Motif ID: PRDM1.p3

Z-value: 1.155


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRDM1hg19_v1_chr6_+_106546736_1065468730.434.0e-01Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_212781969 6.850 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr1_+_212782103 6.203 ATF3
activating transcription factor 3
chr1_-_221915393 2.043 DUSP10
dual specificity phosphatase 10
chr1_-_221915426 1.941 DUSP10
dual specificity phosphatase 10
chr19_+_13105970 1.512 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_221915458 1.499 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr3_-_114343052 1.469 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr11_+_71709951 1.461 NM_001039659
NM_001039660
NM_173044
NM_005699
NM_173042
IL18BP




interleukin 18 binding protein




chr1_+_110453232 1.356 NM_000757
NM_172210
NM_172212
CSF1


colony stimulating factor 1 (macrophage)


chr1_+_110453456 1.331 CSF1
colony stimulating factor 1 (macrophage)
chr19_+_36239445 1.272 LIN37
lin-37 homolog (C. elegans)
chr8_-_145060563 1.260 PARP10
poly (ADP-ribose) polymerase family, member 10
chr11_+_71710971 1.206 NM_001145055
IL18BP
interleukin 18 binding protein
chr22_-_30642683 1.172 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr11_+_71710662 1.141 NM_001145057
IL18BP
interleukin 18 binding protein
chr6_-_29527701 1.120 NM_006398
UBD
ubiquitin D
chr19_-_47735858 1.093 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr6_-_29527477 1.066 UBD
ubiquitin D
chr4_-_153303663 1.032 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr2_+_231280870 0.996 NM_001080391
NM_001206701
NM_001206702
NM_001206703
NM_003113
SP100




SP100 nuclear antigen




chr8_+_56686179 0.963


chr17_+_17398334 0.949


chr6_+_36973409 0.918 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr2_+_231280933 0.918 SP100
SP100 nuclear antigen
chr19_+_36239261 0.912 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr14_-_81864726 0.882 NM_033104
STON2
stonin 2
chr3_-_8543327 0.875 LOC100288428
uncharacterized LOC100288428
chr12_-_57505176 0.867 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr10_+_114135965 0.849 ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_-_79717540 0.837 NM_000880
NM_001199886
NM_001199887
NM_001199888
IL7



interleukin 7



chr20_+_388693 0.830 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr2_+_231280906 0.802 SP100
SP100 nuclear antigen
chr20_+_388963 0.795 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr9_+_123850573 0.782 NM_007018
CNTRL
centriolin
chr10_+_114135937 0.775 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_+_388717 0.765 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr12_-_57505121 0.719 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr20_+_389346 0.681 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr11_-_85338313 0.656 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr2_+_205410716 0.644 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr12_-_71003622 0.609 NM_001206971
NM_001206972
NM_002837
PTPRB


protein tyrosine phosphatase, receptor type, B


chr20_+_388941 0.599 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr10_+_123754141 0.598 TACC2
transforming, acidic coiled-coil containing protein 2
chr15_-_56209305 0.592 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr12_-_57504935 0.584 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr1_-_8075678 0.579 ERRFI1
ERBB receptor feedback inhibitor 1
chr1_-_244006471 0.565 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr1_+_162602308 0.560 DDR2
discoidin domain receptor tyrosine kinase 2
chr4_+_15376174 0.545 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr12_+_6561176 0.534 NM_018009
TAPBPL
TAP binding protein-like
chr1_+_167905921 0.532 DCAF6
DDB1 and CUL4 associated factor 6
chr1_+_167905796 0.519 NM_001017977
NM_001198956
NM_001198957
NM_018442
DCAF6



DDB1 and CUL4 associated factor 6



chr10_+_114136014 0.517 ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_+_76649806 0.503 USO1
USO1 vesicle docking protein homolog (yeast)
chr10_-_35103894 0.495 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr8_-_29120571 0.487 NM_015254
KIF13B
kinesin family member 13B
chr2_+_205410465 0.483 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr4_+_76649739 0.470 USO1
USO1 vesicle docking protein homolog (yeast)
chr7_+_42971938 0.463 NM_031903
MRPL32
mitochondrial ribosomal protein L32
chr10_-_94003002 0.450 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr1_-_150780705 0.441 NM_000396
CTSK
cathepsin K
chr5_+_139889635 0.438


chr10_-_131762017 0.438 NM_001005463
EBF3
early B-cell factor 3
chr17_+_4643318 0.430 NM_001136046
NM_032265
ZMYND15

zinc finger, MYND-type containing 15

chr10_-_13749622 0.423 FRMD4A
FERM domain containing 4A
chr2_+_205410556 0.413 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr1_+_162602198 0.390 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chrX_+_102883647 0.390 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr10_+_5238756 0.381 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr1_+_161494035 0.368 NM_002155
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chr4_+_76649826 0.367 NM_003715
USO1
USO1 vesicle docking protein homolog (yeast)
chr10_+_63808968 0.366 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr19_+_49977817 0.360 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chr11_+_35684658 0.354 TRIM44
tripartite motif containing 44
chr4_+_186990308 0.347 NM_003265
TLR3
toll-like receptor 3
chr5_-_37184945 0.344 C5orf42
chromosome 5 open reading frame 42
chr16_-_73092533 0.341 NM_001164766
ZFHX3
zinc finger homeobox 3
chr1_-_226070032 0.336 TMEM63A
transmembrane protein 63A
chr5_+_131746579 0.330 C5orf56
chromosome 5 open reading frame 56
chr1_+_19971865 0.330 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr9_+_109625347 0.330 NM_021224
ZNF462
zinc finger protein 462
chr21_+_34144410 0.326 C21orf49
chromosome 21 open reading frame 49
chr4_+_152020732 0.323 NM_001006
RPS3A
ribosomal protein S3A
chr11_-_104839263 0.323 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr15_-_42749710 0.310 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr1_-_231560789 0.308 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr15_+_74833517 0.300 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr15_-_80263460 0.300 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr16_+_57023411 0.298 NLRC5
NLR family, CARD domain containing 5
chr11_-_104905849 0.295 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr16_+_50775960 0.291 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr18_+_55816546 0.288 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr6_-_31704272 0.282 CLIC1
chloride intracellular channel 1
chr5_+_6746100 0.279 NM_001171806
PAPD7
PAP associated domain containing 7
chr1_+_162039469 0.277 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr1_-_161168816 0.275 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr11_-_85430117 0.271 NM_206929
SYTL2
synaptotagmin-like 2
chr17_+_57232859 0.267 NM_018304
PRR11
proline rich 11
chr16_-_67970734 0.265 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr2_-_37311415 0.256 HEATR5B
HEAT repeat containing 5B
chr2_-_145275086 0.251 ZEB2
zinc finger E-box binding homeobox 2
chr13_-_41635072 0.248 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_144520918 0.247 LOC728855
uncharacterized LOC728855
chr1_+_2985730 0.241 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr20_+_57470200 0.235 GNAS
GNAS complex locus
chr15_-_80207597 0.228 NM_001100879
ST20
suppressor of tumorigenicity 20
chr3_+_187871473 0.228 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr4_-_48782264 0.227 FRYL
FRY-like
chr11_-_78052925 0.211 NM_012296
GAB2
GRB2-associated binding protein 2
chr17_+_7465284 0.205 NM_015670
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chrX_-_24045302 0.198 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr11_+_113931228 0.196 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr5_-_34043234 0.195 NM_030945
NM_181435
C1QTNF3

C1q and tumor necrosis factor related protein 3

chr7_-_105319608 0.194 NM_138495
ATXN7L1
ataxin 7-like 1
chr16_+_50776012 0.193 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr17_+_7465316 0.188 SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr1_-_8483701 0.179 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr13_+_108921976 0.171 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr5_+_49962920 0.169 PARP8
poly (ADP-ribose) polymerase family, member 8
chr2_+_169643048 0.168 NM_001171631
NOSTRIN
nitric oxide synthase trafficker
chr11_-_796175 0.168 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr19_-_11639929 0.165 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr22_+_39417117 0.163 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr16_-_67970651 0.161 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr7_-_42971730 0.160 PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr7_-_51384331 0.160 COBL
cordon-bleu homolog (mouse)
chr4_-_48782281 0.159 NM_015030
FRYL
FRY-like
chr4_+_88529680 0.153 NM_014208
DSPP
dentin sialophosphoprotein
chr19_+_49838700 0.150 CD37
CD37 molecule
chr11_+_5646206 0.144 NM_021616
TRIM34
tripartite motif containing 34
chr17_+_57233100 0.143 PRR11
proline rich 11
chr14_-_23479328 0.142 NM_001130706
NM_001130708
NM_021944
C14orf93


chromosome 14 open reading frame 93


chr11_-_28129646 0.139 KIF18A
kinesin family member 18A
chr1_+_39922262 0.137 MACF1
microtubule-actin crosslinking factor 1
chr1_-_226070419 0.135 NM_014698
TMEM63A
transmembrane protein 63A
chr4_+_37892698 0.133 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr11_-_77531750 0.130 NM_016578
RSF1
remodeling and spacing factor 1
chr17_-_57232799 0.130 NM_001100595
NM_182620
SKA2

spindle and kinetochore associated complex subunit 2

chr11_-_28129687 0.129 KIF18A
kinesin family member 18A
chr11_-_58343308 0.129 NM_004811
LPXN
leupaxin
chr14_-_69260630 0.127 NM_001244698
NM_004926
ZFP36L1

zinc finger protein 36, C3H type-like 1

chr2_-_37311458 0.126 NM_019024
HEATR5B
HEAT repeat containing 5B
chr10_-_97321094 0.123 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr20_+_13976263 0.121 MACROD2
MACRO domain containing 2
chr5_-_75008245 0.117 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr9_-_123676849 0.116 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr12_-_31479084 0.115 FAM60A
family with sequence similarity 60, member A
chr2_+_238969730 0.115 SCLY
selenocysteine lyase
chr17_+_78237389 0.114


chr8_+_97657592 0.111 PGCP
plasma glutamate carboxypeptidase
chr1_-_244006885 0.109 NM_001206729
AKT3
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
chr22_-_36556781 0.108 NM_145640
APOL3
apolipoprotein L, 3
chr21_-_47704166 0.107 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr4_+_146403955 0.107 NM_001003688
SMAD1
SMAD family member 1
chr15_+_71184781 0.105 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr10_-_73497580 0.102 NM_001168390
C10orf105
chromosome 10 open reading frame 105
chr10_+_62538088 0.101 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr4_-_100140330 0.100 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr15_+_85144219 0.098 NM_001007072
NM_017894
NM_181877
ZSCAN2


zinc finger and SCAN domain containing 2


chr2_+_3627725 0.095 RPS7
ribosomal protein S7
chr8_+_97657581 0.094 PGCP
plasma glutamate carboxypeptidase
chr1_+_161169104 0.094 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr6_-_31704281 0.093 CLIC1
chloride intracellular channel 1
chr3_-_38992051 0.091 NM_014139
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr1_-_150738255 0.091 CTSS
cathepsin S
chr19_+_49838734 0.090 CD37
CD37 molecule
chrX_-_63005212 0.090 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr1_-_144520987 0.090 LOC728855
uncharacterized LOC728855
chr7_-_42971779 0.086 NM_002787
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr20_+_13976014 0.084 NM_080676
MACROD2
MACRO domain containing 2
chr2_+_238969641 0.084 SCLY
selenocysteine lyase
chr9_-_14868974 0.084 FREM1
FRAS1 related extracellular matrix 1
chr12_-_31479120 0.082 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr5_-_16617085 0.082 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr6_-_99797530 0.080 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr2_-_163695028 0.077 KCNH7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr11_+_47430045 0.076 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr11_-_65381747 0.076


chr3_-_160101443 0.074 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr10_+_62538250 0.071 CDK1
cyclin-dependent kinase 1
chr8_+_144640476 0.070 NM_024736
GSDMD
gasdermin D
chr10_+_92980322 0.067 NM_032373
PCGF5
polycomb group ring finger 5
chr2_-_175260349 0.067 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr12_-_31479038 0.066 FAM60A
family with sequence similarity 60, member A
chr8_-_42065037 0.066 PLAT
plasminogen activator, tissue
chr11_+_63753324 0.063 NM_017670
OTUB1
OTU domain, ubiquitin aldehyde binding 1
chr14_-_69262959 0.063 NM_001244701
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr1_+_19972259 0.061 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr12_-_123834984 0.059 NM_001167856
NM_018183
SBNO1

strawberry notch homolog 1 (Drosophila)

chr11_-_28129701 0.058 NM_031217
KIF18A
kinesin family member 18A
chr2_+_231090443 0.058 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chr8_+_143808593 0.058 NM_016647
C8orf55
chromosome 8 open reading frame 55
chrX_-_106362018 0.056 RBM41
RNA binding motif protein 41
chr2_+_238969564 0.056 NM_016510
SCLY
selenocysteine lyase
chr14_-_24615794 0.055 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr5_+_96211643 0.053 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr12_+_57920425 0.052 MBD6
methyl-CpG binding domain protein 6
chr11_-_65381641 0.052 NM_002419
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr10_+_115511212 0.052 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr6_-_28555066 0.050 NM_052923
SCAND3
SCAN domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
519.68 8.63e-04 GO:0045651 positive regulation of macrophage differentiation
59.12 2.30e-03 GO:0010948 negative regulation of cell cycle process
259.88 3.87e-03 GO:0045649 regulation of macrophage differentiation

Nothing significant found in compartment category.

Nothing significant found in function category.