Motif ID: STAT2,4,6.p2

Z-value: 1.531


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT6hg19_v1_chr12_-_57505176_575052190.814.9e-02Click!
STAT4hg19_v1_chr2_-_192015751_192015788-0.562.4e-01Click!
STAT2hg19_v1_chr12_-_56753856_56753911-0.433.9e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_49339667 1.795 HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr8_+_32405727 1.774 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr17_-_76356153 1.695 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr5_+_172483285 1.657 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr6_-_56716713 1.614 DST
dystonin
chr2_-_145277879 1.576 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr14_+_75745480 1.572 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr22_+_38598065 1.415 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr3_-_187463227 1.396 BCL6
B-cell CLL/lymphoma 6
chr8_-_8239188 1.388 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr2_-_145277568 1.370 ZEB2
zinc finger E-box binding homeobox 2
chr22_+_38597938 1.260 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr15_+_85359910 1.196 NM_020778
ALPK3
alpha-kinase 3
chr19_-_49339913 1.144 NM_016246
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr3_-_187463474 1.123 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr8_-_95274540 1.107 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr16_-_3109335 1.099 LOC100507419
uncharacterized LOC100507419
chr6_-_56716412 1.046 DST
dystonin
chr7_+_28530747 1.043 CREB5
cAMP responsive element binding protein 5
chr6_-_91006460 1.035 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr4_+_74606222 1.026 NM_000584
IL8
interleukin 8
chr11_+_71710971 1.013 NM_001145055
IL18BP
interleukin 18 binding protein
chr7_-_149157866 1.011 NM_015694
ZNF777
zinc finger protein 777
chr9_-_110251308 1.007 KLF4
Kruppel-like factor 4 (gut)
chr11_+_71710662 1.002 NM_001145057
IL18BP
interleukin 18 binding protein
chr8_-_95274520 0.992 GEM
GTP binding protein overexpressed in skeletal muscle
chr1_+_201979689 0.961 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr14_+_24779356 0.959 NM_001164692
NM_019839
LTB4R2

leukotriene B4 receptor 2

chr10_+_104154228 0.914 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr12_-_58159386 0.904 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr1_+_212788359 0.895 NM_001206486
ATF3
activating transcription factor 3
chr3_-_101039403 0.894 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr19_-_1132109 0.819 NM_001100122
SBNO2
strawberry notch homolog 2 (Drosophila)
chr8_+_32579350 0.818 NM_001159996
NRG1
neuregulin 1
chr9_-_110251754 0.814 KLF4
Kruppel-like factor 4 (gut)
chr12_+_93964801 0.812 SOCS2
suppressor of cytokine signaling 2
chr19_+_10381763 0.807 ICAM1
intercellular adhesion molecule 1
chr1_-_153930911 0.804 CRTC2
CREB regulated transcription coactivator 2
chr2_+_108994366 0.800 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr1_+_156254069 0.797 NM_032323
TMEM79
transmembrane protein 79
chr14_+_55168831 0.796 SAMD4A
sterile alpha motif domain containing 4A
chr8_-_6420454 0.790 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr13_+_36050885 0.763 NM_001204197
NBEA
neurobeachin
chr19_+_10381516 0.763 NM_000201
ICAM1
intercellular adhesion molecule 1
chr19_-_13947101 0.759 LOC284454
uncharacterized LOC284454
chr10_-_95241943 0.758 NM_013451
NM_133337
MYOF

myoferlin

chrX_-_153210057 0.753 NM_002910
RENBP
renin binding protein
chr2_+_29038862 0.751 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr5_-_137514299 0.751 NM_001164326
NM_006696
NM_139199
BRD8


bromodomain containing 8


chr6_+_31540092 0.749 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr16_-_75285383 0.734 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr17_-_72968790 0.733 NM_030630
C17orf28
chromosome 17 open reading frame 28
chr6_+_30130982 0.724 NM_033229
TRIM15
tripartite motif containing 15
chr1_+_201979747 0.721 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr6_-_76203256 0.720 NM_015687
FILIP1
filamin A interacting protein 1
chr3_-_167371701 0.716 WDR49
WD repeat domain 49
chr6_-_31689455 0.704 NM_025261
LY6G6C
lymphocyte antigen 6 complex, locus G6C
chr1_+_155911479 0.704 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr1_-_153931077 0.704 CRTC2
CREB regulated transcription coactivator 2
chr16_+_24567628 0.700 RBBP6
retinoblastoma binding protein 6
chr17_+_7462064 0.692 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr2_-_74756817 0.683 AUP1
ancient ubiquitous protein 1
chr3_-_134093235 0.677 NM_016201
AMOTL2
angiomotin like 2
chr11_+_61447816 0.675 NM_006133
DAGLA
diacylglycerol lipase, alpha
chrX_-_48980070 0.672 NM_015698
GPKOW
G patch domain and KOW motifs
chr6_-_91006580 0.669 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr19_+_56652689 0.669 ZNF444
zinc finger protein 444
chr1_+_223900328 0.667 CAPN2
calpain 2, (m/II) large subunit
chr11_+_2421983 0.663 TSSC4
tumor suppressing subtransferable candidate 4
chr7_-_104654443 0.660 LOC100216545
uncharacterized LOC100216545
chr17_-_72968750 0.660


chr14_+_20811712 0.653 NM_001042618
NM_005484
PARP2

poly (ADP-ribose) polymerase 2

chr1_+_201857789 0.649 NM_198149
SHISA4
shisa homolog 4 (Xenopus laevis)
chr2_+_28616360 0.642 FOSL2
FOS-like antigen 2
chr1_-_153931096 0.642 NM_181715
CRTC2
CREB regulated transcription coactivator 2
chr15_-_73661604 0.641 NM_005477
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chrX_-_73834427 0.640


chr3_+_187870808 0.639 LPP
LIM domain containing preferred translocation partner in lipoma
chr16_+_67571342 0.633 NM_001193524
FAM65A
family with sequence similarity 65, member A
chr5_+_55149149 0.628 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr14_+_67999915 0.625 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr19_-_46366337 0.617 NM_004819
SYMPK
symplekin
chr1_+_205473768 0.617 CDK18
cyclin-dependent kinase 18
chr17_+_47923271 0.614 NM_001242791
FLJ45513
uncharacterized LOC729220
chr19_+_35491329 0.614 GRAMD1A
GRAM domain containing 1A
chr15_-_45493372 0.612 NM_138356
SHF
Src homology 2 domain containing F
chr22_-_24096551 0.609 NM_013378
VPREB3
pre-B lymphocyte 3
chr19_-_3761621 0.605 NM_004886
APBA3
amyloid beta (A4) precursor protein-binding, family A, member 3
chr12_+_56324945 0.604 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr19_+_35491225 0.604 NM_001136199
NM_020895
GRAMD1A

GRAM domain containing 1A

chr6_-_152702450 0.602 SYNE1
spectrin repeat containing, nuclear envelope 1
chr14_-_105715740 0.602 NM_001242789
BRF1
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
chr1_+_201857997 0.598 SHISA4
shisa homolog 4 (Xenopus laevis)
chr19_+_2328679 0.594 SPPL2B
signal peptide peptidase-like 2B
chr5_-_179285791 0.593 NM_001017987
NM_016175
C5orf45

chromosome 5 open reading frame 45

chr18_+_32173281 0.587 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr3_-_50649110 0.587 NM_013324
NM_145071
CISH

cytokine inducible SH2-containing protein

chr1_+_223900212 0.585 CAPN2
calpain 2, (m/II) large subunit
chr12_+_133656984 0.585 NM_003440
ZNF140
zinc finger protein 140
chr7_-_5463176 0.583 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr19_+_56652529 0.583 NM_001253792
NM_018337
ZNF444

zinc finger protein 444

chr12_-_49245904 0.576 NM_004818
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr7_+_102004286 0.571 NM_001242713
LOC100289561
LOC100630923
uncharacterized LOC100289561
LOC100289561-PRKRIP1 readthrough
chr7_+_74508346 0.567 NM_001003795
GTF2IRD2B
GTF2IRD2
GTF2I repeat domain containing 2B
GTF2I repeat domain containing 2
chr17_-_80291610 0.566 SECTM1
secreted and transmembrane 1
chr6_-_30654406 0.563 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr2_-_175499275 0.562 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr6_+_31691120 0.562 NM_025260
NM_138272
NM_138273
NM_138274
NM_138275
NM_138277
C6orf25





chromosome 6 open reading frame 25





chr9_-_130186491 0.560


chr1_+_223900226 0.560 CAPN2
calpain 2, (m/II) large subunit
chr6_-_143266283 0.559 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr10_+_104155431 0.552 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr22_+_38599026 0.550 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr9_+_92219926 0.547 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr19_+_48111437 0.547 NM_015711
GLTSCR1
glioma tumor suppressor candidate region gene 1
chr9_+_102584136 0.544 NM_006981
NM_173199
NM_173200
NR4A3


nuclear receptor subfamily 4, group A, member 3


chr12_-_93964636 0.539


chr6_-_43595046 0.538 GTPBP2
GTP binding protein 2
chr2_-_208994408 0.536 NM_020989
CRYGC
crystallin, gamma C
chr16_-_3085541 0.534 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr6_-_33756885 0.533 LEMD2
LEM domain containing 2
chr1_+_160336856 0.533 NM_005598
NHLH1
nescient helix loop helix 1
chr21_+_30452872 0.532 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr8_-_124665165 0.525 NM_001081675
KLHL38
kelch-like 38 (Drosophila)
chr19_+_2476122 0.524 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr6_-_30654978 0.524 PPP1R18
protein phosphatase 1, regulatory subunit 18
chrX_-_73834460 0.520 NM_016120
NM_183353
RLIM

ring finger protein, LIM domain interacting

chr14_-_57960432 0.518 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr16_-_74455239 0.517 NM_001011880
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr11_-_65667809 0.510 FOSL1
FOS-like antigen 1
chr19_+_2328628 0.510 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr3_+_122296432 0.509 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr14_+_65453947 0.507


chr1_+_223900061 0.507 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr6_-_111136407 0.506 NM_015076
CDK19
cyclin-dependent kinase 19
chr12_-_39299335 0.506 NM_153634
CPNE8
copine VIII
chr20_+_51589752 0.505 TSHZ2
teashirt zinc finger homeobox 2
chr22_-_31503484 0.505 NM_080430
SELM
selenoprotein M
chr1_+_203274646 0.503 NM_006763
BTG2
BTG family, member 2
chr11_-_125550674 0.501 NM_001612
NM_020069
NM_020107
NM_020108
ACRV1



acrosomal vesicle protein 1



chr21_+_35736322 0.499 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr19_-_40724272 0.496 NM_152479
TTC9B
tetratricopeptide repeat domain 9B
chr19_+_11200124 0.494 LDLR
low density lipoprotein receptor
chr7_-_37025696 0.492 ELMO1
engulfment and cell motility 1
chr19_+_2328685 0.490 SPPL2B
signal peptide peptidase-like 2B
chr6_+_144471631 0.490 NM_003764
STX11
syntaxin 11
chr1_+_151138497 0.488 NM_001204856
NM_024041
SCNM1

sodium channel modifier 1

chr2_+_74757127 0.485 HTRA2
HtrA serine peptidase 2
chr22_+_29138018 0.485 NM_172002
HSCB
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr9_-_4152182 0.485 NM_152629
GLIS3
GLIS family zinc finger 3
chr11_-_89956121 0.485 CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr1_+_110453232 0.483 NM_000757
NM_172210
NM_172212
CSF1


colony stimulating factor 1 (macrophage)


chr8_+_144680073 0.483 NM_032862
TIGD5
tigger transposable element derived 5
chr6_-_43595079 0.473 GTPBP2
GTP binding protein 2
chr6_+_89790412 0.472 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr11_-_64684606 0.472 NM_015104
ATG2A
ATG2 autophagy related 2 homolog A (S. cerevisiae)
chr19_-_55628780 0.471 NM_017607
PPP1R12C
protein phosphatase 1, regulatory subunit 12C
chr6_-_111136616 0.471 CDK19
cyclin-dependent kinase 19
chr16_-_52581713 0.471 NM_001146188
TOX3
TOX high mobility group box family member 3
chr11_-_89956531 0.470 NM_001144073
NM_012124
CHORDC1

cysteine and histidine-rich domain (CHORD) containing 1

chr8_+_128806720 0.468 PVT1
Pvt1 oncogene (non-protein coding)
chr18_+_22040592 0.467 NM_001143828
NM_001160166
NM_021624
HRH4


histamine receptor H4


chr9_+_131464961 0.464 PKN3
protein kinase N3
chr1_+_110453456 0.461 CSF1
colony stimulating factor 1 (macrophage)
chr5_-_64777703 0.457 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr19_+_11200037 0.456 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr8_-_48650703 0.456 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr6_+_138188352 0.456 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr6_-_56507585 0.455 NM_001723
NM_015548
DST

dystonin

chr12_-_11150473 0.454 NM_176889
TAS2R20
taste receptor, type 2, member 20
chrX_-_48900932 0.454 NM_006521
TFE3
transcription factor binding to IGHM enhancer 3
chr7_-_16921596 0.453 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr2_+_28616346 0.453 FOSL2
FOS-like antigen 2
chr10_+_95848811 0.448 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr12_+_53443834 0.446 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_+_43613593 0.446 NM_001101376
FAM183A
family with sequence similarity 183, member A
chr6_+_89790464 0.445 PNRC1
proline-rich nuclear receptor coactivator 1
chr2_-_145275086 0.445 ZEB2
zinc finger E-box binding homeobox 2
chr20_+_35973083 0.443 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr6_-_163148800 0.440 NM_004562
NM_013987
NM_013988
PARK2


parkinson protein 2, E3 ubiquitin protein ligase (parkin)


chr2_+_74756986 0.440 HTRA2
HtrA serine peptidase 2
chr5_-_172198160 0.440 NM_004417
DUSP1
dual specificity phosphatase 1
chrX_-_124097601 0.439 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chr5_+_71502700 0.438 MAP1B
microtubule-associated protein 1B
chr17_-_7760740 0.436 LSMD1
LSM domain containing 1
chr12_-_11002051 0.433 NM_001098538
NM_007244
PRR4

proline rich 4 (lacrimal)

chr6_-_33756905 0.433 NM_181336
LEMD2
LEM domain containing 2
chr19_-_40324747 0.431 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr12_+_121416548 0.430 NM_000545
HNF1A
HNF1 homeobox A
chr12_+_123868608 0.429 NM_020382
SETD8
SET domain containing (lysine methyltransferase) 8
chr3_+_115342302 0.427 GAP43
growth associated protein 43
chr6_-_111136330 0.427 CDK19
cyclin-dependent kinase 19
chr3_-_114866090 0.424 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_9268522 0.422 NM_000014
A2M
alpha-2-macroglobulin
chr17_-_80291903 0.420 NM_003004
SECTM1
secreted and transmembrane 1
chr19_-_4831711 0.419 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr16_+_69726751 0.417 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr12_+_93963597 0.417 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr9_-_110252045 0.416 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr2_-_74756824 0.416 AUP1
ancient ubiquitous protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
8.59 7.44e-03 GO:0009790 embryo development
3.30 1.26e-02 GO:0060255 regulation of macromolecule metabolic process
4.14 1.59e-02 GO:0006355 regulation of transcription, DNA-dependent
3.13 2.09e-02 GO:0080090 regulation of primary metabolic process
3.99 2.16e-02 GO:0051252 regulation of RNA metabolic process
2.16 2.16e-02 GO:0050794 regulation of cellular process
3.09 2.39e-02 GO:0031323 regulation of cellular metabolic process
3.74 3.62e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
3.64 4.45e-02 GO:0010556 regulation of macromolecule biosynthetic process
2.04 4.69e-02 GO:0050789 regulation of biological process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
11.11 5.85e-06 GO:0043565 sequence-specific DNA binding
7.71 9.61e-05 GO:0001071 nucleic acid binding transcription factor activity
7.71 9.61e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
3.73 6.99e-03 GO:0003677 DNA binding
68.42 1.46e-02 GO:0030545 receptor regulator activity
39.55 4.40e-02 GO:0046332 SMAD binding