Motif ID: TBP.p2

Z-value: 2.455


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBPhg19_v1_chr6_+_170863420_1708635080.602.1e-01Click!


Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_35773409 3.651 NM_021175
HAMP
hepcidin antimicrobial peptide
chr6_+_27114860 2.335 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr6_-_26043884 2.183 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr6_-_27775683 2.028 NM_003519
HIST1H2BL
histone cluster 1, H2bl
chr4_+_74735107 2.023 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr15_-_75017710 1.907 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr17_-_70588942 1.804 LOC100499467
uncharacterized LOC100499467
chrX_-_105282714 1.774 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr10_-_92680784 1.744 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr6_+_27100784 1.456 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chrX_-_115594136 1.382 NM_001017978
CXorf61
chromosome X open reading frame 61
chr3_-_169482847 1.295 TERC
telomerase RNA component
chr11_-_18270167 1.187 NM_001199744
NM_001127380
NM_030754
SAA2-SAA4
SAA2

SAA2-SAA4 readthrough
serum amyloid A2

chr13_+_27844936 1.176 RASL11A
RAS-like, family 11, member A
chr16_+_56659584 1.080 NM_175617
MT1E
metallothionein 1E
chr6_+_12290528 1.080 NM_001168319
NM_001955
EDN1

endothelin 1

chr16_+_56659679 1.052 MT1E
metallothionein 1E
chr1_-_11907741 1.046 NM_006172
NPPA
natriuretic peptide A
chr6_+_26217145 1.041 NM_021052
HIST1H2AE
histone cluster 1, H2ae
chr5_+_176811431 1.033 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr15_-_51630735 1.014 NM_000103
NM_031226
CYP19A1

cytochrome P450, family 19, subfamily A, polypeptide 1

chr10_+_96698409 1.002 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr1_-_23885916 0.986 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr6_-_26235160 0.978 NM_005320
HIST1H1D
histone cluster 1, H1d
chr6_+_14118002 0.973 CD83
CD83 molecule
chr19_+_50922194 0.926 NM_001243998
NM_001243999
NM_001244000
NM_003121
SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chr9_-_33447527 0.911 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chrX_+_17393537 0.902 NM_198270
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr11_-_111782447 0.878 NM_001885
CRYAB
crystallin, alpha B
chr1_-_156675237 0.817 NM_001878
NM_001199723
CRABP2

cellular retinoic acid binding protein 2

chr6_-_26032287 0.812 NM_003537
HIST1H3B
histone cluster 1, H3b
chr6_-_26124130 0.797 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chrX_+_153046422 0.792 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr6_-_133035180 0.783 NM_004666
VNN1
vanin 1
chr7_-_128415843 0.777 NM_001708
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr10_-_92681025 0.773 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr11_-_615649 0.759 NM_004031
IRF7
interferon regulatory factor 7
chr1_-_149812733 0.732 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chr6_+_33239798 0.730 NM_022551
RPS18
ribosomal protein S18
chr10_+_54074037 0.725 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr16_-_56701904 0.717 NM_005950
MT1G
metallothionein 1G
chr6_+_33239855 0.707 RPS18
ribosomal protein S18
chr15_+_39873276 0.703 NM_003246
THBS1
thrombospondin 1
chr4_+_74606222 0.701 NM_000584
IL8
interleukin 8
chr3_-_27764197 0.687 EOMES
eomesodermin
chr6_-_26017960 0.664 NM_005325
HIST1H1A
histone cluster 1, H1a
chr9_-_104198045 0.658 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr19_+_12902286 0.652


chr10_-_72201438 0.651 NM_018055
NODAL
nodal homolog (mouse)
chr6_-_27860927 0.644 NM_003514
HIST1H2AM
histone cluster 1, H2am
chr7_+_94285736 0.644 PEG10
paternally expressed 10
chr11_-_2182408 0.633 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough
chr10_+_6244839 0.629 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr2_-_43453724 0.612 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr11_-_615920 0.604 IRF7
interferon regulatory factor 7
chr22_+_24115035 0.591 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr7_+_44836309 0.573 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr9_+_117085302 0.570 NM_000607
ORM1
orosomucoid 1
chr19_+_49468587 0.560 FTL
ferritin, light polypeptide
chr16_-_67965754 0.559 NM_001907
CTRL
chymotrypsin-like
chr7_+_94285620 0.552 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr7_+_94285676 0.541 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr16_+_58534045 0.537 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr5_-_27038650 0.536 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr6_-_134498973 0.535 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr20_-_39317875 0.528 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr6_-_26189303 0.526 NM_003539
HIST1H4D
histone cluster 1, H4d
chr7_-_5570188 0.523 NM_001101
ACTB
actin, beta
chr7_-_45960738 0.522 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr1_-_149858114 0.519 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr2_-_43453146 0.518 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr6_-_27782517 0.518 NM_021066
HIST1H2AJ
histone cluster 1, H2aj
chr12_-_11036815 0.518 NM_006250
PRH1
proline-rich protein HaeIII subfamily 1
chr19_+_1269244 0.509 NM_001280
CIRBP
cold inducible RNA binding protein
chr11_+_43963809 0.504 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr21_-_31852631 0.500 NM_181607
KRTAP19-1
keratin associated protein 19-1
chr6_-_2842069 0.497 NM_030666
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr8_-_144512601 0.496 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr4_-_46391393 0.494 NM_001114175
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr18_+_29171729 0.488 NM_000371
TTR
transthyretin
chr1_-_95007139 0.484 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr12_+_11081833 0.477 NM_005042
NM_001110213
PRH2

proline-rich protein HaeIII subfamily 2

chr19_+_49468656 0.474 FTL
ferritin, light polypeptide
chr11_-_116693907 0.469 NM_000482
APOA4
apolipoprotein A-IV
chr19_+_49468557 0.463 NM_000146
FTL
ferritin, light polypeptide
chr12_-_53298765 0.456 NM_002273
KRT8
keratin 8
chr6_+_27861202 0.453 NM_003527
HIST1H2BO
histone cluster 1, H2bo
chr6_+_36562135 0.447 SRSF3
serine/arginine-rich splicing factor 3
chr4_-_74904329 0.445 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr15_+_45406518 0.440 NM_207581
DUOXA2
dual oxidase maturation factor 2
chr16_+_72097124 0.439 NM_020995
HPR
haptoglobin-related protein
chr17_-_10372875 0.437 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr16_+_89989686 0.431 NM_006086
TUBB3
tubulin, beta 3 class III
chr7_+_157023933 0.429


chr1_-_11918889 0.424 NM_002521
NPPB
natriuretic peptide B
chr11_-_61735067 0.409 FTH1
CPSF7
ferritin, heavy polypeptide 1
cleavage and polyadenylation specific factor 7, 59kDa
chr2_+_8822112 0.400 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr20_+_30193083 0.397 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr1_-_89357181 0.396 GTF2B
general transcription factor IIB
chr4_+_25657434 0.394 NM_001177998
NM_006424
SLC34A2

solute carrier family 34 (sodium phosphate), member 2

chr15_+_69745156 0.391 NM_001003
NM_213725
RPLP1

ribosomal protein, large, P1

chr1_+_154966061 0.388 NM_018655
LENEP
lens epithelial protein
chr1_+_153330329 0.386 NM_002965
S100A9
S100 calcium binding protein A9
chr1_+_86046434 0.386 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr1_-_67266930 0.385 NM_005478
INSL5
insulin-like 5
chr7_+_116593354 0.379 NM_018412
NM_021908
ST7

suppression of tumorigenicity 7

chr11_-_1619481 0.378 NM_001004325
KRTAP5-2
keratin associated protein 5-2
chr1_-_23886284 0.375 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr19_-_41356193 0.373 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr19_+_16435632 0.373 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr22_+_29876180 0.371 NM_021076
NEFH
neurofilament, heavy polypeptide
chr19_+_41497182 0.370 NM_000767
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr17_+_43225834 0.360 HEXIM1
hexamethylene bis-acetamide inducible 1
chr1_-_149785235 0.357 NM_001123375
HIST2H3D
histone cluster 2, H3d
chr17_+_7554415 0.355 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr19_-_33793321 0.352


chr1_-_27481400 0.344 NM_003047
SLC9A1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr8_-_95907423 0.343 NM_057749
CCNE2
cyclin E2
chr10_-_100027943 0.343 NM_032211
LOXL4
lysyl oxidase-like 4
chr16_-_4855159 0.340 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr7_+_116593554 0.340 ST7
suppression of tumorigenicity 7
chr2_-_162930629 0.335 DPP4
dipeptidyl-peptidase 4
chr18_+_21719025 0.330 CABYR
calcium binding tyrosine-(Y)-phosphorylation regulated
chr19_-_2051222 0.329 NM_017572
NM_199054
MKNK2

MAP kinase interacting serine/threonine kinase 2

chr12_-_56359794 0.328 NM_001200053
NM_001200054
PMEL

premelanosome protein

chr4_+_155484131 0.327 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr14_-_21493910 0.326 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr15_+_79165343 0.325 MORF4L1
mortality factor 4 like 1
chr12_-_48119224 0.320 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr6_-_26216871 0.320 NM_003518
HIST1H2BG
NCALD
histone cluster 1, H2bg
neurocalcin delta
chr6_+_26156552 0.318 HIST1H1E
histone cluster 1, H1e
chr7_-_134143804 0.318 AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr7_-_41742666 0.318 NM_002192
INHBA
inhibin, beta A
chr19_+_18496966 0.316 NM_004864
GDF15
growth differentiation factor 15
chr9_-_5437825 0.312 NM_018465
C9orf46
chromosome 9 open reading frame 46
chr6_+_26045611 0.309 NM_003531
HIST1H3C
histone cluster 1, H3c
chr7_+_44836166 0.306 NM_021130
PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr1_-_149783910 0.306 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chr2_-_151344145 0.302 NM_005168
RND3
Rho family GTPase 3
chr3_+_49449638 0.300 NM_022171
TCTA
T-cell leukemia translocation altered gene
chr9_+_117092068 0.300 NM_000608
ORM2
orosomucoid 2
chr6_-_26250832 0.298 NM_021018
HIST1H3J
HIST1H3F
histone cluster 1, H3j
histone cluster 1, H3f
chr11_+_75273245 0.298 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr1_-_35658731 0.296 SFPQ
splicing factor proline/glutamine-rich
chr7_+_94297448 0.295 PEG10
paternally expressed 10
chr1_-_89357246 0.294 NM_001514
GTF2B
general transcription factor IIB
chr6_+_27775898 0.294 NM_003509
HIST1H2AI
HIST1H2AM
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H2am
histone cluster 1, H3f
chr3_-_81810802 0.290 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr6_+_27833033 0.289 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr5_-_140053126 0.287 NM_194249
DND1
dead end homolog 1 (zebrafish)
chr22_+_35777051 0.285 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr1_-_31845818 0.284 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr7_+_44836273 0.284 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr16_+_57406398 0.283 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr6_+_36562139 0.282 SRSF3
serine/arginine-rich splicing factor 3
chr3_-_10332408 0.281 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr6_+_19837599 0.278 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr15_-_63673918 0.271 CA12
carbonic anhydrase XII
chr17_+_7554711 0.270 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr15_-_60690115 0.270 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr6_-_53409897 0.268 NM_001197115
NM_001498
GCLC

glutamate-cysteine ligase, catalytic subunit

chr20_+_42086533 0.264 SRSF6
serine/arginine-rich splicing factor 6
chr16_-_11370305 0.263 NM_002762
PRM2
protamine 2
chr6_+_26204779 0.259 NM_003545
HIST1H4E
histone cluster 1, H4e
chr17_+_7387688 0.257 NM_000937
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr7_-_73097729 0.257 NM_032317
DNAJC30
DnaJ (Hsp40) homolog, subfamily C, member 30
chr8_-_23261632 0.255 LOXL2
lysyl oxidase-like 2
chr16_+_56691854 0.254 NM_005949
MT1F
metallothionein 1F
chr6_+_27777713 0.252 NM_003536
HIST1H3H
histone cluster 1, H3h
chr7_-_16844606 0.250 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr6_+_26156558 0.248 NM_005321
HIST1H1E
histone cluster 1, H1e
chrX_+_38663450 0.246 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr2_+_10262853 0.244 NM_001034
RRM2
ribonucleotide reductase M2
chr14_-_53417808 0.243 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr3_-_129035069 0.242 NM_006026
H1FX
H1 histone family, member X
chr1_-_28908353 0.241 SNHG12
small nucleolar RNA host gene 12 (non-protein coding)
chr11_-_64646053 0.240 NM_006795
EHD1
EH-domain containing 1
chr12_+_56223528 0.238 TMEM198B
transmembrane protein 198B, pseudogene
chrX_+_17393349 0.235 NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr10_+_24497719 0.231 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr6_-_135271206 0.226 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chrX_+_17393806 0.224 NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr10_-_62703822 0.224 NM_001242359
NM_014836
RHOBTB1

Rho-related BTB domain containing 1

chr11_-_111249902 0.224 POU2AF1
POU class 2 associating factor 1
chr3_+_193853937 0.221 HES1
hairy and enhancer of split 1, (Drosophila)
chr1_-_40042461 0.220 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr1_-_33168263 0.219 SYNC
syncoilin, intermediate filament protein
chr3_-_126327397 0.218 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chrX_+_46940235 0.218 RGN
regucalcin (senescence marker protein-30)
chr12_-_27924208 0.217 NM_001146221
MANSC4
MANSC domain containing 4
chr16_-_4854748 0.217 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr8_+_86376130 0.210 NM_000067
CA2
carbonic anhydrase II
chr19_+_41430123 0.206 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr1_-_40042415 0.206 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr9_-_37034358 0.206 NM_016734
PAX5
paired box 5
chr6_-_27835308 0.206 NM_005322
HIST1H1B
histone cluster 1, H1b
chr10_-_72201358 0.206 NODAL
nodal homolog (mouse)
chr2_+_85766100 0.202 NM_005911
MAT2A
methionine adenosyltransferase II, alpha
chr19_+_859658 0.201 NM_001928
CFD
complement factor D (adipsin)
chr19_+_6531009 0.200 NM_003811
TNFSF9
tumor necrosis factor (ligand) superfamily, member 9

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
45.94 7.80e-06 GO:0006334 nucleosome assembly
43.57 1.02e-05 GO:0031497 chromatin assembly
41.44 1.31e-05 GO:0034728 nucleosome organization
39.88 1.59e-05 GO:0065004 protein-DNA complex assembly
37.74 2.10e-05 GO:0071824 protein-DNA complex subunit organization
33.29 3.93e-05 GO:0006323 DNA packaging
31.32 5.33e-05 GO:0006333 chromatin assembly or disassembly
28.58 8.42e-05 GO:0071103 DNA conformation change
12.58 4.69e-03 GO:0034622 cellular macromolecular complex assembly
9.89 1.48e-02 GO:0006325 chromatin organization
9.45 1.83e-02 GO:0034621 cellular macromolecular complex subunit organization
3.78 2.66e-02 GO:0042221 response to chemical stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
70.41 2.55e-07 GO:0000786 nucleosome
44.49 2.63e-06 GO:0032993 protein-DNA complex
18.41 2.12e-04 GO:0000785 chromatin
9.67 4.74e-03 GO:0044427 chromosomal part
8.11 1.09e-02 GO:0005694 chromosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
56.34 4.24e-04 GO:0019825 oxygen binding
31.71 2.40e-03 GO:0004497 monooxygenase activity
105.59 3.61e-03 GO:0008395 steroid hydroxylase activity
25.64 4.51e-03 GO:0005179 hormone activity
70.41 8.27e-03 GO:0070330 aromatase activity
20.64 8.56e-03 GO:0020037 heme binding
65.00 9.72e-03 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
19.39 1.03e-02 GO:0046906 tetrapyrrole binding
18.54 1.17e-02 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
14.95 2.20e-02 GO:0009055 electron carrier activity
14.78 2.28e-02 GO:0001664 G-protein-coupled receptor binding
12.29 3.88e-02 GO:0005506 iron ion binding