Motif ID: POU5F1.p2

Z-value: 2.981


Transcription factors associated with POU5F1.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1



Activity profile for motif POU5F1.p2.

activity profile for motif POU5F1.p2


Sorted Z-values histogram for motif POU5F1.p2

Sorted Z-values for motif POU5F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_67410825 22.601 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr10_+_115312777 7.139 NM_004132
HABP2
hyaluronan binding protein 2
chr1_+_164528914 5.792 PBX1
pre-B-cell leukemia homeobox 1
chr5_-_36301999 5.325 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr17_-_36104874 4.867 HNF1B
HNF1 homeobox B
chr17_+_7554415 4.722 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr5_-_111091947 4.418 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr21_-_36421195 4.336 RUNX1
runt-related transcription factor 1
chr6_+_27100784 4.278 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr14_+_79745653 4.228 NM_001105250
NM_138970
NRXN3

neurexin 3

chr1_-_217262946 4.153 NM_001243506
NM_206594
NM_206595
ESRRG


estrogen-related receptor gamma


chr6_+_26124372 4.061 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr5_-_27038650 3.917 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr6_+_26251826 3.887 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr17_-_36105005 3.693 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr3_-_123603144 3.623 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr5_+_54455945 3.382 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr11_-_27494232 3.341 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr20_-_34243118 3.302 RBM12
RNA binding motif protein 12
chr1_+_170115187 3.244 NM_001136107
METTL11B
methyltransferase like 11B
chrX_+_38660692 3.208 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chrX_+_38660653 3.181 NM_001098790
NM_001098791
MID1IP1

MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))

chr17_+_7554239 3.151 NM_001678
ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr19_-_18314731 3.121 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chrX_-_24665225 3.058 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr1_+_33722158 3.016 NM_152493
ZNF362
zinc finger protein 362
chr16_-_79634610 2.985 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr14_-_92413738 2.950 FBLN5
fibulin 5
chr2_+_16080559 2.925 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chrX_-_33357725 2.920 NM_000109
DMD
dystrophin
chr1_+_192605267 2.865 NM_002927
NM_144766
RGS13

regulator of G-protein signaling 13

chr8_-_102803196 2.765 NCALD
neurocalcin delta
chrX_+_9431314 2.746 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr2_+_16080639 2.714 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr8_+_26435590 2.658 DPYSL2
dihydropyrimidinase-like 2
chr1_+_24840800 2.584 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr10_-_21807120 2.567


chrX_-_24665454 2.557 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr11_-_115375065 2.549 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr16_+_29789560 2.508 NM_152338
ZG16
zymogen granule protein 16 homolog (rat)
chr3_+_181429711 2.465 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr5_-_147162056 2.464 JAKMIP2
janus kinase and microtubule interacting protein 2
chr17_+_38219040 2.428 NM_001190918
NM_003250
NM_199334
THRA


thyroid hormone receptor, alpha


chr21_-_36421461 2.421 RUNX1
runt-related transcription factor 1
chr1_+_39875175 2.407 NM_015038
KIAA0754
KIAA0754
chr13_-_28543143 2.404 CDX2
caudal type homeobox 2
chr9_-_14086901 2.383 NFIB
nuclear factor I/B
chr13_-_61989209 2.352 PCDH20
protocadherin 20
chrX_-_106960268 2.345 NM_004089
TSC22D3
TSC22 domain family, member 3
chr6_-_26033795 2.338 NM_003513
HIST1H2AB
histone cluster 1, H2ab
chr16_-_4323000 2.332 NM_003223
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr1_-_108231122 2.320 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr6_+_167536240 2.297 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr2_+_27310079 2.295 KHK
ketohexokinase (fructokinase)
chr18_-_53089722 2.260 NM_001243233
TCF4
transcription factor 4
chr5_-_111092918 2.248 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr17_+_7554711 2.228 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr17_+_45908992 2.219 NM_033413
LRRC46
leucine rich repeat containing 46
chr5_-_111092865 2.178 C5orf13
chromosome 5 open reading frame 13
chr3_-_186262114 2.162 NM_017541
CRYGS
crystallin, gamma S
chrX_-_13835313 2.133 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr1_+_164528586 2.130 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr12_+_25205488 2.125 LRMP
lymphoid-restricted membrane protein
chr2_+_65663812 2.122 FLJ16124
FLJ16124 protein
chr1_+_87797301 2.112


chr4_+_41614911 2.096 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_-_102462371 2.063 OLFM3
olfactomedin 3
chr7_-_27239724 2.050 NM_000522
HOXA13
homeobox A13
chrX_-_105282714 2.049 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr7_-_92855780 2.007 NM_001039372
HEPACAM2
HEPACAM family member 2
chr4_+_154178525 2.005 TRIM2
tripartite motif containing 2
chr18_+_72922725 1.999 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr7_+_94292737 1.925 PEG10
paternally expressed 10
chr1_-_23885916 1.920 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr8_+_26435466 1.907 DPYSL2
dihydropyrimidinase-like 2
chr8_+_26435339 1.900 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr8_+_24151579 1.868 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr12_-_81763127 1.858 NM_001220479
NM_001220480
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr8_+_56792399 1.851 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr1_+_66458389 1.850 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_+_84222252 1.825 PRSS35
protease, serine, 35
chr16_-_4322695 1.821 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr12_+_25205180 1.812 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr3_-_57234279 1.812 NM_003865
HESX1
HESX homeobox 1
chrX_-_106960028 1.810 TSC22D3
TSC22 domain family, member 3
chr2_-_188419185 1.792 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr17_+_14204326 1.788 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr1_+_244214552 1.785 NM_205768
ZNF238
zinc finger protein 238
chr19_+_17337012 1.771 NM_024578
OCEL1
occludin/ELL domain containing 1
chr6_-_42419782 1.769 NM_033502
TRERF1
transcriptional regulating factor 1
chr1_+_214161279 1.762 PROX1
prospero homeobox 1
chr6_+_27114860 1.750 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr1_+_101185195 1.750 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr3_+_186648273 1.734 NM_173216
NM_173217
ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chr5_-_111312522 1.725 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr18_+_33234532 1.720 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr11_-_94964209 1.694 NM_144665
SESN3
sestrin 3
chr10_-_42863435 1.690 LOC441666
zinc finger protein 91 pseudogene
chr2_-_165551178 1.690 COBLL1
COBL-like 1
chr4_-_164534656 1.683 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chrX_-_13835213 1.681 GPM6B
glycoprotein M6B
chr3_-_71294229 1.674 NM_001244814
FOXP1
forkhead box P1
chr11_+_63057371 1.645 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr9_+_132083294 1.639 NM_001012715
C9orf106
chromosome 9 open reading frame 106
chr1_+_244214576 1.629 ZNF238
zinc finger protein 238
chr4_+_184826427 1.609 NM_020225
STOX2
storkhead box 2
chr3_+_49568370 1.593 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr13_-_86373328 1.581 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr20_+_34556528 1.573 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chrM_-_379 1.566


chr17_-_41276112 1.560 NM_007298
BRCA1
breast cancer 1, early onset
chrX_+_22050920 1.553 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr3_-_14989616 1.548 LOC100505641
uncharacterized LOC100505641
chrX_-_21776158 1.546 NM_014332
SMPX
small muscle protein, X-linked
chr12_-_16760935 1.538 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr5_-_35230548 1.499 PRLR
prolactin receptor
chr1_-_211752052 1.495 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr1_+_92545861 1.492 NM_183242
BTBD8
BTB (POZ) domain containing 8
chr2_-_152118258 1.487 NM_198557
RBM43
RNA binding motif protein 43
chr1_-_216896640 1.486 NM_001243515
NM_001243518
NM_001243519
NM_001438
ESRRG



estrogen-related receptor gamma



chr13_-_28543423 1.478 CDX2
caudal type homeobox 2
chr19_-_44124013 1.471 NM_182498
ZNF428
zinc finger protein 428
chr16_+_30483959 1.470 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr3_-_14989399 1.455 LOC100505641
uncharacterized LOC100505641
chr4_-_186733372 1.451 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr19_-_44123732 1.450 ZNF428
zinc finger protein 428
chr11_+_5653484 1.437 NM_130390
TRIM34
tripartite motif containing 34
chr1_-_217250230 1.432 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr2_+_242127923 1.431 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr14_+_90863302 1.431 NM_006888
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr5_-_73936299 1.430 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr8_+_56792345 1.413 NM_001111097
NM_002350
LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

chr4_+_88896868 1.395 SPP1
secreted phosphoprotein 1
chr12_-_6772252 1.393 NM_001127582
NM_001127583
NM_001127584
NM_001127585
NM_001127586
NM_016162
ING4





inhibitor of growth family, member 4





chr16_+_30484049 1.392 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr16_+_2198607 1.386 NM_014353
RAB26
RAB26, member RAS oncogene family
chr6_-_134498973 1.383 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr4_+_88896838 1.383 SPP1
secreted phosphoprotein 1
chr11_-_119599253 1.375 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr5_+_140602914 1.375 NM_018934
PCDHB14
protocadherin beta 14
chr14_+_78870092 1.372 NM_004796
NRXN3
neurexin 3
chr2_+_189839132 1.360 COL3A1
collagen, type III, alpha 1
chr6_+_112375277 1.358 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr7_+_141478241 1.348 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr15_+_96869156 1.343 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr7_+_43152196 1.336 NM_015052
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr1_-_72748491 1.336


chr1_-_26185847 1.323 NM_024037
C1orf135
chromosome 1 open reading frame 135
chr6_+_84222193 1.320 NM_001170423
NM_153362
PRSS35

protease, serine, 35

chr12_+_51318743 1.318 METTL7A
methyltransferase like 7A
chr11_-_115088628 1.308 CADM1
cell adhesion molecule 1
chr5_-_88119604 1.297 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_+_109384601 1.291 RANBP2
RAN binding protein 2
chr6_+_21593963 1.289 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr12_+_54447660 1.289 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr4_-_141074122 1.288 MAML3
mastermind-like 3 (Drosophila)
chr16_-_28550324 1.284 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr21_-_36421630 1.271 RUNX1
runt-related transcription factor 1
chr13_-_28543290 1.266 NM_001265
CDX2
caudal type homeobox 2
chr12_-_102591547 1.259 NM_002674
PMCH
pro-melanin-concentrating hormone
chr2_+_234601511 1.255 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr5_+_140593508 1.251 NM_018933
PCDHB13
protocadherin beta 13
chr2_+_74120132 1.247 ACTG2
actin, gamma 2, smooth muscle, enteric
chr6_-_134497069 1.241 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr3_+_3841079 1.240 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr1_-_23886284 1.228 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr20_+_19915716 1.221 RIN2
Ras and Rab interactor 2
chr4_+_41700736 1.218 LIMCH1
LIM and calponin homology domains 1
chr5_-_147162251 1.207 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr7_-_56101830 1.206 PSPH
phosphoserine phosphatase
chr11_-_66115016 1.204 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr22_-_31742329 1.203 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr14_+_62462540 1.197 NM_031914
SYT16
synaptotagmin XVI
chr19_-_40562107 1.197 NM_001005851
ZNF780B
zinc finger protein 780B
chr5_+_140743755 1.191 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr2_-_188419049 1.183 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr11_-_118084073 1.176 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr21_-_36421578 1.175 RUNX1
runt-related transcription factor 1
chr10_-_91011586 1.171 NM_000235
NM_001127605
LIPA

lipase A, lysosomal acid, cholesterol esterase

chr21_-_36421586 1.170 NM_001754
RUNX1
runt-related transcription factor 1
chr14_-_92414004 1.169 NM_006329
FBLN5
fibulin 5
chr7_-_150754934 1.165 CDK5
cyclin-dependent kinase 5
chr12_-_81991959 1.164 NM_001220477
NM_001220478
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr14_+_90863365 1.163 CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr4_+_88896801 1.162 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr16_-_28550227 1.159 NUPR1
nuclear protein, transcriptional regulator, 1
chr10_-_13390189 1.156 NM_001195602
NM_001195604
NM_012247
SEPHS1


selenophosphate synthetase 1


chr3_-_148804122 1.153 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chrX_-_15402469 1.153 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr1_+_81771844 1.150 LPHN2
latrophilin 2
chr4_+_113739203 1.146 NM_001127493
ANK2
ankyrin 2, neuronal
chr2_+_232573249 1.141 PTMA
prothymosin, alpha
chr3_-_14989857 1.138 LOC100505641
uncharacterized LOC100505641
chr4_+_114214102 1.133 ANK2
ankyrin 2, neuronal
chrX_-_15288172 1.132 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr10_-_91011516 1.131 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr2_+_232573226 1.131 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr7_+_16793320 1.129 NM_014399
TSPAN13
tetraspanin 13
chr6_+_101846668 1.129 GRIK2
glutamate receptor, ionotropic, kainate 2
chrX_-_63425484 1.126 NM_152424
FAM123B
family with sequence similarity 123B

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.31 3.77e-07 GO:0048731 system development
2.67 1.25e-06 GO:0048513 organ development
2.15 2.60e-06 GO:0048856 anatomical structure development
1.95 2.05e-05 GO:0032502 developmental process
2.00 2.70e-05 GO:0007275 multicellular organismal development
2.67 1.02e-04 GO:0009653 anatomical structure morphogenesis
1.67 3.75e-04 GO:0032501 multicellular organismal process
8.01 4.86e-04 GO:0007156 homophilic cell adhesion
2.54 8.06e-04 GO:0007399 nervous system development
104.89 8.19e-04 GO:0060839 endothelial cell fate commitment
104.89 8.19e-04 GO:0072148 epithelial cell fate commitment
3.68 9.97e-04 GO:0009887 organ morphogenesis
3.23 2.18e-03 GO:0007155 cell adhesion
3.23 2.18e-03 GO:0022610 biological adhesion
4.89 2.70e-03 GO:0016337 cell-cell adhesion
2.12 5.02e-03 GO:0048869 cellular developmental process
2.13 6.79e-03 GO:0030154 cell differentiation
5.27 7.97e-03 GO:0048568 embryonic organ development
7.57 1.06e-02 GO:0060541 respiratory system development
23.31 2.11e-02 GO:0007157 heterophilic cell-cell adhesion
23.31 2.11e-02 GO:0048844 artery morphogenesis
3.03 2.85e-02 GO:0009790 embryo development
10.00 2.86e-02 GO:0046890 regulation of lipid biosynthetic process
2.63 3.14e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
20.98 3.30e-02 GO:0060840 artery development
39.34 4.43e-02 GO:0060850 regulation of transcription involved in cell fate commitment
6.18 4.64e-02 GO:0019216 regulation of lipid metabolic process
2.71 4.95e-02 GO:0009888 tissue development

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.83 4.15e-04 GO:0001071 nucleic acid binding transcription factor activity
2.83 4.15e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
3.27 5.60e-04 GO:0043565 sequence-specific DNA binding
2.76 6.40e-04 GO:0030528 transcription regulator activity
5.41 2.91e-03 GO:0010843 promoter binding
5.20 4.13e-03 GO:0000975 regulatory region DNA binding
5.20 4.13e-03 GO:0001067 regulatory region nucleic acid binding
5.20 4.13e-03 GO:0044212 transcription regulatory region DNA binding
3.52 8.21e-03 GO:0042803 protein homodimerization activity
1.84 2.29e-02 GO:0003677 DNA binding
2.72 4.88e-02 GO:0046983 protein dimerization activity