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Motif ID: SREBF1,2.p2

Z-value: 1.677

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_172967627	7.390		DLX2	distal-less homeobox 2
chr2_-_172967234	4.922	NM_004405	DLX2	distal-less homeobox 2
chr22_+_38599026	4.718	NM_001161573	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr5_-_172198160	4.619	NM_004417	DUSP1	dual specificity phosphatase 1
chr1_+_150255228	4.522	NM_144697	C1orf51	chromosome 1 open reading frame 51
chr16_-_1525040	4.012	NM_001114331 NM_001287	CLCN7	chloride channel 7
chr1_-_11866079	3.987	NM_005957	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)
chr16_-_1525006	3.521		CLCN7	chloride channel 7
chr1_+_11866302	3.428		CLCN6	chloride channel 6
chr5_+_172483285	3.378	NM_001168393 NM_001168394 NM_153607	C5orf41	chromosome 5 open reading frame 41
chr7_+_916178	3.350	NM_015949	GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr16_-_1524926	3.172		CLCN7	chloride channel 7
chr1_-_39325317	3.002	NM_022157	RRAGC	Ras-related GTP binding C
chr8_-_95274540	2.886	NM_005261 NM_181702	GEM	GTP binding protein overexpressed in skeletal muscle
chr16_-_1525020	2.883		CLCN7	chloride channel 7
chr10_-_3827418	2.691	NM_001160124 NM_001160125 NM_001300	KLF6	Kruppel-like factor 6
chr17_-_7137675	2.686		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr1_+_11866206	2.673	NM_001286 NM_021735 NM_021736 NM_021737	CLCN6	chloride channel 6
chr7_+_4815258	2.671	NM_014855	KIAA0415	KIAA0415
chr19_+_45504686	2.628	NM_006509	RELB	v-rel reticuloendotheliosis viral oncogene homolog B
chr1_+_110009099	2.610	NM_001040709	SYPL2	synaptophysin-like 2
chr7_+_28448970	2.604		LOC401317	uncharacterized LOC401317
chr7_+_4815277	2.599		KIAA0415	KIAA0415
chr16_+_89985268	2.583		MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr8_-_95274520	2.528		GEM	GTP binding protein overexpressed in skeletal muscle
chr17_-_7137580	2.524		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr7_+_916240	2.485		GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr10_-_3827205	2.469		KLF6	Kruppel-like factor 6
chr17_-_17140492	2.464	NM_144606 NM_144997	FLCN	folliculin
chr1_+_11866240	2.450		CLCN6	chloride channel 6
chr18_+_9136742	2.436	NM_001083625 NM_015208	ANKRD12	ankyrin repeat domain 12
chr12_+_93964801	2.373		SOCS2	suppressor of cytokine signaling 2
chr10_+_69644341	2.265	NM_012238	SIRT1	sirtuin 1
chr19_-_1237840	2.242	NM_152769	C19orf26	chromosome 19 open reading frame 26
chr11_+_18343794	2.230	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr17_-_7137722	2.229	NM_004422	DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr17_-_79885544	2.218	NM_002359	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr11_+_9685650	2.200		SWAP70	SWAP switching B-cell complex 70kDa subunit
chrX_-_114797017	2.194
chr8_-_54755836	2.175	NM_015941 NM_213619	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr12_+_122356446	2.137	NM_001178003 NM_144668	WDR66	WD repeat domain 66
chr11_+_9685624	2.099	NM_015055	SWAP70	SWAP switching B-cell complex 70kDa subunit
chr9_-_37576248	2.097	NM_012166	FBXO10	F-box protein 10
chr2_-_220042731	2.068		CNPPD1	cyclin Pas1/PHO80 domain containing 1
chr5_-_131132690	2.050		FNIP1	folliculin interacting protein 1
chr19_+_1067293	2.049		HMHA1	histocompatibility (minor) HA-1
chr5_-_131132715	2.047	NM_001008738 NM_133372	FNIP1	folliculin interacting protein 1
chr11_+_9685606	2.038		SWAP70	SWAP switching B-cell complex 70kDa subunit
chr15_-_72668301	2.019	NM_000520	HEXA	hexosaminidase A (alpha polypeptide)
chr8_-_54755821	2.013		ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr19_-_3500620	2.009	NM_031304	DOHH	deoxyhypusine hydroxylase/monooxygenase
chr1_-_11865963	2.009		MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)
chr19_-_41256371	1.997		C19orf54	chromosome 19 open reading frame 54
chr6_+_31982538	1.992	NM_001242823 NM_001252204 NM_007293 NM_001002029	LOC100293534 C4A C4B	complement C4-B-like complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr7_-_100808832	1.986	NM_003378	VGF	VGF nerve growth factor inducible
chr11_+_9595451	1.977		WEE1	WEE1 homolog (S. pombe)
chr5_-_131132642	1.950		FNIP1	folliculin interacting protein 1
chr11_-_61684981	1.917	NM_013401	RAB3IL1	RAB3A interacting protein (rabin3)-like 1
chr11_+_9685653	1.911		SWAP70	SWAP switching B-cell complex 70kDa subunit
chr1_-_205290756	1.910	NM_030952	NUAK2	NUAK family, SNF1-like kinase, 2
chr19_+_5681016	1.904	NM_198704 NM_198705 NM_198533 NM_198707 NM_198706 NM_198708	HSD11B1L	hydroxysteroid (11-beta) dehydrogenase 1-like
chr17_-_18907988	1.902	NM_001039999	FAM83G	family with sequence similarity 83, member G
chr17_+_78075299	1.883	NM_000152 NM_001079803 NM_001079804	GAA	glucosidase, alpha; acid
chrX_-_102319096	1.864	NM_018476	BEX1	brain expressed, X-linked 1
chr10_-_100206657	1.843		HPS1	Hermansky-Pudlak syndrome 1
chr13_+_113951461	1.840	NM_005561	LAMP1	lysosomal-associated membrane protein 1
chr15_+_89182038	1.834	NM_002201	ISG20	interferon stimulated exonuclease gene 20kDa
chr17_-_63052884	1.829	NM_006572	GNA13	guanine nucleotide binding protein (G protein), alpha 13
chr11_+_9595429	1.827		WEE1	WEE1 homolog (S. pombe)
chr7_+_102074002	1.819		ORAI2	ORAI calcium release-activated calcium modulator 2
chr11_-_1593149	1.819	NM_004420	DUSP8	dual specificity phosphatase 8
chr7_-_2354010	1.809		SNX8	sorting nexin 8
chr1_+_44440642	1.804		ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr17_-_42201009	1.793	NM_001015053 NM_005474	HDAC5	histone deacetylase 5
chr11_+_18344113	1.785		GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr8_-_54755546	1.777	NM_213620	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr5_-_131132709	1.775		FNIP1	folliculin interacting protein 1
chr17_-_42200957	1.771		HDAC5	histone deacetylase 5
chr14_-_20923266	1.750	NM_017807	OSGEP	O-sialoglycoprotein endopeptidase
chr10_+_69644708	1.740		SIRT1	sirtuin 1
chr8_-_103667882	1.733	NM_005655	KLF10	Kruppel-like factor 10
chr16_+_69984809	1.732	NM_182619	CLEC18C CLEC18A	C-type lectin domain family 18, member C C-type lectin domain family 18, member A
chr11_+_59522801	1.724		STX3	syntaxin 3
chr6_+_138188352	1.696	NM_006290	TNFAIP3	tumor necrosis factor, alpha-induced protein 3
chr13_-_33002218	1.681	NM_001079691 NM_052818	N4BP2L1	NEDD4 binding protein 2-like 1
chr11_+_118938530	1.647		VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)
chr11_-_67141647	1.639	NM_001166212	CLCF1	cardiotrophin-like cytokine factor 1
chr1_+_44440623	1.627		ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr14_-_20929635	1.626	NM_001100814 NM_144568	TMEM55B	transmembrane protein 55B
chr1_+_44440673	1.621		ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr1_-_193155723	1.619	NM_003783	B3GALT2	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr11_+_75526211	1.615	NM_003369	UVRAG	UV radiation resistance associated gene
chr11_+_9595309	1.610		WEE1	WEE1 homolog (S. pombe)
chr19_+_7587436	1.600	NM_020533	MCOLN1	mucolipin 1
chr17_-_38256905	1.594	NM_021724	NR1D1	nuclear receptor subfamily 1, group D, member 1
chr11_+_9595183	1.593	NM_003390	WEE1	WEE1 homolog (S. pombe)
chr11_+_118938528	1.577		VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)
chr7_+_27135672	1.572		HOTAIRM1	HOXA transcript antisense RNA, myeloid-specific 1 (non-protein coding)
chr17_+_18218569	1.559	NM_144775	SMCR8	Smith-Magenis syndrome chromosome region, candidate 8
chr10_-_100206698	1.540	NM_000195 NM_182639	HPS1	Hermansky-Pudlak syndrome 1
chr11_+_118938473	1.537	NM_021729	VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)
chr7_-_1595746	1.537	NM_001097620	TMEM184A	transmembrane protein 184A
chr3_+_5021096	1.522	NM_003670	BHLHE40	basic helix-loop-helix family, member e40
chr1_+_44440595	1.519	NM_001039457 NM_004047	ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr15_-_72668184	1.511		HEXA	hexosaminidase A (alpha polypeptide)
chr19_+_40854331	1.497	NM_001031696 NM_012268	PLD3	phospholipase D family, member 3
chr5_-_132299263	1.496	NM_014423	AFF4	AF4/FMR2 family, member 4
chr14_+_55168831	1.482		SAMD4A	sterile alpha motif domain containing 4A
chr19_-_12833461	1.480	NM_001136196	TNPO2	transportin 2
chr7_-_27135524	1.480	NM_005522 NM_153620	HOXA1	homeobox A1
chr17_+_62502860	1.480		CEP95	centrosomal protein 95kDa
chr11_+_75526236	1.476		UVRAG	UV radiation resistance associated gene
chr17_-_63052816	1.472
chr19_-_48018277	1.471		NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr19_+_10812111	1.458	NM_031209	QTRT1	queuine tRNA-ribosyltransferase 1
chr7_-_2354050	1.453	NM_013321	SNX8	sorting nexin 8
chr1_+_37940180	1.449		ZC3H12A	zinc finger CCCH-type containing 12A
chr17_-_17140425	1.441		FLCN	folliculin
chr9_-_124855559	1.437		TTLL11	tubulin tyrosine ligase-like family, member 11
chr17_-_63052744	1.434		GNA13	guanine nucleotide binding protein (G protein), alpha 13
chr11_+_118938515	1.433		VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)
chr5_-_132299248	1.433		AFF4	AF4/FMR2 family, member 4
chr5_+_173315313	1.419	NM_030627	CPEB4	cytoplasmic polyadenylation element binding protein 4
chr14_-_68283293	1.419	NM_015346	ZFYVE26	zinc finger, FYVE domain containing 26
chr19_-_45909566	1.418	NM_001142502	PPP1R13L	protein phosphatase 1, regulatory subunit 13 like
chr19_+_40854529	1.418		PLD3	phospholipase D family, member 3
chr17_-_17109630	1.416	NM_178836	PLD6	phospholipase D family, member 6
chr19_-_14606893	1.414		GIPC1	GIPC PDZ domain containing family, member 1
chr19_+_41305041	1.411	NM_080732	EGLN2	egl nine homolog 2 (C. elegans)
chr19_+_41305100	1.410		EGLN2	egl nine homolog 2 (C. elegans)
chr17_+_78075360	1.399		GAA	glucosidase, alpha; acid
chr17_-_38256548	1.391		NR1D1	nuclear receptor subfamily 1, group D, member 1
chr17_+_18218608	1.374		SMCR8	Smith-Magenis syndrome chromosome region, candidate 8
chr22_+_42394728	1.373	NM_152613	WBP2NL	WBP2 N-terminal like
chr19_+_41305333	1.346	NM_053046	EGLN2	egl nine homolog 2 (C. elegans)
chr19_-_41256349	1.341		C19orf54	chromosome 19 open reading frame 54
chr19_+_47759802	1.333		CCDC9	coiled-coil domain containing 9
chr17_-_63052707	1.333		GNA13	guanine nucleotide binding protein (G protein), alpha 13
chr19_-_48018163	1.328		NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr14_-_20929484	1.324		TMEM55B	transmembrane protein 55B
chr14_+_103388992	1.316	NM_030943	AMN	amnionless homolog (mouse)
chr17_+_18218605	1.315		SMCR8	Smith-Magenis syndrome chromosome region, candidate 8
chr3_+_5021141	1.311		BHLHE40	basic helix-loop-helix family, member e40
chr13_-_21635629	1.293		LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)
chr15_-_72410226	1.288	NM_006901	MYO9A	myosin IXA
chr6_+_42018250	1.288	NM_138572	TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr3_+_51428698	1.285	NM_013286	RBM15B	RNA binding motif protein 15B
chr11_-_6640644	1.284		TPP1	tripeptidyl peptidase I
chr22_-_39268230	1.281	NM_014292	CBX6	chromobox homolog 6
chr17_+_57408907	1.280	NM_001005404	YPEL2	yippee-like 2 (Drosophila)
chr19_-_14606939	1.259	NM_005716 NM_202467 NM_202468 NM_202469 NM_202470 NM_202494	GIPC1	GIPC PDZ domain containing family, member 1
chr15_-_72410108	1.259		MYO9A	myosin IXA
chr6_-_31830551	1.257		NEU1	sialidase 1 (lysosomal sialidase)
chr2_+_26395959	1.253	NM_001168241	FAM59B	family with sequence similarity 59, member B
chr17_-_17109601	1.249		PLD6	phospholipase D family, member 6
chr3_-_49823953	1.240		IP6K1	inositol hexakisphosphate kinase 1
chr6_+_160390128	1.240	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr11_+_59522905	1.237		STX3	syntaxin 3
chr16_+_81812925	1.235		PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr16_+_87425946	1.232		MAP1LC3B	microtubule-associated protein 1 light chain 3 beta
chr6_-_91006460	1.228	NM_021813	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr4_-_84376943	1.227	NM_133636	HELQ	helicase, POLQ-like
chr14_-_81687574	1.224	NM_201595	GTF2A1	general transcription factor IIA, 1, 19/37kDa
chr13_-_21635703	1.224	NM_014572	LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)
chr2_-_240323332	1.219		HDAC4	histone deacetylase 4
chr1_-_27226937	1.218	NM_022078	GPATCH3	G patch domain containing 3
chr1_-_27226928	1.212		GPATCH3	G patch domain containing 3
chr17_+_78075390	1.208		GAA	glucosidase, alpha; acid
chr6_-_151773168	1.207	NM_017909	RMND1	required for meiotic nuclear division 1 homolog (S. cerevisiae)
chrX_+_153686620	1.203	NM_017514	PLXNA3	plexin A3
chr11_-_85780088	1.203		PICALM	phosphatidylinositol binding clathrin assembly protein
chr3_+_51428720	1.200		RBM15B	RNA binding motif protein 15B
chr3_+_5021305	1.199		BHLHE40	basic helix-loop-helix family, member e40
chr19_-_47734215	1.191	NM_014417	BBC3	BCL2 binding component 3
chr9_+_6757636	1.184	NM_001146694 NM_001146695 NM_015061	KDM4C	lysine (K)-specific demethylase 4C
chr19_+_4969123	1.183	NM_015015	KDM4B	lysine (K)-specific demethylase 4B
chr7_-_100493481	1.179	NM_000665 NM_015831	ACHE	acetylcholinesterase
chr1_-_100643770	1.179	NM_144620	LRRC39	leucine rich repeat containing 39
chr18_-_46987016	1.165	NM_017653	DYM	dymeclin
chr17_-_74722843	1.162	NM_001081461 NM_015167	JMJD6	jumonji domain containing 6
chr15_+_44084039	1.162	NM_001018108 NM_001199875 NM_001199876	SERF2	small EDRK-rich factor 2
chr17_+_6915952	1.161		RNASEK	ribonuclease, RNase K
chr6_+_42018264	1.157		TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr9_+_130860769	1.154		SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr16_+_87425874	1.151		MAP1LC3B	microtubule-associated protein 1 light chain 3 beta
chr22_-_39636906	1.151	NM_033016	PDGFB	platelet-derived growth factor beta polypeptide
chr7_-_30029284	1.144	NM_001145515 NM_014766 NM_001145513	SCRN1	secernin 1
chr2_-_73340073	1.138	NM_015470	RAB11FIP5	RAB11 family interacting protein 5 (class I)
chr9_-_19127494	1.135	NM_001122	PLIN2	perilipin 2
chr21_-_43430448	1.130	NM_001098402 NM_001098403 NM_020727	ZNF295	zinc finger protein 295
chr19_-_5720136	1.129		LONP1	lon peptidase 1, mitochondrial
chr12_-_109027654	1.128	NM_003006	SELPLG	selectin P ligand
chr19_-_12886263	1.114		HOOK2	hook homolog 2 (Drosophila)
chr5_-_132299191	1.114		AFF4	AF4/FMR2 family, member 4
chr17_-_74722614	1.109		JMJD6	jumonji domain containing 6
chr1_-_145610869	1.109	NM_006468	POLR3C	polymerase (RNA) III (DNA directed) polypeptide C (62kD)
chr17_+_62503079	1.104	NM_138363	CEP95	centrosomal protein 95kDa
chr12_-_49463729	1.101	NM_144593	RHEBL1	Ras homolog enriched in brain like 1
chr17_-_74722629	1.100		JMJD6	jumonji domain containing 6
chr1_-_28559513	1.097	NM_014280	DNAJC8	DnaJ (Hsp40) homolog, subfamily C, member 8

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
9.16	8.84e-03	GO:0030098	lymphocyte differentiation
4.99	1.04e-02	GO:0002520	immune system development
14.79	1.62e-02	GO:0030183	B cell differentiation
10.35	1.89e-02	GO:0042113	B cell activation
18.40	4.69e-02	GO:0007040	lysosome organization
124.18	4.95e-02	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
7.02	4.96e-02	GO:0002521	leukocyte differentiation

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
7.26	6.62e-09	GO:0005773	vacuole
10.84	2.76e-08	GO:0005774	vacuolar membrane
10.35	4.90e-08	GO:0044437	vacuolar part
6.67	3.10e-06	GO:0000323	lytic vacuole
6.67	3.10e-06	GO:0005764	lysosome
9.81	4.34e-05	GO:0005765	lysosomal membrane
1.34	9.23e-03	GO:0043231	intracellular membrane-bounded organelle
1.34	9.70e-03	GO:0043227	membrane-bounded organelle
1.27	4.14e-02	GO:0043229	intracellular organelle
1.27	4.49e-02	GO:0043226	organelle

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
28.66	2.48e-02	GO:0017136	NAD-dependent histone deacetylase activity
28.66	2.48e-02	GO:0034979	NAD-dependent protein deacetylase activity
24.84	3.89e-02	GO:0004407	histone deacetylase activity
24.84	3.89e-02	GO:0033558	protein deacetylase activity