Motif ID: NR4A2.p2

Z-value: 1.061

Transcription factors associated with NR4A2.p2:

monomer

Gene SymbolEntrez IDGene Name
NR4A2 4929 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR4A2hg19_v1_chr2_-_157186681_157186700-0.295.8e-01Click!


Activity profile for motif NR4A2.p2.

activity profile for motif NR4A2.p2


Sorted Z-values histogram for motif NR4A2.p2

Sorted Z-values for motif NR4A2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_72088507 1.952 NM_001126102
NM_005143
HP

haptoglobin

chr16_+_72097124 1.452 NM_020995
HPR
haptoglobin-related protein
chr6_-_24489738 1.397 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr17_+_7533452 1.229 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr12_-_6484557 1.061 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr4_+_41614911 0.969 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr19_-_15590203 0.865 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr2_+_120189342 0.760 NM_183240
TMEM37
transmembrane protein 37
chr5_+_133842276 0.752


chr15_+_43809805 0.752 NM_002373
MAP1A
microtubule-associated protein 1A
chr12_+_56075329 0.699 NM_152637
METTL7B
methyltransferase like 7B
chr5_-_27038650 0.696 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr16_+_58534045 0.681 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr12_+_100750856 0.674 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr11_+_116700620 0.673 NM_000040
APOC3
apolipoprotein C-III
chrX_-_105282714 0.672 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr12_-_63544615 0.671 AVPR1A
arginine vasopressin receptor 1A
chr1_-_190446701 0.661 NM_199051
FAM5C
family with sequence similarity 5, member C
chr3_-_194072004 0.658 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr1_+_170115187 0.645 NM_001136107
METTL11B
methyltransferase like 11B
chr12_-_16759939 0.639 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_56075418 0.627 METTL7B
methyltransferase like 7B
chr15_-_75017710 0.624 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr7_+_73245192 0.620 NM_001305
CLDN4
claudin 4
chr4_-_25032306 0.616 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr11_-_86666211 0.610 NM_012193
FZD4
frizzled family receptor 4
chr3_-_123339178 0.601 MYLK
myosin light chain kinase
chr12_+_25205180 0.601 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr19_+_589849 0.596 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr3_-_123339423 0.596 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr1_+_109642814 0.592 SCARNA2
small Cajal body-specific RNA 2
chr11_+_5653484 0.587 NM_130390
TRIM34
tripartite motif containing 34
chr20_-_62130390 0.573 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr1_+_87797301 0.552


chr15_-_90347173 0.539 ANPEP
alanyl (membrane) aminopeptidase
chr13_+_27844463 0.538 NM_206827
RASL11A
RAS-like, family 11, member A
chrX_+_149613719 0.531 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr16_+_57728711 0.529 NM_032269
CCDC135
coiled-coil domain containing 135
chr12_+_78225068 0.525 NM_014903
NAV3
neuron navigator 3
chr5_-_126409171 0.514 NM_001164478
NM_001164479
C5orf63

chromosome 5 open reading frame 63

chr14_-_23288912 0.510 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_+_7169192 0.509


chr9_+_74764382 0.506 GDA
guanine deaminase
chr15_+_67000929 0.500 NM_001142861
SMAD6
SMAD family member 6
chr22_+_21128378 0.488 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chrX_+_106163605 0.486 NM_020384
CLDN2
claudin 2
chr17_+_48046561 0.482 NM_138281
DLX4
distal-less homeobox 4
chr2_-_178483372 0.479 TTC30A
tetratricopeptide repeat domain 30A
chr9_+_74764417 0.476 GDA
guanine deaminase
chrX_+_106171328 0.472 CLDN2
claudin 2
chr1_+_36690038 0.469 THRAP3
thyroid hormone receptor associated protein 3
chr8_+_40010986 0.468 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr2_-_178417434 0.468 NM_152517
TTC30B
tetratricopeptide repeat domain 30B
chr1_-_205719309 0.467


chr12_-_6484389 0.465 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr8_-_20112691 0.461 NM_021020
LZTS1
leucine zipper, putative tumor suppressor 1
chr12_-_16760935 0.454 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr15_-_90349819 0.450 ANPEP
alanyl (membrane) aminopeptidase
chr13_-_46756326 0.449 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr9_+_129724503 0.448 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr7_+_134212343 0.441 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr1_-_205719340 0.438 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr3_+_186435097 0.434 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr4_+_41614725 0.432 LIMCH1
LIM and calponin homology domains 1
chr1_-_211752052 0.432 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr6_+_34216344 0.432


chr17_+_79679370 0.431 NM_012140
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr7_-_100844192 0.429 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr1_-_144994908 0.429 PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_70093064 0.428 NM_032735
BEST3
bestrophin 3
chr7_-_92855780 0.428 NM_001039372
HEPACAM2
HEPACAM family member 2
chr9_+_4839763 0.424 RCL1
RNA terminal phosphate cyclase-like 1
chr10_-_101841593 0.424 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr22_-_30783301 0.417 NM_001017981
RNF215
ring finger protein 215
chrX_+_106161589 0.415 NM_001171095
CLDN2
claudin 2
chr1_-_144994839 0.414 PDE4DIP
phosphodiesterase 4D interacting protein
chr17_-_34328530 0.411 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr8_+_125463042 0.407 NM_017956
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae)
chr12_-_16759420 0.406 LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_75894919 0.405 NM_001135048
NM_130469
JDP2

Jun dimerization protein 2

chr17_-_36104874 0.405 HNF1B
HNF1 homeobox B
chr1_+_236558715 0.401 NM_080738
EDARADD
EDAR-associated death domain
chr1_-_211751953 0.400 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr3_-_168865521 0.400 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr1_+_9415944 0.399


chr2_-_233877901 0.398 NGEF
neuronal guanine nucleotide exchange factor
chr19_+_1248548 0.393 NM_177401
MIDN
midnolin
chr12_-_46121489 0.391 LOC400027
uncharacterized LOC400027
chr1_-_205719273 0.390 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr4_+_41614933 0.384 LIMCH1
LIM and calponin homology domains 1
chr1_+_36689996 0.383 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr4_+_159593233 0.379 NM_004453
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr19_-_35992798 0.379 NM_001035516
DMKN
dermokine
chr17_+_7554711 0.378 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr10_+_81107242 0.377 PPIF
peptidylprolyl isomerase F
chr20_+_19870209 0.373 NM_018993
RIN2
Ras and Rab interactor 2
chr1_+_81771844 0.370 LPHN2
latrophilin 2
chr7_-_92848837 0.369 NM_198151
HEPACAM2
HEPACAM family member 2
chr15_+_63050761 0.368 TLN2
talin 2
chr20_+_39969420 0.364 NM_022896
LPIN3
lipin 3
chr3_-_50340979 0.362 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr17_-_13972715 0.360


chr20_+_42187705 0.356 SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_211751719 0.356 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr17_+_7533403 0.356 SHBG
sex hormone-binding globulin
chr2_-_231084600 0.352 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr3_-_195938256 0.352 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr19_-_6375859 0.352 NM_004158
PSPN
persephin
chr10_+_81107259 0.351 PPIF
peptidylprolyl isomerase F
chr4_+_114214102 0.351 ANK2
ankyrin 2, neuronal
chr6_-_110679474 0.348 NM_001123364
C6orf186
chromosome 6 open reading frame 186
chr16_+_15489619 0.348 MPV17L
MPV17 mitochondrial membrane protein-like
chr14_-_48144156 0.347 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr1_+_65210724 0.347 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr2_+_112895958 0.345 NM_001128165
NM_153214
FBLN7

fibulin 7

chr7_+_94285676 0.344 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr2_-_169887832 0.342 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr1_-_20126368 0.341 NM_181719
TMCO4
transmembrane and coiled-coil domains 4
chr19_+_36024313 0.340 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr17_+_45908992 0.339 NM_033413
LRRC46
leucine rich repeat containing 46
chr6_-_107077167 0.338 NM_032730
RTN4IP1
reticulon 4 interacting protein 1
chr11_+_7535000 0.338 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_+_200993041 0.337


chr9_-_88874518 0.335 NM_001010907
C9orf153
chromosome 9 open reading frame 153
chr17_+_7184978 0.335 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr19_-_11308184 0.333 NM_001136191
KANK2
KN motif and ankyrin repeat domains 2
chr3_-_124732379 0.328 HEG1
HEG homolog 1 (zebrafish)
chr17_+_9745847 0.328 GLP2R
glucagon-like peptide 2 receptor
chr6_-_30128688 0.327 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr7_+_73498318 0.326 LIMK1
LIM domain kinase 1
chr9_+_74764394 0.326 GDA
guanine deaminase
chr16_+_29789560 0.326 NM_152338
ZG16
zymogen granule protein 16 homolog (rat)
chr11_+_63993720 0.324 NM_001128612
NM_001128613
NM_032344
NUDT22


nudix (nucleoside diphosphate linked moiety X)-type motif 22


chr2_+_170366211 0.323 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr15_+_49170264 0.322 NM_014335
EID1
EP300 interacting inhibitor of differentiation 1
chr15_-_40630272 0.322 C15orf52
chromosome 15 open reading frame 52
chr19_-_3062191 0.320 NM_001130
NM_198970
AES

amino-terminal enhancer of split

chr1_-_217113007 0.320 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr9_+_115983863 0.319 SLC31A1
solute carrier family 31 (copper transporters), member 1
chr20_-_39946119 0.315 ZHX3
zinc fingers and homeoboxes 3
chr1_-_55266870 0.315 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr3_+_100328432 0.315 NM_032787
GPR128
G protein-coupled receptor 128
chrX_-_150067062 0.315 CD99L2
CD99 molecule-like 2
chr6_-_116575170 0.313 NM_021648
TSPYL4
TSPY-like 4
chr3_-_14166370 0.310 NM_001098502
NM_144636
CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr11_-_111782447 0.309 NM_001885
CRYAB
crystallin, alpha B
chr10_+_81107228 0.309 PPIF
peptidylprolyl isomerase F
chr1_+_178995175 0.308 FAM20B
family with sequence similarity 20, member B
chr10_-_21805715 0.307 C10orf140
chromosome 10 open reading frame 140
chr17_-_6616651 0.305 NM_001143838
NM_177550
SLC13A5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr22_+_35779103 0.304 HMOX1
heme oxygenase (decycling) 1
chr5_+_96271773 0.303 LNPEP
leucyl/cystinyl aminopeptidase
chr7_+_94285620 0.303 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr10_-_21814610 0.302 NM_207371
C10orf140
chromosome 10 open reading frame 140
chrX_-_150067127 0.301 NM_001184808
NM_001242614
NM_031462
NM_134445
NM_134446
CD99L2




CD99 molecule-like 2




chr3_-_187009469 0.301 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr9_+_74764266 0.301 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr17_+_7517263 0.301 SHBG
sex hormone-binding globulin
chr1_+_20878931 0.299 NM_207334
FAM43B
family with sequence similarity 43, member B
chr15_+_76352323 0.299 C15orf27
chromosome 15 open reading frame 27
chr15_+_54305100 0.297 NM_001080534
UNC13C
unc-13 homolog C (C. elegans)
chr20_+_42187634 0.296 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr11_+_61560401 0.295 FEN1
flap structure-specific endonuclease 1
chr14_-_95942037 0.294 NM_152592
C14orf49
chromosome 14 open reading frame 49
chr3_-_112358510 0.293 CCDC80
coiled-coil domain containing 80
chrX_-_102531673 0.293 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chrX_-_154299253 0.292 NM_001018024
NM_001018025
MTCP1NB
MTCP1
mature T-cell proliferation 1 neighbor
mature T-cell proliferation 1
chr6_-_34360438 0.291 NM_006703
NUDT3
nudix (nucleoside diphosphate linked moiety X)-type motif 3
chr7_-_107443631 0.291 NM_000111
SLC26A3
solute carrier family 26, member 3
chr12_+_7167979 0.291 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr2_-_190044330 0.291 NM_000393
COL5A2
collagen, type V, alpha 2
chr10_-_74714563 0.291 PLA2G12B
phospholipase A2, group XIIB
chr18_+_44497512 0.290 KATNAL2
katanin p60 subunit A-like 2
chr16_+_19078916 0.290 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr3_-_49459870 0.290 AMT
aminomethyltransferase
chr12_+_56511969 0.289 NM_032786
ZC3H10
zinc finger CCCH-type containing 10
chr14_+_75894508 0.289 NM_001135047
JDP2
Jun dimerization protein 2
chr17_-_27948345 0.288 NM_032854
CORO6
coronin 6
chr17_-_36105005 0.287 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr14_+_24458026 0.287 NM_198083
DHRS4L2
dehydrogenase/reductase (SDR family) member 4 like 2
chr1_-_182573393 0.287 NM_002928
RGS16
regulator of G-protein signaling 16
chr1_+_55107426 0.286 NM_001039464
HEATR8-TTC4
HEATR8
HEATR8-TTC4 readthrough
HEAT repeat containing 8
chr14_+_21498344 0.283 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr16_+_8807426 0.283 ABAT
4-aminobutyrate aminotransferase
chr13_-_46756295 0.283 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr18_-_46469118 0.282 NM_001190823
SMAD7
SMAD family member 7
chr10_-_74714479 0.281 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr3_+_159943252 0.280 NM_001168214
C3orf80
chromosome 3 open reading frame 80
chr22_-_39240016 0.280 NM_014293
NPTXR
neuronal pentraxin receptor
chr8_+_99956630 0.280 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr1_-_111743261 0.279 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr14_-_65409445 0.279 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_+_69240137 0.279 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr15_-_41408329 0.278 NM_017553
INO80
INO80 homolog (S. cerevisiae)
chr20_-_48532036 0.278 SPATA2
spermatogenesis associated 2
chr1_-_169555624 0.278 F5
coagulation factor V (proaccelerin, labile factor)
chr3_-_113464991 0.278 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr22_+_30792929 0.278 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr9_+_140145712 0.277 NM_001004353
C9orf173
chromosome 9 open reading frame 173
chr16_+_14280464 0.276 MKL2
MKL/myocardin-like 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.07 3.04e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
938.33 1.17e-05 GO:0030492 hemoglobin binding
39.26 7.92e-03 GO:0004252 serine-type endopeptidase activity
33.87 1.06e-02 GO:0008236 serine-type peptidase activity
33.28 1.10e-02 GO:0017171 serine hydrolase activity