Motif ID: ETS1,2.p2

Z-value: 1.054


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ETS1hg19_v1_chr11_-_128392061_1283922070.824.5e-02Click!
ETS2hg19_v1_chr21_+_40177847_401779070.157.8e-01Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_1590403 1.388 CDK11A
CDK11B
cyclin-dependent kinase 11A
cyclin-dependent kinase 11B
chr1_-_183559463 1.210 NCF2
neutrophil cytosolic factor 2
chr1_-_183559669 0.935 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr4_+_2813966 0.792 SH3BP2
SH3-domain binding protein 2
chr4_+_2813945 0.790 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr1_-_183560010 0.731 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr8_+_82192717 0.676 NM_001444
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr11_+_2920910 0.644 NM_183233
SLC22A18
solute carrier family 22, member 18
chr3_-_9920471 0.625 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr6_-_109776946 0.599 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr11_+_308106 0.594 NM_006435
IFITM2
interferon induced transmembrane protein 2 (1-8D)
chr11_-_65638672 0.540 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr6_-_109777171 0.529 NM_001159291
NM_022765
MICAL1

microtubule associated monoxygenase, calponin and LIM domain containing 1

chr1_+_24882565 0.529 NM_001010980
C1orf130
chromosome 1 open reading frame 130
chr3_-_9920633 0.519 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr6_-_109776942 0.517 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr6_-_166756026 0.499 SFT2D1
SFT2 domain containing 1
chr19_+_58694444 0.478 ZNF274
zinc finger protein 274
chr15_+_85359910 0.477 NM_020778
ALPK3
alpha-kinase 3
chr6_-_166755990 0.473 NM_145169
SFT2D1
SFT2 domain containing 1
chr3_-_185270258 0.461 NM_139248
LIPH
lipase, member H
chr15_+_59908908 0.458 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr14_-_75330535 0.458 NM_001080408
NM_001243007
PROX2

prospero homeobox 2

chr10_+_114154522 0.452 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_+_21679190 0.448 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr1_-_27286875 0.445 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr7_+_37960162 0.439 NM_001242946
NM_017549
EPDR1

ependymin related protein 1 (zebrafish)

chr7_+_37960418 0.414 EPDR1
ependymin related protein 1 (zebrafish)
chr12_-_123214882 0.413 NM_032554
HCAR1
hydroxycarboxylic acid receptor 1
chr8_-_6420454 0.406 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr7_+_100770378 0.405 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr5_-_75919051 0.403 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_+_1361507 0.397 NM_001146685
TMEM88B
transmembrane protein 88B
chr2_+_153191591 0.389 NM_052905
FMNL2
formin-like 2
chr4_+_110834039 0.386 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr20_-_35201677 0.386


chr8_-_38034212 0.385 NM_014462
LSM1
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr22_-_37640187 0.381 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr7_+_128431449 0.380 NM_001201372
CCDC136
coiled-coil domain containing 136
chr2_+_65663812 0.379 FLJ16124
FLJ16124 protein
chr19_+_9732136 0.378 NM_001242812
LOC284385
uncharacterized LOC284385
chr9_-_130617009 0.377 NM_000118
NM_001114753
ENG

endoglin

chr5_+_158690265 0.377 UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr5_-_43412417 0.376 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr2_+_118846029 0.376 NM_016133
INSIG2
insulin induced gene 2
chr19_+_49838700 0.376 CD37
CD37 molecule
chr22_-_31688329 0.375 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr11_+_9779832 0.370 LOC283104
uncharacterized LOC283104
chr19_+_48774653 0.365 NM_153608
ZNF114
zinc finger protein 114
chr6_-_111888520 0.365 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr2_-_238499713 0.356 NM_022449
RAB17
RAB17, member RAS oncogene family
chr5_-_147763345 0.355


chr12_-_58159386 0.350 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr17_+_7608413 0.350 NM_001406
EFNB3
ephrin-B3
chr2_-_172750724 0.350 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr2_+_143635194 0.348 NM_001032998
NM_001199241
NM_003937
KYNU


kynureninase


chr1_-_1310522 0.347 AURKAIP1
aurora kinase A interacting protein 1
chr4_+_24797203 0.346 SOD3
superoxide dismutase 3, extracellular
chr5_-_172756505 0.341 NM_003714
STC2
stanniocalcin 2
chr4_-_74864296 0.341 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr3_+_46283871 0.339 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr10_-_15902455 0.338 NM_024948
FAM188A
family with sequence similarity 188, member A
chr16_+_81812925 0.334 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr12_+_104682495 0.334 TXNRD1
thioredoxin reductase 1
chr20_+_2276612 0.333 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr2_-_188312872 0.333 NM_005795
CALCRL
calcitonin receptor-like
chr8_+_86157732 0.330 CA13
carbonic anhydrase XIII
chr8_-_38033837 0.330 LSM1
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr12_+_119616594 0.329 NM_014365
HSPB8
heat shock 22kDa protein 8
chr17_-_62097937 0.328 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr4_-_74964836 0.327 CXCL2
chemokine (C-X-C motif) ligand 2
chr19_+_49838673 0.327 NM_001040031
NM_001774
CD37

CD37 molecule

chr17_+_16319087 0.327 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chrX_-_15872938 0.322 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr14_-_24036532 0.319 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr6_-_109776832 0.317 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr19_-_45681454 0.317 NM_024108
TRAPPC6A
trafficking protein particle complex 6A
chr20_-_31172874 0.315 LOC284804
uncharacterized LOC284804
chr6_+_33239798 0.314 NM_022551
RPS18
ribosomal protein S18
chr19_-_39402797 0.313 NM_001243212
LOC643669
uncharacterized LOC643669
chr16_-_279110 0.312


chr3_+_182970853 0.304 NM_032047
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr1_-_86622107 0.303 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr6_+_139349877 0.302 C6orf115
chromosome 6 open reading frame 115
chr10_-_118680978 0.302 KIAA1598
KIAA1598
chr5_+_158690088 0.302 NM_145049
UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr22_+_38864015 0.301 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr6_-_109777085 0.300 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr1_+_116519118 0.300 NM_018420
SLC22A15
solute carrier family 22, member 15
chr16_+_50300461 0.300 ADCY7
adenylate cyclase 7
chr6_-_30080866 0.297 NM_007028
TRIM31
tripartite motif containing 31
chrX_-_15872905 0.297


chr16_-_30394133 0.297 NM_052838
SEPT1
septin 1
chr1_+_16083132 0.295 FBLIM1
filamin binding LIM protein 1
chr6_-_33267128 0.295 NM_001243738
NM_004761
RGL2

ral guanine nucleotide dissociation stimulator-like 2

chr4_-_153601085 0.292 NM_152680
TMEM154
transmembrane protein 154
chr2_+_143635225 0.291 KYNU
kynureninase
chr1_-_144520918 0.290 LOC728855
uncharacterized LOC728855
chr7_-_149194827 0.288 ZNF746
zinc finger protein 746
chr2_+_158114109 0.287 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr8_+_22437983 0.287 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr12_+_56732658 0.286 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr4_+_84457390 0.286 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr5_+_125758818 0.285 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr19_-_19738973 0.285 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr1_-_147931877 0.284 FLJ39739
uncharacterized FLJ39739
chr1_+_15479298 0.282 TMEM51
transmembrane protein 51
chr18_-_19748928 0.282 LOC100128893
uncharacterized LOC100128893
chr7_-_97601654 0.281


chr3_-_8693723 0.281 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr4_-_38858407 0.281 NM_006068
TLR6
toll-like receptor 6
chr2_+_241544819 0.279 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr22_-_38349533 0.278 NM_032561
NM_001207062
C22orf23

chromosome 22 open reading frame 23

chr16_-_74734687 0.275 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr6_+_112408673 0.274 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr19_-_58400287 0.273 NM_001144989
ZNF814
zinc finger protein 814
chr12_-_58135853 0.271 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_+_61722606 0.270 BEST1
bestrophin 1
chr6_+_139349818 0.270 NM_021243
C6orf115
chromosome 6 open reading frame 115
chr6_+_33239855 0.268 RPS18
ribosomal protein S18
chr1_+_186798031 0.266 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr17_+_60501229 0.265 NM_181725
METTL2A
methyltransferase like 2A
chr19_+_58694381 0.264 NM_016324
NM_016325
NM_133502
ZNF274


zinc finger protein 274


chr21_+_26934440 0.264 MIR155HG
MIR155 host gene (non-protein coding)
chr3_+_109128836 0.264 NM_001145553
FLJ25363
uncharacterized LOC401082
chrX_-_138914384 0.263 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr15_+_76352270 0.262 NM_152335
C15orf27
chromosome 15 open reading frame 27
chrX_-_15872871 0.259 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr6_+_30130982 0.259 NM_033229
TRIM15
tripartite motif containing 15
chr17_+_45908992 0.259 NM_033413
LRRC46
leucine rich repeat containing 46
chr3_+_37440967 0.259 NM_178339
NM_178342
C3orf35

chromosome 3 open reading frame 35

chr19_-_52674895 0.258 NM_001102657
ZNF836
zinc finger protein 836
chr4_-_139163222 0.257 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_-_205744543 0.257 NM_001135662
NM_001135663
NM_001135664
NM_003929
RAB7L1



RAB7, member RAS oncogene family-like 1



chr12_+_52306112 0.257 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr8_+_21881587 0.256 NPM2
nucleophosmin/nucleoplasmin 2
chr3_-_139258477 0.256 RBP1
retinol binding protein 1, cellular
chr19_-_19754369 0.256 GMIP
GEM interacting protein
chr4_+_24797084 0.255 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr11_-_118123001 0.255 NM_198275
MPZL3
myelin protein zero-like 3
chr6_-_42858526 0.250 NM_001008739
C6orf226
chromosome 6 open reading frame 226
chr17_+_78356710 0.250 RNF213
ring finger protein 213
chr19_+_57742376 0.250 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr20_+_42839599 0.249 LOC100505783
uncharacterized LOC100505783
chr4_+_141264596 0.247 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr16_-_67260900 0.247 NM_001004055
LRRC29
leucine rich repeat containing 29
chr22_-_43089856 0.245 A4GALT
alpha 1,4-galactosyltransferase
chrX_-_15873094 0.244 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr6_+_41606193 0.243 NM_005586
MDFI
MyoD family inhibitor
chr11_+_17373138 0.242 NM_001202439
B7H6
B7 homolog 6
chr13_+_50018525 0.241 SETDB2
SET domain, bifurcated 2
chr1_+_171810611 0.241 NM_001136127
NM_015569
DNM3

dynamin 3

chr2_+_231280933 0.240 SP100
SP100 nuclear antigen
chr20_-_633808 0.238 SRXN1
sulfiredoxin 1
chr9_-_35618300 0.237 NM_001782
CD72
CD72 molecule
chr1_-_10003321 0.237 LZIC
leucine zipper and CTNNBIP1 domain containing
chr16_-_30107492 0.237 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr12_-_111127582 0.236 NM_001040107
HVCN1
hydrogen voltage-gated channel 1
chr11_+_10472223 0.235 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr11_-_18062304 0.235 NM_004179
TPH1
tryptophan hydroxylase 1
chr3_+_170139027 0.234 NM_001185056
CLDN11
claudin 11
chr3_-_55521330 0.232 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr2_+_177016112 0.231 NM_014621
HOXD4
homeobox D4
chr2_-_175462428 0.231 WIPF1
WAS/WASL interacting protein family, member 1
chr15_+_41136622 0.230 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr20_+_31037447 0.230


chr12_-_105501410 0.229 LOC414300
uncharacterized LOC414300
chr20_-_633844 0.229 NM_080725
SRXN1
sulfiredoxin 1
chr14_+_23341360 0.228 LRP10
low density lipoprotein receptor-related protein 10
chr22_+_50354139 0.226 NM_001001852
PIM3
pim-3 oncogene
chr1_-_31230594 0.226 LAPTM5
lysosomal protein transmembrane 5
chr19_-_49258646 0.225 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr11_-_62389571 0.225 NM_012200
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr8_+_86157693 0.225 NM_198584
CA13
carbonic anhydrase XIII
chr7_+_18548963 0.224 HDAC9
histone deacetylase 9
chr1_-_160313056 0.224 COPA
coatomer protein complex, subunit alpha
chr6_+_83073501 0.224 TPBG
trophoblast glycoprotein
chr1_-_160313029 0.222 COPA
coatomer protein complex, subunit alpha
chr6_+_30104509 0.222 NM_138700
TRIM40
tripartite motif containing 40
chr3_-_13057130 0.222


chr11_+_48002063 0.221 NM_001098503
NM_002843
PTPRJ

protein tyrosine phosphatase, receptor type, J

chr1_+_203595929 0.221 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr18_+_51795848 0.221 NM_007195
POLI
polymerase (DNA directed) iota
chr12_-_123380628 0.220 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr12_-_123380682 0.220 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr10_+_114135965 0.220 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_53600999 0.218 NM_000889
ITGB7
integrin, beta 7
chr16_-_28550227 0.218 NUPR1
nuclear protein, transcriptional regulator, 1
chr15_+_78384926 0.218 NM_001101404
SH2D7
SH2 domain containing 7
chr12_-_123635284 0.218 PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr10_-_5060191 0.217 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chr10_+_5136556 0.217 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr17_-_9479139 0.216 NM_004853
STX8
syntaxin 8
chr16_+_81812899 0.216 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr19_-_32896441 0.216 LOC400684
uncharacterized LOC400684
chr7_+_26677489 0.215 NM_001145531
C7orf71
chromosome 7 open reading frame 71
chr6_+_33589045 0.214 NM_002224
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr7_+_128116782 0.213 NM_018396
METTL2B
methyltransferase like 2B
chr2_-_128439359 0.213 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr3_+_182971213 0.212 B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
402.32 3.00e-04 GO:0050684 regulation of mRNA processing
234.79 8.99e-04 GO:0001824 blastocyst development
104.49 4.62e-03 GO:0007088 regulation of mitosis
104.49 4.62e-03 GO:0051783 regulation of nuclear division
43.77 2.66e-02 GO:0001701 in utero embryonic development
37.94 3.54e-02 GO:0001558 regulation of cell growth
33.62 4.51e-02 GO:0007346 regulation of mitotic cell cycle

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
301.80 1.45e-04 GO:0004693 cyclin-dependent protein kinase activity