Motif ID: PRRX1,2.p2

Z-value: 1.538


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRRX1hg19_v1_chr1_+_170633312_170633413-0.929.7e-03Click!
PRRX2hg19_v1_chr9_+_132428016_132428116-0.246.5e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_94297448 2.653 PEG10
paternally expressed 10
chr6_+_167525294 2.589 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr2_-_99279935 2.557 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr7_-_107443631 2.193 NM_000111
SLC26A3
solute carrier family 26, member 3
chr7_-_96633608 1.935 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr10_-_113933517 1.840 GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr2_+_177016112 1.801 NM_014621
HOXD4
homeobox D4
chr16_+_72088507 1.708 NM_001126102
NM_005143
HP

haptoglobin

chr2_-_77749335 1.601 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr5_+_140602914 1.524 NM_018934
PCDHB14
protocadherin beta 14
chr3_+_180320955 1.512 TTC14
tetratricopeptide repeat domain 14
chrX_-_24690740 1.460 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_-_10372875 1.424 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr10_+_115312777 1.424 NM_004132
HABP2
hyaluronan binding protein 2
chr12_-_10282680 1.403 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chrX_-_129519420 1.403 NM_178471
GPR119
G protein-coupled receptor 119
chr12_+_9142136 1.399 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr1_+_244216506 1.383 NM_006352
ZNF238
zinc finger protein 238
chr1_-_39347258 1.374 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP readthrough
gap junction protein, alpha 9, 59kDa
chr1_+_84630575 1.370 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr9_-_14086901 1.338 NFIB
nuclear factor I/B
chr6_-_32908583 1.335 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr5_+_140782367 1.329 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr5_-_111312522 1.329 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr7_-_84751246 1.317 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr5_+_140529619 1.277 NM_018939
PCDHB6
protocadherin beta 6
chr7_-_14025826 1.223 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr11_-_118084073 1.204 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr5_+_126859157 1.204 PRRC1
proline-rich coiled-coil 1
chr18_-_21891469 1.202 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr7_-_92855780 1.199 NM_001039372
HEPACAM2
HEPACAM family member 2
chr14_-_92413738 1.186 FBLN5
fibulin 5
chr16_-_51185150 1.184 NM_002968
SALL1
sal-like 1 (Drosophila)
chr6_-_87804773 1.177 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr15_+_34261088 1.174 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr11_+_6942204 1.135 NM_001004684
OR2D3
olfactory receptor, family 2, subfamily D, member 3
chr1_+_151032906 1.135 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr20_+_5987897 1.128 NM_001127458
CRLS1
cardiolipin synthase 1
chr5_+_67586466 1.114 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_-_36301999 1.107 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr12_+_89744714 1.102 LOC100131490
uncharacterized LOC100131490
chr5_+_140792507 1.097 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr5_+_140557370 1.091 NM_019120
PCDHB8
protocadherin beta 8
chr4_-_2230957 1.081 NM_181808
POLN
polymerase (DNA directed) nu
chr10_+_111765725 1.079 NM_019903
ADD3
adducin 3 (gamma)
chr1_+_151032866 1.077 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr8_-_102803196 1.073 NCALD
neurocalcin delta
chr8_+_37595366 1.064


chr8_-_102803438 1.050 NM_032041
NCALD
neurocalcin delta
chr1_+_151032683 1.049 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_-_122339186 1.047 NM_139175
RNF133
ring finger protein 133
chr16_+_72097124 1.036 NM_020995
HPR
haptoglobin-related protein
chr8_-_120651019 1.032 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr6_+_26251826 1.019 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr4_-_46125929 1.018 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr8_-_95449131 1.002 NM_001205263
RAD54B
RAD54 homolog B (S. cerevisiae)
chr17_+_67498391 0.986 MAP2K6
mitogen-activated protein kinase kinase 6
chr12_-_16760935 0.980 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr4_-_164534656 0.976 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr1_-_216896640 0.975 NM_001243515
NM_001243518
NM_001243519
NM_001438
ESRRG



estrogen-related receptor gamma



chr6_-_75965845 0.974 TMEM30A
transmembrane protein 30A
chr10_-_70066594 0.972 PBLD
phenazine biosynthesis-like protein domain containing
chr6_+_83072922 0.958 NM_006670
TPBG
trophoblast glycoprotein
chr12_-_24102563 0.954 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr7_+_2557496 0.952 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_+_151032880 0.949 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr8_+_107738239 0.946 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr6_+_131894343 0.942 NM_000045
NM_001244438
ARG1

arginase, liver

chr2_+_132480063 0.916 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr12_-_122240827 0.913


chr6_-_130031278 0.906 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr9_-_77643307 0.906 NM_152420
C9orf41
chromosome 9 open reading frame 41
chr2_+_216946588 0.898 NM_001142310
NM_001142311
NM_001142312
NM_138390
TMEM169



transmembrane protein 169



chr12_-_89745753 0.874 DUSP6
dual specificity phosphatase 6
chr3_+_170139027 0.869 NM_001185056
CLDN11
claudin 11
chr1_-_190446701 0.868 NM_199051
FAM5C
family with sequence similarity 5, member C
chr3_-_12200339 0.858 TIMP4
TIMP metallopeptidase inhibitor 4
chr1_-_232651227 0.852 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr6_+_26365397 0.851 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr10_-_129691202 0.837 NM_152311
CLRN3
clarin 3
chr6_+_105404922 0.836 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr4_+_88754120 0.835 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr3_-_123339178 0.831 MYLK
myosin light chain kinase
chr1_-_173174611 0.829 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_-_73051650 0.827


chr5_+_140480056 0.824 NM_018937
PCDHB3
protocadherin beta 3
chr7_+_95115212 0.819 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr1_+_84768333 0.816 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr1_+_92632608 0.816 NM_015237
KIAA1107
KIAA1107
chr9_+_79115548 0.816 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_-_32385258 0.813 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr1_+_186265404 0.810 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr2_+_158114109 0.806 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr8_+_17396285 0.801 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr10_-_129691047 0.799


chr1_+_84630374 0.799 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_-_27205123 0.793 HOXA9
homeobox A9
chr12_-_89745997 0.792 DUSP6
dual specificity phosphatase 6
chr10_-_52008312 0.787 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr12_+_54422193 0.785 NM_004503
HOXC6
homeobox C6
chr12_-_89746244 0.784 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr4_-_84035908 0.782 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr11_-_115088628 0.781 CADM1
cell adhesion molecule 1
chr4_+_88720701 0.778 NM_004967
IBSP
integrin-binding sialoprotein
chrX_+_99839789 0.769 NM_022144
TNMD
tenomodulin
chr17_-_26220372 0.764 NM_001076680
C17orf108
chromosome 17 open reading frame 108
chr6_+_136172802 0.757 NM_018945
PDE7B
phosphodiesterase 7B
chr9_-_215892 0.754 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr20_-_34243118 0.754 RBM12
RNA binding motif protein 12
chr2_+_179184970 0.752 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr4_-_111563278 0.749 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr1_-_23886284 0.744 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr8_-_17555158 0.731 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr12_+_74931550 0.731 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr5_-_126409171 0.731 NM_001164478
NM_001164479
C5orf63

chromosome 5 open reading frame 63

chr18_+_33234532 0.728 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr9_-_95298251 0.723 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr6_-_123957941 0.713 NM_001251987
NM_006073
TRDN

triadin

chr10_+_102123420 0.712


chr3_-_64672285 0.701 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr12_-_89746238 0.700 DUSP6
dual specificity phosphatase 6
chr4_+_113970784 0.698 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr18_+_72922725 0.698 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chrX_-_131573638 0.691 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr8_-_62602285 0.690 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr3_+_122044010 0.689 NM_005213
CSTA
cystatin A (stefin A)
chr4_-_84035888 0.688 PLAC8
placenta-specific 8
chr3_-_57234279 0.685 NM_003865
HESX1
HESX homeobox 1
chr1_-_197036350 0.683 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr12_-_9913415 0.680 NM_001781
CD69
CD69 molecule
chr1_+_14031349 0.679 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr1_+_50569581 0.678 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr14_+_78870092 0.672 NM_004796
NRXN3
neurexin 3
chr1_-_93342706 0.671 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr2_-_180610768 0.671 NM_001113397
ZNF385B
zinc finger protein 385B
chr5_-_111091947 0.667 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr13_-_95131718 0.666 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr12_-_16759939 0.665 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chrX_-_105282714 0.662 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr17_-_38821286 0.657 NM_152349
KRT222
keratin 222
chr11_+_124120422 0.657 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr20_-_50418946 0.657 NM_020436
SALL4
sal-like 4 (Drosophila)
chr3_-_186262114 0.655 NM_017541
CRYGS
crystallin, gamma S
chr6_-_114384008 0.654 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr2_+_183943511 0.651 DUSP19
dual specificity phosphatase 19
chr14_+_62462540 0.648 NM_031914
SYT16
synaptotagmin XVI
chr2_+_102508333 0.647 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr12_-_24103953 0.644 SOX5
SRY (sex determining region Y)-box 5
chr5_+_69321071 0.635 NM_001178087
NM_022978
NM_021967
NM_022968
SERF1B

SERF1A

small EDRK-rich factor 1B (centromeric)

small EDRK-rich factor 1A (telomeric)

chr2_-_44586854 0.635 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr5_-_35118223 0.628 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr5_+_140593508 0.626 NM_018933
PCDHB13
protocadherin beta 13
chr5_+_140180782 0.619 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr15_-_64673569 0.612 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr5_+_36606667 0.605 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr8_-_20112691 0.604 NM_021020
LZTS1
leucine zipper, putative tumor suppressor 1
chr9_-_107690526 0.600 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr2_-_188312872 0.596 NM_005795
CALCRL
calcitonin receptor-like
chr4_+_110834039 0.596 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr9_-_107690435 0.595 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr9_-_107690336 0.595 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr19_+_35417806 0.595 NM_001099437
NM_001099438
NM_194325
ZNF30


zinc finger protein 30


chr12_+_54410893 0.594 HOXC5
HOXC6
homeobox C5
homeobox C6
chr21_-_36421630 0.593 RUNX1
runt-related transcription factor 1
chr11_+_118398147 0.593 NM_001080441
TTC36
tetratricopeptide repeat domain 36
chr1_-_162346579 0.592 NM_182581
C1orf111
chromosome 1 open reading frame 111
chr3_-_168865521 0.590 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr2_+_183943286 0.588 NM_001142314
NM_080876
DUSP19

dual specificity phosphatase 19

chr4_+_39408541 0.585 KLB
klotho beta
chr1_-_217250230 0.584 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr6_-_75970566 0.584 TMEM30A
transmembrane protein 30A
chr10_+_115310589 0.583 NM_001177660
HABP2
hyaluronan binding protein 2
chr2_-_99871569 0.582 NM_175735
LYG2
lysozyme G-like 2
chr1_+_81771844 0.581 LPHN2
latrophilin 2
chr10_-_21807120 0.579


chr1_+_948846 0.577 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr8_-_17752847 0.575 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr14_-_70883680 0.574 NM_001202547
NM_001202548
NM_001202549
NM_018373
SYNJ2BP-COX16


SYNJ2BP
SYNJ2BP-COX16 readthrough


synaptojanin 2 binding protein
chr1_+_84630014 0.573 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr18_+_21572736 0.572 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr5_+_76435073 0.572


chr2_-_231989755 0.569 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr2_+_166428845 0.569 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr1_+_151611331 0.568 SNX27
sorting nexin family member 27
chr12_+_25205488 0.567 LRMP
lymphoid-restricted membrane protein
chr12_+_74931622 0.565 ATXN7L3B
ataxin 7-like 3B
chr3_+_113616317 0.565 NM_001172105
GRAMD1C
GRAM domain containing 1C
chrX_+_36254050 0.565 NM_001098843
CXorf30
chromosome X open reading frame 30
chr2_-_21228189 0.565 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_-_183387063 0.563 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr14_-_95599794 0.562 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr12_+_64803741 0.558 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr1_+_215178884 0.558 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr4_+_41614911 0.556 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr21_-_36421586 0.556 NM_001754
RUNX1
runt-related transcription factor 1
chrX_+_38211735 0.555 NM_000531
OTC
ornithine carbamoyltransferase
chr12_+_93096618 0.554 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr11_-_31531109 0.554 NM_144981
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr7_-_99774821 0.553 NM_152742
GPC2
glypican 2
chr1_-_108231122 0.550 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.43 4.40e-02 GO:0016337 cell-cell adhesion

Nothing significant found in compartment category.

Nothing significant found in function category.