Motif ID: RORA.p2

Z-value: 0.731


Transcription factors associated with RORA.p2:

Gene SymbolEntrez IDGene Name
RORA 6095 RAR-related orphan receptor A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RORAhg19_v1_chr15_-_61521416_615214330.962.6e-03Click!


Activity profile for motif RORA.p2.

activity profile for motif RORA.p2


Sorted Z-values histogram for motif RORA.p2

Sorted Z-values for motif RORA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RORA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_18535351 2.779 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr12_+_93963597 1.730 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr7_+_101928417 1.113 SH2B2
SH2B adaptor protein 2
chr7_+_101928390 1.083 NM_020979
SH2B2
SH2B adaptor protein 2
chr6_+_37252166 0.989 TBC1D22B
TBC1 domain family, member 22B
chr2_+_29038862 0.973 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr10_-_103578172 0.944 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr18_+_32073245 0.894 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr10_-_103578207 0.891 NM_001142434
NM_012215
MGEA5

meningioma expressed antigen 5 (hyaluronidase)

chr10_-_103578179 0.881 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr10_-_103578181 0.877 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr1_+_46379258 0.838 MAST2
microtubule associated serine/threonine kinase 2
chr18_+_32073343 0.829 DTNA
dystrobrevin, alpha
chr16_-_1832576 0.818 NM_080861
SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr16_-_1832304 0.776 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr17_+_40996596 0.613 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr7_-_100286869 0.613 NM_022574
GIGYF1
GRB10 interacting GYF protein 1
chr12_-_53575121 0.600 CSAD
cysteine sulfinic acid decarboxylase
chr16_-_1832571 0.584 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr7_-_107204705 0.570 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr11_+_13299260 0.541 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr18_+_55816546 0.539 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr9_+_74920329 0.532


chr1_+_67632168 0.511 NM_144701
IL23R
interleukin 23 receptor
chr11_-_70672861 0.478 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr6_+_43738757 0.475 VEGFA
vascular endothelial growth factor A
chr11_+_13299349 0.472 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_-_67271839 0.455 PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
chr3_-_24536176 0.421 NM_000461
NM_001128176
NM_001128177
NM_001252634
THRB



thyroid hormone receptor, beta



chr17_-_2304217 0.406 NM_020310
MNT
MAX binding protein
chr11_+_109963524 0.389 ZC3H12C
zinc finger CCCH-type containing 12C
chr3_-_24536452 0.366 THRB
thyroid hormone receptor, beta
chr2_+_219472618 0.358 PLCD4
phospholipase C, delta 4
chr8_-_6420454 0.350 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr11_+_13299376 0.349 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_+_13299329 0.338 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr6_+_43738394 0.332 VEGFA
vascular endothelial growth factor A
chrX_-_102774416 0.326 NM_080879
RAB40A
RAB40A, member RAS oncogene family
chr3_-_39195034 0.320 CSRNP1
cysteine-serine-rich nuclear protein 1
chr1_+_109255555 0.306 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr10_-_52645430 0.283 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr16_+_27325269 0.280 IL4R
interleukin 4 receptor
chr12_-_10588543 0.277 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr6_+_26104103 0.266 NM_003542
HIST2H4B
HIST1H4C
histone cluster 2, H4b
histone cluster 1, H4c
chrX_-_114797017 0.265


chr16_-_15188089 0.261 NM_018427
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr9_-_110251308 0.260 KLF4
Kruppel-like factor 4 (gut)
chr8_-_144654921 0.253 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr11_+_13299391 0.241 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr16_-_21831730 0.227 RRN3P1
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
chr6_+_43737937 0.201 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr11_-_73720281 0.200 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr10_-_65028825 0.190 NM_004241
JMJD1C
jumonji domain containing 1C
chr11_+_13299372 0.186 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chrX_-_108725284 0.182 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr1_+_178310605 0.182 NM_004841
RASAL2
RAS protein activator like 2
chr15_-_77176191 0.180 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr17_-_33390676 0.176 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr16_+_16326478 0.160 NOMO2
NODAL modulator 2
chr6_+_158734476 0.159 TULP4
tubby like protein 4
chr13_-_52733995 0.151 NM_001146099
NM_002498
NEK3

NIMA (never in mitosis gene a)-related kinase 3

chr1_+_157963062 0.146 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr11_-_129062092 0.145 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr7_-_105319608 0.145 NM_138495
ATXN7L1
ataxin 7-like 1
chrX_+_56755666 0.139 LOC550643
uncharacterized LOC550643
chr1_+_78470593 0.137 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr16_+_16326488 0.136 NOMO2
NODAL modulator 2
chr14_-_75389144 0.132 NM_031464
RPS6KL1
ribosomal protein S6 kinase-like 1
chr12_-_56211503 0.126 SARNP
SAP domain containing ribonucleoprotein
chr16_+_16326471 0.125 NOMO2
NODAL modulator 2
chr1_-_35920081 0.124 KIAA0319L
KIAA0319-like
chr2_+_219472631 0.124 PLCD4
phospholipase C, delta 4
chr20_-_1309782 0.123 SDCBP2
syndecan binding protein (syntenin) 2
chr6_-_24383519 0.122 NM_001195610
DCDC2
doublecortin domain containing 2
chr5_-_154230148 0.121 C5orf4
chromosome 5 open reading frame 4
chr1_+_51701943 0.118 NM_014372
RNF11
ring finger protein 11
chr22_+_21771661 0.116 NM_015094
HIC2
hypermethylated in cancer 2
chr3_-_136471186 0.115 NM_005862
STAG1
stromal antigen 1
chr7_-_86595203 0.107 NM_152748
KIAA1324L
KIAA1324-like
chr17_-_73043079 0.105 ATP5H
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
chr6_+_43738177 0.104 VEGFA
vascular endothelial growth factor A
chr19_-_10491172 0.104 TYK2
tyrosine kinase 2
chr17_+_65916163 0.103 BPTF
bromodomain PHD finger transcription factor
chr12_-_57351381 0.103 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr3_+_141105283 0.100


chr6_-_152623213 0.099 SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_-_161147757 0.098 NM_001199873
NM_001199874
NM_003779
B4GALT3


UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3


chr12_-_56211484 0.095 SARNP
SAP domain containing ribonucleoprotein
chr5_+_64859098 0.094 NM_015342
PPWD1
peptidylprolyl isomerase domain and WD repeat containing 1
chr9_-_41954687 0.091 MGC21881
uncharacterized locus MGC21881
chr3_+_48488113 0.091 ATRIP
ATR interacting protein
chr7_+_112063131 0.089 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr2_+_219472487 0.089 NM_032726
PLCD4
phospholipase C, delta 4
chr7_+_150782881 0.082 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr19_-_50464306 0.081 NM_001135163
NM_052884
SIGLEC11

sialic acid binding Ig-like lectin 11

chr6_-_37225894 0.077 NM_001162900
TMEM217
transmembrane protein 217
chr1_-_51810693 0.074 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chr17_+_40688264 0.071 NAGLU
N-acetylglucosaminidase, alpha
chr16_+_1833003 0.071


chr12_+_113376301 0.069 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr3_-_184095927 0.068 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr6_+_4836331 0.068 NM_001143970
CDYL
chromodomain protein, Y-like
chr16_+_16326454 0.067 NOMO2
NODAL modulator 2
chr3_+_9944295 0.066 NM_153483
IL17RE
interleukin 17 receptor E
chr19_+_57791794 0.064 NM_006635
ZNF460
zinc finger protein 460
chr3_+_48488180 0.063 NM_032166
NM_130384
TREX1
ATRIP

three prime repair exonuclease 1
ATR interacting protein

chr12_+_113376001 0.062 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr9_-_139292888 0.061 NM_003086
SNAPC4
small nuclear RNA activating complex, polypeptide 4, 190kDa
chr19_+_50321503 0.059 NM_030973
MED25
mediator complex subunit 25
chr10_+_81070578 0.056 ZMIZ1
zinc finger, MIZ-type containing 1
chr17_+_73043319 0.053 KCTD2
potassium channel tetramerisation domain containing 2
chr11_+_61102035 0.052 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr1_+_59775749 0.051 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr1_-_103496768 0.050 COL11A1
collagen, type XI, alpha 1
chr15_-_75135479 0.050 ULK3
unc-51-like kinase 3 (C. elegans)
chr9_+_123884043 0.049 CNTRL
centriolin
chr12_+_65672682 0.048 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr6_-_134373618 0.048 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr15_-_75135480 0.048 ULK3
unc-51-like kinase 3 (C. elegans)
chr17_+_40688189 0.045 NAGLU
N-acetylglucosaminidase, alpha
chr6_-_30181197 0.045 NM_001242783
NM_003449
TRIM26

tripartite motif containing 26

chr5_+_137688270 0.044 NM_016604
KDM3B
lysine (K)-specific demethylase 3B
chr19_+_55996537 0.042 NM_020378
NAT14
N-acetyltransferase 14 (GCN5-related, putative)
chr15_-_66084438 0.039 DENND4A
DENN/MADD domain containing 4A
chr15_+_45422130 0.039 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr1_-_205744543 0.038 NM_001135662
NM_001135663
NM_001135664
NM_003929
RAB7L1



RAB7, member RAS oncogene family-like 1



chr10_+_18041217 0.037 NM_001098844
TMEM236
transmembrane protein 236
chr1_-_19217384 0.036 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr22_+_21738039 0.035 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr15_+_102501826 0.033 LOC100134445
WASH1
WASH3P
uncharacterized LOC100134445
WAS protein family homolog 1
WAS protein family homolog 3 pseudogene
chr12_+_65672422 0.030 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr10_-_105845619 0.030 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr6_+_143929316 0.029 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr10_+_114043413 0.029 NM_058222
TECTB
tectorin beta
chr9_-_139342563 0.028 SEC16A
SEC16 homolog A (S. cerevisiae)
chr22_-_20427814 0.028 PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr7_+_115863004 0.026 NM_152829
TES
testis derived transcript (3 LIM domains)
chr11_-_72380107 0.024 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr16_-_12009918 0.024 GSPT1
G1 to S phase transition 1
chr17_-_73043040 0.024 NM_001003785
NM_006356
ATP5H

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d

chr3_+_23987514 0.023 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chrX_-_23925947 0.021 NM_024122
APOO
apolipoprotein O
chr17_-_26697358 0.021 NM_000638
VTN
vitronectin
chrM_+_5769 0.021


chr7_+_152161119 0.020 LOC100128822
uncharacterized LOC100128822
chr2_+_27851514 0.019 NM_001145047
NM_001145048
NM_001145049
GPN1


GPN-loop GTPase 1


chr17_+_26989193 0.019 SUPT6H
suppressor of Ty 6 homolog (S. cerevisiae)
chr10_-_52645384 0.019 A1CF
APOBEC1 complementation factor
chr12_+_105153258 0.019 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_+_31883020 0.018 NM_001199037
SERINC2
serine incorporator 2
chr15_-_75135429 0.018 ULK3
unc-51-like kinase 3 (C. elegans)
chr1_+_28764660 0.016 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr10_-_105845556 0.015 COL17A1
collagen, type XVII, alpha 1
chr5_+_66124603 0.015 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_51701914 0.013 RNF11
ring finger protein 11
chr2_-_216003068 0.012 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr6_+_31913920 0.010 CFB
complement factor B
chr11_-_47615902 0.010 NM_031909
C1QTNF4
C1q and tumor necrosis factor related protein 4
chr1_+_171750807 0.010 METTL13
methyltransferase like 13
chr6_-_111927082 0.009 TRAF3IP2
TRAF3 interacting protein 2
chr6_-_35696359 0.009 NM_001145775
FKBP5
FK506 binding protein 5
chr3_+_132318980 0.008 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chrX_-_132092224 0.007 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr4_+_52917440 0.007 NM_145263
SPATA18
spermatogenesis associated 18 homolog (rat)
chr11_-_18258383 0.006 NM_006512
SAA4
serum amyloid A4, constitutive
chr12_+_60083125 0.005 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr5_+_61708565 0.001 NM_016338
IPO11
importin 11
chr7_-_42971779 0.000 NM_002787
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
59.99 9.76e-05 GO:0071375 cellular response to peptide hormone stimulus
44.38 2.43e-04 GO:0032870 cellular response to hormone stimulus
41.37 3.01e-04 GO:0071495 cellular response to endogenous stimulus
40.84 3.13e-04 GO:0043434 response to peptide hormone stimulus
256.11 5.51e-04 GO:0007259 JAK-STAT cascade
23.15 1.75e-03 GO:0009725 response to hormone stimulus
21.97 2.05e-03 GO:0071310 cellular response to organic substance
21.12 2.31e-03 GO:0009719 response to endogenous stimulus
15.22 6.27e-03 GO:0070887 cellular response to chemical stimulus
49.92 1.49e-02 GO:0032869 cellular response to insulin stimulus
11.36 1.54e-02 GO:0010033 response to organic substance
39.52 2.38e-02 GO:0032868 response to insulin stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4222.00 1.71e-07 GO:0008269 JAK pathway signal transduction adaptor activity
172.57 2.00e-04 GO:0005070 SH3/SH2 adaptor activity
140.97 3.01e-04 GO:0035591 signaling adaptor activity
71.20 1.19e-03 GO:0030674 protein binding, bridging
66.73 1.36e-03 GO:0060090 binding, bridging