Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.554


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF7hg19_v1_chr5_+_133450353_1334506850.532.8e-01Click!
TCF7L2hg19_v1_chr10_+_114709963_1147106410.443.8e-01Click!
TCF7L1hg19_v1_chr2_+_85360373_85360946-0.394.4e-01Click!
LEF1hg19_v1_chr4_-_109089444_1090901540.384.6e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_42234562 1.024 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr6_-_29527477 0.822 UBD
ubiquitin D
chr20_-_44006876 0.790 NM_014477
TP53TG5
TP53 target 5
chr12_-_122296619 0.775 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chrX_+_12993224 0.693 NM_021109
TMSB4X
thymosin beta 4, X-linked
chr22_-_31688329 0.664 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr5_-_135290521 0.639 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chrX_-_105282714 0.613 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr6_-_29527701 0.608 NM_006398
UBD
ubiquitin D
chr2_-_231989755 0.581 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr4_-_100065372 0.567 NM_000670
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr17_-_39093671 0.561 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr7_+_139528951 0.557 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr11_-_87908551 0.547 NM_022337
RAB38
RAB38, member RAS oncogene family
chr14_-_21572374 0.535


chr12_-_49582296 0.529 TUBA1A
tubulin, alpha 1a
chr22_+_24105207 0.502 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr12_-_49582800 0.466 NM_006009
TUBA1A
tubulin, alpha 1a
chr4_+_39063851 0.466 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr4_-_70626429 0.462 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr17_-_39092714 0.453 KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_170633312 0.432 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr4_+_109543670 0.431 RPL34
ribosomal protein L34
chr19_+_35782988 0.425 NM_001199216
NM_002361
NM_080600
MAG


myelin associated glycoprotein


chr10_+_114154522 0.416 ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_+_1718424 0.415 NM_001012416
KRTAP5-6
keratin associated protein 5-6
chr1_-_178062734 0.412 LOC100302401
uncharacterized LOC100302401
chr2_-_39348127 0.397 SOS1
son of sevenless homolog 1 (Drosophila)
chr2_+_172378856 0.389 NM_001127383
NM_024843
CYBRD1

cytochrome b reductase 1

chr17_+_7533452 0.383 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr13_+_24144402 0.380 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr6_+_34216344 0.372


chr20_+_33299315 0.367 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr19_+_50084586 0.365 NM_000951
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr3_+_151488214 0.360 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr14_-_65409445 0.356 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr7_+_142982039 0.355 NM_001242773
NM_001242774
NM_001242775
NM_001242776
NM_001242777
NM_153345
TMEM139





transmembrane protein 139





chr15_+_41136622 0.351 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr4_-_109089444 0.341 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr15_+_41136178 0.333 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr19_-_17375522 0.332 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr15_+_40294749 0.327 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr14_-_94443065 0.316 NM_001202429
ASB2
ankyrin repeat and SOCS box containing 2
chr3_+_46448678 0.316 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr4_-_157892545 0.315 NM_016205
PDGFC
platelet derived growth factor C
chr14_+_74486049 0.309 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr17_-_10372875 0.305 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr19_-_3028901 0.304 NM_003260
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr18_-_25757351 0.301 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr10_-_91295310 0.300 NM_213606
SLC16A12
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
chr2_+_171571800 0.296 NM_001003845
SP5
Sp5 transcription factor
chr17_-_42081836 0.292 NM_004160
PYY
peptide YY
chr12_-_11139510 0.287 NM_176890
TAS2R50
taste receptor, type 2, member 50
chr10_-_73848278 0.285 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_-_91794589 0.282 NM_001161528
LRRD1
leucine-rich repeats and death domain containing 1
chr4_-_157892466 0.276 PDGFC
platelet derived growth factor C
chr16_+_28996146 0.276 NM_001014989
LAT
linker for activation of T cells
chr4_-_157892054 0.273 PDGFC
platelet derived growth factor C
chr20_-_43977023 0.271 NM_002999
SDC4
syndecan 4
chr1_+_160160284 0.271 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr2_-_208031570 0.270 KLF7
Kruppel-like factor 7 (ubiquitous)
chr17_-_39580657 0.269 NM_003770
KRT37
keratin 37
chr3_-_134093235 0.262 NM_016201
AMOTL2
angiomotin like 2
chr10_-_73848766 0.261 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr7_+_80275967 0.251 CD36
CD36 molecule (thrombospondin receptor)
chr17_+_75447325 0.251 SEPT9
septin 9
chr10_-_126107493 0.249 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr6_+_143929316 0.248 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr18_-_46469118 0.245 NM_001190823
SMAD7
SMAD family member 7
chr9_-_35563895 0.244 NM_001099951
NM_001164310
FAM166B

family with sequence similarity 166, member B

chr19_+_1026271 0.243 NM_004368
NM_201277
CNN2

calponin 2

chr6_+_27925018 0.239 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr10_+_73723992 0.239 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr18_-_25756946 0.237 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr18_+_59992519 0.235 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr11_-_10590078 0.230 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr1_+_161185084 0.229 NM_004106
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr14_+_85996512 0.227 FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_+_196760 0.226 NM_053280
ODF3
outer dense fiber of sperm tails 3
chr3_-_123339423 0.225 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr6_-_32145841 0.224 NM_032741
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr17_+_7812703 0.223 CHD3
chromodomain helicase DNA binding protein 3
chr11_+_56143099 0.222 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr11_+_65122281 0.222 NM_145719
TIGD3
tigger transposable element derived 3
chr19_+_1026608 0.221 CNN2
calponin 2
chr2_+_179184970 0.220 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr1_-_6479880 0.220 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr20_-_39317875 0.219 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr11_+_100862719 0.218 NM_032021
TMEM133
transmembrane protein 133
chr3_-_139195300 0.217 NM_004164
RBP2
retinol binding protein 2, cellular
chr1_+_174844655 0.215 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr11_-_75921785 0.214 WNT11
wingless-type MMTV integration site family, member 11
chr10_+_54074037 0.213 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr14_-_23451704 0.212 NM_032876
AJUBA
ajuba LIM protein
chr10_-_96829074 0.211 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr13_-_50367027 0.210 NM_002267
KPNA3
karyopherin alpha 3 (importin alpha 4)
chr1_+_100111430 0.210 NM_017734
PALMD
palmdelphin
chr1_+_9299902 0.209 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr5_-_114515733 0.207 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr12_-_16759939 0.207 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_98897622 0.206 LOC643770
uncharacterized LOC643770
chr19_-_11450254 0.206 NM_004283
RAB3D
RAB3D, member RAS oncogene family
chr15_+_71184781 0.205 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr2_+_71127725 0.204 VAX2
ventral anterior homeobox 2
chr1_+_59762486 0.204 NM_001113411
NM_018291
FGGY

FGGY carbohydrate kinase domain containing

chr4_-_103266396 0.204 NM_001135147
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr9_-_104147261 0.203 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr21_+_35736322 0.202 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr1_-_16345284 0.199 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr17_-_38020421 0.199 NM_012481
NM_183228
NM_183229
NM_183230
NM_183231
NM_183232
IKZF3





IKAROS family zinc finger 3 (Aiolos)





chr19_+_1026627 0.199 CNN2
calponin 2
chr6_-_2840683 0.198 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr2_+_71127715 0.197 NM_012476
VAX2
ventral anterior homeobox 2
chr7_+_65958643 0.196


chrX_-_73512376 0.196 FTX
FTX transcript, XIST regulator (non-protein coding)
chr13_-_72440557 0.196 DACH1
dachshund homolog 1 (Drosophila)
chr4_+_106067031 0.193 NM_017628
TET2
tet methylcytosine dioxygenase 2
chr2_+_47596447 0.193 EPCAM
epithelial cell adhesion molecule
chr1_-_183559669 0.192 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr2_+_187454987 0.191 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr4_+_77953942 0.191 SEPT11
septin 11
chr2_-_86564632 0.189 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr15_+_89631625 0.185 ABHD2
abhydrolase domain containing 2
chr14_+_85996454 0.184 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_+_60635014 0.183 NM_207341
ZP1
zona pellucida glycoprotein 1 (sperm receptor)
chr5_-_83016850 0.182 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr10_-_73848530 0.181 NM_001244950
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr16_+_2286467 0.180 NM_001374
DNASE1L2
deoxyribonuclease I-like 2
chr2_+_47596286 0.180 NM_002354
EPCAM
epithelial cell adhesion molecule
chr2_+_172378756 0.179 CYBRD1
cytochrome b reductase 1
chr16_-_18812691 0.178 NM_015161
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr5_+_133450353 0.178 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr4_-_68621803 0.177 NM_000406
NM_001012763
GNRHR

gonadotropin-releasing hormone receptor

chr10_-_5045967 0.177 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr17_+_41052813 0.177 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr3_+_156392369 0.177 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr5_+_161494647 0.176 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr20_+_30598244 0.174 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr15_+_89631731 0.173 ABHD2
abhydrolase domain containing 2
chr11_+_10830752 0.171


chr15_+_48010685 0.170 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr19_-_7990974 0.170 NM_206833
CTXN1
cortexin 1
chr17_+_3379295 0.170 NM_000049
ASPA
aspartoacylase
chr15_-_55880508 0.169 PYGO1
pygopus homolog 1 (Drosophila)
chr11_+_58874614 0.168 NM_001142703
NM_001142704
NM_198947
FAM111B


family with sequence similarity 111, member B


chr1_+_170115187 0.167 NM_001136107
METTL11B
methyltransferase like 11B
chr12_-_15114495 0.167 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr16_+_57702156 0.164 NM_170776
GPR97
G protein-coupled receptor 97
chr6_-_27440459 0.163 NM_007149
ZNF184
zinc finger protein 184
chr6_-_160679789 0.163 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr12_-_58209840 0.162 NM_006576
AVIL
advillin
chr3_-_160283311 0.162 KPNA4
karyopherin alpha 4 (importin alpha 3)
chr7_+_137761177 0.161 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr1_+_149858466 0.161 NM_003517
HIST2H2AC
histone cluster 2, H2ac
chr8_+_120079423 0.159 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr18_-_24445652 0.158 NM_001650
AQP4
aquaporin 4
chrX_-_153599581 0.157 FLNA
filamin A, alpha
chr6_+_27114860 0.157 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chrX_+_152760346 0.157 NM_001711
BGN
biglycan
chr14_-_21572789 0.157 NM_001102454
ZNF219
zinc finger protein 219
chr19_+_8274179 0.157 NM_024552
CERS4
ceramide synthase 4
chr8_-_125716430 0.156 MTSS1
metastasis suppressor 1
chr6_+_159070994 0.154 NM_001009991
NM_001242384
NM_001242394
NM_001242395
SYTL3



synaptotagmin-like 3



chrX_-_153200208 0.154 NM_003491
NAA10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr4_+_90033967 0.153 NM_145715
TIGD2
tigger transposable element derived 2
chr12_+_80603232 0.153 NM_173591
OTOGL
otogelin-like
chr4_-_103266286 0.153 NM_022154
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_-_62475060 0.152 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr6_+_64282449 0.151 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr3_-_123339178 0.151 MYLK
myosin light chain kinase
chr7_+_73245192 0.150 NM_001305
CLDN4
claudin 4
chr17_+_19990334 0.148 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr7_+_140103842 0.148 NM_001008749
RAB19
RAB19, member RAS oncogene family
chrX_-_135962929 0.148 NM_001164803
NM_002139
RBMX

RNA binding motif protein, X-linked

chr5_+_177631534 0.148 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr5_+_55149149 0.146 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr11_-_75917450 0.146 NM_004626
WNT11
wingless-type MMTV integration site family, member 11
chr7_+_20370324 0.145 ITGB8
integrin, beta 8
chr3_-_160283361 0.145 NM_002268
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr7_-_32982574 0.143 RP9P
retinitis pigmentosa 9 pseudogene
chr15_+_89631695 0.143 ABHD2
abhydrolase domain containing 2
chr10_-_93669184 0.142 NM_152429
FGFBP3
fibroblast growth factor binding protein 3
chr9_-_36400817 0.142 NM_194328
NM_194332
RNF38

ring finger protein 38

chr20_-_17511973 0.141 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr7_-_134143864 0.141 NM_001628
AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr5_+_140235594 0.141 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr13_-_72441312 0.141 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr6_-_33547833 0.140 BAK1
BCL2-antagonist/killer 1
chr4_-_17806820 0.139 DCAF16
DDB1 and CUL4 associated factor 16
chr3_-_164796275 0.138 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr21_-_43735705 0.138 NM_003226
TFF3
trefoil factor 3 (intestinal)
chrX_-_128788913 0.136 NM_017413
APLN
apelin
chr17_-_38721701 0.136 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr11_+_94800055 0.136 NM_032102
SRSF8
serine/arginine-rich splicing factor 8
chr3_-_9921933 0.136 NM_001199551
NM_001199552
CIDEC

cell death-inducing DFFA-like effector c

chr1_+_32042125 0.135 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr3_+_132318980 0.134 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr22_-_42336222 0.134 NM_001110215
CENPM
centromere protein M
chr6_+_64281910 0.133 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr9_-_36400212 0.133 NM_022781
NM_194329
RNF38

ring finger protein 38


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.