Motif ID: EN1,2.p2

Z-value: 0.911


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2



Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_87248942 0.983 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr6_+_17282931 0.883 NM_153020
RBM24
RNA binding motif protein 24
chrM_+_10123 0.813


chr2_+_88047603 0.494 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr12_+_21679190 0.405 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr5_+_147582338 0.377 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr9_-_34691135 0.349 NM_006274
CCL19
chemokine (C-C motif) ligand 19
chr6_-_30080866 0.341 NM_007028
TRIM31
tripartite motif containing 31
chr17_-_43487747 0.326 ARHGAP27
Rho GTPase activating protein 27
chr8_-_87755880 0.318 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr11_+_62475113 0.313 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr6_+_26273143 0.304 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr14_-_65409445 0.296 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_-_158300517 0.296 NM_004288
CYTIP
cytohesin 1 interacting protein
chr3_+_46448678 0.294 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr6_+_116782555 0.294 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr1_+_86934525 0.288 NM_001285
CLCA1
chloride channel accessory 1
chr12_-_105322056 0.287 NM_032148
SLC41A2
solute carrier family 41, member 2
chr10_+_114154522 0.286 ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_+_141490016 0.278 NM_018980
TAS2R5
taste receptor, type 2, member 5
chr6_+_42123143 0.271 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr2_+_234601511 0.261 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr7_+_141463896 0.260 NM_016943
TAS2R3
taste receptor, type 2, member 3
chr9_+_74920329 0.259


chr6_-_119470336 0.249 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr2_-_158182154 0.244 NM_020711
ERMN
ermin, ERM-like protein
chr5_+_54455945 0.242 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr1_+_171217632 0.225 NM_002021
FMO1
flavin containing monooxygenase 1
chr8_-_122653493 0.224 NM_005328
HAS2
hyaluronan synthase 2
chr17_+_37821598 0.224 NM_003673
TCAP
titin-cap (telethonin)
chr6_-_41703938 0.218 NM_001167827
TFEB
transcription factor EB
chr4_-_40516567 0.217 RBM47
RNA binding motif protein 47
chr7_+_30174343 0.216 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr4_-_88243994 0.216 NM_001136230
NM_178135
HSD17B13

hydroxysteroid (17-beta) dehydrogenase 13

chr12_-_48597074 0.212 NM_001004134
OR10AD1
olfactory receptor, family 10, subfamily AD, member 1
chr11_-_6790187 0.212 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr1_+_32674694 0.209 NM_001099434
DCDC2B
doublecortin domain containing 2B
chr7_-_115670774 0.209 TFEC
transcription factor EC
chr12_-_18243052 0.203 NM_024730
RERGL
RERG/RAS-like
chr1_-_27732069 0.200 WASF2
WAS protein family, member 2
chr19_-_14169970 0.197 NM_001145028
PALM3
paralemmin 3
chr2_-_145277879 0.195 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr2_-_198540583 0.192 NM_144629
RFTN2
raftlin family member 2
chr11_+_6128913 0.191 NM_001005181
OR56B4
olfactory receptor, family 56, subfamily B, member 4
chr10_+_114133775 0.191 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_188312872 0.190 NM_005795
CALCRL
calcitonin receptor-like
chr15_-_42386657 0.186 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr17_-_63009302 0.180 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chrX_+_65384078 0.179 NM_001130860
NM_014799
HEPH

hephaestin

chr12_+_56732658 0.178 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr9_+_33026482 0.176 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr10_+_114133838 0.171 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_-_5863126 0.169 NM_001005167
OR52E6
olfactory receptor, family 52, subfamily E, member 6
chrX_-_76937157 0.169 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr11_+_6220375 0.167 NM_001005178
OR52W1
olfactory receptor, family 52, subfamily W, member 1
chr3_-_27498244 0.164 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr13_+_42712177 0.163 NM_001204505
NM_001204506
DGKH

diacylglycerol kinase, eta

chr15_+_71433787 0.162 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr3_-_38992051 0.162 NM_014139
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr20_+_34556528 0.162 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr12_-_10542616 0.160 NM_007360
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr5_-_145483877 0.160 NM_001029869
PLAC8L1
PLAC8-like 1
chr7_+_28452143 0.160 NM_182898
CREB5
cAMP responsive element binding protein 5
chr12_-_10978867 0.157 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr12_-_71148383 0.157 NM_130846
NM_001207016
PTPRR

protein tyrosine phosphatase, receptor type, R

chr12_-_99548471 0.156 NM_001204068
NM_001204069
NM_001204070
NM_020140
NM_181670
NM_001204066
ANKS1B





ankyrin repeat and sterile alpha motif domain containing 1B





chr11_-_5537815 0.154 NM_145053
UBQLNL
ubiquilin-like
chr16_+_68563977 0.154 ZFP90
zinc finger protein 90 homolog (mouse)
chr6_-_41006927 0.154 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr6_-_43595046 0.153 GTPBP2
GTP binding protein 2
chr2_-_161056573 0.153 NM_000888
ITGB6
integrin, beta 6
chr1_+_201708648 0.152 NAV1
neuron navigator 1
chr7_+_140103842 0.152 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr3_-_126327397 0.147 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr1_-_28520379 0.146 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr12_+_6554032 0.146 NM_001242
CD27
CD27 molecule
chr5_-_77844975 0.144 LHFPL2
lipoma HMGIC fusion partner-like 2
chr17_+_7384720 0.144 NM_001102614
SLC35G6
solute carrier family 35, member G6
chr2_-_142889269 0.143 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr1_-_33813261 0.143


chr1_-_26680620 0.143 NM_001039775
AIM1L
absent in melanoma 1-like
chr4_+_89299874 0.140 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr7_-_44105162 0.139 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr3_-_183273407 0.139 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr2_-_152590983 0.139 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr6_+_30104509 0.139 NM_138700
TRIM40
tripartite motif containing 40
chr9_-_96108695 0.137 NM_001098808
C9orf129
chromosome 9 open reading frame 129
chr4_-_7436614 0.135 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr1_+_196946666 0.135 NM_030787
CFHR5
complement factor H-related 5
chr3_+_169539709 0.134 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr6_+_14117857 0.132 NM_001040280
NM_004233
CD83

CD83 molecule

chr6_-_43595079 0.128 GTPBP2
GTP binding protein 2
chr9_-_34729463 0.128 NM_001141917
FAM205A
family with sequence similarity 205, member A
chr7_+_130020289 0.126 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr6_-_56507585 0.125 NM_001723
NM_015548
DST

dystonin

chr20_+_54987167 0.123 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr22_+_50986461 0.120 NM_138433
KLHDC7B
kelch domain containing 7B
chr1_-_168106727 0.119 GPR161
G protein-coupled receptor 161
chr5_+_140501399 0.117 PCDHB4
protocadherin beta 4
chr21_-_34883620 0.116 GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr11_-_101454658 0.115 NM_004621
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr7_-_135412921 0.115 NM_012450
SLC13A4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr22_+_25591072 0.113 KIAA1671
KIAA1671
chr6_+_123100860 0.112 FABP7
fatty acid binding protein 7, brain
chr1_-_42800902 0.109 NM_014947
FOXJ3
forkhead box J3
chr8_+_11142314 0.108 MTMR9
myotubularin related protein 9
chr2_+_191301020 0.107 MFSD6
major facilitator superfamily domain containing 6
chr6_-_76782204 0.107 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr20_+_43803539 0.106 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr10_-_104179468 0.106 PSD
pleckstrin and Sec7 domain containing
chr1_-_32707198 0.105 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr17_-_56591900 0.105 MTMR4
myotubularin related protein 4
chr6_-_87804773 0.105 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr12_-_71148063 0.105 PTPRR
protein tyrosine phosphatase, receptor type, R
chr5_-_41870702 0.104 NM_000436
OXCT1
3-oxoacid CoA transferase 1
chr10_+_45406629 0.103 NM_001123376
TMEM72
transmembrane protein 72
chr10_-_62149487 0.103 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_-_41742666 0.103 NM_002192
INHBA
inhibin, beta A
chr6_-_30128688 0.102 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr15_+_45021218 0.102 TRIM69
tripartite motif containing 69
chrX_-_70474402 0.102 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3

chr5_-_41870500 0.101 OXCT1
3-oxoacid CoA transferase 1
chr12_-_71148331 0.101 PTPRR
protein tyrosine phosphatase, receptor type, R
chr4_+_74281884 0.101 ALB
albumin
chr3_+_45927995 0.100 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chrX_+_16141423 0.099 NM_005314
GRPR
gastrin-releasing peptide receptor
chr2_-_26541916 0.099 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr6_-_32013806 0.099 NM_032470
TNXB
tenascin XB
chr7_+_28530747 0.099 CREB5
cAMP responsive element binding protein 5
chr6_-_41715078 0.098 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr14_+_88490893 0.098 LOC283587
uncharacterized LOC283587
chrX_-_102510048 0.097 NM_001006684
NM_153333
TCEAL8

transcription elongation factor A (SII)-like 8

chr7_-_50800018 0.096 NM_001001549
NM_005311
GRB10

growth factor receptor-bound protein 10

chr9_+_139846767 0.096 NM_178536
LCN12
lipocalin 12
chr4_-_82126200 0.094 NM_006259
PRKG2
protein kinase, cGMP-dependent, type II
chr5_-_64777703 0.093 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr2_+_143635194 0.092 NM_001032998
NM_001199241
NM_003937
KYNU


kynureninase


chr3_-_46249787 0.092 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr3_-_52488030 0.092 NM_003280
TNNC1
troponin C type 1 (slow)
chr10_-_94003002 0.091 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr12_+_53817638 0.090 NM_001164690
NM_001164691
NM_020547
AMHR2


anti-Mullerian hormone receptor, type II


chr11_+_65266642 0.089


chr21_+_34697277 0.089 IFNAR1
interferon (alpha, beta and omega) receptor 1
chr14_-_77889231 0.088 NM_001113475
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr1_-_42800623 0.087 NM_001198851
FOXJ3
forkhead box J3
chr7_-_141673572 0.085 NM_176817
TAS2R38
taste receptor, type 2, member 38
chrX_+_18709044 0.085 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr1_+_40420837 0.084 MFSD2A
major facilitator superfamily domain containing 2A
chr8_+_11141983 0.083 NM_015458
MTMR9
myotubularin related protein 9
chr6_+_101846668 0.083 GRIK2
glutamate receptor, ionotropic, kainate 2
chrX_-_48327739 0.083 SLC38A5
solute carrier family 38, member 5
chr2_-_183387063 0.083 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr22_-_46373007 0.082 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr6_-_51952368 0.082 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr7_-_120498128 0.082 NM_012338
TSPAN12
tetraspanin 12
chr1_-_161039649 0.082 ARHGAP30
Rho GTPase activating protein 30
chr1_+_33938231 0.081 NM_145238
ZSCAN20
zinc finger and SCAN domain containing 20
chr2_-_172750724 0.081 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr7_-_107880492 0.080 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr19_-_56704420 0.080 NM_001080456
ZSCAN5B
zinc finger and SCAN domain containing 5B
chr15_+_93443559 0.080 CHD2
chromodomain helicase DNA binding protein 2
chrX_-_70473941 0.079 ZMYM3
zinc finger, MYM-type 3
chr1_+_154300275 0.079 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr6_-_154651214 0.079 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr2_-_55199894 0.079


chr6_+_127664496 0.078


chr22_-_43089856 0.077 A4GALT
alpha 1,4-galactosyltransferase
chr2_+_143635225 0.077 KYNU
kynureninase
chr11_+_111789600 0.077 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr16_+_66995099 0.077 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr12_-_122296619 0.077 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr11_+_66395733 0.077


chr6_-_36304584 0.076 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chr3_+_2933898 0.076 NM_001206956
NM_175613
CNTN4

contactin 4

chr9_-_117568292 0.076 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr1_+_203020310 0.076 NM_015053
PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr3_+_189507448 0.076 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr20_-_35374530 0.076 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr14_-_94919085 0.075 NM_001080451
SERPINA11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr15_-_77176191 0.075 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr1_+_32050510 0.075 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr15_+_59903980 0.075 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr4_-_2230957 0.075 NM_181808
POLN
polymerase (DNA directed) nu
chr10_+_32856650 0.075 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr12_-_323255 0.074 NM_001122848
NM_001206931
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr20_-_35374468 0.074 NDRG3
NDRG family member 3
chrX_+_100805415 0.074 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chrX_-_109683457 0.074 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr7_+_128578246 0.074 NM_032643
IRF5
interferon regulatory factor 5
chr1_+_31882411 0.073 NM_001199038
SERINC2
serine incorporator 2
chr3_-_18480203 0.073 NM_001131010
SATB1
SATB homeobox 1
chr3_-_186262114 0.073 NM_017541
CRYGS
crystallin, gamma S
chrX_-_47489703 0.072 NM_002621
CFP
complement factor properdin
chr1_-_168106810 0.072 GPR161
G protein-coupled receptor 161
chr1_-_166135951 0.072 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr12_-_57630867 0.071 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr5_+_173472692 0.071 NM_015980
HMP19
HMP19 protein
chr12_-_13103317 0.071 NM_018654
GPRC5D
G protein-coupled receptor, family C, group 5, member D
chr1_-_193075186 0.071 NM_001243399
NM_016066
GLRX2

glutaredoxin 2

chr11_+_36589562 0.070 NM_000448
RAG1
recombination activating gene 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.