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• Activity deltas table
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Motif ID: JUN.p2

Z-value: 2.398

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr19_+_45971249	11.269	NM_001114171 NM_006732	FOSB	FBJ murine osteosarcoma viral oncogene homolog B
chr11_-_1593149	8.310	NM_004420	DUSP8	dual specificity phosphatase 8
chr5_-_172198160	6.543	NM_004417	DUSP1	dual specificity phosphatase 1
chr19_+_49375677	6.081		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr19_+_49375638	5.913	NM_014330	PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr19_+_49375679	5.893		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr7_+_28448970	5.085		LOC401317	uncharacterized LOC401317
chr12_-_123380608	4.626
chr8_-_95274540	4.620	NM_005261 NM_181702	GEM	GTP binding protein overexpressed in skeletal muscle
chr4_+_75480628	4.585	NM_001657	AREG	amphiregulin
chr1_+_212782103	4.495		ATF3	activating transcription factor 3
chr6_-_91006580	4.479	NM_001170794	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr22_+_38597938	4.442	NM_001161572 NM_001161574 NM_012323	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr6_-_91006460	4.170	NM_021813	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr12_-_123380682	4.164	NM_024667	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr6_+_139456240	3.878	NM_016217	HECA	headcase homolog (Drosophila)
chr8_-_95274520	3.825		GEM	GTP binding protein overexpressed in skeletal muscle
chr19_+_45504686	3.720	NM_006509	RELB	v-rel reticuloendotheliosis viral oncogene homolog B
chr1_-_59249687	3.637	NM_002228	JUN	jun proto-oncogene
chr22_+_38598065	3.608		MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr12_-_123380628	3.575		VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr19_+_11649578	3.487	NM_001299	CNN1	calponin 1, basic, smooth muscle
chr2_+_28615695	3.314		FOSL2	FOS-like antigen 2
chr8_+_128806720	3.313		PVT1	Pvt1 oncogene (non-protein coding)
chr6_+_135818938	3.234		LINC00271	long intergenic non-protein coding RNA 271
chr7_+_128312345	3.173	NM_001012454 NM_001128926	FAM71F2	family with sequence similarity 71, member F2
chr2_+_28615771	3.115	NM_005253	FOSL2	FOS-like antigen 2
chr2_+_28615668	3.069		FOSL2	FOS-like antigen 2
chr1_+_212738675	2.889	NM_001030287	ATF3	activating transcription factor 3
chr1_-_713985	2.858		LOC100288069	general transcription factor IIi pseudogene
chr7_-_100808832	2.851	NM_003378	VGF	VGF nerve growth factor inducible
chr21_-_43430448	2.629	NM_001098402 NM_001098403 NM_020727	ZNF295	zinc finger protein 295
chr2_+_220408742	2.579	NM_001005209	TMEM198	transmembrane protein 198
chr1_-_221915393	2.237		DUSP10	dual specificity phosphatase 10
chr10_-_3827418	2.150	NM_001160124 NM_001160125 NM_001300	KLF6	Kruppel-like factor 6
chr3_-_8543327	2.138		LOC100288428	uncharacterized LOC100288428
chr1_-_221915426	2.135		DUSP10	dual specificity phosphatase 10
chr14_+_23352430	2.068	NM_173527	REM2	RAS (RAD and GEM)-like GTP binding 2
chr12_-_12715244	2.032	NM_030640	DUSP16	dual specificity phosphatase 16
chr7_+_28725597	2.026	NM_001011666	CREB5	cAMP responsive element binding protein 5
chr1_-_221915458	2.009	NM_007207 NM_144729	DUSP10	dual specificity phosphatase 10
chr3_+_156544075	1.999	NM_001004316 NM_001193283	LEKR1	leucine, glutamate and lysine rich 1
chr5_-_57755787	1.997	NM_001252226 NM_006622	PLK2	polo-like kinase 2
chr3_-_50374875	1.990	NM_170713	RASSF1	Ras association (RalGDS/AF-6) domain family member 1
chr10_-_3827205	1.989		KLF6	Kruppel-like factor 6
chr1_+_212781969	1.972	NM_001040619 NM_001206484 NM_001206488 NM_001674	ATF3	activating transcription factor 3
chr1_+_32827797	1.968	NM_052841	TSSK3	testis-specific serine kinase 3
chrX_+_133941204	1.950	NM_001170782 NM_001170784 NM_001170779 NM_001170781 NM_001170783 NM_138819	FAM122C	family with sequence similarity 122C
chr9_+_130860769	1.934		SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr20_+_34203746	1.919	NM_003116	SPAG4	sperm associated antigen 4
chr2_+_149632772	1.917	NM_004522	KIF5C	kinesin family member 5C
chr3_+_50297644	1.905
chr12_-_132628841	1.849	NM_175066	DDX51	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr11_+_73087396	1.839	NM_152222	RELT	RELT tumor necrosis factor receptor
chr20_-_44600939	1.836		ZNF335	zinc finger protein 335
chr19_-_460995	1.830	NM_012435	SHC2	SHC (Src homology 2 domain containing) transforming protein 2
chr2_+_149632836	1.783		KIF5C	kinesin family member 5C
chr18_+_23806385	1.767	NM_005640	TAF4B	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr14_+_103995535	1.735		TRMT61A	tRNA methyltransferase 61 homolog A (S. cerevisiae)
chr1_+_203274646	1.720	NM_006763	BTG2	BTG family, member 2
chr9_+_34179047	1.713		UBAP1	ubiquitin associated protein 1
chr1_-_16482426	1.689	NM_004431	EPHA2	EPH receptor A2
chr19_-_47734215	1.676	NM_014417	BBC3	BCL2 binding component 3
chr2_-_172967627	1.670		DLX2	distal-less homeobox 2
chr19_+_13263890	1.663		IER2	immediate early response 2
chr10_+_134210691	1.626	NM_001098637 NM_138499	PWWP2B	PWWP domain containing 2B
chr10_+_104154228	1.610	NM_001077493 NM_001077494	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr1_+_16010816	1.602	NM_015164	PLEKHM2	pleckstrin homology domain containing, family M (with RUN domain) member 2
chr3_-_50374795	1.597		RASSF1	Ras association (RalGDS/AF-6) domain family member 1
chr9_+_102584136	1.584	NM_006981 NM_173199 NM_173200	NR4A3	nuclear receptor subfamily 4, group A, member 3
chr3_+_141087298	1.565		ZBTB38	zinc finger and BTB domain containing 38
chr8_-_144623579	1.548		ZC3H3	zinc finger CCCH-type containing 3
chr8_-_144623611	1.542	NM_015117	ZC3H3	zinc finger CCCH-type containing 3
chr5_-_64777703	1.541	NM_197941	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr22_+_21771661	1.520	NM_015094	HIC2	hypermethylated in cancer 2
chr14_+_103995473	1.501	NM_152307	TRMT61A	tRNA methyltransferase 61 homolog A (S. cerevisiae)
chr5_-_178054072	1.499		CLK4	CDC-like kinase 4
chr17_+_27071008	1.484	NM_004295	TRAF4	TNF receptor-associated factor 4
chr4_+_108745718	1.482	NM_001136258	SGMS2	sphingomyelin synthase 2
chr1_-_193155723	1.480	NM_003783	B3GALT2	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr17_+_4802866	1.474	NM_001145536	C17orf107	chromosome 17 open reading frame 107
chr1_+_16010838	1.457		PLEKHM2	pleckstrin homology domain containing, family M (with RUN domain) member 2
chr10_+_99079017	1.457	NM_005479	FRAT1	frequently rearranged in advanced T-cell lymphomas
chr9_+_130860816	1.431	NM_052901 NM_001006643	SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr19_-_55628780	1.427	NM_017607	PPP1R12C	protein phosphatase 1, regulatory subunit 12C
chr19_-_18392048	1.424		JUND	jun D proto-oncogene
chr8_-_29207795	1.420	NM_001394	DUSP4	dual specificity phosphatase 4
chr11_+_64692052	1.417	NM_006244	PPP2R5B	protein phosphatase 2, regulatory subunit B', beta
chr5_-_178054089	1.417		CLK4	CDC-like kinase 4
chr20_-_44600787	1.409	NM_022095	ZNF335	zinc finger protein 335
chr3_-_156877882	1.403		CCNL1	cyclin L1
chr1_+_45266035	1.398	NM_004073	PLK3	polo-like kinase 3
chr7_+_112090463	1.379	NM_001550	IFRD1	interferon-related developmental regulator 1
chr14_+_67999915	1.374	NM_020715	PLEKHH1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr12_-_49504612	1.350		LMBR1L	limb region 1 homolog (mouse)-like
chr9_+_139221931	1.344	NM_001145638 NM_015597	GPSM1	G-protein signaling modulator 1
chr9_-_99382073	1.342	NM_003671 NM_033331	CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr6_+_89791510	1.334		PNRC1	proline-rich nuclear receptor coactivator 1
chr16_+_29912146	1.325	NM_181718	ASPHD1	aspartate beta-hydroxylase domain containing 1
chr4_-_2010961	1.324	NM_005663	WHSC2	Wolf-Hirschhorn syndrome candidate 2
chr3_-_47933997	1.321		MAP4	microtubule-associated protein 4
chr11_+_111749947	1.315	NM_022761	C11orf1	chromosome 11 open reading frame 1
chr3_-_99594915	1.315	NM_014890	FILIP1L	filamin A interacting protein 1-like
chr3_-_187463474	1.314	NM_001706	BCL6	B-cell CLL/lymphoma 6
chr19_-_48614013	1.293	NM_001159322 NM_001159323 NM_003706	PLA2G4C	phospholipase A2, group IVC (cytosolic, calcium-independent)
chr6_-_135818786	1.290		AHI1	Abelson helper integration site 1
chr2_+_220144024	1.284	NM_001039550 NM_006736	DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2
chr19_-_18392436	1.278		JUND	jun D proto-oncogene
chr2_+_43864405	1.278		PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr4_+_88571453	1.277	NM_001079911 NM_004407	DMP1	dentin matrix acidic phosphoprotein 1
chr10_-_31320772	1.272	NM_001143766 NM_001143767 NM_001143768 NM_001143770 NM_001143771 NM_182755	ZNF438	zinc finger protein 438
chr7_-_45128492	1.272	NM_001146334	NACAD	NAC alpha domain containing
chr19_-_42759279	1.268	NM_006494	ERF	Ets2 repressor factor
chr15_+_78556901	1.247	NM_001130182	DNAJA4	DnaJ (Hsp40) homolog, subfamily A, member 4
chr15_-_60884615	1.239	NM_134262	RORA	RAR-related orphan receptor A
chr5_+_137673223	1.235	NM_001135647	FAM53C	family with sequence similarity 53, member C
chr19_-_59066372	1.234		CHMP2A	charged multivesicular body protein 2A
chr12_+_132628978	1.227	NM_024078	NOC4L	nucleolar complex associated 4 homolog (S. cerevisiae)
chr20_+_32254303	1.223	NM_001024675	ACTL10	actin-like 10
chr12_-_57914287	1.216	NM_001195053 NM_001195054 NM_001195055 NM_001195056 NM_001195057 NM_004083	DDIT3	DNA-damage-inducible transcript 3
chr2_+_43864433	1.212	NM_172069	PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr4_+_119512890	1.202		LOC729218	uncharacterized LOC729218
chr3_-_50374749	1.201		RASSF1	Ras association (RalGDS/AF-6) domain family member 1
chr3_-_133614296	1.199		RAB6B	RAB6B, member RAS oncogene family
chr5_-_145483877	1.196	NM_001029869	PLAC8L1	PLAC8-like 1
chr10_+_5566923	1.188	NM_005185	CALML3	calmodulin-like 3
chr19_-_18392413	1.187	NM_005354	JUND	jun D proto-oncogene
chr2_-_86850935	1.175		RNF103	ring finger protein 103
chr17_-_13505217	1.172	NM_006042	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr5_-_175964824	1.160		RNF44	ring finger protein 44
chr11_+_66610882	1.159	NM_001032279 NM_005133	RCE1	RCE1 homolog, prenyl protein protease (S. cerevisiae)
chr17_-_8059637	1.143		PER1	period homolog 1 (Drosophila)
chr7_+_20370324	1.142		ITGB8	integrin, beta 8
chr9_+_130830595	1.135		SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr9_+_35490018	1.133		RUSC2	RUN and SH3 domain containing 2
chr9_-_34397786	1.130	NM_032596	C9orf24	chromosome 9 open reading frame 24
chr19_+_55795766	1.127		BRSK1	BR serine/threonine kinase 1
chr2_+_228678556	1.125	NM_001130046 NM_004591	CCL20	chemokine (C-C motif) ligand 20
chr2_+_33172368	1.119	NM_206943	LTBP1	latent transforming growth factor beta binding protein 1
chr11_-_69519105	1.116	NM_005117	FGF19	fibroblast growth factor 19
chr9_+_130830447	1.115	NM_001006641	SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr18_+_77439798	1.112	NM_004715 NM_048368	CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr8_+_56686179	1.105
chr1_+_45266048	1.102		PLK3	polo-like kinase 3
chr16_-_54320367	1.099	NM_024336	IRX3	iroquois homeobox 3
chr19_+_13858687	1.095	NM_030818	CCDC130	coiled-coil domain containing 130
chr2_+_70142236	1.091		MXD1	MAX dimerization protein 1
chr10_-_64576074	1.088		EGR2	early growth response 2
chr2_+_37571752	1.086	NM_012413	QPCT	glutaminyl-peptide cyclotransferase
chr2_+_149633173	1.080
chr11_+_18343794	1.074	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr4_-_2010685	1.063		WHSC2	Wolf-Hirschhorn syndrome candidate 2
chr10_+_1094996	1.062
chr7_-_140624280	1.059	NM_004333	BRAF	v-raf murine sarcoma viral oncogene homolog B1
chr4_-_89618928	1.057	NM_153757	NAP1L5	nucleosome assembly protein 1-like 5
chr12_-_49504646	1.056	NM_018113	LMBR1L	limb region 1 homolog (mouse)-like
chr5_-_16617085	1.056	NM_001034850	FAM134B	family with sequence similarity 134, member B
chr8_-_101322245	1.055	NM_183419	RNF19A	ring finger protein 19A
chr9_+_12693385	1.051	NM_000550	TYRP1	tyrosinase-related protein 1
chr2_-_86850959	1.045	NM_001198951 NM_001198952 NM_005667	RNF103	ring finger protein 103
chr15_-_80215663	1.044	NM_001100880 NM_001199757	ST20	suppressor of tumorigenicity 20
chr5_-_178054001	1.039	NM_020666	CLK4	CDC-like kinase 4
chr5_-_54468833	1.034	NM_001145734 NM_001170402 NM_152623	CDC20B	cell division cycle 20 homolog B (S. cerevisiae)
chr17_-_8055684	1.032	NM_002616	PER1	period homolog 1 (Drosophila)
chr17_-_8151373	1.031	NM_025099	CTC1	CTS telomere maintenance complex component 1
chr4_+_103422479	1.031	NM_001165412 NM_003998	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr13_+_24144402	1.025	NM_001204459 NM_148957	TNFRSF19	tumor necrosis factor receptor superfamily, member 19
chr9_-_73029539	1.024	NM_001206	KLF9	Kruppel-like factor 9
chr6_-_88411872	1.021		AKIRIN2	akirin 2
chr19_-_42759151	1.021		ERF	Ets2 repressor factor
chr12_+_56915587	1.018	NM_002898	RBMS2	RNA binding motif, single stranded interacting protein 2
chr17_-_62833264	1.017		PLEKHM1P	pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chr9_+_35489989	1.014	NM_014806	RUSC2	RUN and SH3 domain containing 2
chr3_-_133614421	1.011	NM_016577	RAB6B	RAB6B, member RAS oncogene family
chr13_+_97928196	1.009		MBNL2	muscleblind-like 2 (Drosophila)
chr1_+_157963310	1.003		KIRREL	kin of IRRE like (Drosophila)
chr18_+_77439843	1.001		CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr10_-_64576123	0.997	NM_000399 NM_001136177 NM_001136179	EGR2	early growth response 2
chr14_+_55738871	0.993	NM_152231	FBXO34	F-box protein 34
chr2_+_70142303	0.990		MXD1	MAX dimerization protein 1
chr1_+_27719151	0.990	NM_005281	GPR3	G protein-coupled receptor 3
chr4_-_2010702	0.989		WHSC2	Wolf-Hirschhorn syndrome candidate 2
chr11_+_62475113	0.988	NM_012202	GNG3	guanine nucleotide binding protein (G protein), gamma 3
chr9_-_33402505	0.985	NM_001170	AQP7	aquaporin 7
chr19_+_55795533	0.983	NM_032430	BRSK1	BR serine/threonine kinase 1
chr21_+_47546427	0.983		COL6A2	collagen, type VI, alpha 2
chr2_+_10186284	0.980
chr3_+_150125983	0.972		TSC22D2	TSC22 domain family, member 2
chr7_+_123295860	0.962	NM_207163	LMOD2	leiomodin 2 (cardiac)
chr6_+_31783280	0.950	NM_005345	HSPA1A	heat shock 70kDa protein 1A
chr17_-_4607422	0.944		PELP1	proline, glutamate and leucine rich protein 1
chr1_+_46379258	0.942		MAST2	microtubule associated serine/threonine kinase 2
chr17_-_4607414	0.941		PELP1	proline, glutamate and leucine rich protein 1
chr16_-_88772732	0.937	NM_001171815	RNF166	ring finger protein 166
chrX_-_52987610	0.931	NM_001242491	FAM156A FAM156B	family with sequence similarity 156, member A family with sequence similarity 156, member B
chrX_+_84498993	0.930	NM_021998	ZNF711	zinc finger protein 711
chr19_+_57791794	0.930	NM_006635	ZNF460	zinc finger protein 460
chr3_+_158288952	0.929	NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_022443	MLF1	myeloid leukemia factor 1
chr10_-_18940515	0.928	NM_182543	NSUN6	NOP2/Sun domain family, member 6
chr10_+_63808968	0.922	NM_001244638	ARID5B	AT rich interactive domain 5B (MRF1-like)

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
2.10	9.24e-05	GO:0080090	regulation of primary metabolic process
2.07	1.40e-04	GO:0031323	regulation of cellular metabolic process
2.12	1.62e-04	GO:0060255	regulation of macromolecule metabolic process
3.66	2.55e-04	GO:0006351	transcription, DNA-dependent
27.76	4.87e-04	GO:0000188	inactivation of MAPK activity
1.92	9.38e-04	GO:0019222	regulation of metabolic process
3.30	1.27e-03	GO:0032774	RNA biosynthetic process
2.28	2.78e-03	GO:0051252	regulation of RNA metabolic process
2.43	9.47e-03	GO:0016070	RNA metabolic process
1.75	9.92e-03	GO:0044260	cellular macromolecule metabolic process
2.37	1.00e-02	GO:0010467	gene expression
2.06	1.25e-02	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
8.03	1.55e-02	GO:0006470	protein dephosphorylation
2.03	1.64e-02	GO:0048518	positive regulation of biological process
13.37	2.01e-02	GO:0043407	negative regulation of MAP kinase activity
2.00	2.35e-02	GO:0051171	regulation of nitrogen compound metabolic process
1.65	2.63e-02	GO:0043170	macromolecule metabolic process
7.28	2.91e-02	GO:0016311	dephosphorylation
2.00	3.17e-02	GO:0031326	regulation of cellular biosynthetic process
2.02	3.35e-02	GO:0010468	regulation of gene expression
2.05	3.38e-02	GO:0048522	positive regulation of cellular process
2.12	3.41e-02	GO:0090304	nucleic acid metabolic process
1.97	3.97e-02	GO:0009889	regulation of biosynthetic process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.60	2.61e-03	GO:0005634	nucleus
1.25	1.87e-02	GO:0044424	intracellular part
1.23	3.17e-02	GO:0005622	intracellular
1.29	3.42e-02	GO:0043229	intracellular organelle
1.29	3.68e-02	GO:0043226	organelle
57.74	4.45e-02	GO:0033256	I-kappaB/NF-kappaB complex

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
3.74	1.93e-06	GO:0001071	nucleic acid binding transcription factor activity
3.74	1.93e-06	GO:0003700	sequence-specific DNA binding transcription factor activity
55.52	1.98e-06	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
51.56	3.07e-06	GO:0033549	MAP kinase phosphatase activity
20.63	4.57e-05	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
3.82	2.23e-04	GO:0043565	sequence-specific DNA binding
8.94	6.32e-03	GO:0004725	protein tyrosine phosphatase activity
6.40	1.26e-02	GO:0004721	phosphoprotein phosphatase activity
2.00	1.50e-02	GO:0003677	DNA binding