Motif ID: PITX1..3.p2

Z-value: 3.265


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX1hg19_v1_chr5_-_134369841_1343699780.901.5e-02Click!
PITX2hg19_v1_chr4_-_111544206_111544345-0.542.7e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_74483806 6.698 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr7_-_98805088 6.267 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr1_-_213020947 5.859 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr11_-_1606480 5.539 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr15_+_85359910 5.459 NM_020778
ALPK3
alpha-kinase 3
chr19_-_47735858 5.402 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr19_+_48964505 4.569 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr12_+_52416615 4.363 NM_001202233
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr22_-_24096551 4.219 NM_013378
VPREB3
pre-B lymphocyte 3
chr1_+_212788359 3.708 NM_001206486
ATF3
activating transcription factor 3
chr19_-_2256415 3.654 NM_144616
JSRP1
junctional sarcoplasmic reticulum protein 1
chr6_-_44233499 3.596 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr19_-_48614013 3.563 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr22_+_29834571 3.448 NM_021026
RFPL1
ret finger protein-like 1
chr19_+_10222196 3.285 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr7_-_100858312 3.229 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr6_-_27858569 3.091 NM_003535
HIST1H3J
histone cluster 1, H3j
chr1_+_26503973 3.049 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr4_+_2627158 3.021 NM_003704
FAM193A
family with sequence similarity 193, member A
chr11_-_46612913 2.997 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr17_+_7384720 2.977 NM_001102614
SLC35G6
solute carrier family 35, member G6
chr19_+_49375679 2.841 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr19_+_49375677 2.837 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr19_+_49375638 2.793 NM_014330
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr19_-_51893791 2.785 NM_001193623
LOC147646
uncharacterized LOC147646
chr19_+_544026 2.759 NM_005317
GZMM
granzyme M (lymphocyte met-ase 1)
chr7_+_1570321 2.747 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr12_-_49177876 2.733 NM_015270
ADCY6
adenylate cyclase 6
chr6_-_31648140 2.683 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr16_+_89984286 2.675 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr19_-_55836668 2.572 NM_001085488
TMEM150B
transmembrane protein 150B
chr12_-_52225700 2.515 NM_001013690
FIGNL2
fidgetin-like 2
chr21_+_35736322 2.436 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr2_-_211018294 2.410 C2orf67
chromosome 2 open reading frame 67
chr20_+_51801821 2.371 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr10_-_92681025 2.368 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_+_26504024 2.344 CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr3_+_10206562 2.321 NM_001570
IRAK2
interleukin-1 receptor-associated kinase 2
chr2_+_169643048 2.295 NM_001171631
NOSTRIN
nitric oxide synthase trafficker
chr12_-_6756533 2.270 NM_032489
ACRBP
acrosin binding protein
chr7_+_99724319 2.235 NM_203397
MBLAC1
metallo-beta-lactamase domain containing 1
chr4_-_88243994 2.213 NM_001136230
NM_178135
HSD17B13

hydroxysteroid (17-beta) dehydrogenase 13

chr15_+_71433787 2.208 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr19_-_45908288 2.195 NM_006663
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr14_+_68168602 2.154 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr17_-_79838899 2.142


chr16_+_67571342 2.141 NM_001193524
FAM65A
family with sequence similarity 65, member A
chr1_+_28655512 2.108 NM_001127350
NM_017638
MED18

mediator complex subunit 18

chr4_-_74964996 2.106 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr16_+_230332 2.102 NM_005331
HBQ1
hemoglobin, theta 1
chr6_-_42162693 2.039 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr14_-_89016806 2.013 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr2_+_10186284 2.002


chr12_-_123594974 2.001 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr22_+_20918810 1.998 MED15
mediator complex subunit 15
chrX_-_23761396 1.998 NM_001033583
NM_001037171
ACOT9

acyl-CoA thioesterase 9

chr19_+_47759730 1.997 NM_015603
CCDC9
coiled-coil domain containing 9
chr15_-_23115243 1.953 LOC283683
uncharacterized LOC283683
chr11_+_65101224 1.949 NM_006268
DPF2
D4, zinc and double PHD fingers family 2
chr16_-_21854755 1.935 LOC100132247
NPIPL3
LOC613037
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
nuclear pore complex interacting protein pseudogene
chr20_+_361272 1.919 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr15_-_41836458 1.889 NM_015540
RPAP1
RNA polymerase II associated protein 1
chr6_-_31763551 1.856 NM_006295
VARS
valyl-tRNA synthetase
chr15_-_41836442 1.787 RPAP1
RNA polymerase II associated protein 1
chr11_-_69490014 1.767 ORAOV1
oral cancer overexpressed 1
chr19_+_17622420 1.758 NM_012088
PGLS
6-phosphogluconolactonase
chr19_+_17622445 1.755 PGLS
6-phosphogluconolactonase
chr11_+_65101345 1.735 DPF2
D4, zinc and double PHD fingers family 2
chr10_-_99161013 1.731 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr6_-_44233244 1.720 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr7_+_73868236 1.716 GTF2IRD1
GTF2I repeat domain containing 1
chr10_-_99160987 1.695 RRP12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr16_-_75301950 1.682 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr7_-_99680358 1.680 ZNF3
zinc finger protein 3
chr19_-_12792698 1.678 NM_001930
NM_013406
DHPS

deoxyhypusine synthase

chr16_+_50321822 1.657 NM_001114
ADCY7
adenylate cyclase 7
chr2_+_203130480 1.635 NM_015934
NOP58
NOP58 ribonucleoprotein homolog (yeast)
chr16_+_4382224 1.629 NM_032575
GLIS2
GLIS family zinc finger 2
chr11_-_9225780 1.625 DENND5A
DENN/MADD domain containing 5A
chr19_-_55549612 1.623 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr18_+_3453771 1.622 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr8_+_38965049 1.619 NM_145004
ADAM32
ADAM metallopeptidase domain 32
chr10_-_125853102 1.589 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr15_+_42696957 1.586 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr1_+_10534992 1.575 NM_004565
PEX14
peroxisomal biogenesis factor 14
chr19_+_2389768 1.571 NM_182973
TMPRSS9
transmembrane protease, serine 9
chr7_+_73868397 1.569 GTF2IRD1
GTF2I repeat domain containing 1
chr7_+_48128225 1.544 NM_181597
UPP1
uridine phosphorylase 1
chr15_+_32933869 1.535 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr1_+_995109 1.529 LOC100288175
uncharacterized LOC100288175
chr9_+_131464770 1.527 NM_013355
PKN3
protein kinase N3
chr4_-_184243578 1.527 NM_001185149
CLDN24
claudin 24
chr12_-_117537090 1.489 NM_001168325
NM_017899
TESC

tescalcin

chr4_-_74864296 1.479 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr6_-_74161978 1.469 MB21D1
Mab-21 domain containing 1
chr9_-_27005649 1.465 NM_022901
LRRC19
leucine rich repeat containing 19
chr17_-_7493389 1.452 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr7_+_73868111 1.431 NM_001199207
NM_005685
NM_016328
GTF2IRD1


GTF2I repeat domain containing 1


chr7_-_143956720 1.421 NM_001005328
OR2A7
olfactory receptor, family 2, subfamily A, member 7
chr1_+_186369703 1.421 NM_022375
OCLM
oculomedin
chr7_-_47988036 1.404 NM_138295
PKD1L1
polycystic kidney disease 1 like 1
chr19_+_45596159 1.401 PPP1R37
protein phosphatase 1, regulatory subunit 37
chr7_-_100061893 1.401 NM_001004323
C7orf61
chromosome 7 open reading frame 61
chr7_-_140302311 1.400 NM_015689
DENND2A
DENN/MADD domain containing 2A
chr9_+_135894806 1.398 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr7_-_99756329 1.381 C7orf43
chromosome 7 open reading frame 43
chr10_-_69752385 1.369 HERC4
hect domain and RLD 4
chr17_+_40703983 1.366 NM_000413
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chr6_-_88038995 1.343 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr2_-_74542149 1.340 NM_021196
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr9_+_129567260 1.338 NM_001135776
NM_014007
ZBTB43

zinc finger and BTB domain containing 43

chr3_-_109035239 1.334 NM_138815
DPPA2
developmental pluripotency associated 2
chr1_+_10509775 1.333 NM_001302
CORT
cortistatin
chr11_-_62607627 1.327 NM_018093
WDR74
WD repeat domain 74
chr20_+_36011936 1.327 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr3_+_9691198 1.319 MTMR14
myotubularin related protein 14
chr7_+_17382900 1.319 AHR
aryl hydrocarbon receptor
chr7_-_99756275 1.316 NM_018275
C7orf43
chromosome 7 open reading frame 43
chr13_-_46961634 1.309 NM_025113
KIAA0226L
KIAA0226-like
chr14_-_75530716 1.308 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr17_+_40086875 1.306 NM_031421
TTC25
tetratricopeptide repeat domain 25
chr2_+_219575507 1.304 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr4_+_41983712 1.277 NM_001029955
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr1_+_95558072 1.275 NM_001199679
TMEM56
transmembrane protein 56
chr8_-_101315457 1.270 NM_015435
RNF19A
ring finger protein 19A
chr19_+_4183350 1.268 NM_133475
ANKRD24
ankyrin repeat domain 24
chr6_+_31598366 1.260 PRRC2A
proline-rich coiled-coil 2A
chr16_+_67001377 1.251 NM_001185176
CES3
carboxylesterase 3
chr9_+_6720862 1.239 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr16_+_30210548 1.236 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr3_-_50375650 1.236 NM_170712
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr20_-_62436855 1.235 NM_025224
ZBTB46
zinc finger and BTB domain containing 46
chr20_+_361675 1.231 TRIB3
tribbles homolog 3 (Drosophila)
chr1_-_38019828 1.228 NM_024700
SNIP1
Smad nuclear interacting protein 1
chr22_-_18484183 1.228 MICAL3
microtubule associated monoxygenase, calponin and LIM domain containing 3
chr16_+_88003623 1.226 NM_001173543
BANP
BTG3 associated nuclear protein
chr8_-_124749573 1.223 NM_001003954
NM_004306
ANXA13

annexin A13

chr5_+_55147206 1.213 NM_001242637
NM_001242638
NM_139017
IL31RA


interleukin 31 receptor A


chr16_-_3074225 1.207 NM_001002017
NM_001002018
NM_017885
HCFC1R1


host cell factor C1 regulator 1 (XPO1 dependent)


chr17_-_56769375 1.202 NM_001201457
NM_031272
NM_198393
TEX14


testis expressed 14


chr7_+_74508346 1.199 NM_001003795
GTF2IRD2B
GTF2IRD2
GTF2I repeat domain containing 2B
GTF2I repeat domain containing 2
chr1_-_150738292 1.197 NM_001199739
NM_004079
CTSS

cathepsin S

chr17_+_7982752 1.188


chr19_+_48774653 1.185 NM_153608
ZNF114
zinc finger protein 114
chr8_-_124253584 1.182 NM_032847
C8orf76
chromosome 8 open reading frame 76
chr9_-_117156684 1.179 NM_030767
AKNA
AT-hook transcription factor
chr3_+_9691116 1.175 NM_001077525
NM_001077526
NM_022485
MTMR14


myotubularin related protein 14


chr9_-_110252045 1.171 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr16_+_90015138 1.160 NM_001242816
NM_001242817
NM_001242818
NM_001242820
NM_001242821
NM_001242822
NM_017702
NM_207514
DEF8







differentially expressed in FDCP 8 homolog (mouse)







chr3_-_121740968 1.160 NM_001199799
NM_001199800
NM_175924
ILDR1


immunoglobulin-like domain containing receptor 1


chr2_-_197664335 1.157 NM_001206774
NM_012086
GTF3C3

general transcription factor IIIC, polypeptide 3, 102kDa

chr10_+_96443250 1.157 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr1_+_151009028 1.156 NM_001159642
NM_138278
BNIPL

BCL2/adenovirus E1B 19kD interacting protein like

chr12_-_15865847 1.153 EPS8
epidermal growth factor receptor pathway substrate 8
chr10_+_70502251 1.149 CCAR1
cell division cycle and apoptosis regulator 1
chr19_+_11200146 1.139 LDLR
low density lipoprotein receptor
chr7_+_23530136 1.135 RPS2P32
ribosomal protein S2 pseudogene 32
chr9_+_132388404 1.126 NM_014064
METTL11A
methyltransferase like 11A
chr14_+_21756135 1.124 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr6_-_43423785 1.112 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chr7_-_1595746 1.110 NM_001097620
TMEM184A
transmembrane protein 184A
chr20_-_33999780 1.108 NM_001184977
NM_018244
NM_199487
UQCC


ubiquinol-cytochrome c reductase complex chaperone


chr19_+_48828627 1.108 NM_001425
EMP3
epithelial membrane protein 3
chr9_-_35115844 1.103 NM_025182
FAM214B
family with sequence similarity 214, member B
chr11_-_73720281 1.102 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr3_-_15382874 1.098 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr4_+_72904848 1.097 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr22_+_39795745 1.096 NM_006116
NM_153497
TAB1

TGF-beta activated kinase 1/MAP3K7 binding protein 1

chr7_+_72848108 1.095 NM_003508
FZD9
frizzled family receptor 9
chr14_-_73453651 1.093 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr10_-_70287249 1.089 NM_152707
SLC25A16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr19_+_47759802 1.087 CCDC9
coiled-coil domain containing 9
chr3_+_9691184 1.086 MTMR14
myotubularin related protein 14
chr16_-_29937354 1.078 KCTD13
potassium channel tetramerisation domain containing 13
chr19_-_46142662 1.075 NM_012155
EML2
echinoderm microtubule associated protein like 2
chr19_-_3969734 1.072 NM_001348
DAPK3
death-associated protein kinase 3
chr17_-_4607431 1.061 NM_014389
PELP1
proline, glutamate and leucine rich protein 1
chr8_-_141468677 1.060 NM_031466
TRAPPC9
trafficking protein particle complex 9
chr1_-_221910801 1.059 NM_144728
DUSP10
dual specificity phosphatase 10
chr22_+_24819855 1.059 ADORA2A
adenosine A2a receptor
chr13_-_21635703 1.057 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr7_-_100231135 1.050 NM_001206855
TFR2
transferrin receptor 2
chr15_-_65398578 1.043 NM_001163692
UBAP1L
ubiquitin associated protein 1-like
chrX_+_69488154 1.043 NM_004312
ARR3
arrestin 3, retinal (X-arrestin)
chr1_-_150738255 1.041 CTSS
cathepsin S
chr19_+_45542295 1.033 NM_007056
CLASRP
CLK4-associating serine/arginine rich protein
chr4_+_62362838 1.026 NM_015236
LPHN3
latrophilin 3
chr7_+_100770378 1.023 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr9_+_132388451 1.023 METTL11A
methyltransferase like 11A
chr2_-_216249682 1.022 FN1
fibronectin 1
chr19_-_3500937 1.019 NM_001145165
DOHH
deoxyhypusine hydroxylase/monooxygenase
chr14_-_64006402 1.018 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr1_-_150849211 1.018 NM_001197325
NM_001668
NM_178427
ARNT


aryl hydrocarbon receptor nuclear translocator


chr1_-_151826042 1.017 NM_182578
THEM5
thioesterase superfamily member 5
chr3_+_194304717 1.017


chr22_-_38240341 1.016 NM_138797
ANKRD54
ankyrin repeat domain 54
chr19_+_4488690 1.014 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr5_-_70320940 1.011 NM_004536
NM_022892
NAIP

NLR family, apoptosis inhibitory protein

chr12_+_120740123 1.010 NM_012240
SIRT4
sirtuin 4
chr1_-_40349169 1.009 NM_017646
TRIT1
tRNA isopentenyltransferase 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.