Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 2.098


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HBP1hg19_v1_chr7_+_106809405_1068094740.988.2e-04Click!
HMGB3hg19_v1_chrX_+_150151757_150151857-0.962.1e-03Click!
UBTFhg19_v1_chr17_-_42296923_42296942-0.953.9e-03Click!
HMGB2hg19_v1_chr4_-_174254730_174255020-0.882.1e-02Click!
SSRP1hg19_v1_chr11_-_57103324_57103375-0.266.2e-01Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_45971249 6.014 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr6_+_89790464 4.898 PNRC1
proline-rich nuclear receptor coactivator 1
chr6_+_89790412 4.835 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr1_-_193155723 4.675 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr7_+_18535351 4.659 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr3_-_114790221 4.093 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr19_+_13134782 4.088 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr10_-_32667543 3.765 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr7_+_28452143 3.647 NM_182898
CREB5
cAMP responsive element binding protein 5
chr6_-_138189313 3.615


chr1_+_86046434 3.605 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr7_+_28725597 3.406 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr19_+_13906207 3.387 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr6_-_56716713 3.319 DST
dystonin
chrX_+_123234462 3.003 STAG2
stromal antigen 2
chr22_+_38598065 2.981 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr17_+_27573874 2.966 NM_005208
CRYBA1
crystallin, beta A1
chr19_-_47734215 2.921 NM_014417
BBC3
BCL2 binding component 3
chr8_-_6420454 2.907 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr4_-_184243578 2.878 NM_001185149
CLDN24
claudin 24
chr12_-_16757944 2.866 LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_-_11232901 2.835 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr3_-_47933997 2.791 MAP4
microtubule-associated protein 4
chr6_-_11232883 2.757 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_-_16424391 2.738 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr17_+_36861398 2.669 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr11_+_5968576 2.595 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr3_-_114478117 2.588 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr22_+_38599026 2.524 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr4_-_83347778 2.513 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr6_-_11232900 2.505 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_76203256 2.459 NM_015687
FILIP1
filamin A interacting protein 1
chr5_+_172483285 2.453 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr2_-_152590983 2.329 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr9_-_4299915 2.321 GLIS3
GLIS family zinc finger 3
chr2_+_149633173 2.313


chr6_+_12290528 2.304 NM_001168319
NM_001955
EDN1

endothelin 1

chr12_+_52445185 2.304 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr3_-_48700317 2.299 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr7_-_16505292 2.295 NM_015464
SOSTDC1
sclerostin domain containing 1
chr18_+_3451589 2.274 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr6_-_91006460 2.266 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr7_+_28448970 2.264 LOC401317
uncharacterized LOC401317
chr6_-_91006580 2.254 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr4_+_118955499 2.253 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr5_+_137673223 2.232 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr6_+_21666645 2.163 LINC00340
long intergenic non-protein coding RNA 340
chr7_+_107110501 2.149 NM_005295
GPR22
G protein-coupled receptor 22
chr7_-_27183225 2.146 NM_019102
HOXA5
homeobox A5
chr17_-_49124128 2.144 NM_001251971
SPAG9
sperm associated antigen 9
chr18_+_7946885 2.137 PTPRM
protein tyrosine phosphatase, receptor type, M
chr3_-_114866090 2.127 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr8_-_29206321 2.123 NM_057158
DUSP4
dual specificity phosphatase 4
chr6_-_56716412 2.102 DST
dystonin
chr5_-_39425297 2.092 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr15_+_93443418 2.085 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr5_-_39424930 2.046 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr6_-_111888520 2.026 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr15_+_93443559 1.999 CHD2
chromodomain helicase DNA binding protein 2
chr19_+_11649578 1.995 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr5_-_64777703 1.941 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr3_+_141105283 1.933


chr20_+_51588945 1.931 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr2_+_171571800 1.928 NM_001003845
SP5
Sp5 transcription factor
chr19_+_13135368 1.913 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_+_13135809 1.892 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_177140062 1.851 FAM5B
family with sequence similarity 5, member B
chr19_+_13135745 1.835 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr14_-_24020766 1.829 NM_033400
ZFHX2
zinc finger homeobox 2
chr7_+_18535817 1.828 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr3_+_88188261 1.768 NM_018293
ZNF654
zinc finger protein 654
chr3_-_114343052 1.766 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_99548471 1.752 NM_001204068
NM_001204069
NM_001204070
NM_020140
NM_181670
NM_001204066
ANKS1B





ankyrin repeat and sterile alpha motif domain containing 1B





chr14_-_57960432 1.739 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr6_+_26156558 1.726 NM_005321
HIST1H1E
histone cluster 1, H1e
chr2_-_160472960 1.701 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr13_+_97794050 1.693 MBNL2
muscleblind-like 2 (Drosophila)
chr2_+_29038862 1.664 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr15_+_71433787 1.659 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr15_+_90544608 1.655 NM_198526
ZNF710
zinc finger protein 710
chr10_+_63661012 1.647 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr18_-_48724031 1.646 NM_016626
MEX3C
mex-3 homolog C (C. elegans)
chr6_+_37137882 1.631 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr20_+_32150139 1.631 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr17_+_36861857 1.628 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr2_+_33359607 1.617 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr6_-_128222175 1.599 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr4_-_184241926 1.594 NM_001111319
CLDN22
claudin 22
chr2_+_86668488 1.575 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr14_-_73493744 1.573 NM_021260
ZFYVE1
zinc finger, FYVE domain containing 1
chr3_-_135913276 1.556 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr12_-_99548867 1.548 NM_001204067
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr9_+_103340335 1.543 NM_001018116
MURC
muscle-related coiled-coil protein
chr2_+_86668428 1.539 KDM3A
lysine (K)-specific demethylase 3A
chr13_-_60325073 1.536


chr19_-_40324747 1.528 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr7_+_18548899 1.528 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr3_+_187943192 1.524 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr15_+_71839540 1.518 THSD4
thrombospondin, type I, domain containing 4
chr1_-_155177685 1.514 NM_001252607
NM_001252608
NM_007112
THBS3


thrombospondin 3


chr1_+_167298280 1.509 NM_001198783
POU2F1
POU class 2 homeobox 1
chr19_+_18118921 1.494 NM_015683
ARRDC2
arrestin domain containing 2
chr22_+_31477231 1.491 NM_006932
NM_134269
NM_134270
SMTN


smoothelin


chr10_-_75193297 1.490 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr3_+_183353355 1.483 NM_017644
KLHL24
kelch-like 24 (Drosophila)
chr2_+_86668270 1.470 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr7_-_16921596 1.463 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr8_-_103666018 1.445 NM_001032282
KLF10
Kruppel-like factor 10
chr5_-_172198160 1.442 NM_004417
DUSP1
dual specificity phosphatase 1
chr13_+_97928414 1.436 MBNL2
muscleblind-like 2 (Drosophila)
chr1_+_177140530 1.431 NM_021165
FAM5B
family with sequence similarity 5, member B
chr6_-_139613114 1.429 NM_153235
TXLNB
taxilin beta
chr1_-_213020947 1.415 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr5_-_39425030 1.411 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr12_-_102872329 1.395 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_178840079 1.395 NM_004673
ANGPTL1
angiopoietin-like 1
chr14_-_61190458 1.385 NM_017420
SIX4
SIX homeobox 4
chr7_+_102553343 1.378 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr13_+_52436116 1.371 NM_031290
CCDC70
coiled-coil domain containing 70
chr6_+_26156552 1.370 HIST1H1E
histone cluster 1, H1e
chr2_-_208030613 1.365 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr5_-_148758787 1.363 NM_014443
IL17B
interleukin 17B
chr11_-_64684606 1.356 NM_015104
ATG2A
ATG2 autophagy related 2 homolog A (S. cerevisiae)
chr2_+_169923531 1.355 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr3_-_187454247 1.347 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr1_+_203020310 1.346 NM_015053
PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr6_+_7579692 1.346 DSP
desmoplakin
chr11_+_46299585 1.344 CREB3L1
cAMP responsive element binding protein 3-like 1
chr3_+_19189969 1.343 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr14_-_71275732 1.333 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr12_-_28124915 1.332 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr12_+_14538232 1.320 ATF7IP
activating transcription factor 7 interacting protein
chr19_+_7660698 1.318 NM_001080429
NM_020902
CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chr11_-_129062092 1.312 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr15_+_80364902 1.312 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr15_+_99191671 1.310 IGF1R
insulin-like growth factor 1 receptor
chr11_-_16497917 1.307 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr15_-_56209305 1.300 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr5_+_173472692 1.299 NM_015980
HMP19
HMP19 protein
chr10_-_62332666 1.298 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_+_71494460 1.297 NM_031889
ENAM
enamelin
chr10_-_94003002 1.286 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr2_-_158182154 1.282 NM_020711
ERMN
ermin, ERM-like protein
chr16_+_69726751 1.281 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr5_+_55147206 1.272 NM_001242637
NM_001242638
NM_139017
IL31RA


interleukin 31 receptor A


chr7_-_139876718 1.260 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr20_-_22566092 1.259 NM_153675
FOXA2
forkhead box A2
chr2_-_225370687 1.253 CUL3
cullin 3
chr20_-_22564893 1.234 FOXA2
forkhead box A2
chr9_-_4300028 1.234 NM_001042413
GLIS3
GLIS family zinc finger 3
chr10_-_11574273 1.231 NM_001080491
USP6NL
USP6 N-terminal like
chr11_-_84634437 1.221 NM_001364
DLG2
discs, large homolog 2 (Drosophila)
chr10_-_14372807 1.213 NM_018027
FRMD4A
FERM domain containing 4A
chr10_+_112631675 1.209 PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
chr15_+_83477972 1.205 NM_001080435
WHAMM
WAS protein homolog associated with actin, golgi membranes and microtubules
chr3_+_136676706 1.199 NM_144717
IL20RB
interleukin 20 receptor beta
chr10_-_13749622 1.192 FRMD4A
FERM domain containing 4A
chr5_-_39394423 1.188 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_+_109204904 1.186 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_+_18330044 1.184 HDAC9
histone deacetylase 9
chr16_+_50300461 1.175 ADCY7
adenylate cyclase 7
chr5_+_172484353 1.175 C5orf41
chromosome 5 open reading frame 41
chr1_-_221915458 1.172 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr22_+_38597938 1.169 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr9_-_4152182 1.167 NM_152629
GLIS3
GLIS family zinc finger 3
chr1_-_221915393 1.166 DUSP10
dual specificity phosphatase 10
chr19_-_3979828 1.164 EEF2
eukaryotic translation elongation factor 2
chr1_-_221910801 1.160 NM_144728
DUSP10
dual specificity phosphatase 10
chr5_+_78532338 1.155


chr13_+_97928196 1.152 MBNL2
muscleblind-like 2 (Drosophila)
chr13_+_24144402 1.151 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr2_+_228678556 1.148 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr12_-_117319231 1.148 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr7_+_18548963 1.147 HDAC9
histone deacetylase 9
chr10_+_22605300 1.145 NM_001204062
NM_012071
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr11_-_85430117 1.143 NM_206929
SYTL2
synaptotagmin-like 2
chrX_+_70765479 1.136 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr16_-_75272524 1.134 BCAR1
breast cancer anti-estrogen resistance 1
chr4_+_123161119 1.134 KIAA1109
KIAA1109
chr7_+_28530747 1.131 CREB5
cAMP responsive element binding protein 5
chr15_-_86338017 1.130 KLHL25
kelch-like 25 (Drosophila)
chr22_-_40859423 1.129 MKL1
megakaryoblastic leukemia (translocation) 1
chr4_-_2263808 1.128 MXD4
MAX dimerization protein 4
chrM_+_2211 1.121


chr13_+_36050885 1.120 NM_001204197
NBEA
neurobeachin
chr17_-_39092714 1.120 KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_211018294 1.112 C2orf67
chromosome 2 open reading frame 67
chr22_+_40440664 1.111 NM_001024843
TNRC6B
trinucleotide repeat containing 6B
chr5_+_138678130 1.106 NM_001033112
PAIP2
poly(A) binding protein interacting protein 2
chr7_+_17382900 1.103 AHR
aryl hydrocarbon receptor
chr9_+_96846710 1.099 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chr14_-_21572789 1.097 NM_001102454
ZNF219
zinc finger protein 219
chr12_-_86230158 1.094 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr1_+_201476283 1.090


chr11_-_46615584 1.089 AMBRA1
autophagy/beclin-1 regulator 1
chr19_+_48964505 1.088 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr2_+_171571936 1.087


chr1_+_167298382 1.077 POU2F1
POU class 2 homeobox 1
chr2_-_208994408 1.077 NM_020989
CRYGC
crystallin, gamma C
chr17_-_46703613 1.076 NM_024017
HOXB9
homeobox B9

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.73 4.34e-09 GO:0050794 regulation of cellular process
2.25 5.13e-08 GO:0060255 regulation of macromolecule metabolic process
2.57 5.55e-08 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.65 7.57e-08 GO:0050789 regulation of biological process
2.50 1.45e-07 GO:0010556 regulation of macromolecule biosynthetic process
2.63 2.01e-07 GO:0006355 regulation of transcription, DNA-dependent
2.58 2.15e-07 GO:0051252 regulation of RNA metabolic process
2.43 4.22e-07 GO:0010468 regulation of gene expression
2.14 4.72e-07 GO:0080090 regulation of primary metabolic process
2.37 6.29e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.37 6.29e-07 GO:0031326 regulation of cellular biosynthetic process
2.34 9.41e-07 GO:0009889 regulation of biosynthetic process
2.30 1.84e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.56 2.01e-06 GO:0065007 biological regulation
2.07 2.41e-06 GO:0031323 regulation of cellular metabolic process
2.43 2.78e-06 GO:0048519 negative regulation of biological process
2.49 4.84e-06 GO:0048523 negative regulation of cellular process
3.87 4.84e-06 GO:0051173 positive regulation of nitrogen compound metabolic process
1.97 5.73e-06 GO:0019222 regulation of metabolic process
3.83 1.24e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.61 1.93e-05 GO:0031328 positive regulation of cellular biosynthetic process
4.20 2.21e-05 GO:0010629 negative regulation of gene expression
3.55 2.70e-05 GO:0009891 positive regulation of biosynthetic process
4.08 3.74e-05 GO:0045893 positive regulation of transcription, DNA-dependent
4.06 3.97e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.93 5.68e-05 GO:0032502 developmental process
4.27 8.30e-05 GO:0045892 negative regulation of transcription, DNA-dependent
3.88 8.50e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
3.23 9.30e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
4.19 1.14e-04 GO:0051253 negative regulation of RNA metabolic process
3.80 1.22e-04 GO:0051254 positive regulation of RNA metabolic process
3.95 1.36e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.76 1.44e-04 GO:0010628 positive regulation of gene expression
3.90 1.66e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
3.73 1.70e-04 GO:0031327 negative regulation of cellular biosynthetic process
3.57 1.75e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
3.65 2.40e-04 GO:0009890 negative regulation of biosynthetic process
2.15 5.40e-04 GO:0048522 positive regulation of cellular process
4.50 1.06e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.93 1.26e-03 GO:0048856 anatomical structure development
3.06 1.36e-03 GO:0010605 negative regulation of macromolecule metabolic process
2.03 1.38e-03 GO:0048518 positive regulation of biological process
1.84 3.19e-03 GO:0007275 multicellular organismal development
2.60 3.39e-03 GO:0009893 positive regulation of metabolic process
13.91 3.40e-03 GO:0010594 regulation of endothelial cell migration
2.65 3.71e-03 GO:0031325 positive regulation of cellular metabolic process
2.83 4.95e-03 GO:0009892 negative regulation of metabolic process
2.82 1.36e-02 GO:0031324 negative regulation of cellular metabolic process
2.13 1.81e-02 GO:0048513 organ development
2.52 2.11e-02 GO:0010604 positive regulation of macromolecule metabolic process
3.63 2.73e-02 GO:0048646 anatomical structure formation involved in morphogenesis
3.55 3.52e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.80 3.98e-02 GO:0051128 regulation of cellular component organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.86 8.93e-03 GO:0005912 adherens junction
1.48 1.16e-02 GO:0005634 nucleus
5.29 1.82e-02 GO:0070161 anchoring junction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.29 3.37e-06 GO:0001071 nucleic acid binding transcription factor activity
3.29 3.37e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.96 3.57e-03 GO:0003677 DNA binding
3.06 3.75e-03 GO:0043565 sequence-specific DNA binding
1.40 7.20e-03 GO:0005515 protein binding
108.95 1.22e-02 GO:0019871 sodium channel inhibitor activity
25.15 2.96e-02 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
23.35 3.75e-02 GO:0033549 MAP kinase phosphatase activity