Motif ID: HES1.p2

Z-value: 0.885


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HES1hg19_v1_chr3_+_193853930_1938539360.843.6e-02Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_639878 0.537 NM_020637
FGF22
fibroblast growth factor 22
chr16_-_1821503 0.533 NME3
non-metastatic cells 3, protein expressed in
chr2_-_200715895 0.484 FONG
uncharacterized LOC348751
chr16_+_29817810 0.474 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr9_-_138391696 0.458 NM_001048265
NM_144654
C9orf116

chromosome 9 open reading frame 116

chr17_+_40274755 0.440 NM_033194
HSPB9
heat shock protein, alpha-crystallin-related, B9
chr1_-_211751719 0.439 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr3_+_126261178 0.425 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr11_-_67397383 0.420 NM_001243750
NM_181843
NUDT8

nudix (nucleoside diphosphate linked moiety X)-type motif 8

chr16_+_56642477 0.418 NM_005953
MT2A
metallothionein 2A
chr11_+_12132063 0.382 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr6_+_26217145 0.378 NM_021052
HIST1H2AE
histone cluster 1, H2ae
chr21_-_46359685 0.366 C21orf67
chromosome 21 open reading frame 67
chr16_-_1821709 0.327 NM_002513
NME3
non-metastatic cells 3, protein expressed in
chr8_-_11204998 0.321 LOC100129129
uncharacterized LOC100129129
chr16_-_85784628 0.310 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr10_-_14879967 0.308 NM_001029954
CDNF
cerebral dopamine neurotrophic factor
chr1_-_156675237 0.307 NM_001878
NM_001199723
CRABP2

cellular retinoic acid binding protein 2

chr4_+_74735107 0.305 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr9_-_139981102 0.305 LOC100289341
uncharacterized LOC100289341
chr21_+_46359966 0.293


chr11_-_87908551 0.292 NM_022337
RAB38
RAB38, member RAS oncogene family
chr21_-_47878592 0.291


chr5_-_472916 0.281 PP7080
uncharacterized LOC25845
chr2_-_135476541 0.280 NM_030923
TMEM163
transmembrane protein 163
chr16_+_2653350 0.279 LOC652276
potassium channel tetramerisation domain containing 5 pseudogene
chr19_+_30302861 0.269 NM_001238
CCNE1
cyclin E1
chr21_-_46962281 0.266 NM_001205206
NM_194255
SLC19A1

solute carrier family 19 (folate transporter), member 1

chr1_-_205290756 0.263 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr14_+_105941061 0.260 NM_001312
CRIP2
cysteine-rich protein 2
chr11_+_1331048 0.260 LOC255512
uncharacterized LOC255512
chr3_+_52273247 0.260


chr19_+_8478181 0.256 NM_001005415
NM_001005416
NM_016496
MARCH2


membrane-associated ring finger (C3HC4) 2


chr4_-_184425610 0.255 LOC389247
uncharacterized LOC389247
chrX_-_140271205 0.251 LDOC1
leucine zipper, down-regulated in cancer 1
chr8_+_144349564 0.248 NM_138465
GLI4
GLI family zinc finger 4
chr7_-_150946031 0.248 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr11_-_75917450 0.247 NM_004626
WNT11
wingless-type MMTV integration site family, member 11
chr19_+_8274179 0.247 NM_024552
CERS4
ceramide synthase 4
chr10_+_92922696 0.246 PCGF5
polycomb group ring finger 5
chrX_+_21392396 0.246 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chrX_-_140271275 0.244 LDOC1
leucine zipper, down-regulated in cancer 1
chr22_+_24115035 0.241 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr19_+_1104614 0.240 NM_001039848
GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr20_+_13976263 0.237 MACROD2
MACRO domain containing 2
chr22_+_29663997 0.233 NM_001163285
NM_001163286
NM_001163287
NM_005243
NM_013986
EWSR1




Ewing sarcoma breakpoint region 1




chr1_+_3689308 0.230 NM_001163724
LOC388588
uncharacterized protein LOC388588
chr15_+_39873276 0.228 NM_003246
THBS1
thrombospondin 1
chr2_-_96657538 0.228 ANKRD36C
ankyrin repeat domain 36C
chr16_+_30710461 0.228 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr1_+_157963310 0.227 KIRREL
kin of IRRE like (Drosophila)
chrX_-_140271293 0.220 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr12_-_69326946 0.218 NM_001005502
NM_198320
CPM

carboxypeptidase M

chr1_-_17764811 0.217 RCC2
regulator of chromosome condensation 2
chr19_+_797452 0.214 PTBP1
polypyrimidine tract binding protein 1
chr20_+_57267818 0.210 NM_024663
NPEPL1
aminopeptidase-like 1
chr10_+_114710785 0.209 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr2_+_8822112 0.208 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr2_-_62733475 0.206 NM_198276
TMEM17
transmembrane protein 17
chr8_-_97273795 0.205 NM_015942
MTERFD1
MTERF domain containing 1
chr18_+_48086402 0.203 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr19_-_46272102 0.202


chr12_-_33049664 0.202 NM_001005242
NM_004572
PKP2

plakophilin 2

chr16_+_15489619 0.202 MPV17L
MPV17 mitochondrial membrane protein-like
chr7_+_98246595 0.202 NM_002523
NPTX2
neuronal pentraxin II
chr3_+_110790774 0.202 NM_001243288
PVRL3
poliovirus receptor-related 3
chr20_-_34542205 0.201 SCAND1
SCAN domain containing 1
chr14_+_102027687 0.201 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr6_+_45390284 0.198 RUNX2
runt-related transcription factor 2
chr22_-_46659218 0.198 NM_006071
PKDREJ
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
chr17_+_45727303 0.198 KPNB1
karyopherin (importin) beta 1
chr15_+_41786055 0.196 NM_002220
ITPKA
inositol-trisphosphate 3-kinase A
chr9_+_34958171 0.195 NM_015297
KIAA1045
KIAA1045
chr11_+_65029312 0.194 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr8_+_42396716 0.194 NM_138436
NM_001135674
NM_001135675
C8orf40


chromosome 8 open reading frame 40


chr18_+_596997 0.193 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr19_+_797448 0.193 PTBP1
polypyrimidine tract binding protein 1
chr18_-_46476708 0.192 SMAD7
SMAD family member 7
chr8_+_96037186 0.192 NM_152416
C8orf38
chromosome 8 open reading frame 38
chr17_-_66287256 0.192 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr1_-_11120081 0.192 NM_003132
SRM
spermidine synthase
chr7_-_130353579 0.191 NM_012133
COPG2
coatomer protein complex, subunit gamma 2
chr14_+_105953531 0.189 CRIP1
cysteine-rich protein 1 (intestinal)
chr12_+_90103470 0.187 LOC338758
uncharacterized LOC338758
chr9_-_38424422 0.186 NM_001007563
IGFBPL1
insulin-like growth factor binding protein-like 1
chr11_-_74204708 0.184 NM_001144869
LIPT2
lipoyl(octanoyl) transferase 2 (putative)
chr13_-_78492906 0.183 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr7_+_26242007 0.183


chr20_-_32274154 0.182 NM_005225
E2F1
E2F transcription factor 1
chr3_+_140770742 0.181 NM_080862
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr3_+_42700837 0.181 ZBTB47
zinc finger and BTB domain containing 47
chr5_-_142783225 0.181 NM_000176
NM_001020825
NM_001024094
NM_001204258
NM_001204259
NM_001204260
NM_001204261
NM_001204262
NM_001204263
NM_001204264
NM_001204265
NR3C1










nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)










chr16_-_4852571 0.181 NM_024589
ROGDI
rogdi homolog (Drosophila)
chr17_+_45726838 0.179 KPNB1
karyopherin (importin) beta 1
chr7_-_73038814 0.179 NM_032951
NM_032952
NM_032953
NM_032954
MLXIPL



MLX interacting protein-like



chr17_-_48207113 0.178 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr1_-_19615203 0.177 NM_012067
AKR7A3
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
chr20_-_32274070 0.176 E2F1
E2F transcription factor 1
chr16_+_15489586 0.176 NM_001128423
NM_173803
MPV17L

MPV17 mitochondrial membrane protein-like

chr2_-_25474948 0.175 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr13_+_27825689 0.175 NM_000982
RPL21
ribosomal protein L21
chr9_-_139440237 0.174 NM_017617
NOTCH1
notch 1
chr1_-_110613233 0.174 NM_006492
ALX3
ALX homeobox 3
chr1_-_223537400 0.173 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr11_-_116968986 0.173 NM_025164
SIK3
SIK family kinase 3
chr20_-_8000370 0.172 NM_021156
TMX4
thioredoxin-related transmembrane protein 4
chr17_+_46019022 0.172 PNPO
pyridoxamine 5'-phosphate oxidase
chr7_-_47621741 0.172 NM_022748
TNS3
tensin 3
chr17_+_45727274 0.171 NM_002265
KPNB1
karyopherin (importin) beta 1
chr1_+_87797301 0.170


chr19_+_33685489 0.170 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr19_+_33072087 0.170 NM_004708
PDCD5
programmed cell death 5
chr2_+_128458943 0.169 SFT2D3
SFT2 domain containing 3
chr11_-_1593149 0.169 NM_004420
DUSP8
dual specificity phosphatase 8
chr1_-_92949045 0.169 GFI1
growth factor independent 1 transcription repressor
chr3_+_140770412 0.169 SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr22_+_29664216 0.169 EWSR1
Ewing sarcoma breakpoint region 1
chr18_+_33877630 0.168 NM_025135
FHOD3
formin homology 2 domain containing 3
chr16_+_4421774 0.167 NM_138440
VASN
vasorin
chr4_+_108852671 0.167 NM_183075
CYP2U1
cytochrome P450, family 2, subfamily U, polypeptide 1
chr13_-_79980379 0.167 RBM26
RNA binding motif protein 26
chr1_-_17764989 0.166 RCC2
regulator of chromosome condensation 2
chr20_-_50159247 0.166 NM_012340
NM_173091
NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

chr19_+_1269244 0.165 NM_001280
CIRBP
cold inducible RNA binding protein
chr19_+_35759967 0.165 USF2
upstream transcription factor 2, c-fos interacting
chr19_+_41770273 0.164 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr1_-_98386458 0.163 DPYD
dihydropyrimidine dehydrogenase
chr12_-_75723804 0.162 NM_032606
CAPS2
calcyphosine 2
chr16_+_28722781 0.161 NM_001099661
NM_001037808
NM_003752
EIF3CL
EIF3C

eukaryotic translation initiation factor 3, subunit C-like
eukaryotic translation initiation factor 3, subunit C

chr1_+_226271314 0.160


chr16_+_28722977 0.160 EIF3C
eukaryotic translation initiation factor 3, subunit C
chr12_-_133263988 0.160 POLE
polymerase (DNA directed), epsilon
chr18_-_46477080 0.159 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr19_+_35760002 0.158 USF2
upstream transcription factor 2, c-fos interacting
chr2_-_178129294 0.158 NFE2L2
nuclear factor (erythroid-derived 2)-like 2
chr16_+_447175 0.157 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr7_-_102105161 0.157 ALKBH4
alkB, alkylation repair homolog 4 (E. coli)
chr5_+_157158322 0.157 NM_017872
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr16_+_29817426 0.157 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr13_-_37494370 0.155 NM_001127217
NM_005905
SMAD9

SMAD family member 9

chr1_-_98386594 0.155 NM_000110
NM_001160301
DPYD

dihydropyrimidine dehydrogenase

chr16_-_79634610 0.155 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr16_+_30709913 0.155


chr1_-_110052285 0.154 NM_020703
AMIGO1
adhesion molecule with Ig-like domain 1
chr17_+_53343170 0.153 HLF
hepatic leukemia factor
chr5_-_43040147 0.153 NM_001014279
C5orf39
chromosome 5 open reading frame 39
chr1_-_229761793 0.153 NM_001025247
NM_014409
TAF5L

TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

chr7_+_5322553 0.153 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr1_+_228353428 0.152 NM_001010867
IBA57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr3_-_59035700 0.152 NM_198463
C3orf67
chromosome 3 open reading frame 67
chr20_-_30795346 0.151 NM_002657
PLAGL2
pleiomorphic adenoma gene-like 2
chr19_+_17970670 0.151 NM_000980
RPL18A
ribosomal protein L18a
chr3_-_50649080 0.151 CISH
cytokine inducible SH2-containing protein
chr12_-_54982271 0.151 NM_006741
PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr5_-_132166223 0.150


chr3_-_183543295 0.150 NM_024871
MAP6D1
MAP6 domain containing 1
chr5_-_32444829 0.149 NM_016107
ZFR
zinc finger RNA binding protein
chr1_-_178062734 0.147 LOC100302401
uncharacterized LOC100302401
chr20_-_62680880 0.147 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr1_-_211751953 0.147 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr6_+_106959729 0.147 NM_001624
AIM1
absent in melanoma 1
chr5_+_75699003 0.147 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr5_-_142783288 0.146 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr19_+_7895110 0.145 NM_145245
EVI5L
ecotropic viral integration site 5-like
chr9_-_139981268 0.145 LOC100289341
uncharacterized LOC100289341
chr13_+_100633416 0.145


chr18_-_77793914 0.145


chr13_-_21099914 0.145 NM_015974
CRYL1
crystallin, lambda 1
chr2_-_136633934 0.145 MCM6
minichromosome maintenance complex component 6
chr16_+_58283819 0.144 NM_001142302
NM_014157
CCDC113

coiled-coil domain containing 113

chr16_+_29818694 0.144 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr9_-_72287097 0.144 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr2_-_27712520 0.144 NM_015662
IFT172
intraflagellar transport 172 homolog (Chlamydomonas)
chr1_-_98386525 0.144 DPYD
dihydropyrimidine dehydrogenase
chr10_+_129705359 0.144 PTPRE
protein tyrosine phosphatase, receptor type, E
chr1_-_11751677 0.143 NM_001127325
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr11_+_75479766 0.143 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr17_+_73257944 0.143 MRPS7
mitochondrial ribosomal protein S7
chr11_-_777470 0.143 NM_182612
PDDC1
Parkinson disease 7 domain containing 1
chr16_+_84733606 0.142 USP10
ubiquitin specific peptidase 10
chr20_+_6748744 0.142 NM_001200
BMP2
bone morphogenetic protein 2
chr2_-_74734498 0.142 PCGF1
polycomb group ring finger 1
chr1_-_211752052 0.141 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr2_+_102314162 0.141 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr19_-_58858900 0.141 A1BG
alpha-1-B glycoprotein
chrX_-_3631295 0.141 PRKX
protein kinase, X-linked
chr7_-_47621635 0.141 TNS3
tensin 3
chr7_-_130353561 0.140 COPG2
coatomer protein complex, subunit gamma 2
chr1_+_38259458 0.140 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr19_-_1863425 0.140 KLF16
Kruppel-like factor 16
chr19_+_35759880 0.140 NM_003367
NM_207291
USF2

upstream transcription factor 2, c-fos interacting

chr19_-_18717467 0.140 CRLF1
cytokine receptor-like factor 1
chr15_+_51633712 0.140 NM_181789
GLDN
gliomedin
chr19_+_1104068 0.139 GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr10_+_104474297 0.139 NM_178858
SFXN2
sideroflexin 2
chr13_+_100633977 0.139 NM_007129
ZIC2
Zic family member 2
chr17_+_34842472 0.139 NM_004773
ZNHIT3
zinc finger, HIT-type containing 3
chr2_+_181845088 0.138 NM_182678
NM_006357
UBE2E3

ubiquitin-conjugating enzyme E2E 3

chr12_+_123259055 0.138 NM_201435
CCDC62
coiled-coil domain containing 62
chr20_-_8000254 0.138 TMX4
thioredoxin-related transmembrane protein 4

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.