Motif ID: KLF12.p2

Z-value: 4.199


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF12hg19_v1_chr13_-_74707913_747080650.661.6e-01Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_1606480 6.491 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr16_-_67978422 6.177 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr5_+_137801178 5.349 NM_001964
EGR1
early growth response 1
chr1_+_32827797 4.680 NM_052841
TSSK3
testis-specific serine kinase 3
chr11_+_62475113 4.449 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr5_+_137801166 4.132 EGR1
early growth response 1
chr22_+_31489343 4.117 SMTN
smoothelin
chr6_+_149721494 3.897 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr7_+_28448970 3.880 LOC401317
uncharacterized LOC401317
chr20_+_61867234 3.782 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr6_-_11382501 3.663 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_+_62475165 3.620 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr1_-_213020947 3.604 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr1_-_38471170 3.525 NM_001243878
NM_004468
FHL3

four and a half LIM domains 3

chr19_+_2249112 3.415 NM_000479
AMH
anti-Mullerian hormone
chr8_-_6420454 3.340 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr4_-_74964836 3.295 CXCL2
chemokine (C-X-C motif) ligand 2
chr3_-_169482847 3.232 TERC
telomerase RNA component
chr12_-_58159386 3.191 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr1_+_170633312 3.163 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr7_+_127233688 3.129 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr1_-_91182777 3.082 NM_020063
BARHL2
BarH-like homeobox 2
chr22_+_31487315 3.069 SMTN
smoothelin
chr12_+_57482886 3.036 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr12_+_57482922 3.016 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr1_-_32827843 3.000 NM_001167676
LOC100128071
uncharacterized LOC100128071
chr1_+_200842082 2.984 NM_005298
GPR25
G protein-coupled receptor 25
chr19_+_36208917 2.979 NM_014727
MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr12_+_121416294 2.976 HNF1A
HNF1 homeobox A
chr7_+_18535351 2.959 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr13_+_97999289 2.920


chr7_+_123295860 2.905 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr5_-_172198160 2.890 NM_004417
DUSP1
dual specificity phosphatase 1
chr19_+_13263890 2.845 IER2
immediate early response 2
chr14_-_75530716 2.843 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr19_-_46285752 2.840 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr16_-_67977956 2.837 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr19_-_46283281 2.751


chr8_-_29206321 2.742 NM_057158
DUSP4
dual specificity phosphatase 4
chr12_+_121416548 2.739 NM_000545
HNF1A
HNF1 homeobox A
chr7_-_27135524 2.731 NM_005522
NM_153620
HOXA1

homeobox A1

chrX_+_49126299 2.667 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory subunit 3F

chr6_-_44233244 2.642 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr6_-_152702450 2.636 SYNE1
spectrin repeat containing, nuclear envelope 1
chr15_-_65360297 2.633 NM_016563
RASL12
RAS-like, family 12
chr3_-_87040268 2.625 VGLL3
vestigial like 3 (Drosophila)
chr2_+_169659099 2.587 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr6_+_89790464 2.570 PNRC1
proline-rich nuclear receptor coactivator 1
chr7_+_28475233 2.538 NM_004904
CREB5
cAMP responsive element binding protein 5
chr2_+_28616360 2.535 FOSL2
FOS-like antigen 2
chr10_-_32636134 2.522 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr11_-_65667809 2.514 FOSL1
FOS-like antigen 1
chr1_+_203274646 2.506 NM_006763
BTG2
BTG family, member 2
chr1_-_221915393 2.501 DUSP10
dual specificity phosphatase 10
chr17_+_27071008 2.483 NM_004295
TRAF4
TNF receptor-associated factor 4
chr2_+_220408742 2.467 NM_001005209
TMEM198
transmembrane protein 198
chr1_-_33841142 2.465 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr2_-_74709965 2.453 CCDC142
coiled-coil domain containing 142
chrX_+_70364680 2.424 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3


chr14_+_58765209 2.418 NM_002892
NM_023000
NM_023001
ARID4A


AT rich interactive domain 4A (RBP1-like)


chr6_+_89790412 2.415 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr4_-_74904329 2.408 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr19_+_49376488 2.384 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr10_-_32636084 2.384 NM_025209
EPC1
enhancer of polycomb homolog 1 (Drosophila)
chrX_+_49126480 2.365 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr15_+_64791618 2.358 NM_015042
ZNF609
zinc finger protein 609
chr16_+_30675777 2.352 NM_001105079
FBRS
fibrosin
chr22_-_20004251 2.331 NM_001670
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr9_+_35538890 2.318 RUSC2
RUN and SH3 domain containing 2
chr10_-_92681025 2.318 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_-_172166202 2.315 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr1_+_201857997 2.310 SHISA4
shisa homolog 4 (Xenopus laevis)
chr2_+_70142236 2.309 MXD1
MAX dimerization protein 1
chr4_-_74964996 2.309 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr6_-_31648140 2.286 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr1_-_221915458 2.280 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr8_-_145060594 2.278 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr10_-_92680784 2.269 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr7_+_64498643 2.266 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr9_+_35538628 2.264 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr6_+_43457214 2.264 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr7_-_151071696 2.246


chr2_-_74710356 2.232 NM_032779
CCDC142
coiled-coil domain containing 142
chr8_-_8239188 2.229 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr3_-_99833348 2.216 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr19_+_9271367 2.181


chr12_-_53575121 2.176 CSAD
cysteine sulfinic acid decarboxylase
chr7_+_100081549 2.175 NM_173564
NYAP1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
chr1_-_221915426 2.169 DUSP10
dual specificity phosphatase 10
chr17_-_36831156 2.163 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr9_+_139972195 2.158 UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr10_+_104404195 2.155 NM_030912
TRIM8
tripartite motif containing 8
chr19_+_45504686 2.153 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr19_-_46285746 2.144 DMPK
dystrophia myotonica-protein kinase
chr2_+_220408352 2.139 TMEM198
transmembrane protein 198
chr8_+_128806720 2.129 PVT1
Pvt1 oncogene (non-protein coding)
chr9_-_4299574 2.128 GLIS3
GLIS family zinc finger 3
chr20_-_3149070 2.123 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr14_+_58765275 2.119 ARID4A
AT rich interactive domain 4A (RBP1-like)
chrX_+_49126326 2.116 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr17_-_40828441 2.098 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr19_+_2476122 2.094 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr9_+_139247508 2.084 NM_001145639
GPSM1
G-protein signaling modulator 1
chr6_+_108881010 2.061 NM_201559
FOXO3
forkhead box O3
chr15_+_89182038 2.049 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr19_+_45971249 2.048 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr3_+_50306578 2.036 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr8_-_145060563 2.025 PARP10
poly (ADP-ribose) polymerase family, member 10
chr1_+_177140530 2.020 NM_021165
FAM5B
family with sequence similarity 5, member B
chr8_-_95274540 2.006 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr19_+_7660698 1.984 NM_001080429
NM_020902
CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chr19_-_14260728 1.980 LPHN1
latrophilin 1
chr5_-_81046858 1.973 SSBP2
single-stranded DNA binding protein 2
chr10_-_77159851 1.970 ZNF503
zinc finger protein 503
chr15_+_85359910 1.952 NM_020778
ALPK3
alpha-kinase 3
chr3_+_119421865 1.951 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr6_-_33266297 1.949 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr14_+_24837225 1.941 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chrX_+_95939661 1.935 NM_006729
NM_007309
DIAPH2

diaphanous homolog 2 (Drosophila)

chr14_-_61190458 1.925 NM_017420
SIX4
SIX homeobox 4
chr9_-_123689172 1.920 NM_005658
TRAF1
TNF receptor-associated factor 1
chr19_+_827821 1.919 NM_001700
AZU1
azurocidin 1
chr3_-_133614421 1.912 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr6_-_41703345 1.905 TFEB
transcription factor EB
chr11_-_117100551 1.892 PCSK7
proprotein convertase subtilisin/kexin type 7
chr12_+_119616594 1.885 NM_014365
HSPB8
heat shock 22kDa protein 8
chr11_-_1619481 1.884 NM_001004325
KRTAP5-2
keratin associated protein 5-2
chr22_-_37915209 1.880 NM_014550
CARD10
caspase recruitment domain family, member 10
chr6_-_143266283 1.878 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr15_+_78556485 1.876 NM_018602
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr12_-_58160823 1.869 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_-_1507810 1.867 NM_001172223
MOB2
MOB kinase activator 2
chr14_+_103592663 1.865 NM_006291
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr6_-_30652434 1.863 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr9_+_130860769 1.861 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr9_+_130860816 1.855 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr11_+_6220375 1.854 NM_001005178
OR52W1
olfactory receptor, family 52, subfamily W, member 1
chr4_+_74735107 1.847 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr3_-_42814734 1.844 NM_144719
CCDC13
coiled-coil domain containing 13
chr12_+_57482674 1.844 NM_005967
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr12_-_51591949 1.844 NM_002702
POU6F1
POU class 6 homeobox 1
chr10_-_32635842 1.808 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr22_-_40859423 1.807 MKL1
megakaryoblastic leukemia (translocation) 1
chr17_-_37353731 1.801 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr3_+_50306305 1.800 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr5_+_55149149 1.799 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr12_+_79258517 1.798 SYT1
synaptotagmin I
chr22_-_39268169 1.795 CBX6
chromobox homolog 6
chr19_+_17830302 1.794 NM_018174
MAP1S
microtubule-associated protein 1S
chr19_+_36209125 1.793 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr14_+_55168831 1.786 SAMD4A
sterile alpha motif domain containing 4A
chr5_-_81046943 1.778 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr14_-_24020766 1.775 NM_033400
ZFHX2
zinc finger homeobox 2
chr8_-_95274520 1.771 GEM
GTP binding protein overexpressed in skeletal muscle
chr17_+_18855477 1.769 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr17_+_7743233 1.768 NM_001080424
KDM6B
lysine (K)-specific demethylase 6B
chr5_-_176936857 1.764 NM_024872
DOK3
docking protein 3
chr1_-_114354906 1.757 NM_018364
RSBN1
round spermatid basic protein 1
chr17_-_7232455 1.749 NM_001005408
NM_032442
NEURL4

neuralized homolog 4 (Drosophila)

chrX_-_103087106 1.738 NM_016370
RAB9B
RAB9B, member RAS oncogene family
chr12_-_54778298 1.738 ZNF385A
zinc finger protein 385A
chr12_+_120740123 1.737 NM_012240
SIRT4
sirtuin 4
chr22_-_39268214 1.735 CBX6
chromobox homolog 6
chr1_-_221910801 1.732 NM_144728
DUSP10
dual specificity phosphatase 10
chr7_+_107110501 1.716 NM_005295
GPR22
G protein-coupled receptor 22
chr7_-_100882100 1.706 NM_001185080
CLDN15
claudin 15
chr16_-_2159853 1.698 PKD1
polycystic kidney disease 1 (autosomal dominant)
chr4_-_185726865 1.695 ACSL1
acyl-CoA synthetase long-chain family member 1
chr1_-_155177685 1.690 NM_001252607
NM_001252608
NM_007112
THBS3


thrombospondin 3


chr8_-_8175860 1.683 SGK223
homolog of rat pragma of Rnd2
chr13_+_24144402 1.676 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr4_+_108745718 1.670 NM_001136258
SGMS2
sphingomyelin synthase 2
chr6_-_33267128 1.670 NM_001243738
NM_004761
RGL2

ral guanine nucleotide dissociation stimulator-like 2

chr17_-_1395950 1.669 NM_001080779
MYO1C
myosin IC
chr16_-_75301950 1.669 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chrX_-_48828250 1.660 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr2_+_29038862 1.658 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr11_-_62475060 1.656 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr12_-_26277807 1.650 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr19_+_11649578 1.641 NM_001299
CNN1
calponin 1, basic, smooth muscle
chrX_-_69479516 1.626 NM_002565
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr9_+_34179058 1.624 UBAP1
ubiquitin associated protein 1
chr19_+_544026 1.620 NM_005317
GZMM
granzyme M (lymphocyte met-ase 1)
chr1_+_110036657 1.620 NM_001134402
NM_001134400
NM_001134403
NM_001134404
NM_182580
CYB561D1




cytochrome b-561 domain containing 1




chr13_-_110438896 1.618 NM_003749
IRS2
insulin receptor substrate 2
chr12_+_79258588 1.617 SYT1
synaptotagmin I
chr22_+_31480981 1.612 NM_001207018
SMTN
smoothelin
chr11_-_63933204 1.610 MACROD1
MACRO domain containing 1
chr17_-_17399494 1.589 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr20_-_3154169 1.585 ProSAPiP1
ProSAPiP1 protein
chr12_-_112630525 1.584 C12orf51
chromosome 12 open reading frame 51
chr1_-_114354864 1.581 RSBN1
round spermatid basic protein 1
chr7_+_18330044 1.581 HDAC9
histone deacetylase 9
chr19_-_46000159 1.580 NM_005619
NM_206900
RTN2

reticulon 2

chr12_+_7045437 1.575


chr17_-_1548992 1.562 NM_003693
NM_145350
NM_145352
SCARF1


scavenger receptor class F, member 1


chr9_+_35490018 1.560 RUSC2
RUN and SH3 domain containing 2
chr2_+_70142303 1.560 MXD1
MAX dimerization protein 1
chr3_-_87040246 1.555 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr6_-_43595079 1.553 GTPBP2
GTP binding protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.30 4.39e-03 GO:0050789 regulation of biological process
2.26 7.69e-03 GO:0031328 positive regulation of cellular biosynthetic process
2.42 9.19e-03 GO:0051254 positive regulation of RNA metabolic process
2.32 1.11e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
2.22 1.11e-02 GO:0009891 positive regulation of biosynthetic process
1.50 1.21e-02 GO:0031323 regulation of cellular metabolic process
1.30 1.86e-02 GO:0050794 regulation of cellular process
1.66 1.88e-02 GO:0051252 regulation of RNA metabolic process
1.59 2.14e-02 GO:0031326 regulation of cellular biosynthetic process
1.51 2.20e-02 GO:0060255 regulation of macromolecule metabolic process
1.50 2.27e-02 GO:0007275 multicellular organismal development
1.47 2.52e-02 GO:0023052 signaling
2.32 2.95e-02 GO:0010628 positive regulation of gene expression
1.44 3.15e-02 GO:0019222 regulation of metabolic process
1.57 3.19e-02 GO:0009889 regulation of biosynthetic process
1.60 3.46e-02 GO:0048522 positive regulation of cellular process
1.26 3.90e-02 GO:0065007 biological regulation
2.21 3.98e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.34 4.85e-02 GO:0045893 positive regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.33 7.26e-03 GO:0005634 nucleus

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.26 1.34e-04 GO:0001071 nucleic acid binding transcription factor activity
2.26 1.34e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
2.42 9.63e-04 GO:0043565 sequence-specific DNA binding
1.61 6.37e-03 GO:0003677 DNA binding