Motif ID: SRF.p3

Z-value: 3.115


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRFhg19_v1_chr6_+_43139201_431393860.991.9e-04Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_137801178 26.253 NM_001964
EGR1
early growth response 1
chr5_+_137801166 24.080 EGR1
early growth response 1
chr19_+_45971249 10.618 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr11_-_65667809 7.742 FOSL1
FOS-like antigen 1
chr12_+_52445185 7.689 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr14_+_75745480 6.671 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr9_+_92219926 6.115 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr19_+_49376488 5.940 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr11_-_65667860 5.774 NM_005438
FOSL1
FOS-like antigen 1
chr22_+_31480981 5.680 NM_001207018
SMTN
smoothelin
chr10_-_64576074 4.477 EGR2
early growth response 2
chr19_+_2476122 4.418 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr7_+_112120907 4.248 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr10_-_64576123 4.181 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr6_-_29527701 4.057 NM_006398
UBD
ubiquitin D
chr2_+_87754991 3.563 LINC00152
long intergenic non-protein coding RNA 152
chr19_+_48958765 3.495 NM_013348
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr19_-_36247917 3.277 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr11_-_65667858 3.210 FOSL1
FOS-like antigen 1
chr4_+_108814419 3.127 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr3_-_99594915 2.965 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr9_+_139249251 2.954 NM_001200003
GPSM1
G-protein signaling modulator 1
chr6_-_109775423 2.812 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr19_+_13135368 2.806 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_+_13134782 2.801 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_181057835 2.783 IER5
immediate early response 5
chr1_+_223889253 2.769 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr10_-_90712510 2.722 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_-_11907741 2.713 NM_006172
NPPA
natriuretic peptide A
chr20_-_62258330 2.700 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chr2_-_106015423 2.658 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr12_+_75874512 2.608 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr3_+_187930720 2.433 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr6_-_29527477 2.410 UBD
ubiquitin D
chr1_+_16085245 2.315 NM_017556
FBLIM1
filamin binding LIM protein 1
chr6_-_26108320 2.295 NM_005323
HIST1H1T
histone cluster 1, H1t
chr7_-_27183225 2.089 NM_019102
HOXA5
homeobox A5
chrX_-_153602928 2.076 FLNA
filamin A, alpha
chr11_-_1606480 2.072 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr17_+_41003184 1.965 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr12_-_50616425 1.817 NM_001113547
LIMA1
LIM domain and actin binding 1
chr6_-_88411948 1.793 AKIRIN2
akirin 2
chr15_-_65360297 1.784 NM_016563
RASL12
RAS-like, family 12
chr11_-_16430425 1.759 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr10_-_29923900 1.731 NM_021738
SVIL
supervillin
chr17_+_16318911 1.709 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr2_-_161056762 1.695 ITGB6
integrin, beta 6
chr3_+_63953419 1.680 NM_001128149
ATXN7
ataxin 7
chr1_+_167599503 1.655 RCSD1
RCSD domain containing 1
chr1_-_935469 1.623 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr20_-_62258422 1.611 GMEB2
glucocorticoid modulatory element binding protein 2
chr19_+_1026608 1.582 CNN2
calponin 2
chr17_+_16318848 1.572 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr10_+_31610063 1.568 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr21_-_47704166 1.548 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr6_-_86388419 1.542 SNHG5
small nucleolar RNA host gene 5 (non-protein coding)
chr6_+_43139190 1.531 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr15_+_45406518 1.518 NM_207581
DUOXA2
dual oxidase maturation factor 2
chr2_-_225378320 1.474 CUL3
cullin 3
chr3_-_156878481 1.401 NM_020307
CCNL1
cyclin L1
chr18_-_3219846 1.380 MYOM1
myomesin 1, 185kDa
chr17_+_57915192 1.363


chr6_+_43138919 1.344 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr19_+_1026582 1.323 CNN2
calponin 2
chr17_-_4890920 1.311 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr19_-_46283763 1.283 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr6_-_88411872 1.278 AKIRIN2
akirin 2
chrX_-_153602998 1.274 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr19_+_1026624 1.244 CNN2
calponin 2
chr2_-_161056573 1.243 NM_000888
ITGB6
integrin, beta 6
chr6_-_88411649 1.243 AKIRIN2
akirin 2
chr2_+_87755059 1.237 LINC00152
long intergenic non-protein coding RNA 152
chr7_-_107643330 1.225 NM_002291
LAMB1
laminin, beta 1
chr6_-_76203256 1.207 NM_015687
FILIP1
filamin A interacting protein 1
chr17_-_1389323 1.197 MYO1C
myosin IC
chr16_+_56966025 1.186 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_+_54372659 1.178 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr22_+_38004676 1.151 GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr7_+_143078399 1.099 ZYX
zyxin
chr4_+_89299874 1.098 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr7_+_143078444 1.061 ZYX
zyxin
chr4_+_81118639 1.054 NM_001099403
PRDM8
PR domain containing 8
chr22_+_38004865 1.054 GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr7_+_143078358 1.048 NM_001010972
NM_003461
ZYX

zyxin

chr14_+_105267378 1.038 ZBTB42
zinc finger and BTB domain containing 42
chr17_-_4890664 1.035 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr22_+_38004454 1.015 NM_001001560
NM_001001561
NM_001172687
NM_013365
GGA1



golgi-associated, gamma adaptin ear containing, ARF binding protein 1



chr7_+_143078395 1.012 ZYX
zyxin
chr18_-_3219986 0.999 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr5_-_124080773 0.991 NM_020747
ZNF608
zinc finger protein 608
chr19_+_1026627 0.987 CNN2
calponin 2
chr6_+_43139201 0.980 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr8_-_22550708 0.975 NM_004430
EGR3
early growth response 3
chr6_+_144612872 0.944 NM_007124
UTRN
utrophin
chr2_-_216248184 0.926 FN1
fibronectin 1
chr15_+_71433787 0.911 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr7_+_143078447 0.905 ZYX
zyxin
chr3_-_185641596 0.870 TRA2B
transformer 2 beta homolog (Drosophila)
chr7_+_143078457 0.868 ZYX
zyxin
chr6_+_151561508 0.861 AKAP12
A kinase (PRKA) anchor protein 12
chr10_+_88428263 0.860 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr6_+_151561094 0.854 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr11_-_85780899 0.841 NM_001206947
PICALM
phosphatidylinositol binding clathrin assembly protein
chr5_+_176875325 0.840 NM_001174102
PRR7
proline rich 7 (synaptic)
chr17_-_79479831 0.836 NM_001199954
NM_001614
ACTG1

actin, gamma 1

chr20_-_42815732 0.803 JPH2
junctophilin 2
chr16_-_67977956 0.758 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr12_+_50497790 0.752 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr3_+_187871473 0.740 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_-_39684585 0.739 NM_002276
KRT19
keratin 19
chr19_+_56153417 0.729 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr7_+_143078608 0.711 ZYX
zyxin
chrX_-_153599719 0.711 FLNA
filamin A, alpha
chr14_-_74226634 0.708 C14orf43
chromosome 14 open reading frame 43
chr5_+_6746100 0.696 NM_001171806
PAPD7
PAP associated domain containing 7
chr14_-_74226890 0.695 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr12_+_62654120 0.690 NM_001252078
NM_001252079
NM_006313
USP15


ubiquitin specific peptidase 15


chr22_-_36784055 0.688 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr6_-_16761600 0.687 NM_000332
NM_001128164
ATXN1

ataxin 1

chr18_-_47806361 0.677 NM_001204151
MBD1
methyl-CpG binding domain protein 1
chr19_-_15343767 0.663 NM_001142886
EPHX3
epoxide hydrolase 3
chr1_-_935352 0.662 HES4
hairy and enhancer of split 4 (Drosophila)
chr17_-_79479780 0.639 ACTG1
actin, gamma 1
chr5_-_39425297 0.611 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr3_+_49027281 0.606 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr11_+_63580922 0.603 NM_138471
C11orf84
chromosome 11 open reading frame 84
chr14_-_102553344 0.598 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr15_-_70390226 0.592 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr4_-_185747051 0.565 ACSL1
acyl-CoA synthetase long-chain family member 1
chr11_+_66314373 0.561 NM_001104
ACTN3
actinin, alpha 3
chr1_+_154975041 0.556 NM_001252405
NM_015872
ZBTB7B

zinc finger and BTB domain containing 7B

chr10_+_123922940 0.544 TACC2
transforming, acidic coiled-coil containing protein 2
chr4_-_10118444 0.512 WDR1
WD repeat domain 1
chr16_+_22103861 0.512 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr3_+_25470067 0.508 RARB
retinoic acid receptor, beta
chr10_-_131762374 0.507 EBF3
early B-cell factor 3
chr1_+_219347123 0.488 NM_138794
LYPLAL1
lysophospholipase-like 1
chr18_+_29598444 0.479 NM_017831
RNF125
ring finger protein 125
chr4_+_15376174 0.472 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr1_+_11994710 0.472 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr6_-_88411984 0.472 NM_018064
AKIRIN2
akirin 2
chr7_+_115863004 0.466 NM_152829
TES
testis derived transcript (3 LIM domains)
chr17_-_73505914 0.442 NM_001142643
CASKIN2
CASK interacting protein 2
chr6_+_158402887 0.442 NM_003898
SYNJ2
synaptojanin 2
chr19_-_12792698 0.439 NM_001930
NM_013406
DHPS

deoxyhypusine synthase

chr4_-_88450243 0.433 SPARCL1
SPARC-like 1 (hevin)
chr2_-_242212244 0.429 NM_001243900
NM_203346
HDLBP

high density lipoprotein binding protein

chr4_-_10118460 0.409 WDR1
WD repeat domain 1
chr1_+_219347195 0.407 LYPLAL1
lysophospholipase-like 1
chr4_+_24797084 0.402 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr17_+_41003360 0.392


chr17_-_41132019 0.392 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr10_+_114043413 0.386 NM_058222
TECTB
tectorin beta
chrX_+_70521627 0.384 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr12_+_6881669 0.383 NM_002286
LAG3
lymphocyte-activation gene 3
chr9_-_134585107 0.381 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr19_+_47813074 0.375 NM_001736
C5AR1
complement component 5a receptor 1
chr14_-_94442894 0.373 ASB2
ankyrin repeat and SOCS box containing 2
chr17_-_74099855 0.365 NM_001013839
NM_001145297
NM_001145298
NM_001145299
NM_015219
EXOC7




exocyst complex component 7




chr12_+_110436960 0.365 ANKRD13A
ankyrin repeat domain 13A
chr2_-_208031570 0.353 KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_-_151344145 0.350 NM_005168
RND3
Rho family GTPase 3
chr1_-_150552077 0.342 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr6_+_44214786 0.340 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr5_-_142000899 0.336 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr11_-_57282315 0.331 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr12_-_57443858 0.327 NM_005379
MYO1A
myosin IA
chr4_+_77227882 0.326 STBD1
starch binding domain 1
chr19_-_58858900 0.324 A1BG
alpha-1-B glycoprotein
chr17_-_79792923 0.322 NM_001007533
PPP1R27
protein phosphatase 1, regulatory subunit 27
chr11_+_58390145 0.320 NM_000614
CNTF
ciliary neurotrophic factor
chr11_-_123065836 0.309 CLMP
CXADR-like membrane protein
chr20_-_33872505 0.306 NM_181468
EIF6
eukaryotic translation initiation factor 6
chr7_-_107204705 0.296 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr4_-_88450601 0.288 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr19_-_12792676 0.287 DHPS
deoxyhypusine synthase
chr17_-_1389013 0.286 NM_001080950
MYO1C
myosin IC
chr18_+_3247527 0.285 NM_006471
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr4_-_140060601 0.283 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr17_-_49124128 0.263 NM_001251971
SPAG9
sperm associated antigen 9
chr3_-_9834065 0.259 TADA3
transcriptional adaptor 3
chr3_-_42642571 0.255 NM_001201572
SEC22C
SEC22 vesicle trafficking protein homolog C (S. cerevisiae)
chrX_-_11284094 0.252 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr3_-_157221362 0.250 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr19_+_1026271 0.248 NM_004368
NM_201277
CNN2

calponin 2

chr1_+_151512760 0.245 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr1_+_43996478 0.237 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr18_+_54318561 0.234 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr20_-_33735060 0.227 NM_001145025
NM_018217
EDEM2

ER degradation enhancer, mannosidase alpha-like 2

chr15_-_45406345 0.224 NM_014080
DUOX2
dual oxidase 2
chr6_+_158402916 0.218 SYNJ2
synaptojanin 2
chr11_-_84634219 0.218 DLG2
discs, large homolog 2 (Drosophila)
chr6_+_158402928 0.214 SYNJ2
synaptojanin 2
chr1_-_150552005 0.209 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr15_-_59665069 0.209 NM_004998
MYO1E
myosin IE
chr18_-_37380249 0.207 LOC647946
uncharacterized LOC647946
chr4_+_87968191 0.207 AFF1
AF4/FMR2 family, member 1
chr5_-_56247915 0.207 NM_152622
MIER3
mesoderm induction early response 1, family member 3
chr19_-_50168866 0.204 IRF3
interferon regulatory factor 3
chr7_-_80548322 0.188 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.75 2.82e-04 GO:0010628 positive regulation of gene expression
6.77 6.26e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
5.72 9.32e-04 GO:0045893 positive regulation of transcription, DNA-dependent
5.33 1.83e-03 GO:0051254 positive regulation of RNA metabolic process
4.32 2.25e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
4.78 5.10e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
4.70 6.01e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
4.56 7.96e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.92 1.11e-02 GO:0032501 multicellular organismal process
4.25 1.51e-02 GO:0031328 positive regulation of cellular biosynthetic process
4.18 1.77e-02 GO:0009891 positive regulation of biosynthetic process
2.43 4.73e-02 GO:0010468 regulation of gene expression
15.34 4.83e-02 GO:0007015 actin filament organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.18 3.69e-05 GO:0015629 actin cytoskeleton
14.72 1.66e-03 GO:0005925 focal adhesion
14.02 2.11e-03 GO:0005924 cell-substrate adherens junction
13.50 2.53e-03 GO:0030055 cell-substrate junction
31.21 8.96e-03 GO:0001725 stress fiber
1.44 1.08e-02 GO:0043229 intracellular organelle
29.13 1.10e-02 GO:0032432 actin filament bundle
1.44 1.14e-02 GO:0043226 organelle
9.79 1.17e-02 GO:0005912 adherens junction
97.07 1.32e-02 GO:0031430 M band
26.49 1.47e-02 GO:0042641 actomyosin
8.84 1.87e-02 GO:0070161 anchoring junction
2.85 1.94e-02 GO:0005856 cytoskeleton
1.71 3.83e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.99 9.04e-04 GO:0030528 transcription regulator activity