Motif ID: NFE2L2.p2

Z-value: 1.819


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2L2hg19_v1_chr2_-_178129858_178129858-0.078.9e-01Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_56075329 4.576 NM_152637
METTL7B
methyltransferase like 7B
chr12_+_56075418 4.152 METTL7B
methyltransferase like 7B
chr3_-_186262114 4.117 NM_017541
CRYGS
crystallin, gamma S
chr10_+_115312777 3.791 NM_004132
HABP2
hyaluronan binding protein 2
chr20_+_34742656 3.143 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr11_+_62380212 2.832 NM_000327
ROM1
retinal outer segment membrane protein 1
chr5_-_151150939 2.650 LOC100652758
uncharacterized LOC100652758
chr7_+_73245192 2.636 NM_001305
CLDN4
claudin 4
chr17_+_30771520 2.597 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr16_+_30076993 2.578 NM_001243177
NM_184041
ALDOA

aldolase A, fructose-bisphosphate

chr7_-_1498961 2.540 MICALL2
MICAL-like 2
chr17_+_30771532 2.514 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771522 2.505 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771485 2.484 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_76921205 2.468 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_+_154966061 2.434 NM_018655
LENEP
lens epithelial protein
chr16_+_2083264 2.404 NM_001252073
NM_001252075
NM_001252076
SLC9A3R2


solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2


chr17_+_30771494 2.290 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr5_-_95158365 2.143 GLRX
glutaredoxin (thioltransferase)
chr16_+_30077146 2.045 ALDOA
aldolase A, fructose-bisphosphate
chr16_+_30077120 2.017 ALDOA
aldolase A, fructose-bisphosphate
chr19_-_49658645 2.016 NM_002152
HRC
histidine rich calcium binding protein
chr7_+_93551015 1.999 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr6_+_56819923 1.993 BEND6
BEN domain containing 6
chr2_+_133174146 1.936 NM_001508
GPR39
G protein-coupled receptor 39
chr7_-_93519990 1.925 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr5_-_149535420 1.891 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr5_-_95158465 1.890 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr11_+_72983246 1.885 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr7_+_134212343 1.872 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr18_+_21452981 1.869 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_-_33366838 1.860 NM_033504
TMEM54
transmembrane protein 54
chr16_-_69760444 1.849 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chrX_+_9431314 1.815 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr2_-_169887832 1.672 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chrX_-_24665225 1.658 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_-_76921453 1.657 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr4_+_154178525 1.639 TRIM2
tripartite motif containing 2
chr12_-_70083055 1.627 NM_152439
BEST3
bestrophin 3
chr14_+_103800678 1.581 EIF5
eukaryotic translation initiation factor 5
chr5_-_149535309 1.575 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr17_+_80317122 1.544 NM_207459
TEX19
testis expressed 19
chr17_+_14204326 1.536 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr14_-_65409445 1.522 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chrX_-_24665454 1.508 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr1_-_94374949 1.448 GCLM
glutamate-cysteine ligase, modifier subunit
chr18_+_158586 1.427 USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr18_+_21693316 1.399 TTC39C
tetratricopeptide repeat domain 39C
chr1_+_14075917 1.392 PRDM2
PR domain containing 2, with ZNF domain
chr10_-_71892514 1.369 AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chrX_-_154493736 1.362 NM_171998
RAB39B
RAB39B, member RAS oncogene family
chr1_+_14075931 1.360 PRDM2
PR domain containing 2, with ZNF domain
chr1_-_114302093 1.337 PHTF1
putative homeodomain transcription factor 1
chr2_+_120189342 1.333 NM_183240
TMEM37
transmembrane protein 37
chrX_+_99899162 1.315 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr16_+_56642477 1.308 NM_005953
MT2A
metallothionein 2A
chr10_-_71892596 1.286 NM_001198696
NM_032797
AIFM2

apoptosis-inducing factor, mitochondrion-associated, 2

chr1_-_94374986 1.285 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr6_+_44195008 1.197 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr9_+_140135738 1.193 TUBB4B
tubulin, beta 4B class IVb
chr12_-_56101465 1.182 ITGA7
integrin, alpha 7
chr16_+_57662301 1.167 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr6_-_134496833 1.163 SGK1
serum/glucocorticoid regulated kinase 1
chr5_-_33892292 1.162 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr5_-_75919051 1.160 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr2_-_224866616 1.148 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr22_+_21986968 1.137 NM_152612
CCDC116
coiled-coil domain containing 116
chrX_-_106960268 1.122 NM_004089
TSC22D3
TSC22 domain family, member 3
chr1_-_55266870 1.122 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr9_+_140083053 1.116 NM_003731
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr16_+_30418885 1.110 ZNF771
zinc finger protein 771
chr19_-_36004553 1.092 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr17_-_38721701 1.088 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr20_-_633844 1.085 NM_080725
SRXN1
sulfiredoxin 1
chr17_+_21191347 1.078 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr7_+_116312412 1.074 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr2_+_231921625 1.066 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr6_+_32121228 1.050 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr15_-_40630272 1.048 C15orf52
chromosome 15 open reading frame 52
chr12_-_56101667 1.043 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr6_+_74405505 1.041 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr1_-_94375028 1.035 GCLM
glutamate-cysteine ligase, modifier subunit
chr17_-_28618836 1.033 BLMH
bleomycin hydrolase
chr18_+_158480 0.991 NM_001037334
NM_005151
USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

chr7_+_23286277 0.987 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr17_+_48610077 0.975 EPN3
epsin 3
chr16_+_28505920 0.964 NM_018690
APOBR
apolipoprotein B receptor
chr8_-_125740378 0.963 MTSS1
metastasis suppressor 1
chr1_-_177939347 0.949 SEC16B
SEC16 homolog B (S. cerevisiae)
chr14_+_79745653 0.944 NM_001105250
NM_138970
NRXN3

neurexin 3

chr10_+_85899184 0.944 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr9_+_140135698 0.936 NM_006088
TUBB4B
tubulin, beta 4B class IVb
chr6_+_74405764 0.935 CD109
CD109 molecule
chr3_-_56809594 0.935 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr17_-_65362667 0.929 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr16_+_74330730 0.928 PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr10_+_91061705 0.928 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr11_-_118134956 0.922 MPZL2
myelin protein zero-like 2
chr21_-_46237966 0.900 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr17_-_72889704 0.894 NM_178128
FADS6
fatty acid desaturase domain family, member 6
chr14_+_45605143 0.894 FANCM
Fanconi anemia, complementation group M
chr7_+_23286390 0.893 GPNMB
glycoprotein (transmembrane) nmb
chr12_+_64798050 0.891 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr17_-_11900688 0.888 NM_144680
ZNF18
zinc finger protein 18
chr8_-_125580745 0.887 MTSS1
metastasis suppressor 1
chr21_+_33031932 0.884 NM_000454
SOD1
superoxide dismutase 1, soluble
chr12_+_78225068 0.876 NM_014903
NAV3
neuron navigator 3
chr7_+_23286384 0.872 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_225616556 0.871 NM_194442
LBR
lamin B receptor
chr8_-_30585220 0.868 GSR
glutathione reductase
chr6_+_56819706 0.863 NM_152731
BEND6
BEN domain containing 6
chr1_-_201123560 0.861 TMEM9
transmembrane protein 9
chr9_-_77502635 0.860 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr6_+_1611544 0.858 FOXC1
forkhead box C1
chr6_+_74405909 0.852 CD109
CD109 molecule
chr14_+_69726868 0.852 GALNTL1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
chr6_-_134497069 0.850 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr11_-_118134986 0.845 MPZL2
myelin protein zero-like 2
chr12_+_56137063 0.844 NM_005811
GDF11
growth differentiation factor 11
chr2_-_142889269 0.840 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr17_-_65362635 0.839 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr8_+_120220554 0.839 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr21_-_46237882 0.833 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chrX_-_133930234 0.824 NM_001170756
NM_145284
FAM122B

family with sequence similarity 122B

chr7_-_150721551 0.821 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr22_+_21369441 0.814 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr4_-_21699317 0.813 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr16_-_1429612 0.807 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr1_+_154377847 0.802 IL6R
interleukin 6 receptor
chr1_-_204329043 0.795 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr16_+_74330660 0.781 NM_002811
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr11_-_118134868 0.778


chr3_-_46608039 0.777 NM_024512
LRRC2
leucine rich repeat containing 2
chr13_-_41768533 0.775 NM_032138
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chrX_-_154563735 0.773 NM_001289
CLIC2
chloride intracellular channel 2
chr17_+_18625335 0.769 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr13_-_41768392 0.760 KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr9_-_100935173 0.760 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr6_-_24877453 0.758 NM_015864
FAM65B
family with sequence similarity 65, member B
chrX_-_119445306 0.750 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr6_-_24645955 0.749 NM_001168375
NM_001168376
NM_001168374
NM_001168377
NM_014809
KIAA0319




KIAA0319




chr7_-_17980102 0.748 NM_015132
SNX13
sorting nexin 13
chr6_+_43266008 0.725 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr4_+_41258941 0.724 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr9_+_130922471 0.723 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr18_-_72921280 0.722 NM_175907
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr22_+_45072936 0.719 PRR5
proline rich 5 (renal)
chrX_+_99899388 0.719 SRPX2
sushi-repeat containing protein, X-linked 2
chr11_+_63448868 0.715 NM_006054
NM_201428
NM_201429
NM_201430
RTN3



reticulon 3



chr7_-_98467483 0.713 TMEM130
transmembrane protein 130
chr12_-_10282680 0.713 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr8_-_93977715 0.709 NM_001191036
C8orf83
chromosome 8 open reading frame 83
chr17_+_2497233 0.704 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr5_+_140868721 0.702 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr16_-_72206023 0.702 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chrX_-_15511358 0.701 PIR
pirin (iron-binding nuclear protein)
chr17_-_28619183 0.698 NM_000386
BLMH
bleomycin hydrolase
chr15_-_29562008 0.695 NM_138704
NDNL2
necdin-like 2
chr17_+_28707495 0.687 NM_001199775
CPD
carboxypeptidase D
chr20_+_42187705 0.681 SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_177939049 0.680 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr16_+_58534045 0.673 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr19_+_34855594 0.670 NM_001184722
NM_000175
GPI

glucose-6-phosphate isomerase

chr12_-_76478347 0.670 NAP1L1
nucleosome assembly protein 1-like 1
chr6_+_36410800 0.669 KCTD20
potassium channel tetramerisation domain containing 20
chrX_+_149531439 0.664 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr7_+_23286420 0.659 GPNMB
glycoprotein (transmembrane) nmb
chr14_+_69726680 0.659 NM_001168368
NM_020692
GALNTL1

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1

chr6_-_84140758 0.659 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr12_-_121711980 0.657 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr19_+_1248548 0.657 NM_177401
MIDN
midnolin
chr9_-_77503009 0.657 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr1_+_14075861 0.653 NM_001007257
PRDM2
PR domain containing 2, with ZNF domain
chr7_+_139528951 0.653 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr14_+_103801160 0.649 NM_183004
EIF5
eukaryotic translation initiation factor 5
chr1_-_114301753 0.644 NM_006608
PHTF1
putative homeodomain transcription factor 1
chr11_-_3862183 0.640 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr19_-_6502224 0.638 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chrX_+_30671602 0.631 GK
glycerol kinase
chr12_-_102591547 0.627 NM_002674
PMCH
pro-melanin-concentrating hormone
chr18_-_48346297 0.626 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr11_+_77850824 0.624 LOC100289388
uncharacterized LOC100289388
chr6_+_34206567 0.623 NM_145905
HMGA1
high mobility group AT-hook 1
chr6_-_84140854 0.613 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_+_3366589 0.613 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr6_+_50786438 0.612 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr9_-_99801365 0.608 NM_001333
CTSL2
cathepsin L2
chr11_-_3862137 0.603 RHOG
ras homolog gene family, member G (rho G)
chr6_-_35888816 0.602 SRPK1
SRSF protein kinase 1
chr22_+_38035718 0.597 SH3BP1
SH3-domain binding protein 1
chr2_-_224467049 0.597 SCG2
secretogranin II
chr16_-_67517715 0.596 NM_001138
AGRP
agouti related protein homolog (mouse)
chrX_-_15511710 0.595 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr3_-_71774407 0.589 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr22_+_45072687 0.584 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr15_-_64385988 0.578 NM_001014812
NM_032231
FAM96A

family with sequence similarity 96, member A

chr3_+_148447966 0.578 NM_032049
AGTR1
angiotensin II receptor, type 1
chr1_-_150208441 0.578 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr20_+_35504514 0.577 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr20_+_42187634 0.573 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.74 2.44e-03 GO:0016324 apical plasma membrane
7.76 8.65e-03 GO:0045177 apical part of cell

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
9.34 1.75e-02 GO:0004866 endopeptidase inhibitor activity
8.98 2.11e-02 GO:0061135 endopeptidase regulator activity
8.86 2.24e-02 GO:0030414 peptidase inhibitor activity