_52668599 0.817 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr12_-_23737507 0.813 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr4_+_39408541 0.811 KLB
klotho beta
chrX_-_24665225 0.811 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr12_+_123944385 0.800 NM_180699
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr15_-_50838901 0.791 NM_203494
USP50
ubiquitin specific peptidase 50
chr10_+_24755459 0.790 KIAA1217
KIAA1217
chr7_+_73245192 0.786 NM_001305
CLDN4
claudin 4
chr18_-_21891469 0.786 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr8_-_95449131 0.769 NM_001205263
RAD54B
RAD54 homolog B (S. cerevisiae)
chr17_-_56084571 0.762 SRSF1
serine/arginine-rich splicing factor 1
chr17_-_56084590 0.759 SRSF1
serine/arginine-rich splicing factor 1
chr1_-_232651227 0.758 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr7_+_95115212 0.748 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr15_-_76304762 0.738 NM_138573
NRG4
neuregulin 4
chr7_-_150945731 0.728 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr19_-_36303766 0.710 PRODH2
proline dehydrogenase (oxidase) 2
chr3_+_49568370 0.702 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr20_-_45976626 0.701 ZMYND8
zinc finger, MYND-type containing 8
chr6_-_2840683 0.696 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr1_+_81771844 0.696 LPHN2
latrophilin 2
chr5_+_140602914 0.693 NM_018934
PCDHB14
protocadherin beta 14
chr15_-_55652777 0.692 CCPG1
cell cycle progression 1
chr4_+_120056938 0.680 NM_016599
MYOZ2
myozenin 2
chr1_-_226187027 0.672 C1orf55
chromosome 1 open reading frame 55
chr3_+_100328432 0.669 NM_032787
GPR128
G protein-coupled receptor 128
chr5_+_140579182 0.667 NM_018931
PCDHB11
protocadherin beta 11
chr1_-_217113007 0.664 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr18_-_64271215 0.662 NM_021153
CDH19
cadherin 19, type 2
chr6_+_130339715 0.656 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr3_-_15563160 0.648 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr1_-_31196429 0.645 NM_002379
MATN1
matrilin 1, cartilage matrix protein
chr2_+_96991934 0.644 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-trisphosphate receptor interacting protein-like 1

chr20_+_54967692 0.641 NM_001033522
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr7_+_128379428 0.641 CALU
calumenin
chr18_+_29171729 0.640 NM_000371
TTR
transthyretin
chr7_+_128379400 0.637 CALU
calumenin
chr1_-_120311466 0.631 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr12_-_57410275 0.625 NM_001178054
NM_013251
TAC3

tachykinin 3

chr7_+_128379452 0.624 CALU
calumenin
chr13_-_46756295 0.622 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_88427535 0.620 NM_001443
FABP1
fatty acid binding protein 1, liver
chrX_-_10535476 0.610 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr3_-_119379269 0.608 NM_022135
POPDC2
popeye domain containing 2
chr4_-_76957139 0.602 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr1_+_63063186 0.597 NM_014495
ANGPTL3
angiopoietin-like 3
chr4_+_110834039 0.596 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr3_-_186262114 0.594 NM_017541
CRYGS
crystallin, gamma S
chr9_+_118916069 0.589 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr2_+_211458078 0.586 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr4_-_70518964 0.584 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr3_-_52488030 0.580 NM_003280
TNNC1
troponin C type 1 (slow)
chrX_+_99899162 0.577 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr5_-_154230212 0.573 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr6_+_26365397 0.568 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr3_-_112359863 0.567 CCDC80
coiled-coil domain containing 80
chrX_-_100307042 0.566 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr11_+_61248584 0.563 NM_001170753
NM_145017
PPP1R32

protein phosphatase 1, regulatory subunit 32

chr17_+_7517263 0.559 SHBG
sex hormone-binding globulin
chr1_-_226186987 0.558 C1orf55
chromosome 1 open reading frame 55
chrX_-_55020510 0.556 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr11_+_72983246 0.555 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr13_-_49975734 0.554 NM_030925
CAB39L
calcium binding protein 39-like
chr16_+_24788568 0.554 TNRC6A
trinucleotide repeat containing 6A
chr16_+_24857551 0.547 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr12_-_70004941 0.543 NM_201550
LRRC10
leucine rich repeat containing 10
chr1_-_24469571 0.543 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr4_-_186733372 0.540 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr1_-_226187055 0.531 NM_152608
C1orf55
chromosome 1 open reading frame 55
chr1_-_33647626 0.527 NM_018207
TRIM62
tripartite motif containing 62
chr1_-_149858114 0.527 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr12_+_86268072 0.525 NM_006183
NTS
neurotensin
chr22_+_21128378 0.525 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr3_-_168864325 0.524 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr5_+_42549657 0.521 NM_001242404
GHR
growth hormone receptor
chr22_+_35779103 0.519 HMOX1
heme oxygenase (decycling) 1
chr12_+_56075329 0.517 NM_152637
METTL7B
methyltransferase like 7B
chr7_-_150945701 0.508 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr6_-_13408368 0.506 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr1_+_244214576 0.500 ZNF238
zinc finger protein 238
chr1_-_39347258 0.498 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP readthrough
gap junction protein, alpha 9, 59kDa
chr3_+_195943382 0.497 NM_152672
OSTalpha
organic solute transporter alpha
chr19_+_20959109 0.491


chr7_+_129932973 0.486 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr13_-_46756326 0.486 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_+_53645369 0.483 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr2_+_191301020 0.482 MFSD6
major facilitator superfamily domain containing 6
chr14_+_51026742 0.474 NM_015915
NM_181598
ATL1

atlastin GTPase 1

chr5_+_140501399 0.472 PCDHB4
protocadherin beta 4
chr9_+_684193 0.469


chr6_+_26402464 0.468 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr17_-_72869068 0.468 NM_004110
NM_024417
FDXR

ferredoxin reductase

chr20_+_54967405 0.462 NM_001033521
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr3_-_98312384 0.462 NM_000097
CPOX
coproporphyrinogen oxidase
chr17_+_43224683 0.459 NM_006460
HEXIM1
hexamethylene bis-acetamide inducible 1
chr6_-_117996369 0.458


chr13_-_46756291 0.456 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr20_+_54967572 0.452 NM_001324
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr11_+_118958696 0.452 NM_001024382
HMBS
hydroxymethylbilane synthase
chr9_-_75567915 0.448 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr5_+_42565963 0.448 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chrX_+_22050920 0.446 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr17_+_6939236 0.444 NM_201566
SLC16A13
solute carrier family 16, member 13 (monocarboxylic acid transporter 13)
chr3_+_155860750 0.443 NM_003471
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_+_50574601 0.441 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_-_168864066 0.435 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr6_-_31514620 0.434 NM_001204078
NM_130463
NM_138282
ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chr3_-_112359565 0.430 CCDC80
coiled-coil domain containing 80
chr19_-_13213513 0.429 LYL1
lymphoblastic leukemia derived sequence 1
chr2_-_165551178 0.427 COBLL1
COBL-like 1
chr21_-_36421195 0.425 RUNX1
runt-related transcription factor 1
chr3_-_57234279 0.424 NM_003865
HESX1
HESX homeobox 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.01 1.67e-04 GO:0006629 lipid metabolic process
23.28 9.77e-04 GO:0055088 lipid homeostasis
9.83 2.74e-03 GO:0008202 steroid metabolic process
16.53 5.32e-03 GO:0008203 cholesterol metabolic process
15.37 7.58e-03 GO:0016125 sterol metabolic process
4.20 8.06e-03 GO:0032879 regulation of localization
4.73 1.66e-02 GO:0051049 regulation of transport
43.88 1.78e-02 GO:0033344 cholesterol efflux
153.54 2.69e-02 GO:0032488 Cdc42 protein signal transduction
11.56 2.98e-02 GO:0006805 xenobiotic metabolic process
11.56 2.98e-02 GO:0071466 cellular response to xenobiotic stimulus
36.86 3.06e-02 GO:0032371 regulation of sterol transport
36.86 3.06e-02 GO:0032374 regulation of cholesterol transport
11.47 3.09e-02 GO:0009410 response to xenobiotic stimulus
122.83 4.48e-02 GO:0034380 high-density lipoprotein particle assembly

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
83.76 5.37e-04 GO:0017127 cholesterol transporter activity
70.87 9.26e-04 GO:0015248 sterol transporter activity
15.37 1.33e-02 GO:0004497 monooxygenase activity
20.49 4.27e-02 GO:0019825 oxygen binding