Motif ID: KLF4.p3

Z-value: 2.045


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF4hg19_v1_chr9_-_110252045_1102520480.929.7e-03Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_3388219 3.494 NM_001009984
C20orf194
chromosome 20 open reading frame 194
chr19_+_45504686 3.001 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr9_-_110251754 2.922 KLF4
Kruppel-like factor 4 (gut)
chr1_+_995109 2.902 LOC100288175
uncharacterized LOC100288175
chr13_-_110438896 2.898 NM_003749
IRS2
insulin receptor substrate 2
chr19_-_47734215 2.711 NM_014417
BBC3
BCL2 binding component 3
chr21_-_37528578 2.683 LOC100506428
uncharacterized LOC100506428
chr6_+_37137882 2.445 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr20_-_3388586 2.350 C20orf194
chromosome 20 open reading frame 194
chr1_-_38471170 2.323 NM_001243878
NM_004468
FHL3

four and a half LIM domains 3

chr19_+_55795766 2.290 BRSK1
BR serine/threonine kinase 1
chr22_+_50354428 2.276 PIM3
pim-3 oncogene
chr5_+_172484353 2.264 C5orf41
chromosome 5 open reading frame 41
chr9_+_139972195 2.209 UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr19_+_47778099 2.159 NM_178511
PRR24
proline rich 24
chr19_-_38878663 2.116 NM_152657
GGN
gametogenetin
chr15_-_72410108 2.030 MYO9A
myosin IXA
chr19_+_42788605 2.022 NM_015125
CIC
capicua homolog (Drosophila)
chr12_-_57914287 2.010 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr7_+_64498643 1.999 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr1_+_212782103 1.957 ATF3
activating transcription factor 3
chr9_+_139971938 1.933 NM_207309
UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr7_+_1570321 1.931 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr2_+_10183630 1.899 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr8_+_22457098 1.898 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr3_-_114866090 1.877 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr7_-_100493481 1.835 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr19_-_46000159 1.830 NM_005619
NM_206900
RTN2

reticulon 2

chr19_+_41284161 1.803 RAB4B-EGLN2
RAB4B
RAB4B-EGLN2 readthrough
RAB4B, member RAS oncogene family
chr16_-_66959418 1.774 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr19_+_4969123 1.750 NM_015015
KDM4B
lysine (K)-specific demethylase 4B
chr5_+_172483285 1.750 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr14_-_105767328 1.725 NM_001242788
NM_001242790
NM_001519
BRF1


BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)


chr15_-_72410226 1.713 NM_006901
MYO9A
myosin IXA
chr10_+_104155431 1.709 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr8_+_8086103 1.704 FLJ10661
family with sequence similarity 86, member A pseudogene
chr16_-_2185824 1.685 NM_000296
NM_001009944
PKD1

polycystic kidney disease 1 (autosomal dominant)

chr12_+_52400725 1.683 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr22_+_50354139 1.663 NM_001001852
PIM3
pim-3 oncogene
chr9_-_110252045 1.662 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr16_-_402617 1.650 NM_003502
NM_181050
AXIN1

axin 1

chr20_-_3154169 1.640 ProSAPiP1
ProSAPiP1 protein
chr19_-_10679328 1.633 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr19_-_50143350 1.623 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr11_-_33722285 1.596 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr7_+_100081549 1.567 NM_173564
NYAP1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
chr22_+_31477231 1.562 NM_006932
NM_134269
NM_134270
SMTN


smoothelin


chr19_-_18632886 1.544 NM_006532
ELL
elongation factor RNA polymerase II
chr16_+_1203240 1.543 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr1_-_156470538 1.542 MEF2D
myocyte enhancer factor 2D
chr17_-_74497406 1.533 NM_024599
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr19_-_1237840 1.523 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr19_+_47759802 1.520 CCDC9
coiled-coil domain containing 9
chr19_+_55795533 1.513 NM_032430
BRSK1
BR serine/threonine kinase 1
chr2_+_30369868 1.512 YPEL5
yippee-like 5 (Drosophila)
chr17_+_7758380 1.510 NM_203411
TMEM88
transmembrane protein 88
chr17_+_43299277 1.500 NM_005892
FMNL1
formin-like 1
chr19_-_56135931 1.496 ZNF784
zinc finger protein 784
chr2_-_145274916 1.494 ZEB2
zinc finger E-box binding homeobox 2
chr1_+_160336856 1.482 NM_005598
NHLH1
nescient helix loop helix 1
chr19_+_7660698 1.475 NM_001080429
NM_020902
CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chr22_+_51039178 1.473 MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr22_-_50708720 1.471 NM_002751
MAPK11
mitogen-activated protein kinase 11
chr19_-_46283281 1.469


chr1_+_28585959 1.465 NM_031459
SESN2
sestrin 2
chr19_-_56135934 1.461 NM_203374
ZNF784
zinc finger protein 784
chr1_-_156470506 1.461 NM_005920
MEF2D
myocyte enhancer factor 2D
chrX_-_48828250 1.452 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr19_+_41305100 1.452 EGLN2
egl nine homolog 2 (C. elegans)
chr1_+_45266048 1.452 PLK3
polo-like kinase 3
chr11_-_65667809 1.439 FOSL1
FOS-like antigen 1
chr14_-_71275732 1.434 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr19_+_41305041 1.433 NM_080732
EGLN2
egl nine homolog 2 (C. elegans)
chr19_-_18632857 1.429 ELL
elongation factor RNA polymerase II
chr17_-_72968790 1.424 NM_030630
C17orf28
chromosome 17 open reading frame 28
chr5_+_141016516 1.417 NM_001130029
NM_173828
RELL2

RELT-like 2

chr10_+_13142055 1.416 NM_001008211
NM_001008212
NM_001008213
NM_021980
OPTN



optineurin



chr8_-_144650998 1.404 C8orf73
chromosome 8 open reading frame 73
chr16_+_30676098 1.404 FBRS
fibrosin
chr19_+_33166312 1.404 NM_207391
RGS9BP
regulator of G protein signaling 9 binding protein
chr19_+_4969126 1.404 KDM4B
lysine (K)-specific demethylase 4B
chr12_+_57482922 1.398 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr8_-_145013628 1.393 NM_201384
PLEC
plectin
chr3_-_129830273 1.389


chr7_+_28448970 1.385 LOC401317
uncharacterized LOC401317
chr17_-_18907988 1.376 NM_001039999
FAM83G
family with sequence similarity 83, member G
chr2_+_30369749 1.365 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr9_-_139890984 1.363 NM_004669
CLIC3
chloride intracellular channel 3
chr16_-_89768094 1.363 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr22_+_38597938 1.362 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr17_-_72968750 1.357


chr6_-_44233499 1.350 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr1_+_212781969 1.350 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr16_-_29606639 1.324


chr13_+_73633097 1.307 NM_001730
KLF5
Kruppel-like factor 5 (intestinal)
chr11_+_46299161 1.303 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr5_+_177540465 1.301 NM_015111
N4BP3
NEDD4 binding protein 3
chr16_+_30675777 1.287 NM_001105079
FBRS
fibrosin
chr7_+_73082157 1.280 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr22_+_38599026 1.279 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr12_-_112819755 1.276 NM_001109662
C12orf51
chromosome 12 open reading frame 51
chr3_-_129830320 1.275


chr17_+_78234626 1.274 NM_020914
NM_020954
RNF213

ring finger protein 213

chr11_-_1593149 1.271 NM_004420
DUSP8
dual specificity phosphatase 8
chr6_-_44233244 1.266 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr22_+_38598065 1.265 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr17_-_42081836 1.263 NM_004160
PYY
peptide YY
chr20_-_56884488 1.263 PPP4R1L
protein phosphatase 4, regulatory subunit 1-like
chr3_-_132441302 1.260 NM_153240
NPHP3-ACAD11
NPHP3
NPHP3-ACAD11 readthrough
nephronophthisis 3 (adolescent)
chr17_+_81037504 1.255 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr19_+_36266366 1.248 NM_001172630
NM_052948
ARHGAP33

Rho GTPase activating protein 33

chr11_+_45907046 1.242 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr9_-_35115844 1.239 NM_025182
FAM214B
family with sequence similarity 214, member B
chr2_+_30369800 1.236 YPEL5
yippee-like 5 (Drosophila)
chr7_-_2354050 1.232 NM_013321
SNX8
sorting nexin 8
chr1_-_33815411 1.231 PHC2
polyhomeotic homolog 2 (Drosophila)
chr5_+_137673953 1.222 FAM53C
family with sequence similarity 53, member C
chr19_+_47759730 1.220 NM_015603
CCDC9
coiled-coil domain containing 9
chr1_+_45266035 1.217 NM_004073
PLK3
polo-like kinase 3
chr19_-_11373117 1.216 NM_020812
DOCK6
dedicator of cytokinesis 6
chr14_-_105767274 1.212 BRF1
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
chr1_-_1475739 1.205 NM_001114748
TMEM240
transmembrane protein 240
chr7_-_2354010 1.205 SNX8
sorting nexin 8
chr14_+_75745480 1.204 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr11_+_45907198 1.201 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr9_+_139221931 1.198 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr11_+_46299554 1.195 CREB3L1
cAMP responsive element binding protein 3-like 1
chr13_+_52027435 1.192


chr6_-_31633587 1.189 NM_001199238
NM_001199239
GPANK1

G patch domain and ankyrin repeats 1

chr19_+_13906207 1.183 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr16_-_30381487 1.174 NM_015527
TBC1D10B
TBC1 domain family, member 10B
chr14_+_105331581 1.172 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr8_+_144680073 1.170 NM_032862
TIGD5
tigger transposable element derived 5
chr8_-_145050896 1.165 NM_000445
PLEC
plectin
chr12_+_57482674 1.157 NM_005967
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr7_-_4923246 1.155 NM_018059
RADIL
Ras association and DIL domains
chr9_+_140500097 1.152 ARRDC1
arrestin domain containing 1
chr16_-_3074225 1.151 NM_001002017
NM_001002018
NM_017885
HCFC1R1


host cell factor C1 regulator 1 (XPO1 dependent)


chr6_-_33285718 1.150 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr1_-_59249687 1.150 NM_002228
JUN
jun proto-oncogene
chr19_-_4065467 1.142 ZBTB7A
zinc finger and BTB domain containing 7A
chr6_-_41702734 1.141 NM_007162
TFEB
transcription factor EB
chr6_-_33266700 1.139 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr11_-_65667860 1.139 NM_005438
FOSL1
FOS-like antigen 1
chr19_-_46285645 1.136 DMPK
dystrophia myotonica-protein kinase
chr19_-_10679620 1.136 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr17_-_49198084 1.135 NM_001130527
NM_001130528
NM_003971
SPAG9


sperm associated antigen 9


chr1_-_156470565 1.135 MEF2D
myocyte enhancer factor 2D
chr7_-_99756275 1.129 NM_018275
C7orf43
chromosome 7 open reading frame 43
chr12_+_57482886 1.127 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr6_+_138188352 1.125 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr19_+_48828820 1.121 EMP3
epithelial membrane protein 3
chr19_+_49622480 1.121 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr8_-_145016691 1.119 NM_201383
PLEC
plectin
chr11_+_46299585 1.115 CREB3L1
cAMP responsive element binding protein 3-like 1
chr16_+_3062456 1.114 NM_020982
CLDN9
claudin 9
chr8_+_144329105 1.113 NM_173832
ZFP41
zinc finger protein 41 homolog (mouse)
chr6_-_33266735 1.108 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr12_+_50017340 1.108 NM_012272
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr19_+_40697516 1.105 NM_002446
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr11_-_64684606 1.104 NM_015104
ATG2A
ATG2 autophagy related 2 homolog A (S. cerevisiae)
chr5_-_176037091 1.095 NM_052899
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr6_-_33285493 1.094 NM_005453
ZBTB22
zinc finger and BTB domain containing 22
chr9_-_35732389 1.092 NM_006289
TLN1
talin 1
chr1_+_45265896 1.089 PLK3
polo-like kinase 3
chr2_+_28615668 1.088 FOSL2
FOS-like antigen 2
chr11_-_1606480 1.083 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr7_-_98741375 1.079 SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr2_-_145275086 1.079 ZEB2
zinc finger E-box binding homeobox 2
chr3_-_126194761 1.078 NM_001040653
NM_025112
ZXDC

ZXD family zinc finger C

chr9_-_110251308 1.076 KLF4
Kruppel-like factor 4 (gut)
chr22_+_43506753 1.075 NM_001197
BIK
BCL2-interacting killer (apoptosis-inducing)
chr16_+_67198678 1.072 HSF4
heat shock transcription factor 4
chr5_+_141016567 1.071 RELL2
RELT-like 2
chr2_-_73339911 1.068 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr8_-_103667882 1.067 NM_005655
KLF10
Kruppel-like factor 10
chr15_+_40733302 1.066 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr10_-_126849556 1.065 NM_001083914
CTBP2
C-terminal binding protein 2
chr6_+_108882104 1.063 FOXO3
forkhead box O3
chr5_+_173315313 1.061 NM_030627
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr17_-_7166263 1.057 NM_001185023
NM_001307
CLDN7

claudin 7

chr8_+_32405727 1.054 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr2_+_149633173 1.054


chr16_+_30406432 1.050 NM_001214909
ZNF48
zinc finger protein 48
chr11_-_65686439 1.046 NM_001135635
NM_031450
C11orf68

chromosome 11 open reading frame 68

chr1_+_110753313 1.045 NM_001039574
NM_004978
KCNC4

potassium voltage-gated channel, Shaw-related subfamily, member 4

chr19_-_1111972 1.043 SBNO2
strawberry notch homolog 2 (Drosophila)
chr9_+_140500054 1.042 NM_152285
ARRDC1
arrestin domain containing 1
chr22_-_41032684 1.041 NM_020831
MKL1
megakaryoblastic leukemia (translocation) 1
chr19_-_41196419 1.041 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr1_+_35331533 1.036


chr9_+_140500136 1.034 ARRDC1
arrestin domain containing 1
chr22_+_51039100 1.032 NM_012324
MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr19_+_41305333 1.031 NM_053046
EGLN2
egl nine homolog 2 (C. elegans)
chr19_+_36209125 1.029 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr1_-_38273852 1.029 NM_024640
YRDC
yrdC domain containing (E. coli)
chr19_-_7701852 1.019


chr4_-_82392971 1.019 RASGEF1B
RasGEF domain family, member 1B
chr22_-_20004251 1.017 NM_001670
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chrX_-_153599581 1.013 FLNA
filamin A, alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.38 6.54e-04 GO:0006351 transcription, DNA-dependent
3.05 3.35e-03 GO:0032774 RNA biosynthetic process
1.84 3.91e-03 GO:0032502 developmental process
1.51 4.10e-03 GO:0050794 regulation of cellular process
1.49 4.48e-03 GO:0050789 regulation of biological process
2.11 8.40e-03 GO:0048519 negative regulation of biological process
1.86 1.06e-02 GO:0060255 regulation of macromolecule metabolic process
5.48 1.08e-02 GO:0000165 MAPKKK cascade
8.31 1.54e-02 GO:0031098 stress-activated protein kinase signaling cascade
1.43 1.60e-02 GO:0065007 biological regulation
1.81 2.18e-02 GO:0007275 multicellular organismal development
2.07 2.33e-02 GO:0051252 regulation of RNA metabolic process
2.09 2.75e-02 GO:0006355 regulation of transcription, DNA-dependent
4.82 3.25e-02 GO:0071900 regulation of protein serine/threonine kinase activity
1.77 4.00e-02 GO:0080090 regulation of primary metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.15 1.40e-04 GO:0001071 nucleic acid binding transcription factor activity
3.15 1.40e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
39.08 3.87e-04 GO:0070412 R-SMAD binding
1.46 2.16e-03 GO:0005515 protein binding
25.40 2.51e-03 GO:0043621 protein self-association
14.12 4.15e-03 GO:0046332 SMAD binding
5.78 4.21e-03 GO:0019901 protein kinase binding
3.17 7.14e-03 GO:0043565 sequence-specific DNA binding
1.99 8.53e-03 GO:0003677 DNA binding
4.93 1.44e-02 GO:0019900 kinase binding
3.08 1.68e-02 GO:0046983 protein dimerization activity
3.83 2.30e-02 GO:0000988 protein binding transcription factor activity
3.83 2.30e-02 GO:0000989 transcription factor binding transcription factor activity
27.22 2.54e-02 GO:0019894 kinesin binding
3.21 3.34e-02 GO:0008092 cytoskeletal protein binding