Motif ID: LHX3,4.p2

Z-value: 0.472


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LHX4hg19_v1_chr1_+_180199432_1801994410.039.6e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_56143099 0.899 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr12_-_10282680 0.692 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr15_+_34261088 0.679 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr10_+_91152321 0.549 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr12_-_16760935 0.488 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chrX_-_102531673 0.484 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr7_+_94297448 0.482 PEG10
paternally expressed 10
chr8_+_32785485 0.409


chr2_+_88047603 0.365 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr2_-_99871569 0.333 NM_175735
LYG2
lysozyme G-like 2
chr20_-_18477811 0.327 NM_006606
RBBP9
retinoblastoma binding protein 9
chr12_+_54410893 0.326 HOXC5
HOXC6
homeobox C5
homeobox C6
chr3_-_195310770 0.298 APOD
apolipoprotein D
chr5_-_111093792 0.293 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr10_+_102222797 0.280 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr2_-_99279935 0.278 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr5_+_140557370 0.276 NM_019120
PCDHB8
protocadherin beta 8
chrX_-_24690740 0.276 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr6_+_26440699 0.271 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr9_-_14086901 0.264 NFIB
nuclear factor I/B
chr1_-_190446701 0.259 NM_199051
FAM5C
family with sequence similarity 5, member C
chr1_+_244216506 0.252 NM_006352
ZNF238
zinc finger protein 238
chr5_+_140792507 0.245 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr19_+_49199227 0.238 NM_000511
NM_001097638
FUT2

fucosyltransferase 2 (secretor status included)

chr12_-_54653369 0.238 NM_001127321
CBX5
chromobox homolog 5
chr1_+_244214576 0.234 ZNF238
zinc finger protein 238
chr14_+_62462540 0.233 NM_031914
SYT16
synaptotagmin XVI
chrM_-_379 0.227


chr1_+_81771844 0.217 LPHN2
latrophilin 2
chr1_+_155853546 0.215 SYT11
synaptotagmin XI
chr6_-_2635297 0.214 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr12_-_54653317 0.211 NM_001127322
CBX5
chromobox homolog 5
chr11_-_124973204 0.208 NM_001080546
TMEM218
transmembrane protein 218
chr8_-_102803196 0.207 NCALD
neurocalcin delta
chr1_+_145487301 0.206 LIX1L
Lix1 homolog (mouse)-like
chr5_+_140729723 0.206 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr1_+_43253660 0.205 NM_001242750
LOC100129924
uncharacterized LOC100129924
chr9_-_215892 0.200 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr2_-_134179325 0.197 NCKAP5
NCK-associated protein 5
chr9_+_125133322 0.197 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_-_217113007 0.192 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr3_-_168865521 0.190 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr16_-_71610948 0.190 NM_000353
TAT
tyrosine aminotransferase
chr6_+_3259134 0.187 NM_001128591
NM_001128592
NM_001135750
PSMG4


proteasome (prosome, macropain) assembly chaperone 4


chr19_-_36303766 0.185 PRODH2
proline dehydrogenase (oxidase) 2
chrX_-_13835313 0.184 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr8_+_17396285 0.184 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr3_+_113616317 0.180 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr1_-_232651227 0.177 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr5_-_95158365 0.175 GLRX
glutaredoxin (thioltransferase)
chr6_+_26402464 0.175 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr5_+_36608430 0.174 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_140529619 0.173 NM_018939
PCDHB6
protocadherin beta 6
chr20_+_5987897 0.172 NM_001127458
CRLS1
cardiolipin synthase 1
chr1_+_244214552 0.171 NM_205768
ZNF238
zinc finger protein 238
chr6_-_75965845 0.171 TMEM30A
transmembrane protein 30A
chr4_+_22694547 0.168 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr9_-_95298251 0.167 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr8_-_62602285 0.165 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr10_+_102732285 0.163 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr6_+_130339715 0.162 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr10_-_21786186 0.160 C10orf114
chromosome 10 open reading frame 114
chr9_+_118916069 0.159 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr5_+_36606667 0.157 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_29236171 0.156 NM_005249
FOXG1
forkhead box G1
chr20_-_6104056 0.155 NM_017671
FERMT1
fermitin family member 1
chr5_+_40909558 0.155 NM_000587
C7
complement component 7
chr12_+_54422193 0.154 NM_004503
HOXC6
homeobox C6
chr5_+_132209354 0.152 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr7_-_14025826 0.148 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr20_-_34117447 0.146 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr2_+_177016112 0.146 NM_014621
HOXD4
homeobox D4
chr1_+_63063186 0.145 NM_014495
ANGPTL3
angiopoietin-like 3
chr14_+_75898836 0.142 NM_001135049
JDP2
Jun dimerization protein 2
chr10_-_42863435 0.141 LOC441666
zinc finger protein 91 pseudogene
chr1_-_93342706 0.139 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr3_+_149192367 0.139 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr6_-_132910824 0.139 NM_003967
TAAR5
trace amine associated receptor 5
chr3_-_186262114 0.137 NM_017541
CRYGS
crystallin, gamma S
chr6_-_32157511 0.137 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr4_-_23891608 0.136 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_+_31496738 0.136 NM_001011700
MCCD1
mitochondrial coiled-coil domain 1
chr3_+_186739643 0.135 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr11_-_118123001 0.134 NM_198275
MPZL3
myelin protein zero-like 3
chr7_+_23286390 0.131 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_144997110 0.130 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr7_+_157023933 0.128


chr2_+_102508333 0.128 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr6_+_26087447 0.127 NM_000410
NM_139003
NM_139004
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011
HFE








hemochromatosis








chr7_+_23286420 0.127 GPNMB
glycoprotein (transmembrane) nmb
chr15_+_96869156 0.127 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr6_+_167525294 0.127 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr20_-_52199635 0.126 NM_006526
ZNF217
zinc finger protein 217
chr7_-_64023454 0.126 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr4_+_41614911 0.126 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr3_-_195310985 0.126 NM_001647
APOD
apolipoprotein D
chr12_+_64798050 0.124 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr3_+_73110809 0.124 NM_018029
EBLN2
endogenous Bornavirus-like nucleoprotein 2
chr3_+_159943252 0.124 NM_001168214
C3orf80
chromosome 3 open reading frame 80
chr2_+_166326156 0.119 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chrX_-_21776158 0.118 NM_014332
SMPX
small muscle protein, X-linked
chr5_-_156485969 0.118 NM_001173393
HAVCR1
hepatitis A virus cellular receptor 1
chr6_+_114178516 0.116 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chrX_-_24665225 0.116 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr12_+_57157091 0.115 NM_003725
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
chr5_-_156486128 0.115 HAVCR1
hepatitis A virus cellular receptor 1
chr8_+_107738239 0.115 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_+_84768333 0.114 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr6_+_136172802 0.112 NM_018945
PDE7B
phosphodiesterase 7B
chr11_-_76998462 0.112 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr7_-_122339186 0.111 NM_139175
RNF133
ring finger protein 133
chr11_+_89392464 0.109 NM_153696
FOLH1B
folate hydrolase 1B
chr7_+_23286386 0.109 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_76435073 0.108


chr6_+_31913708 0.108 NM_001710
CFB
complement factor B
chr8_+_132991171 0.107 EFR3A
EFR3 homolog A (S. cerevisiae)
chr7_+_23286384 0.107 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_36606456 0.106 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr5_+_42565963 0.105 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr4_-_146859960 0.105


chr14_+_95027760 0.104 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr10_-_21786205 0.103 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chrX_+_36254050 0.102 NM_001098843
CXorf30
chromosome X open reading frame 30
chr5_+_166711842 0.101 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr5_+_96212167 0.101 ERAP2
endoplasmic reticulum aminopeptidase 2
chr4_+_88896838 0.100 SPP1
secreted phosphoprotein 1
chr14_-_47812394 0.100 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr8_-_102803438 0.099 NM_032041
NCALD
neurocalcin delta
chr4_-_76957139 0.098 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr5_+_67586466 0.098 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_+_28317687 0.097 NM_001242894
NM_001242895
NM_024493
ZKSCAN3


zinc finger with KRAB and SCAN domains 3


chr1_-_197036350 0.097 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr3_-_11623829 0.096 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr5_+_40909617 0.095 C7
complement component 7
chr12_+_93096618 0.094 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr2_+_207406815 0.093 ADAM23
ADAM metallopeptidase domain 23
chr9_+_79093256 0.093 NM_001097635
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_-_39347258 0.093 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP readthrough
gap junction protein, alpha 9, 59kDa
chr2_+_202047620 0.093 NM_001206524
NM_001206542
NM_001230
NM_032974
NM_032976
NM_032977
CASP10





caspase 10, apoptosis-related cysteine peptidase





chr2_+_183943286 0.092 NM_001142314
NM_080876
DUSP19

dual specificity phosphatase 19

chr15_-_73051650 0.092


chr3_-_126327397 0.092 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr6_+_161123224 0.091 NM_000301
NM_001168338
PLG

plasminogen

chr12_-_15091441 0.090 NM_152321
ERP27
endoplasmic reticulum protein 27
chr14_-_61115906 0.090 NM_005982
SIX1
SIX homeobox 1
chr11_-_71524890 0.089 LOC285407
asparagine-linked glycosylation 1 homolog pseudogene
chr11_+_99426872 0.088 NM_175566
CNTN5
contactin 5
chr6_+_49518112 0.087 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chr9_+_124329398 0.087 NM_032552
DAB2IP
DAB2 interacting protein
chr2_-_158300517 0.087 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_+_131894343 0.086 NM_000045
NM_001244438
ARG1

arginase, liver

chr1_+_61869699 0.086 NFIA
nuclear factor I/A
chrX_+_48687282 0.086 NM_181532
ERAS
ES cell expressed Ras
chr16_+_15489586 0.085 NM_001128423
NM_173803
MPV17L

MPV17 mitochondrial membrane protein-like

chr1_+_151630710 0.085 SNX27
sorting nexin family member 27
chr2_+_183608329 0.085 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr12_+_131438451 0.084 NM_198827
GPR133
G protein-coupled receptor 133
chr3_-_57234279 0.084 NM_003865
HESX1
HESX homeobox 1
chr2_-_224866616 0.083 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr4_-_46125929 0.083 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr6_-_32908583 0.083 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr8_-_102803178 0.083 NCALD
neurocalcin delta
chr7_-_14029641 0.083 NM_001163147
NM_004956
ETV1

ets variant 1

chrX_+_28605558 0.082 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr8_+_22844918 0.082 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr8_+_123963649 0.081 ZHX2
zinc fingers and homeoboxes 2
chr6_-_24719286 0.080 NM_030939
C6orf62
chromosome 6 open reading frame 62
chrX_-_77225134 0.080 NM_001029891
PGAM4
phosphoglycerate mutase family member 4
chr4_+_88896868 0.080 SPP1
secreted phosphoprotein 1
chr5_-_58295758 0.080 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_+_150399980 0.080 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr4_-_155511838 0.078 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr9_+_125132785 0.078 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_+_125133228 0.077 NM_000962
NM_080591
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr9_+_4839763 0.077 RCL1
RNA terminal phosphate cyclase-like 1
chr4_+_77953942 0.076 SEPT11
septin 11
chr3_-_93692898 0.075 NM_000313
PROS1
protein S (alpha)
chr2_-_178787522 0.075 NM_001077358
PDE11A
phosphodiesterase 11A
chrX_-_13835187 0.075 GPM6B
glycoprotein M6B
chr2_+_202047803 0.075 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr3_+_171561138 0.074 NM_001164436
TMEM212
transmembrane protein 212
chr3_-_9291251 0.074 NM_001033117
NM_014850
SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

chr22_-_22863504 0.074 NM_080764
ZNF280B
zinc finger protein 280B
chrX_+_24073071 0.073 EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr1_+_212965169 0.073 NM_001042552
NM_001042553
NM_001146169
NM_001146170
NM_001146171
TATDN3




TatD DNase domain containing 3




chr17_-_67057046 0.073 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr6_-_64029847 0.072 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr8_-_125716430 0.071 MTSS1
metastasis suppressor 1
chr11_-_5701371 0.071 TRIM5
tripartite motif containing 5
chr14_+_70236266 0.071 SRSF5
serine/arginine-rich splicing factor 5
chr6_-_66417069 0.070 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr2_-_183387063 0.070 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr1_+_50574601 0.070 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_-_95158465 0.069 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr11_-_115088628 0.069 CADM1
cell adhesion molecule 1
chr6_+_27777713 0.069 NM_003536
HIST1H3H
histone cluster 1, H3h
chr20_+_62795826 0.069 NM_004535
MYT1
myelin transcription factor 1
chr2_+_68961912 0.068 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr20_+_57022460 0.068 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr2_-_288181 0.068 NM_001002919
FAM150B
family with sequence similarity 150, member B

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.