Motif ID: ATF2.p2

Z-value: 1.310


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ATF2hg19_v1_chr2_-_176032850_1760329410.246.4e-01Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_7462064 1.105 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr7_-_41742666 1.080 NM_002192
INHBA
inhibin, beta A
chr7_+_28448970 1.072 LOC401317
uncharacterized LOC401317
chr4_-_153601085 1.008 NM_152680
TMEM154
transmembrane protein 154
chr19_+_18723666 0.959 NM_012109
TMEM59L
transmembrane protein 59-like
chr16_-_54962707 0.880 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr8_+_128806720 0.847 PVT1
Pvt1 oncogene (non-protein coding)
chr4_+_85504056 0.835 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr6_-_91006460 0.777 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr3_-_8543327 0.774 LOC100288428
uncharacterized LOC100288428
chr5_+_71502700 0.744 MAP1B
microtubule-associated protein 1B
chr8_-_95274540 0.732 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr6_-_91006580 0.722 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr22_+_50925212 0.719 NM_017584
MIOX
myo-inositol oxygenase
chr20_+_19915716 0.715 RIN2
Ras and Rab interactor 2
chr4_-_186456580 0.706 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr6_-_99797530 0.700 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr6_-_46293215 0.674 RCAN2
regulator of calcineurin 2
chr1_+_212782103 0.671 ATF3
activating transcription factor 3
chr15_-_83621350 0.648 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr5_-_172198160 0.647 NM_004417
DUSP1
dual specificity phosphatase 1
chr15_-_63674074 0.638 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr18_+_23806385 0.628 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr15_-_63673918 0.623 CA12
carbonic anhydrase XII
chr12_-_117319231 0.621 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr4_+_74606222 0.591 NM_000584
IL8
interleukin 8
chr19_-_49622278 0.588 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr12_-_123380628 0.588 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr8_-_67090690 0.552 NM_000756
CRH
corticotropin releasing hormone
chr7_+_28725597 0.550 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr4_-_23891608 0.529 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_-_29595746 0.528 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr12_-_123380682 0.522 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr6_-_46459010 0.519 NM_001251974
RCAN2
regulator of calcineurin 2
chr19_+_45504686 0.516 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr12_-_123201319 0.509 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr2_-_188312872 0.489 NM_005795
CALCRL
calcitonin receptor-like
chr10_-_5045967 0.486 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr9_+_126774028 0.482 LHX2
LIM homeobox 2
chr2_+_219745243 0.474 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr4_-_110354914 0.470 1/2-SBSRNA4
lncRNA_BC009800
chr10_-_104211244 0.462 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr19_-_39402797 0.460 NM_001243212
LOC643669
uncharacterized LOC643669
chr17_+_4643318 0.457 NM_001136046
NM_032265
ZMYND15

zinc finger, MYND-type containing 15

chr8_-_95274520 0.456 GEM
GTP binding protein overexpressed in skeletal muscle
chr13_-_101185944 0.448 NM_033110
A2LD1
AIG2-like domain 1
chr6_-_3227776 0.447 NM_178012
TUBB2B
tubulin, beta 2B class IIb
chr10_-_3827418 0.441 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr22_+_38597938 0.430 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr8_+_99076749 0.419 NM_001170806
NM_173549
C8orf47

chromosome 8 open reading frame 47

chr9_+_116111811 0.412 NM_017688
BSPRY
B-box and SPRY domain containing
chr6_+_89791510 0.408 PNRC1
proline-rich nuclear receptor coactivator 1
chr14_+_68086633 0.408 ARG2
arginase, type II
chr20_+_2276612 0.405 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr12_+_56915587 0.399 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr17_-_7165788 0.398 CLDN7
claudin 7
chr15_+_71839540 0.392 THSD4
thrombospondin, type I, domain containing 4
chr5_+_140165875 0.392 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr8_+_38243958 0.389 NM_001199659
NM_144652
LETM2

leucine zipper-EF-hand containing transmembrane protein 2

chr20_+_42193754 0.387 NM_001199264
SGK2
serum/glucocorticoid regulated kinase 2
chr5_+_71403040 0.385 NM_005909
MAP1B
microtubule-associated protein 1B
chr12_-_123187842 0.383 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr11_-_118123001 0.383 NM_198275
MPZL3
myelin protein zero-like 3
chr9_+_126773851 0.378 NM_004789
LHX2
LIM homeobox 2
chr6_+_139456240 0.376 NM_016217
HECA
headcase homolog (Drosophila)
chrX_-_118925556 0.370 NM_001000
RPL39
ribosomal protein L39
chr12_-_123380608 0.364


chr17_+_41052813 0.361 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr11_-_77184549 0.359 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr10_-_61900659 0.357 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr8_+_26240522 0.355 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr22_+_38598065 0.339 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr3_+_170075449 0.334 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr7_+_38217919 0.329 STARD3NL
STARD3 N-terminal like
chr5_-_178054089 0.328 CLK4
CDC-like kinase 4
chr10_-_73848263 0.319 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr12_+_56552141 0.316 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr6_-_46293404 0.312 RCAN2
regulator of calcineurin 2
chr11_-_8892909 0.307 ST5
suppression of tumorigenicity 5
chr1_+_212781969 0.306 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr1_-_109849613 0.301 NM_001010985
MYBPHL
myosin binding protein H-like
chr9_-_73028278 0.301 KLF9
Kruppel-like factor 9
chr11_+_61447816 0.297 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr5_+_118691549 0.293 NM_014350
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr14_+_105219516 0.290 SIVA1
SIVA1, apoptosis-inducing factor
chr1_-_102462371 0.288 OLFM3
olfactomedin 3
chr2_-_161130151 0.283 RBMS1
RNA binding motif, single stranded interacting protein 1
chr11_+_111749947 0.282 NM_022761
C11orf1
chromosome 11 open reading frame 1
chr3_-_64211111 0.282 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr19_+_6135650 0.281 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr17_-_73178930 0.281 SUMO2
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
chr14_+_68086655 0.279 ARG2
arginase, type II
chr15_-_60884615 0.279 NM_134262
RORA
RAR-related orphan receptor A
chr2_-_158182154 0.277 NM_020711
ERMN
ermin, ERM-like protein
chr1_+_201476283 0.277


chr8_-_21966812 0.273 NM_024815
NUDT18
nudix (nucleoside diphosphate linked moiety X)-type motif 18
chr14_+_61447831 0.271 NM_001172702
NM_153811
SLC38A6

solute carrier family 38, member 6

chr7_-_27205123 0.270 HOXA9
homeobox A9
chr14_-_50329567 0.269 RN7SL2
RNA, 7SL, cytoplasmic 2
chr8_-_10697382 0.268 PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr1_+_33546700 0.268 NM_052998
ADC
arginine decarboxylase
chr16_-_3068161 0.263 NM_021195
CLDN6
claudin 6
chr6_-_134373618 0.263 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr5_-_75919051 0.262 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_+_52082755 0.257 OSBPL9
oxysterol binding protein-like 9
chr2_+_108994366 0.257 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr10_+_95517565 0.253 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr3_+_170075494 0.252 SKIL
SKI-like oncogene
chr5_+_118691692 0.252 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr19_-_3985343 0.252 EEF2
eukaryotic translation elongation factor 2
chr2_-_224903324 0.249 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr2_+_29038862 0.248 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr10_-_3827205 0.248 KLF6
Kruppel-like factor 6
chr12_-_91505215 0.247 LUM
lumican
chr3_-_55521330 0.247 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr1_+_65730423 0.246 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr7_-_45128492 0.245 NM_001146334
NACAD
NAC alpha domain containing
chr1_+_151032150 0.244 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_-_59249687 0.244 NM_002228
JUN
jun proto-oncogene
chr14_+_68086570 0.243 NM_001172
ARG2
arginase, type II
chr4_+_170581212 0.243 NM_001243374
CLCN3
chloride channel 3
chrX_-_13835187 0.242 GPM6B
glycoprotein M6B
chr14_+_102276125 0.240 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr11_+_9596233 0.237 NM_001143976
WEE1
WEE1 homolog (S. pombe)
chr4_-_170533762 0.236 NM_001199397
NM_001199398
NM_001199399
NM_001199400
NM_012224
NEK1




NIMA (never in mitosis gene a)-related kinase 1




chr17_+_33914320 0.236 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr7_+_30174343 0.235 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr10_-_73848278 0.233 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr3_-_133614421 0.232 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr4_-_170533536 0.230 NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr4_-_70518964 0.230 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr11_-_1593149 0.230 NM_004420
DUSP8
dual specificity phosphatase 8
chr14_+_24563369 0.230 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr6_+_56819923 0.230 BEND6
BEN domain containing 6
chr3_+_170075521 0.227 SKIL
SKI-like oncogene
chr19_-_3985460 0.226 NM_001961
EEF2
eukaryotic translation elongation factor 2
chr5_-_54468833 0.225 NM_001145734
NM_001170402
NM_152623
CDC20B


cell division cycle 20 homolog B (S. cerevisiae)


chr17_-_19651586 0.225 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_+_7461591 0.223 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr1_+_174933904 0.223 NM_001243764
RABGAP1L
RAB GTPase activating protein 1-like
chr4_-_122791468 0.222 NM_018190
NM_176824
BBS7

Bardet-Biedl syndrome 7

chr1_-_102462789 0.222 NM_058170
OLFM3
olfactomedin 3
chr4_+_145567147 0.221 NM_022475
HHIP
hedgehog interacting protein
chr19_-_18392413 0.220 NM_005354
JUND
jun D proto-oncogene
chr10_+_99496897 0.219 ZFYVE27
zinc finger, FYVE domain containing 27
chr17_+_33914278 0.217 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr4_+_6784462 0.217 KIAA0232
KIAA0232
chr9_-_32552550 0.214 TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr5_+_54455945 0.214 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr1_-_1293907 0.214 NM_032348
MXRA8
matrix-remodelling associated 8
chr16_+_29912146 0.213 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chrX_+_118108575 0.211 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr11_-_35440514 0.211 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_+_35639734 0.210 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr11_-_73472057 0.209 NM_001243718
NM_002869
NM_198896
RAB6A


RAB6A, member RAS oncogene family


chr10_-_73848309 0.208 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr6_-_47277646 0.207 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr17_-_73179069 0.206 SUMO2
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
chr17_-_37009961 0.206 NM_000978
SNORA21
RPL23
small nucleolar RNA, H/ACA box 21
ribosomal protein L23
chr15_-_82336880 0.202 MEX3B
mex-3 homolog B (C. elegans)
chr14_+_61447949 0.202 SLC38A6
solute carrier family 38, member 6
chr4_+_74702272 0.202 NM_002993
CXCL6
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chr5_+_68513561 0.202 NM_033281
MRPS36
mitochondrial ribosomal protein S36
chr18_+_77160243 0.201 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr7_-_122342965 0.201 NM_198085
RNF148
ring finger protein 148
chr9_-_32552573 0.200 NM_001195622
NM_005802
TOPORS

topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

chr19_-_18392436 0.200 JUND
jun D proto-oncogene
chr20_+_34203746 0.200 NM_003116
SPAG4
sperm associated antigen 4
chr1_-_221915458 0.200 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr2_+_220408742 0.199 NM_001005209
TMEM198
transmembrane protein 198
chr8_-_10697290 0.199 NM_017884
PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr17_-_73179030 0.198 SUMO2
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
chr12_+_10365415 0.198 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr4_+_108745718 0.197 NM_001136258
SGMS2
sphingomyelin synthase 2
chr1_+_196946666 0.196 NM_030787
CFHR5
complement factor H-related 5
chr8_+_117778741 0.195 NM_032334
UTP23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr21_-_27253197 0.194 APP
amyloid beta (A4) precursor protein
chr3_-_112359962 0.190 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr9_+_70856838 0.189 NM_201453
CBWD5
CBWD3
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 6
chr1_-_150552127 0.189 NM_001197320
NM_021960
NM_182763
MCL1


myeloid cell leukemia sequence 1 (BCL2-related)


chr19_-_18392048 0.189 JUND
jun D proto-oncogene
chr11_-_119187811 0.189 NM_006500
MCAM
melanoma cell adhesion molecule
chr8_-_101964258 0.189 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr5_-_64777703 0.188 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr3_+_119500866 0.187 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr2_+_70142303 0.185 MXD1
MAX dimerization protein 1
chr6_-_47277511 0.184 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr11_-_82782883 0.183 NM_014488
RAB30
RAB30, member RAS oncogene family
chr10_+_99496847 0.183 NM_001002262
NM_001174119
NM_001174120
NM_001174121
NM_001174122
NM_144588
ZFYVE27





zinc finger, FYVE domain containing 27





chr14_+_61447929 0.183 SLC38A6
solute carrier family 38, member 6
chr16_-_53537112 0.182 NM_001012398
NM_022476
AKTIP

AKT interacting protein

chr20_-_35201677 0.182


chr6_-_31633390 0.182 NM_001199240
GPANK1
G patch domain and ankyrin repeats 1
chr13_+_96085852 0.181 NM_001160100
NM_182848
CLDN10

claudin 10

chr10_+_5005601 0.181 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr9_+_36169384 0.181 NM_005893
CCIN
calicin
chr1_-_201476241 0.181 CSRP1
cysteine and glycine-rich protein 1
chr17_-_73179093 0.180 NM_001005849
NM_006937
SUMO2

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)

chr1_-_154164551 0.179 NM_152263
TPM3
tropomyosin 3
chr5_+_174151531 0.177 NM_002449
MSX2
msh homeobox 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
140.97 1.36e-03 GO:0050864 regulation of B cell activation
41.04 1.62e-02 GO:0051249 regulation of lymphocyte activation
37.28 1.97e-02 GO:0002694 regulation of leukocyte activation
35.88 2.13e-02 GO:0050865 regulation of cell activation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
11.58 3.44e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
43.77 1.59e-03 GO:0005125 cytokine activity