Motif ID: NKX6-1,2.p2

Z-value: 1.450


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX6-1hg19_v1_chr4_-_85419386_854193860.118.4e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_27844463 1.237 NM_206827
RASL11A
RAS-like, family 11, member A
chr6_-_26043884 1.125 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr8_-_82607206 0.925 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr11_-_71524890 0.783 LOC285407
asparagine-linked glycosylation 1 homolog pseudogene
chr5_+_38445577 0.736 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr1_-_150738292 0.732 NM_001199739
NM_004079
CTSS

cathepsin S

chr6_+_3259134 0.701 NM_001128591
NM_001128592
NM_001135750
PSMG4


proteasome (prosome, macropain) assembly chaperone 4


chrX_-_23855456 0.700 RPL9
ribosomal protein L9
chr1_-_150738232 0.646 CTSS
cathepsin S
chr1_+_182419255 0.599 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr1_-_150738255 0.588 CTSS
cathepsin S
chr21_-_31852631 0.585 NM_181607
KRTAP19-1
keratin associated protein 19-1
chr5_+_81601165 0.581 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr7_+_94297448 0.558 PEG10
paternally expressed 10
chr4_+_88896899 0.541 SPP1
secreted phosphoprotein 1
chr13_+_27844936 0.539 RASL11A
RAS-like, family 11, member A
chr2_+_210444364 0.535 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr4_-_70725792 0.532 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr2_-_228244005 0.528 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr4_+_151503076 0.500 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr5_+_31193852 0.500 CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr20_-_18477811 0.495 NM_006606
RBBP9
retinoblastoma binding protein 9
chr16_+_28565225 0.491 NM_138414
CCDC101
coiled-coil domain containing 101
chr1_-_54483802 0.485 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr11_-_125550674 0.485 NM_001612
NM_020069
NM_020107
NM_020108
ACRV1



acrosomal vesicle protein 1



chr2_+_210444154 0.479 MAP2
microtubule-associated protein 2
chr10_-_52008312 0.478 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr3_-_138048727 0.463 NM_178130
NME9
NME gene family member 9
chr4_+_74347461 0.453 NM_001133
AFM
afamin
chr5_+_31193761 0.449 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr6_+_5030202 0.448 LOC100129461
uncharacterized LOC100129461
chr12_+_32654976 0.442 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_+_186798031 0.435 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr7_-_102283237 0.425 NM_001114403
UPK3BL
uroplakin 3B-like
chr21_-_36421195 0.406 RUNX1
runt-related transcription factor 1
chr10_-_96829074 0.403 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr8_+_79428335 0.398 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr13_+_24144402 0.390 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr5_-_111091947 0.366 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr1_+_170115187 0.362 NM_001136107
METTL11B
methyltransferase like 11B
chr12_+_25205488 0.356 LRMP
lymphoid-restricted membrane protein
chr12_+_54410893 0.349 HOXC5
HOXC6
homeobox C5
homeobox C6
chr4_+_88896801 0.349 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr7_-_92855780 0.326 NM_001039372
HEPACAM2
HEPACAM family member 2
chr5_+_140729723 0.325 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr7_-_107880492 0.321 NM_001037132
NRCAM
neuronal cell adhesion molecule
chrX_+_36254050 0.321 NM_001098843
CXorf30
chromosome X open reading frame 30
chr14_-_57960432 0.320 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr3_-_79817058 0.315 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr18_-_51690988 0.314 MBD2
methyl-CpG binding domain protein 2
chr21_-_36421578 0.310 RUNX1
runt-related transcription factor 1
chr6_+_132859426 0.306 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr11_-_62521533 0.304 NM_024784
ZBTB3
zinc finger and BTB domain containing 3
chr5_+_68513624 0.301 MRPS36
mitochondrial ribosomal protein S36
chr5_-_58295758 0.301 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_+_68071386 0.292 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr19_-_46526555 0.290 NM_005091
PGLYRP1
peptidoglycan recognition protein 1
chrX_-_33229428 0.286 NM_004006
DMD
dystrophin
chr17_+_68100994 0.282 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr6_+_39760138 0.279


chr4_-_70518964 0.274 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr6_+_53883713 0.273 NM_138569
MLIP
muscular LMNA-interacting protein
chr6_+_26199712 0.271 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr5_+_149997205 0.271 NM_001166209
SYNPO
synaptopodin
chr21_-_36421630 0.271 RUNX1
runt-related transcription factor 1
chr21_-_31874407 0.266 NM_181611
KRTAP19-5
keratin associated protein 19-5
chr8_+_132991171 0.265 EFR3A
EFR3 homolog A (S. cerevisiae)
chr1_+_168545710 0.261 NM_002995
XCL1
chemokine (C motif) ligand 1
chr12_-_10573041 0.261 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr13_+_103459495 0.260 NM_001204425
BIVM-ERCC5
BIVM
BIVM-ERCC5 readthrough
basic, immunoglobulin-like variable motif containing
chr18_-_46477080 0.258 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr21_-_36421586 0.251 NM_001754
RUNX1
runt-related transcription factor 1
chrX_-_24690740 0.249 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr12_+_21284127 0.248 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr5_+_140566655 0.248 NM_019119
PCDHB9
protocadherin beta 9
chr2_-_178787522 0.248 NM_001077358
PDE11A
phosphodiesterase 11A
chr6_-_146056896 0.247 NM_001018041
NM_005670
EPM2A

epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)

chr1_+_147400498 0.246 NM_016334
GPR89B
GPR89A
G protein-coupled receptor 89B
G protein-coupled receptor 89A
chr1_+_61869699 0.234 NFIA
nuclear factor I/A
chr8_+_9953061 0.232 NM_001135671
NM_001199729
MSRA

methionine sulfoxide reductase A

chr21_-_36421461 0.231 RUNX1
runt-related transcription factor 1
chr4_-_170077807 0.231 SH3RF1
SH3 domain containing ring finger 1
chr10_-_115423640 0.231 NM_006175
NM_198060
NRAP

nebulin-related anchoring protein

chr6_+_114178516 0.231 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr19_-_49220213 0.230 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr6_-_133084585 0.229 NM_078488
VNN2
vanin 2
chr6_-_135271206 0.225 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr7_-_41742666 0.225 NM_002192
INHBA
inhibin, beta A
chr3_-_71294229 0.225 NM_001244814
FOXP1
forkhead box P1
chr6_-_49712055 0.224 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr2_+_211342405 0.222 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr1_-_17766142 0.217 RCC2
regulator of chromosome condensation 2
chr5_+_140782367 0.217 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr20_+_23345020 0.217 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr17_-_38821286 0.214 NM_152349
KRT222
keratin 222
chr14_+_74083547 0.214 NM_001037162
ACOT6
acyl-CoA thioesterase 6
chr10_+_72163899 0.213 EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr13_-_47470967 0.211 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr3_-_151987332 0.210 LOC401093
uncharacterized LOC401093
chr4_+_88896868 0.208 SPP1
secreted phosphoprotein 1
chr6_+_132873829 0.208 NM_053278
TAAR8
trace amine associated receptor 8
chr4_+_88896838 0.207 SPP1
secreted phosphoprotein 1
chr18_-_24722757 0.204 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr17_-_56494889 0.203 RNF43
ring finger protein 43
chr6_+_26402464 0.202 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr3_-_168865521 0.198 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr4_+_15704752 0.191 BST1
bone marrow stromal cell antigen 1
chr19_-_48759141 0.190 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr14_-_60097314 0.190 RTN1
reticulon 1
chr10_+_74870209 0.189 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr1_+_84647342 0.189 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_231084600 0.188 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr1_+_145477018 0.187 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr14_-_95599794 0.186 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr2_+_102508333 0.185 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr10_-_113933517 0.185 GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr9_-_77643307 0.184 NM_152420
C9orf41
chromosome 9 open reading frame 41
chr5_+_42565963 0.183 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr14_-_71001731 0.182 NM_003814
ADAM20
ADAM metallopeptidase domain 20
chr3_+_49547867 0.182 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr12_-_54653369 0.180 NM_001127321
CBX5
chromobox homolog 5
chr18_+_72922725 0.179 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr12_-_109458844 0.179 NM_018711
SVOP
SV2 related protein homolog (rat)
chr12_-_54653317 0.178 NM_001127322
CBX5
chromobox homolog 5
chr2_-_74382352 0.178


chr19_-_41812991 0.176


chr1_+_12403045 0.176 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr2_-_183387063 0.176 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr6_-_138820580 0.174


chr1_+_192605267 0.173 NM_002927
NM_144766
RGS13

regulator of G-protein signaling 13

chr2_+_202047803 0.172 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr11_-_124190092 0.171 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr2_+_183608329 0.168 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr7_+_28725597 0.167 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr5_+_140800536 0.167 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr7_-_92848837 0.166 NM_198151
HEPACAM2
HEPACAM family member 2
chr22_-_38881529 0.163 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr2_+_190540710 0.162 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chr1_-_17766241 0.161 NM_018715
RCC2
regulator of chromosome condensation 2
chr4_+_74606222 0.161 NM_000584
IL8
interleukin 8
chr2_-_175712276 0.160 NM_001206602
CHN1
chimerin (chimaerin) 1
chrX_+_41548225 0.159 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr9_+_34652125 0.158 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr5_-_135290521 0.158 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr4_-_39523132 0.156 UGDH
UDP-glucose 6-dehydrogenase
chr4_+_155484131 0.155 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_-_138893666 0.154 NM_020464
NHSL1
NHS-like 1
chr22_+_46731297 0.152 NM_018006
TRMU
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
chr10_-_94257470 0.152 NM_001165946
IDE
insulin-degrading enzyme
chr22_-_19435727 0.151 NM_001166242
NM_173793
C22orf39

chromosome 22 open reading frame 39

chr18_-_47018777 0.151 RPL17
ribosomal protein L17
chr15_+_34261088 0.150 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chrX_-_10535476 0.150 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr4_-_110723127 0.149 CFI
complement factor I
chr1_+_147400553 0.146 GPR89B
GPR89A
G protein-coupled receptor 89B
G protein-coupled receptor 89A
chr3_+_49506079 0.146 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr1_+_174844655 0.146 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr5_+_95066628 0.145 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr1_+_201617529 0.145 NAV1
neuron navigator 1
chr5_+_42565562 0.144 NM_001242406
GHR
growth hormone receptor
chr6_-_24583454 0.144 NM_001252328
KIAA0319
KIAA0319
chr1_+_151611331 0.143 SNX27
sorting nexin family member 27
chr4_-_110723334 0.141 NM_000204
CFI
complement factor I
chr5_+_140749830 0.141 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr3_-_57234279 0.140 NM_003865
HESX1
HESX homeobox 1
chr7_+_137761177 0.140 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr11_+_12308446 0.139 NM_032867
MICALCL
MICAL C-terminal like
chr3_-_42843217 0.139


chr1_-_109935869 0.138 NM_001205228
SORT1
sortilin 1
chr3_+_49568370 0.137 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr1_-_173020011 0.137 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr2_+_102508377 0.136 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr7_+_55433140 0.136 NM_018697
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr12_+_48166929 0.136 NM_017842
SLC48A1
solute carrier family 48 (heme transporter), member 1
chr5_-_43040147 0.136 NM_001014279
C5orf39
chromosome 5 open reading frame 39
chr1_-_217250230 0.135 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr12_+_7023490 0.135 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr2_-_202563353 0.135 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr16_-_54962707 0.131 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr1_-_6420719 0.131 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr12_-_16760935 0.129 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr1_+_157963062 0.127 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr5_+_140739589 0.125 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr2_-_166060552 0.124 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr2_-_151344145 0.122 NM_005168
RND3
Rho family GTPase 3
chr12_+_57943843 0.122 NM_004984
KIF5A
kinesin family member 5A
chr3_-_169587598 0.122 NM_024727
LRRC31
leucine rich repeat containing 31
chr4_-_17806820 0.121 DCAF16
DDB1 and CUL4 associated factor 16
chr10_+_72163914 0.121 EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr19_+_24269877 0.121 NM_203282
ZNF254
zinc finger protein 254
chr12_-_46357949 0.120


chr1_-_149858114 0.120 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr4_-_186733372 0.120 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr17_+_38975343 0.120 NM_001195387
NM_145274
NM_001195386
TMEM99


transmembrane protein 99


chr13_+_108922560 0.119 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr15_-_89456549 0.117 MFGE8
milk fat globule-EGF factor 8 protein
chr15_-_89456592 0.116 NM_001114614
NM_005928
MFGE8

milk fat globule-EGF factor 8 protein

chr6_-_138820578 0.115 NM_001144060
NHSL1
NHS-like 1
chr14_-_60097531 0.115 NM_206852
RTN1
reticulon 1
chr17_+_28268622 0.114 NM_198529
EFCAB5
EF-hand calcium binding domain 5

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.