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Motif ID: TFAP2{A,C}.p2

Z-value: 3.232

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_43299277	7.703	NM_005892	FMNL1	formin-like 1
chr11_-_1593149	5.955	NM_004420	DUSP8	dual specificity phosphatase 8
chr19_+_42788605	4.013	NM_015125	CIC	capicua homolog (Drosophila)
chr7_-_100493481	3.949	NM_000665 NM_015831	ACHE	acetylcholinesterase
chr5_+_172483285	3.932	NM_001168393 NM_001168394 NM_153607	C5orf41	chromosome 5 open reading frame 41
chr6_+_17281773	3.610	NM_001143942	RBM24	RNA binding motif protein 24
chr12_-_117319231	3.355	NM_003806	HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)
chr11_-_78128765	3.320		GAB2	GRB2-associated binding protein 2
chr19_+_7660698	3.259	NM_001080429 NM_020902	CAMSAP3	calmodulin regulated spectrin-associated protein family, member 3
chr17_+_17584772	3.252	NM_030665	RAI1	retinoic acid induced 1
chr9_-_110251308	3.242		KLF4	Kruppel-like factor 4 (gut)
chr7_+_1570321	3.185	NM_002360	MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr1_+_178063272	3.150		RASAL2	RAS protein activator like 2
chr6_-_143266283	3.131	NM_006734	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2
chr10_-_77159851	3.107		ZNF503	zinc finger protein 503
chr1_+_16010838	3.045		PLEKHM2	pleckstrin homology domain containing, family M (with RUN domain) member 2
chr10_-_77161424	3.038	NM_032772	ZNF503	zinc finger protein 503
chr10_-_77161136	2.992		ZNF503	zinc finger protein 503
chr1_+_201857997	2.916		SHISA4	shisa homolog 4 (Xenopus laevis)
chr19_+_40697516	2.886	NM_002446	MAP3K10	mitogen-activated protein kinase kinase kinase 10
chr22_-_46933066	2.869	NM_014246	CELSR1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr2_-_145274916	2.867		ZEB2	zinc finger E-box binding homeobox 2
chr12_-_123635284	2.851		PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2
chr19_+_13906207	2.791	NM_023072	ZSWIM4	zinc finger, SWIM-type containing 4
chr10_-_3827418	2.777	NM_001160124 NM_001160125 NM_001300	KLF6	Kruppel-like factor 6
chr4_+_139936938	2.744	NM_012118	CCRN4L	CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr7_+_100081549	2.695	NM_173564	NYAP1	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
chr20_+_2673193	2.656	NM_001110514	EBF4	early B-cell factor 4
chr19_+_4969126	2.654		KDM4B	lysine (K)-specific demethylase 4B
chr4_+_108745718	2.626	NM_001136258	SGMS2	sphingomyelin synthase 2
chr11_+_46299585	2.593		CREB3L1	cAMP responsive element binding protein 3-like 1
chr11_+_61447816	2.581	NM_006133	DAGLA	diacylglycerol lipase, alpha
chr3_+_184097860	2.570	NM_003741	CHRD	chordin
chr1_+_16010816	2.569	NM_015164	PLEKHM2	pleckstrin homology domain containing, family M (with RUN domain) member 2
chr15_-_61521416	2.554		RORA	RAR-related orphan receptor A
chr10_-_77161539	2.548		ZNF503	zinc finger protein 503
chr19_-_1848447	2.540	NM_020695	REXO1	REX1, RNA exonuclease 1 homolog (S. cerevisiae)
chr9_+_35605275	2.515	NM_006285	TESK1	testis-specific kinase 1
chrX_+_49126480	2.512		PPP1R3F	protein phosphatase 1, regulatory subunit 3F
chr19_+_36208917	2.512	NM_014727	MLL4	myeloid/lymphoid or mixed-lineage leukemia 4
chr5_-_57755787	2.499	NM_001252226 NM_006622	PLK2	polo-like kinase 2
chr10_+_104404195	2.483	NM_030912	TRIM8	tripartite motif containing 8
chr19_+_34972866	2.479	NM_001080436	WTIP	Wilms tumor 1 interacting protein
chr19_+_45504686	2.464	NM_006509	RELB	v-rel reticuloendotheliosis viral oncogene homolog B
chr19_+_49376488	2.453		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr15_-_60884615	2.450	NM_134262	RORA	RAR-related orphan receptor A
chr11_-_65667809	2.447		FOSL1	FOS-like antigen 1
chr5_-_11904127	2.413		CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr22_+_50354428	2.410		PIM3	pim-3 oncogene
chr19_-_1848359	2.405		REXO1	REX1, RNA exonuclease 1 homolog (S. cerevisiae)
chr19_+_4969123	2.371	NM_015015	KDM4B	lysine (K)-specific demethylase 4B
chr19_-_47734215	2.329	NM_014417	BBC3	BCL2 binding component 3
chr1_-_33430285	2.318	NM_001127361 NM_153341	RNF19B	ring finger protein 19B
chr16_-_54319966	2.313		IRX3	iroquois homeobox 3
chr19_-_55628780	2.297	NM_017607	PPP1R12C	protein phosphatase 1, regulatory subunit 12C
chr7_+_1581072	2.276		MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr19_+_36209125	2.269		MLL4	myeloid/lymphoid or mixed-lineage leukemia 4
chr11_+_46299554	2.261		CREB3L1	cAMP responsive element binding protein 3-like 1
chr19_+_45971249	2.260	NM_001114171 NM_006732	FOSB	FBJ murine osteosarcoma viral oncogene homolog B
chr16_-_75272524	2.259		BCAR1	breast cancer anti-estrogen resistance 1
chr12_-_96184510	2.243	NM_021229	NTN4	netrin 4
chr5_+_179248089	2.242		SQSTM1	sequestosome 1
chr22_+_50354139	2.230	NM_001001852	PIM3	pim-3 oncogene
chr22_+_38599026	2.226	NM_001161573	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr9_-_86432546	2.214	NM_001135953 NM_025211	GKAP1	G kinase anchoring protein 1
chr9_+_35605614	2.197		TESK1	testis-specific kinase 1
chr5_+_179247841	2.185	NM_003900	SQSTM1	sequestosome 1
chr20_+_4129466	2.184		SMOX	spermine oxidase
chr3_-_134093235	2.178	NM_016201	AMOTL2	angiomotin like 2
chrX_+_152953751	2.155	NM_001142805 NM_005629	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr18_-_74207145	2.144	NM_014643	ZNF516	zinc finger protein 516
chr10_-_32636084	2.126	NM_025209	EPC1	enhancer of polycomb homolog 1 (Drosophila)
chr11_-_61684981	2.123	NM_013401	RAB3IL1	RAB3A interacting protein (rabin3)-like 1
chr1_+_46269283	2.117	NM_015112	MAST2	microtubule associated serine/threonine kinase 2
chr1_+_223900328	2.110		CAPN2	calpain 2, (m/II) large subunit
chr8_-_144512601	2.102	NM_201589	MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chrX_+_49126299	2.097	NM_001184745 NM_033215	PPP1R3F	protein phosphatase 1, regulatory subunit 3F
chr1_+_212782103	2.096		ATF3	activating transcription factor 3
chr2_-_73340073	2.093	NM_015470	RAB11FIP5	RAB11 family interacting protein 5 (class I)
chr14_+_75745480	2.093	NM_005252	FOS	FBJ murine osteosarcoma viral oncogene homolog
chr5_+_179247911	2.093		SQSTM1	sequestosome 1
chr1_+_32827797	2.088	NM_052841	TSSK3	testis-specific serine kinase 3
chrX_+_153686620	2.085	NM_017514	PLXNA3	plexin A3
chr4_+_79472851	2.065		ANXA3	annexin A3
chr16_+_1203240	2.064	NM_001005407 NM_021098	CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit
chr19_+_35491329	2.047		GRAMD1A	GRAM domain containing 1A
chr1_-_33815411	2.042		PHC2	polyhomeotic homolog 2 (Drosophila)
chr16_-_75285383	2.029	NM_001170717 NM_014567	BCAR1	breast cancer anti-estrogen resistance 1
chr12_+_110152186	2.027	NM_032829	C12orf34	chromosome 12 open reading frame 34
chr1_-_33815498	2.013	NM_004427	PHC2	polyhomeotic homolog 2 (Drosophila)
chr11_-_63536112	2.012	NM_001144936	C11orf95	chromosome 11 open reading frame 95
chr11_+_46299161	2.012	NM_052854	CREB3L1	cAMP responsive element binding protein 3-like 1
chr22_+_31489343	2.001		SMTN	smoothelin
chr15_-_61521478	2.001	NM_134261	RORA	RAR-related orphan receptor A
chr12_+_133067156	1.994	NM_001142641	FBRSL1	fibrosin-like 1
chr19_-_344778	1.993	NM_017550	MIER2	mesoderm induction early response 1, family member 2
chr15_+_40733302	1.989	NM_014952	BAHD1	bromo adjacent homology domain containing 1
chr20_+_51589752	1.980		TSHZ2	teashirt zinc finger homeobox 2
chr11_-_67141008	1.964	NM_013246	CLCF1	cardiotrophin-like cytokine factor 1
chr9_+_35605339	1.964		TESK1	testis-specific kinase 1
chr18_-_48723689	1.957		MEX3C	mex-3 homolog C (C. elegans)
chr16_+_30406711	1.934	NM_152652	ZNF48	zinc finger protein 48
chr8_-_29207795	1.925	NM_001394	DUSP4	dual specificity phosphatase 4
chr10_-_100027943	1.923	NM_032211	LOXL4	lysyl oxidase-like 4
chr1_-_224033673	1.916	NM_001031685 NM_005426	TP53BP2	tumor protein p53 binding protein, 2
chr1_-_224033603	1.916		TP53BP2	tumor protein p53 binding protein, 2
chr6_+_157099262	1.909		ARID1B	AT rich interactive domain 1B (SWI1-like)
chr5_+_179247903	1.908		SQSTM1	sequestosome 1
chr15_+_90544608	1.897	NM_198526	ZNF710	zinc finger protein 710
chr7_+_150076405	1.897	NM_173680	ZNF775	zinc finger protein 775
chr2_-_73340058	1.894		RAB11FIP5	RAB11 family interacting protein 5 (class I)
chr7_+_101460881	1.894	NM_181552	CUX1	cut-like homeobox 1
chr14_+_55034633	1.891		SAMD4A	sterile alpha motif domain containing 4A
chr14_+_67999915	1.878	NM_020715	PLEKHH1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr2_-_73339911	1.878		RAB11FIP5	RAB11 family interacting protein 5 (class I)
chr6_+_157099873	1.874		ARID1B	AT rich interactive domain 1B (SWI1-like)
chr17_-_74497406	1.874	NM_024599	RHBDF2	rhomboid 5 homolog 2 (Drosophila)
chr9_-_37576248	1.869	NM_012166	FBXO10	F-box protein 10
chr2_+_28616360	1.868		FOSL2	FOS-like antigen 2
chr16_+_30675777	1.848	NM_001105079	FBRS	fibrosin
chr8_+_81398416	1.848	NM_001105539 NM_023929	ZBTB10	zinc finger and BTB domain containing 10
chrX_+_49126326	1.847		PPP1R3F	protein phosphatase 1, regulatory subunit 3F
chr12_-_96184346	1.846		NTN4	netrin 4
chr10_-_32635842	1.843		EPC1	enhancer of polycomb homolog 1 (Drosophila)
chr1_-_156675237	1.840	NM_001878 NM_001199723	CRABP2	cellular retinoic acid binding protein 2
chr19_-_46389307	1.836	NM_015649	IRF2BP1	interferon regulatory factor 2 binding protein 1
chr5_-_39425030	1.835		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr9_+_35605449	1.827		TESK1	testis-specific kinase 1
chr2_+_220408352	1.825		TMEM198	transmembrane protein 198
chr22_-_20792107	1.824	NM_153334 NM_182895	SCARF2	scavenger receptor class F, member 2
chr4_+_109088677	1.821		LOC641518	uncharacterized LOC641518
chr22_+_31487315	1.810		SMTN	smoothelin
chr5_-_39424930	1.806		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_-_169482847	1.805		TERC	telomerase RNA component
chr12_-_112037024	1.783		ATXN2	ataxin 2
chr9_+_139971938	1.781	NM_207309	UAP1L1	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr12_-_51611476	1.778		POU6F1	POU class 6 homeobox 1
chr11_-_78128852	1.776	NM_080491	GAB2	GRB2-associated binding protein 2
chr1_-_247494990	1.773	NM_032752	ZNF496	zinc finger protein 496
chr2_+_205410716	1.770		PARD3B	par-3 partitioning defective 3 homolog B (C. elegans)
chr11_+_64692052	1.769	NM_006244	PPP2R5B	protein phosphatase 2, regulatory subunit B', beta
chr6_+_36098261	1.763	NM_002754	MAPK13	mitogen-activated protein kinase 13
chr1_+_157963310	1.755		KIRREL	kin of IRRE like (Drosophila)
chr11_-_63933493	1.748	NM_014067	MACROD1	MACRO domain containing 1
chr5_+_14143287	1.748	NM_007118	TRIO	triple functional domain (PTPRF interacting)
chr16_-_68002455	1.747	NM_001145961 NM_001145962 NM_005072	SLC12A4	solute carrier family 12 (potassium/chloride transporters), member 4
chr4_+_79472741	1.742	NM_005139	ANXA3	annexin A3
chrX_-_108868250	1.742	NM_012282	KCNE1L	KCNE1-like
chr17_-_63557615	1.740	NM_004655	AXIN2	axin 2
chr19_+_13263890	1.736		IER2	immediate early response 2
chr19_-_1863425	1.731		KLF16	Kruppel-like factor 16
chr22_+_38598065	1.729		MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr19_+_10828813	1.726		DNM2	dynamin 2
chr19_+_39897457	1.726	NM_003407	ZFP36	zinc finger protein 36, C3H type, homolog (mouse)
chr6_+_157099203	1.724
chr5_-_11903964	1.723	NM_001332	CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr7_+_1580009	1.722		MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr20_-_43729607	1.722	NM_002251	KCNS1	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr8_+_128806720	1.715		PVT1	Pvt1 oncogene (non-protein coding)
chr16_-_54320328	1.711		IRX3	iroquois homeobox 3
chr19_-_4065467	1.709		ZBTB7A	zinc finger and BTB domain containing 7A
chr5_-_39425297	1.706	NM_001244871 NM_001343	DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr7_-_152133071	1.705	NM_170606	MLL3	myeloid/lymphoid or mixed-lineage leukemia 3
chr2_+_205410465	1.704	NM_057177 NM_152526 NM_205863	PARD3B	par-3 partitioning defective 3 homolog B (C. elegans)
chr1_+_45265896	1.702		PLK3	polo-like kinase 3
chr16_+_30676098	1.702		FBRS	fibrosin
chr1_+_45266035	1.700	NM_004073	PLK3	polo-like kinase 3
chr12_+_133195365	1.693	NM_012226 NM_016318 NM_170682 NM_170683 NM_174872 NM_174873	P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2
chr9_+_99212379	1.691	NM_014282	HABP4	hyaluronan binding protein 4
chr1_+_178063237	1.690		RASAL2	RAS protein activator like 2
chr17_-_17399494	1.684	NM_001199989 NM_016084	RASD1	RAS, dexamethasone-induced 1
chr11_+_13984139	1.680	NM_006108	SPON1	spondin 1, extracellular matrix protein
chr10_-_3827205	1.680		KLF6	Kruppel-like factor 6
chr14_-_21566497	1.680		ZNF219	zinc finger protein 219
chr17_-_63557764	1.680		AXIN2	axin 2
chr16_+_30406432	1.678	NM_001214909	ZNF48	zinc finger protein 48
chr9_-_29738	1.672	NM_182905	WASH1	WAS protein family homolog 1
chr16_-_75299713	1.671	NM_001170720 NM_001170714 NM_001170718	BCAR1	breast cancer anti-estrogen resistance 1
chr17_-_43394326	1.671	NM_003954	MAP3K14	mitogen-activated protein kinase kinase kinase 14
chr4_-_967327	1.670	NM_001347	DGKQ	diacylglycerol kinase, theta 110kDa
chr12_+_93964801	1.669		SOCS2	suppressor of cytokine signaling 2
chr1_+_223900212	1.661		CAPN2	calpain 2, (m/II) large subunit
chr19_-_460995	1.659	NM_012435	SHC2	SHC (Src homology 2 domain containing) transforming protein 2
chr1_-_214724844	1.656		PTPN14	protein tyrosine phosphatase, non-receptor type 14
chr1_+_178063302	1.656		RASAL2	RAS protein activator like 2
chr1_+_86046434	1.655	NM_001554	CYR61	cysteine-rich, angiogenic inducer, 61
chr20_+_4129409	1.642	NM_175839 NM_175840 NM_175841 NM_175842	SMOX	spermine oxidase
chr1_-_228135587	1.642	NM_003395	WNT9A	wingless-type MMTV integration site family, member 9A
chr17_-_36762105	1.631	NM_025248	SRCIN1	SRC kinase signaling inhibitor 1
chr1_-_156470538	1.627		MEF2D	myocyte enhancer factor 2D
chr2_+_171571800	1.623	NM_001003845	SP5	Sp5 transcription factor
chr22_-_41032623	1.621		MKL1	megakaryoblastic leukemia (translocation) 1
chr13_+_73633097	1.617	NM_001730	KLF5	Kruppel-like factor 5 (intestinal)
chr6_+_108881010	1.616	NM_201559	FOXO3	forkhead box O3
chr7_-_152132924	1.604		MLL3	myeloid/lymphoid or mixed-lineage leukemia 3
chr16_-_52580805	1.602	NM_001080430	TOX3	TOX high mobility group box family member 3
chr6_-_44233244	1.602		NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr9_-_38069082	1.598		SHB	Src homology 2 domain containing adaptor protein B
chr10_-_79686279	1.593	NM_004747	DLG5	discs, large homolog 5 (Drosophila)
chr15_+_100106132	1.593	NM_001130926 NM_001130927 NM_001171894 NM_005587	MEF2A	myocyte enhancer factor 2A

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
1.90	1.16e-10	GO:0060255	regulation of macromolecule metabolic process
1.83	5.11e-10	GO:0031323	regulation of cellular metabolic process
1.83	9.99e-10	GO:0080090	regulation of primary metabolic process
1.45	2.97e-09	GO:0050789	regulation of biological process
1.48	3.76e-09	GO:0050794	regulation of cellular process
1.74	5.41e-09	GO:0019222	regulation of metabolic process
2.07	7.04e-09	GO:0051252	regulation of RNA metabolic process
1.97	1.45e-08	GO:0010468	regulation of gene expression
1.39	1.20e-07	GO:0065007	biological regulation
1.91	4.59e-07	GO:0010556	regulation of macromolecule biosynthetic process
1.92	5.98e-07	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.85	9.06e-07	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.90	9.40e-07	GO:0048522	positive regulation of cellular process
1.96	1.10e-06	GO:0006355	regulation of transcription, DNA-dependent
1.83	1.81e-06	GO:0048518	positive regulation of biological process
1.81	3.60e-06	GO:0009889	regulation of biosynthetic process
1.81	4.34e-06	GO:0031326	regulation of cellular biosynthetic process
1.80	4.50e-06	GO:0051171	regulation of nitrogen compound metabolic process
2.28	3.89e-04	GO:0006357	regulation of transcription from RNA polymerase II promoter
9.34	4.95e-04	GO:0001704	formation of primary germ layer
1.95	1.27e-03	GO:0009653	anatomical structure morphogenesis
2.40	4.55e-03	GO:0009890	negative regulation of biosynthetic process
1.52	5.87e-03	GO:0007275	multicellular organismal development
1.66	5.98e-03	GO:0048519	negative regulation of biological process
2.02	6.02e-03	GO:0010604	positive regulation of macromolecule metabolic process
1.72	6.49e-03	GO:0030154	cell differentiation
2.58	6.54e-03	GO:0051253	negative regulation of RNA metabolic process
2.38	7.87e-03	GO:0031327	negative regulation of cellular biosynthetic process
1.48	9.08e-03	GO:0032502	developmental process
2.40	9.09e-03	GO:0010558	negative regulation of macromolecule biosynthetic process
1.68	1.06e-02	GO:0048523	negative regulation of cellular process
2.34	1.09e-02	GO:0009790	embryo development
1.74	1.15e-02	GO:0048583	regulation of response to stimulus
2.54	1.29e-02	GO:0045892	negative regulation of transcription, DNA-dependent
2.35	1.40e-02	GO:0051254	positive regulation of RNA metabolic process
2.43	1.43e-02	GO:0010629	negative regulation of gene expression
1.68	1.64e-02	GO:0048869	cellular developmental process
1.46	2.46e-02	GO:0023052	signaling
1.49	2.50e-02	GO:0007165	signal transduction
1.84	2.58e-02	GO:0009966	regulation of signal transduction
2.20	2.66e-02	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.35	2.70e-02	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.92	2.74e-02	GO:0031325	positive regulation of cellular metabolic process
2.60	2.75e-02	GO:0048646	anatomical structure formation involved in morphogenesis
2.32	3.50e-02	GO:0001932	regulation of protein phosphorylation
1.75	3.59e-02	GO:0023051	regulation of signaling
2.06	3.68e-02	GO:0050793	regulation of developmental process
2.08	3.76e-02	GO:0006351	transcription, DNA-dependent
1.86	4.16e-02	GO:0051239	regulation of multicellular organismal process
2.25	4.35e-02	GO:0010628	positive regulation of gene expression
2.25	4.35e-02	GO:0042325	regulation of phosphorylation
2.14	4.85e-02	GO:0051173	positive regulation of nitrogen compound metabolic process
2.31	4.93e-02	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.44	5.92e-06	GO:0005634	nucleus
1.18	1.37e-04	GO:0005622	intracellular
1.16	4.66e-03	GO:0044424	intracellular part

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
2.61	4.20e-08	GO:0001071	nucleic acid binding transcription factor activity
2.61	4.20e-08	GO:0003700	sequence-specific DNA binding transcription factor activity
1.87	7.64e-07	GO:0003677	DNA binding
2.77	2.64e-06	GO:0043565	sequence-specific DNA binding
2.35	6.37e-06	GO:0030528	transcription regulator activity
1.64	8.23e-06	GO:0003676	nucleic acid binding
1.17	3.53e-04	GO:0005488	binding
1.74	4.58e-04	GO:0008270	zinc ion binding
1.66	1.08e-03	GO:0046914	transition metal ion binding
1.27	3.57e-03	GO:0005515	protein binding
2.62	5.20e-03	GO:0004674	protein serine/threonine kinase activity
2.89	9.99e-03	GO:0016564	transcription repressor activity
7.10	1.34e-02	GO:0046332	SMAD binding
2.82	1.43e-02	GO:0016563	transcription activator activity
2.88	1.73e-02	GO:0008134	transcription factor binding
1.39	2.11e-02	GO:0046872	metal ion binding
2.14	2.91e-02	GO:0046983	protein dimerization activity
3.23	3.30e-02	GO:0019901	protein kinase binding
1.38	3.38e-02	GO:0043169	cation binding
14.05	3.62e-02	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
14.05	3.62e-02	GO:0070412	R-SMAD binding
1.38	3.74e-02	GO:0043167	ion binding
13.04	4.98e-02	GO:0033549	MAP kinase phosphatase activity