Motif ID: HNF1A.p2

Z-value: 1.282


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v1_chr12_+_121416548_1214165690.049.4e-01Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_99344421 2.290 HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr1_-_197036350 1.478 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr4_+_74347461 1.288 NM_001133
AFM
afamin
chr10_+_115312777 1.112 NM_004132
HABP2
hyaluronan binding protein 2
chr1_+_48688356 0.986 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr19_-_36303766 0.835 PRODH2
proline dehydrogenase (oxidase) 2
chr12_+_20963637 0.804 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chrX_-_15683153 0.738 NM_020665
TMEM27
transmembrane protein 27
chrX_-_105282714 0.708 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr12_+_25205488 0.651 LRMP
lymphoid-restricted membrane protein
chr2_+_234668914 0.648 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr3_+_186383770 0.635 NM_000412
HRG
histidine-rich glycoprotein
chr14_+_95027760 0.565 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr4_-_72649734 0.559 NM_000583
GC
group-specific component (vitamin D binding protein)
chr15_+_62939509 0.539 NM_015059
TLN2
talin 2
chr19_-_33360641 0.520 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chr19_-_36303724 0.519 PRODH2
proline dehydrogenase (oxidase) 2
chr20_+_42984088 0.506 HNF4A
hepatocyte nuclear factor 4, alpha
chr4_+_155484131 0.501 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr20_+_43030005 0.488 HNF4A
hepatocyte nuclear factor 4, alpha
chr7_-_50633042 0.476 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr6_-_24383519 0.462 NM_001195610
DCDC2
doublecortin domain containing 2
chr2_-_228244005 0.456 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr3_-_164796275 0.445 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr20_+_43029936 0.442 HNF4A
hepatocyte nuclear factor 4, alpha
chr4_-_155511838 0.438 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr20_+_43029973 0.426 HNF4A
hepatocyte nuclear factor 4, alpha
chr10_+_99344079 0.424 NM_001134670
NM_138413
HOGA1

4-hydroxy-2-oxoglutarate aldolase 1

chr7_-_47579192 0.408 TNS3
tensin 3
chr17_+_73553883 0.404 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr20_+_42984338 0.401 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr19_-_36304200 0.384 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr4_+_69962191 0.383 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr19_-_58864820 0.382 NM_130786
A1BG
alpha-1-B glycoprotein
chr17_+_1646143 0.380 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr5_-_135290521 0.379 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr5_-_147211141 0.377 SPINK1
serine peptidase inhibitor, Kazal type 1
chr8_-_17752847 0.369 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr14_-_94855120 0.367 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr3_-_169587598 0.364 NM_024727
LRRC31
leucine rich repeat containing 31
chr14_-_94854910 0.355 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr19_+_799281 0.347 PTBP1
polypyrimidine tract binding protein 1
chr4_-_70080448 0.334 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr5_-_147211235 0.330 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr20_+_43029865 0.329 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr4_-_69817478 0.329 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr7_+_94292737 0.323 PEG10
paternally expressed 10
chr6_-_52628272 0.323 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr17_-_64225496 0.321 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_+_114066554 0.320 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr7_-_107443631 0.314 NM_000111
SLC26A3
solute carrier family 26, member 3
chr17_+_1646129 0.310 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chrX_+_36065052 0.297 NM_173695
CXorf59
chromosome X open reading frame 59
chr17_+_73642645 0.287 NM_001162997
C17orf110
chromosome 17 open reading frame 110
chr12_+_10331556 0.285 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr14_-_94789641 0.284 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chrX_+_107288199 0.280 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr13_+_51915167 0.277 NM_001101320
SERPINE3
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
chr10_-_101690655 0.253 DNMBP
dynamin binding protein
chr6_+_167536240 0.247 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chrX_-_33146543 0.242 NM_004010
NM_004009
DMD

dystrophin

chrX_+_70435087 0.234 GJB1
gap junction protein, beta 1, 32kDa
chr8_-_124749573 0.233 NM_001003954
NM_004306
ANXA13

annexin A13

chr10_-_52645384 0.232 A1CF
APOBEC1 complementation factor
chr19_-_10213332 0.230 NM_031917
ANGPTL6
angiopoietin-like 6
chr4_+_74301932 0.228 NM_001134
AFP
alpha-fetoprotein
chr5_+_175976342 0.225 NM_017675
CDHR2
cadherin-related family member 2
chr6_+_31623668 0.224 NM_019101
APOM
apolipoprotein M
chr7_+_104752312 0.223 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr6_+_31623688 0.223 APOM
apolipoprotein M
chr4_+_187187342 0.223 F11
coagulation factor XI
chr10_-_52645430 0.222 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr10_-_32667543 0.214 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr4_+_187187117 0.214 NM_000128
F11
coagulation factor XI
chr12_-_56679729 0.205 CS
citrate synthase
chr2_-_88427535 0.202 NM_001443
FABP1
fatty acid binding protein 1, liver
chr20_+_62371218 0.201 SLC2A4RG
SLC2A4 regulator
chr7_-_44580857 0.200 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr3_-_141719188 0.197 NM_001178140
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_-_70725792 0.195 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr15_+_58724174 0.194 NM_000236
LIPC
lipase, hepatic
chr18_+_29171729 0.194 NM_000371
TTR
transthyretin
chr1_+_17906941 0.193 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr2_+_102508333 0.192 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr20_+_42187634 0.191 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr15_-_90349819 0.191 ANPEP
alanyl (membrane) aminopeptidase
chr4_-_110723127 0.191 CFI
complement factor I
chr19_-_3062911 0.188 NM_198969
AES
amino-terminal enhancer of split
chr17_+_1646290 0.184 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr11_+_46740759 0.183 F2
coagulation factor II (thrombin)
chr12_-_10573041 0.180 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr7_+_95115212 0.177 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr5_+_140529619 0.173 NM_018939
PCDHB6
protocadherin beta 6
chr1_-_198906536 0.173 LOC100131234
familial acute myelogenous leukemia related factor
chrX_+_70435048 0.172 NM_001097642
GJB1
gap junction protein, beta 1, 32kDa
chr1_+_94057518 0.172 LOC100129046
uncharacterized LOC100129046
chr3_-_161089747 0.172 NM_001040100
SPTSSB
serine palmitoyltransferase, small subunit B
chr7_-_27166638 0.171 NM_153631
HOXA3
homeobox A3
chr17_-_67138013 0.170 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr2_-_102003923 0.168 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr3_+_149192479 0.167 TM4SF4
transmembrane 4 L six family member 4
chr3_-_57234279 0.166 NM_003865
HESX1
HESX homeobox 1
chr4_-_110723334 0.165 NM_000204
CFI
complement factor I
chr2_+_102508377 0.159 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr15_-_51397472 0.156 NM_207381
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr3_+_63953419 0.156 NM_001128149
ATXN7
ataxin 7
chr9_-_215892 0.155 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr11_-_118900078 0.154 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr9_-_123812535 0.152 NM_001735
C5
complement component 5
chr8_-_95220769 0.150 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr20_+_62371109 0.149 NM_020062
SLC2A4RG
SLC2A4 regulator
chr12_-_113841654 0.143 NM_006843
SDS
serine dehydratase
chr22_-_22337131 0.139 NM_003935
TOP3B
topoisomerase (DNA) III beta
chr6_+_31707724 0.139 NM_002441
NM_025259
NM_172165
NM_172166
MSH5-C6orf26
MSH5



MSH5-C6orf26 readthrough (non-protein coding)
mutS homolog 5 (E. coli)



chr1_+_199996729 0.138 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr6_-_25874439 0.138 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr2_+_234526290 0.136 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr1_+_207262211 0.136 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr11_+_561449 0.135 NM_001143994
NM_003475
RASSF7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr2_-_134179325 0.135 NCKAP5
NCK-associated protein 5
chr3_+_149192367 0.135 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr6_-_31681845 0.133


chr16_+_57728711 0.132 NM_032269
CCDC135
coiled-coil domain containing 135
chr5_-_111093251 0.129 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr10_-_121602030 0.127 MCMBP
minichromosome maintenance complex binding protein
chr1_+_94057581 0.126 LOC100129046
uncharacterized LOC100129046
chr12_+_20724797 0.123 NM_001244683
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr20_+_32250089 0.123 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr20_+_42187705 0.121 SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_1711453 0.116 NM_001198994
NADK
NAD kinase
chr16_+_89696775 0.115 DPEP1
dipeptidase 1 (renal)
chr1_-_154578775 0.111 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr11_-_71746966 0.109


chr19_+_39616384 0.105 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr10_+_96698409 0.105 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chrX_-_131547536 0.102 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr21_-_36231794 0.102 RUNX1
runt-related transcription factor 1
chr17_-_27053948 0.100 NM_001160407
TLCD1
TLC domain containing 1
chr5_-_111093792 0.099 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr3_+_184016985 0.097 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr11_-_101787252 0.096 NM_178127
ANGPTL5
angiopoietin-like 5
chr12_+_21284127 0.096 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr1_-_153585504 0.094 NM_080388
S100A16
S100 calcium binding protein A16
chr7_-_92855780 0.094 NM_001039372
HEPACAM2
HEPACAM family member 2
chr4_+_86699858 0.094 ARHGAP24
Rho GTPase activating protein 24
chr20_+_2944918 0.094 PTPRA
protein tyrosine phosphatase, receptor type, A
chr4_-_100212085 0.093 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr17_+_68071386 0.089 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr6_-_33548017 0.084 NM_001188
BAK1
BCL2-antagonist/killer 1
chr1_-_230849936 0.084 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr12_-_18243052 0.083 NM_024730
RERGL
RERG/RAS-like
chr4_-_987163 0.078 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr12_-_24102563 0.077 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr1_+_119911395 0.075 NM_001005783
NM_016527
HAO2

hydroxyacid oxidase 2 (long chain)

chr2_+_62934030 0.075 NM_001142614
EHBP1
EH domain binding protein 1
chr8_+_98703361 0.075 MTDH
metadherin
chr15_+_63889551 0.074 NM_203373
FBXL22
F-box and leucine-rich repeat protein 22
chr19_+_45417576 0.073 APOC1
apolipoprotein C-I
chr3_-_71353910 0.073 NM_001244812
FOXP1
forkhead box P1
chr14_-_94759594 0.073 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr7_-_14025826 0.073 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr12_-_54653317 0.071 NM_001127322
CBX5
chromobox homolog 5
chr9_+_130860769 0.070 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr5_-_111091947 0.067 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr3_+_158991035 0.066 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr10_-_74114865 0.065 NM_001002762
NM_017626
DNAJB12

DnaJ (Hsp40) homolog, subfamily B, member 12

chr3_+_158991090 0.065 SCHIP1
schwannomin interacting protein 1
chr7_+_129015483 0.064 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr17_+_59477473 0.064 TBX2
T-box 2
chr6_+_106534210 0.064 PRDM1
PR domain containing 1, with ZNF domain
chr6_-_108145507 0.064 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr14_+_65171243 0.063 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr10_+_111765725 0.063 NM_019903
ADD3
adducin 3 (gamma)
chr16_-_87970107 0.063 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr12_+_56624500 0.063 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr5_-_83016850 0.062 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr11_+_46740736 0.062 NM_000506
F2
coagulation factor II (thrombin)
chr5_+_76435073 0.061


chr14_-_94759556 0.061 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr11_-_3803310 0.060 NUP98
nucleoporin 98kDa
chr4_+_57036360 0.059 NM_020722
KIAA1211
KIAA1211
chr3_-_126327397 0.059 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr11_+_46740769 0.058 F2
coagulation factor II (thrombin)
chr11_+_64323089 0.058 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr12_+_70133179 0.057 NM_175623
NM_175625
RAB3IP

RAB3A interacting protein (rabin3)

chr1_-_36107444 0.057 NM_002794
PSMB2
proteasome (prosome, macropain) subunit, beta type, 2
chr16_+_21245015 0.057 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr9_+_130860816 0.057 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr16_-_4896197 0.055 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr19_-_58067724 0.054 NM_001039654
ZNF550
zinc finger protein 550
chr10_+_77542518 0.053 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr6_+_64231626 0.052 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr14_-_47812394 0.052 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr17_+_78935063 0.052 RPTOR
regulatory associated protein of MTOR, complex 1
chr2_-_169103886 0.051 NM_013233
STK39
serine threonine kinase 39
chr11_-_104827421 0.050 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr14_-_94759360 0.048 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr3_+_141105283 0.048


chr16_+_76343734 0.046 NM_138994
CNTNAP4
contactin associated protein-like 4
chr3_+_160394946 0.045 NM_025047
ARL14
ADP-ribosylation factor-like 14

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.