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Motif ID: HLF.p2

Z-value: 1.710

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr16_+_72088507	5.012	NM_001126102 NM_005143	HP	haptoglobin
chr16_+_72097124	4.546	NM_020995	HPR	haptoglobin-related protein
chr3_+_186383770	3.343	NM_000412	HRG	histidine-rich glycoprotein
chr19_+_35773409	3.276	NM_021175	HAMP	hepcidin antimicrobial peptide
chr9_-_107666046	2.723		ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1
chr1_-_230849936	2.539		AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_99279935	2.401	NM_001160154	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr12_-_46121248	2.371		LOC400027	uncharacterized LOC400027
chr6_+_131894343	2.352	NM_000045 NM_001244438	ARG1	arginase, liver
chr16_+_30484049	2.345		ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr8_+_24151579	2.267	NM_014265 NM_021777	ADAM28	ADAM metallopeptidase domain 28
chr5_+_126112314	2.154	NM_005573	LMNB1	lamin B1
chr16_+_30483959	2.046	NM_001114380 NM_002209	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr6_-_24489738	1.978	NM_177483 NM_001503	GPLD1	glycosylphosphatidylinositol specific phospholipase D1
chr1_-_230849863	1.955		AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr10_-_82049178	1.706	NM_000429	MAT1A	methionine adenosyltransferase I, alpha
chr9_+_117092068	1.701	NM_000608	ORM2	orosomucoid 2
chr3_+_186435097	1.645	NM_000893 NM_001102416 NM_001166451	KNG1	kininogen 1
chr12_-_46121489	1.607		LOC400027	uncharacterized LOC400027
chr1_-_230849847	1.607		AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr5_-_147162251	1.561	NM_014790	JAKMIP2	janus kinase and microtubule interacting protein 2
chrX_+_152224862	1.554		PNMA3	paraneoplastic antigen MA3
chr9_-_95298251	1.502	NM_001197295 NM_001197296 NM_001393	ECM2	extracellular matrix protein 2, female organ and adipocyte specific
chr1_+_150954498	1.480	NM_003568	ANXA9	annexin A9
chr19_-_18314731	1.466	NM_002866	RAB3A	RAB3A, member RAS oncogene family
chr8_-_120651019	1.463	NM_001040092 NM_001130863 NM_006209	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2
chr9_+_117085302	1.446	NM_000607	ORM1	orosomucoid 1
chr6_+_56819923	1.425		BEND6	BEN domain containing 6
chr11_+_63057371	1.324	NM_001039752	SLC22A10	solute carrier family 22, member 10
chr5_+_150632612	1.289	NM_000405 NM_001167607	GM2A	GM2 ganglioside activator
chr2_-_73869493	1.270	NM_003960	NAT8	N-acetyltransferase 8 (GCN5-related, putative)
chr3_-_170744458	1.257		SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2
chr17_-_36956145	1.252	NM_003559	PIP4K2B	phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr17_-_10372875	1.230	NM_017533	MYH4	myosin, heavy chain 4, skeletal muscle
chr3_-_190580464	1.223	NM_001146686	GMNC	geminin coiled-coil domain containing
chr1_+_154377847	1.203		IL6R	interleukin 6 receptor
chrX_+_152224765	1.190	NM_013364	PNMA3	paraneoplastic antigen MA3
chr11_-_116663106	1.178	NM_001166598 NM_052968	APOA5	apolipoprotein A-V
chr17_-_34328530	1.174		CCL14-CCL15 CCL15	CCL14-CCL15 readthrough chemokine (C-C motif) ligand 15
chr2_+_65663812	1.156		FLJ16124	FLJ16124 protein
chr17_+_67498391	1.131		MAP2K6	mitogen-activated protein kinase kinase 6
chr5_-_140012730	1.104		CD14	CD14 molecule
chr19_-_47617008	1.095	NM_015168	ZC3H4	zinc finger CCCH-type containing 4
chr2_+_179184970	1.087	NM_145739	OSBPL6	oxysterol binding protein-like 6
chr1_-_173174611	1.084		TNFSF4	tumor necrosis factor (ligand) superfamily, member 4
chr6_+_34216344	1.075
chr8_+_40010986	1.064	NM_020130	C8orf4	chromosome 8 open reading frame 4
chr22_+_35462125	1.056	NM_001008494	ISX	intestine-specific homeobox
chr1_-_62785067	1.033	NM_181712	KANK4	KN motif and ankyrin repeat domains 4
chr12_+_29376596	1.024	NM_018099	FAR2	fatty acyl CoA reductase 2
chr12_+_16500075	1.017	NM_145792	MGST1	microsomal glutathione S-transferase 1
chr2_-_169887832	0.976	NM_003742	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr3_-_195938256	0.975	NM_001039617	ZDHHC19	zinc finger, DHHC-type containing 19
chr20_-_5100443	0.956	NM_182649	PCNA	proliferating cell nuclear antigen
chr3_-_169587598	0.946	NM_024727	LRRC31	leucine rich repeat containing 31
chr8_-_103137134	0.929	NM_001040630	NCALD	neurocalcin delta
chr9_-_118416	0.928	NM_207305	FOXD4	forkhead box D4
chr5_+_149151502	0.925	NM_001172699	PPARGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr15_+_63050761	0.909		TLN2	talin 2
chr6_-_30080866	0.901	NM_007028	TRIM31	tripartite motif containing 31
chr10_+_74653338	0.897	NM_152635	OIT3	oncoprotein induced transcript 3
chr8_+_120079423	0.890	NM_006438	COLEC10	collectin sub-family member 10 (C-type lectin)
chr20_+_33759773	0.886	NM_006404	PROCR	protein C receptor, endothelial
chr10_+_89267589	0.882	NM_001178118	MINPP1	multiple inositol-polyphosphate phosphatase 1
chr16_-_53537112	0.877	NM_001012398 NM_022476	AKTIP	AKT interacting protein
chr19_-_46088074	0.872		OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr5_-_53606387	0.863	NM_019087	ARL15	ADP-ribosylation factor-like 15
chr1_-_102462789	0.856	NM_058170	OLFM3	olfactomedin 3
chrX_+_9431314	0.847	NM_001139466 NM_001139467 NM_001139468	TBL1X	transducin (beta)-like 1X-linked
chr6_-_114384008	0.839	NM_153612	HS3ST5	heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chrX_-_33229428	0.834	NM_004006	DMD	dystrophin
chr1_+_151032150	0.828	NM_006818	MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_+_129724503	0.792	NM_001190728	RALGPS1	Ral GEF with PH domain and SH3 binding motif 1
chr15_-_66790068	0.791	NM_006049	SNAPC5	small nuclear RNA activating complex, polypeptide 5, 19kDa
chr5_-_111091947	0.784	NM_001142483	C5orf13	chromosome 5 open reading frame 13
chr19_-_6459735	0.781	NM_024103	SLC25A23	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr16_+_31711914	0.780		KIAA0664L3	KIAA0664-like 3
chr3_-_195306274	0.774		APOD	apolipoprotein D
chr19_-_49622278	0.769	NM_018111	C19orf73	chromosome 19 open reading frame 73
chr17_+_74536114	0.764	NM_001077620	PRCD	progressive rod-cone degeneration
chr16_+_57406398	0.756	NM_002996	CX3CL1	chemokine (C-X3-C motif) ligand 1
chr5_-_147162264	0.754		JAKMIP2	janus kinase and microtubule interacting protein 2
chr17_-_34329083	0.742	NM_032965	CCL15	chemokine (C-C motif) ligand 15
chr16_+_19079220	0.733	NM_001190983	COQ7	coenzyme Q7 homolog, ubiquinone (yeast)
chr3_+_101280679	0.726	NM_017819	RG9MTD1	RNA (guanine-9-) methyltransferase domain containing 1
chr2_-_158300517	0.719	NM_004288	CYTIP	cytohesin 1 interacting protein
chr20_+_42187634	0.704	NM_170693	SGK2	serum/glucocorticoid regulated kinase 2
chr1_-_154600446	0.704	NM_001025107	ADAR	adenosine deaminase, RNA-specific
chr17_-_41277409	0.701	NM_007297 NM_007299 NM_007294 NM_007300	BRCA1	breast cancer 1, early onset
chr2_-_190627923	0.700	NM_022353	OSGEPL1	O-sialoglycoprotein endopeptidase-like 1
chr14_+_75894508	0.693	NM_001135047	JDP2	Jun dimerization protein 2
chr4_+_69962191	0.690	NM_001074	UGT2B7	UDP glucuronosyltransferase 2 family, polypeptide B7
chr5_-_58882274	0.681	NM_006203	PDE4D	phosphodiesterase 4D, cAMP-specific
chr1_+_229440128	0.680	NM_006542	SPHAR	S-phase response (cyclin related)
chr15_-_23034365	0.678		NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2
chr2_-_88427535	0.675	NM_001443	FABP1	fatty acid binding protein 1, liver
chr16_+_68057144	0.673	NM_017803	DUS2L	dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
chr2_-_110962539	0.663		NPHP1	nephronophthisis 1 (juvenile)
chr4_+_108911008	0.660		HADH	hydroxyacyl-CoA dehydrogenase
chr5_+_36606667	0.660		SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_36606456	0.656	NM_001166696 NM_004172	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_-_23285011	0.655	NM_001126105	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_-_154600383	0.650		ADAR	adenosine deaminase, RNA-specific
chr21_+_45079375	0.650	NM_015056	RRP1B	ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr1_-_102462371	0.642		OLFM3	olfactomedin 3
chr1_+_192605267	0.641	NM_002927 NM_144766	RGS13	regulator of G-protein signaling 13
chr20_+_62372436	0.632		SLC2A4RG	SLC2A4 regulator
chr10_+_91152321	0.629	NM_001548	IFIT1	interferon-induced protein with tetratricopeptide repeats 1
chr14_-_23284617	0.626		SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_+_140501399	0.622		PCDHB4	protocadherin beta 4
chr17_-_41277304	0.622		BRCA1	breast cancer 1, early onset
chr15_-_63674074	0.608	NM_001218 NM_206925	CA12	carbonic anhydrase XII
chr9_+_36169384	0.608	NM_005893	CCIN	calicin
chr10_+_99496938	0.606		ZFYVE27	zinc finger, FYVE domain containing 27
chrX_-_117251302	0.596	NM_001168301	KLHL13	kelch-like 13 (Drosophila)
chr1_+_196857143	0.593	NM_001201550 NM_001201551 NM_006684	CFHR4	complement factor H-related 4
chr5_+_95997871	0.588	NM_001042440	CAST	calpastatin
chr7_+_151722774	0.582	NM_022087	GALNT11	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr7_-_83824216	0.576	NM_006080	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr17_-_34328607	0.575		CCL14-CCL15	CCL14-CCL15 readthrough
chr12_+_124773709	0.574	NM_181709	FAM101A	family with sequence similarity 101, member A
chr21_+_45138973	0.573	NM_003681	PDXK	pyridoxal (pyridoxine, vitamin B6) kinase
chr7_-_129592711	0.571	NM_001202498	UBE2H	ubiquitin-conjugating enzyme E2H
chr6_+_27833033	0.570	NM_003511	HIST1H2AI HIST1H2AL	histone cluster 1, H2ai histone cluster 1, H2al
chr11_-_18062304	0.567	NM_004179	TPH1	tryptophan hydroxylase 1
chr13_-_41768533	0.564	NM_032138	KBTBD7	kelch repeat and BTB (POZ) domain containing 7
chr1_+_40839368	0.558	NM_022733	SMAP2	small ArfGAP2
chr7_-_129592794	0.557	NM_003344 NM_182697	UBE2H	ubiquitin-conjugating enzyme E2H
chr16_-_30457197	0.553	NM_012248	SEPHS2	selenophosphate synthetase 2
chr9_-_77503009	0.543	NM_017662	TRPM6	transient receptor potential cation channel, subfamily M, member 6
chr3_-_12586962	0.540	NM_001195279	LOC100129480	uncharacterized LOC100129480
chr1_-_62784971	0.536		KANK4	KN motif and ankyrin repeat domains 4
chr19_-_41356193	0.533	NM_000762	CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6
chr3_-_185655833	0.532	NM_001243879 NM_004593	TRA2B	transformer 2 beta homolog (Drosophila)
chr15_-_42840910	0.522		LRRC57	leucine rich repeat containing 57
chr2_-_152684882	0.517		ARL5A	ADP-ribosylation factor-like 5A
chr17_-_41322211	0.513		BRCA1	breast cancer 1, early onset
chr9_-_77643307	0.513	NM_152420	C9orf41	chromosome 9 open reading frame 41
chr20_+_23342786	0.510		GZF1	GDNF-inducible zinc finger protein 1
chr19_-_35992798	0.508	NM_001035516	DMKN	dermokine
chr9_-_6015606	0.508	NM_001243202 NM_001243203 NM_012416	RANBP6	RAN binding protein 6
chr9_+_111624545	0.507	NM_006687	ACTL7A	actin-like 7A
chr8_+_38585703	0.502	NM_001146216	TACC1	transforming, acidic coiled-coil containing protein 1
chr1_-_109935869	0.498	NM_001205228	SORT1	sortilin 1
chr7_-_15601574	0.494	NM_001004320	AGMO	alkylglycerol monooxygenase
chr1_-_230850335	0.492	NM_000029	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_-_2840683	0.490		SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr6_-_30028755	0.485		ZNRD1-AS1	ZNRD1 antisense RNA 1 (non-protein coding)
chr2_-_191872322	0.484		STAT1	signal transducer and activator of transcription 1, 91kDa
chr5_+_140718353	0.484	NM_018915 NM_032009	PCDHGA2	protocadherin gamma subfamily A, 2
chr3_+_122044010	0.484	NM_005213	CSTA	cystatin A (stefin A)
chr2_+_201756639	0.483	NM_001142356	NIF3L1	NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr19_+_36486042	0.476	NM_001042631	SDHAF1	succinate dehydrogenase complex assembly factor 1
chr7_+_94297448	0.474		PEG10	paternally expressed 10
chr6_-_56407681	0.462
chr7_-_122342965	0.462	NM_198085	RNF148	ring finger protein 148
chr6_+_101846668	0.459		GRIK2	glutamate receptor, ionotropic, kainate 2
chr5_+_150399980	0.456	NM_002084	GPX3	glutathione peroxidase 3 (plasma)
chr3_-_185655806	0.452		TRA2B	transformer 2 beta homolog (Drosophila)
chr1_+_100111430	0.451	NM_017734	PALMD	palmdelphin
chr10_-_98325100	0.449		TM9SF3	transmembrane 9 superfamily member 3
chr1_+_119683006	0.449
chr9_-_14398981	0.447	NM_001190738	NFIB	nuclear factor I/B
chr11_-_33795892	0.442	NM_012175 NM_033406	FBXO3	F-box protein 3
chr6_-_64029847	0.438	NM_001143940 NM_016571	LGSN	lengsin, lens protein with glutamine synthetase domain
chr10_-_104211244	0.434	NM_024886	C10orf95	chromosome 10 open reading frame 95
chr20_+_23342844	0.433		GZF1	GDNF-inducible zinc finger protein 1
chr12_-_8043743	0.431		SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14
chr5_+_140729723	0.430	NM_018922 NM_032095	PCDHGB1	protocadherin gamma subfamily B, 1
chr1_-_173176314	0.430	NM_003326	TNFSF4	tumor necrosis factor (ligand) superfamily, member 4
chr5_+_42548314	0.428	NM_001242403	GHR	growth hormone receptor
chr19_+_49109999	0.427	NM_133498	SPACA4	sperm acrosome associated 4
chr19_-_46088021	0.425		OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr12_+_65224214	0.420
chr8_+_98788014	0.420		LAPTM4B	lysosomal protein transmembrane 4 beta
chr2_-_86422892	0.419	NM_001100169 NM_001100170 NM_006839	IMMT	inner membrane protein, mitochondrial
chr3_+_155860750	0.416	NM_003471	KCNAB1	potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_+_40839429	0.415		SMAP2	small ArfGAP2
chr7_-_45026204	0.411		SNHG15	small nucleolar RNA host gene 15 (non-protein coding)
chr3_+_124303505	0.406	NM_007064	KALRN	kalirin, RhoGEF kinase
chr2_-_32490688	0.406	NM_001199139 NM_021209	NLRC4	NLR family, CARD domain containing 4
chr15_-_63673918	0.405		CA12	carbonic anhydrase XII
chr15_-_83621350	0.404	NM_004839 NM_199330	HOMER2	homer homolog 2 (Drosophila)
chr9_-_77643179	0.402		C9orf41	chromosome 9 open reading frame 41
chr3_-_93782066	0.400	NM_001195643	DHFRL1	dihydrofolate reductase-like 1
chr20_+_42187705	0.397		SGK2	serum/glucocorticoid regulated kinase 2
chr6_-_116447225	0.397	NM_000493	COL10A1	collagen, type X, alpha 1
chr12_+_7013896	0.397	NM_001135217 NM_006992 NM_201650	LRRC23	leucine rich repeat containing 23
chr5_+_95998170	0.394		CAST	calpastatin
chr6_+_131148544	0.394	NM_001195597	LOC100507203	uncharacterized LOC100507203
chr11_-_6462129	0.389	NM_000613	HPX	hemopexin
chr19_-_36233311	0.388	NM_024660	IGFLR1	IGF-like family receptor 1
chr1_-_204121144	0.388	NM_018208	ETNK2	ethanolamine kinase 2
chr3_+_141457035	0.388	NM_001201370 NM_014245 NM_183237	RNF7	ring finger protein 7
chr11_+_3818953	0.387	NM_001145438	PGAP2	post-GPI attachment to proteins 2
chr4_-_100485173	0.385	NM_001134665 NM_001134666	RG9MTD2	RNA (guanine-9-) methyltransferase domain containing 2
chr4_+_108911042	0.382		HADH	hydroxyacyl-CoA dehydrogenase
chr14_-_23284565	0.378		SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr4_-_38858407	0.378	NM_006068	TLR6	toll-like receptor 6
chr16_-_30457168	0.376		SEPHS2	selenophosphate synthetase 2

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
15.99	5.22e-03	GO:0032496	response to lipopolysaccharide
10.36	7.95e-03	GO:0009617	response to bacterium
14.53	8.31e-03	GO:0002237	response to molecule of bacterial origin
47.55	1.24e-02	GO:0071825	protein-lipid complex subunit organization
47.55	1.24e-02	GO:0071827	plasma lipoprotein particle organization
9.31	1.45e-02	GO:0006954	inflammatory response
5.04	1.88e-02	GO:0006952	defense response
5.53	2.79e-02	GO:0044255	cellular lipid metabolic process
35.33	3.08e-02	GO:0097006	regulation of plasma lipoprotein particle levels
33.42	3.65e-02	GO:0006953	acute-phase response
31.71	4.28e-02	GO:0071222	cellular response to lipopolysaccharide

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
3.91	7.50e-06	GO:0005576	extracellular region
5.56	1.69e-05	GO:0044421	extracellular region part
6.11	7.28e-05	GO:0005615	extracellular space
137.32	6.86e-03	GO:0045179	apical cortex

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
18.16	6.75e-06	GO:0001871	pattern binding
18.16	6.75e-06	GO:0030247	polysaccharide binding
16.84	9.59e-05	GO:0005539	glycosaminoglycan binding
18.58	4.95e-04	GO:0008201	heparin binding
7.92	1.71e-03	GO:0030246	carbohydrate binding
137.32	6.45e-03	GO:0030492	hemoglobin binding
137.32	6.45e-03	GO:0060229	lipase activator activity